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sentences

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3).
T2 88-131 Sentence denotes Effects of autophosphorylation on activity.
T3 132-283 Sentence denotes p21-activated protein kinase gamma-PAK (Pak2, PAK I) is cleaved by CPP32 (caspase 3) during apoptosis and plays a key role in regulation of cell death.
T4 284-500 Sentence denotes In vitro, CPP32 cleaves recombinant gamma-PAK into two peptides; 1-212 contains the majority of the regulatory domain whereas 213-524 contains 34 amino acids of the regulatory domain plus the entire catalytic domain.
T5 501-581 Sentence denotes Following cleavage, both peptides become autophosphorylated with [gamma-32P]ATP.
T6 582-848 Sentence denotes Peptide 1-212 migrates at 27,000 daltons (p27) upon SDS-polyacrylamide gel electrophoresis and at 32,000 daltons following autophosphorylation on serine (p27P); the catalytic subunit migrates at 34,000 daltons (p34) before and after autophosphorylation on threonine.
T7 849-982 Sentence denotes Following caspase cleavage, a significant lag (approximately 5 min) is observed before autophosphorylation and activity are detected.
T8 983-1138 Sentence denotes When gamma-PAK is autophosphorylated with ATP(Mg) alone and then cleaved, only p27 contains phosphate, and the enzyme is inactive with exogenous substrate.
T9 1139-1307 Sentence denotes After autophosphorylation of gamma-PAK in the presence of Cdc42(GTPgammaS) or histone 4, both cleavage products contain phosphate and gamma-PAK is catalytically active.
T10 1308-1436 Sentence denotes Mutation of the conserved Thr-402 to alanine greatly reduces autophosphorylation and protein kinase activity following cleavage.
T11 1437-1658 Sentence denotes Thus activation of gamma-PAK via cleavage by CPP32 is a two-step mechanism wherein autophosphorylation of the regulatory domain is a priming step, and activation coincides with autophosphorylation of the catalytic domain.

2015-BEL-Sample

Id Subject Object Predicate Lexical cue
T1 71-283 cat(p(HGNC:CASP3)) directlyIncreases kin(p(HGNC:PAK2)) denotes P32 (caspase 3). Effects of autophosphorylation on activity. p21-activated protein kinase gamma-PAK (Pak2, PAK I) is cleaved by CPP32 (caspase 3) during apoptosis and plays a key role in regulation of cell death.

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20000042 71-283 cat(p(HGNC:CASP3)) directlyIncreases kin(p(HGNC:PAK2)) denotes P32 (caspase 3). Effects of autophosphorylation on activity. p21-activated protein kinase gamma-PAK (Pak2, PAK I) is cleaved by CPP32 (caspase 3) during apoptosis and plays a key role in regulation of cell death.
BEL:20000042 71-282 cat(p(HGNC:CASP3)) directlyIncreases kin(p(HGNC:PAK2)) denotes P32 (caspase 3). Effects of autophosphorylation on activity. p21-activated protein kinase gamma-PAK (Pak2, PAK I) is cleaved by CPP32 (caspase 3) during apoptosis and plays a key role in regulation of cell death
BEL:20001174 132-499 cat(p(HGNC:CASP3)) directlyIncreases kin(p(HGNC:PAK2)) denotes p21-activated protein kinase gamma-PAK (Pak2, PAK I) is cleaved by CPP32 (caspase 3) during apoptosis and plays a key role in regulation of cell death. In vitro, CPP32 cleaves recombinant gamma-PAK into two peptides; 1-212 contains the majority of the regulatory domain whereas 213-524 contains 34 amino acids of the regulatory domain plus the entire catalytic domain