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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 12-20 protein denotes cytokine
T2 166-169 protein denotes IgE
T3 173-182 protein denotes cytokines
T4 198-224 protein denotes STAT transcription factors
T5 243-246 protein denotes IgE
T6 250-254 protein denotes IL-4
T7 259-264 protein denotes IL-13
T8 302-348 protein denotes intracellular signal-transducing protein Stat6
T9 376-379 protein denotes IgE
T10 399-411 protein denotes interferon-y
T11 413-422 protein denotes IFN-gamma
T12 457-462 protein denotes Statl
T13 549-552 protein denotes IgE
T14 607-610 protein denotes IgE
T15 653-661 protein denotes cytokine
T16 690-695 protein denotes Stat6
T17 706-711 cell_type denotes PBMCs
T18 765-768 protein denotes IgE
T19 814-817 protein denotes IgE
T20 879-882 protein denotes IgE
T21 933-937 protein denotes IL-4
T22 1087-1091 protein denotes IL-4
T23 1169-1172 protein denotes IgE
T24 1194-1199 protein denotes IL-13
T25 1236-1241 protein denotes Stat6
T26 1261-1266 cell_type denotes PBMCs
T27 1335-1340 protein denotes Stat6
T28 1392-1396 protein denotes IL-4
T29 1496-1503 cell_type denotes B cells
T30 1534-1537 protein denotes IgE
T31 1550-1555 cell_type denotes PBMCs
T32 1640-1643 protein denotes IgE
T33 1719-1723 protein denotes IL-4
T34 1733-1738 protein denotes IL-13
T35 1788-1792 protein denotes IL-4
T36 1847-1852 protein denotes Stat6
T37 1867-1872 cell_type denotes PBMCs
T38 1972-1975 protein denotes IgE
T39 2010-2013 protein denotes IgE
T40 2052-2059 cell_type denotes B cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-91 Sentence denotes Analysis of cytokine signaling in patients with extrinsic asthma and hyperimmunoglobulin E.
S2 92-225 Sentence denotes BACKGROUND: Recent data suggest that the regulation of class switching to IgE by cytokines is mediated by STAT transcription factors.
S3 226-463 Sentence denotes The induction of IgE by IL-4 and IL-13 occurs through the activation of the intracellular signal-transducing protein Stat6, whereas the inhibition of IgE class switching by interferon-y (IFN-gamma) occurs through the activation of Statl.
S4 464-696 Sentence denotes OBJECTIVE: We hypothesized that in extrinsic asthma or in cases of markedly elevated IgE (ie, hyperimmunoglobulin E [HIE]) increased levels of IgE may be associated with alterations in the cytokine levels or the activation of Stat6.
S5 697-914 Sentence denotes METHODS: PBMCs and sera from 8 patients with extrinsic asthma (mean IgE, 285+/-100 IU/mL), 3 patients with HIE (mean IgE, 7050+/-1122 IU/mL), and 14 nonatopic control subjects (mean IgE, 112+/-28 IU/mL) were analyzed.
S6 915-1180 Sentence denotes RESULTS: The mean IL-4 level detected by ELISA was much greater in patients with HIE than control subjects (88.6+/-11.5 pg/mL vs 11.5+/-7.1 pg/mL, P = .005), and increased IL-4 levels among patients with both asthma and HIE correlated with the increased IgE levels.
S7 1181-1225 Sentence denotes In contrast, IL-13 levels were not elevated.
S8 1226-1319 Sentence denotes Levels of Stat6 protein present in PBMCs did not differ in the patients and control subjects.
S9 1320-1451 Sentence denotes Examination of Stat6 DNA-binding activity demonstrated no activation of IL-4 signaling in patients with either HIE or acute asthma.
S10 1452-1595 Sentence denotes Interestingly, evidence for the presence of B cells that have already switched to IgE was seen in PBMCs of several patients with asthma or HIE.
S11 1596-1976 Sentence denotes CONCLUSION: These results indicate that (1) IgE production in asthma and HIE usually is associated with elevated levels of IL-4, but not IL-13, in the peripheral blood; (2) the increased sera IL-4 levels in asthma and HIE are not sufficient to induce Stat6 activation in PBMCs; and (3) evidence of switch recombination to epsilon may be detected in isolated cases of elevated IgE.
S12 1977-2174 Sentence denotes This implies that high levels of IgE in these patients either results from B cells that have already undergone class switching, from Ig class switching that is localized to target tissues, or both.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C3 48-64 NP denotes extrinsic asthma
C4 69-90 NP denotes hyperimmunoglobulin E
C2 48-90 NP denotes extrinsic asthma and hyperimmunoglobulin E
C1 34-90 NP denotes patients with extrinsic asthma and hyperimmunoglobulin E
C5 147-162 NP denotes class switching
C6 166-169 NP denotes IgE
C7 243-246 NP denotes IgE
C8 250-254 NP denotes IL-4
C10 298-348 NP denotes the intracellular signal-transducing protein Stat6
C9 280-348 NP denotes the activation of the intracellular signal-transducing protein Stat6
C11 499-515 NP denotes extrinsic asthma
C13 607-610 NP denotes IgE
C12 587-610 NP denotes increased levels of IgE
C15 690-695 NP denotes Stat6
C14 672-695 NP denotes the activation of Stat6
C16 742-758 NP denotes extrinsic asthma
C18 804-807 NP denotes HIE
C17 788-807 NP denotes 3 patients with HIE
C19 843-872 NP denotes 14 nonatopic control subjects
C21 996-999 NP denotes HIE
C20 982-999 NP denotes patients with HIE
C22 1005-1021 NP denotes control subjects
C24 1119-1138 NP denotes both asthma and HIE
C23 1105-1138 NP denotes patients with both asthma and HIE
C25 1155-1179 NP denotes the increased IgE levels
C26 1236-1249 NP denotes Stat6 protein
C27 1261-1266 NP denotes PBMCs
C28 1285-1297 NP denotes the patients
C29 1302-1318 NP denotes control subjects
C30 1431-1434 NP denotes HIE
C31 1496-1503 NP denotes B cells
C32 1504-1508 NP denotes that
C33 1534-1537 NP denotes IgE
C34 1581-1587 NP denotes asthma
C35 1591-1594 NP denotes HIE
C37 1658-1664 NP denotes asthma
C38 1669-1672 NP denotes HIE
C36 1658-1672 NP denotes asthma and HIE
C39 1719-1723 NP denotes IL-4
C41 1803-1809 NP denotes asthma
C42 1814-1817 NP denotes HIE
C40 1803-1817 NP denotes asthma and HIE
C43 1847-1863 NP denotes Stat6 activation
C44 1867-1873 NP denotes PBMCs;
C45 2010-2013 NP denotes IgE
C46 2017-2031 NP denotes these patients
C47 2052-2059 NP denotes B cells
C48 2060-2064 NP denotes that
C49 2088-2103 NP denotes class switching
C50 2110-2128 NP denotes Ig class switching
C51 2129-2133 NP denotes that
R1 C7 C6 coref-ident IgE,IgE
R2 C11 C3 coref-ident extrinsic asthma,extrinsic asthma
R3 C13 C7 coref-ident IgE,IgE
R4 C15 C10 coref-ident Stat6,the intracellular signal-transducing protein Stat6
R5 C14 C9 coref-ident the activation of Stat6,the activation of the intracellular signal-transducing protein Stat6
R6 C16 C11 coref-ident extrinsic asthma,extrinsic asthma
R7 C18 C4 coref-ident HIE,hyperimmunoglobulin E
R8 C21 C18 coref-ident HIE,HIE
R9 C20 C17 coref-ident patients with HIE,3 patients with HIE
R10 C22 C19 coref-ident control subjects,14 nonatopic control subjects
R11 C24 C2 coref-ident both asthma and HIE,extrinsic asthma and hyperimmunoglobulin E
R12 C23 C1 coref-ident patients with both asthma and HIE,patients with extrinsic asthma and hyperimmunoglobulin E
R13 C25 C12 coref-ident the increased IgE levels,increased levels of IgE
R14 C26 C15 coref-ident Stat6 protein,Stat6
R15 C28 C23 coref-ident the patients,patients with both asthma and HIE
R16 C29 C22 coref-ident control subjects,control subjects
R17 C30 C21 coref-ident HIE,HIE
R18 C32 C31 coref-relat that,B cells
R19 C33 C13 coref-ident IgE,IgE
R20 C35 C30 coref-ident HIE,HIE
R21 C37 C34 coref-ident asthma,asthma
R22 C38 C35 coref-ident HIE,HIE
R23 C36 C24 coref-ident asthma and HIE,both asthma and HIE
R24 C39 C8 coref-ident IL-4,IL-4
R25 C41 C37 coref-ident asthma,asthma
R26 C42 C38 coref-ident HIE,HIE
R27 C40 C36 coref-ident asthma and HIE,asthma and HIE
R28 C43 C14 coref-ident Stat6 activation,the activation of Stat6
R29 C44 C27 coref-ident PBMCs;,PBMCs
R30 C45 C33 coref-ident IgE,IgE
R31 C46 C28 coref-ident these patients,the patients
R32 C48 C47 coref-relat that,B cells
R33 C49 C5 coref-ident class switching,class switching
R34 C51 C50 coref-relat that,Ig class switching

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 12-20 protein_family_or_group denotes cytokine
T2 48-64 other_name denotes extrinsic asthma
T3 69-90 other_name denotes hyperimmunoglobulin E
T4 166-169 protein_family_or_group denotes IgE
T5 173-182 protein_family_or_group denotes cytokines
T6 198-224 protein_family_or_group denotes STAT transcription factors
T7 243-246 protein_family_or_group denotes IgE
T8 250-254 protein_molecule denotes IL-4
T9 259-264 protein_molecule denotes IL-13
T10 302-348 protein_molecule denotes intracellular signal-transducing protein Stat6
T11 376-379 protein_family_or_group denotes IgE
T12 399-411 protein_molecule denotes interferon-y
T13 413-422 protein_molecule denotes IFN-gamma
T14 457-462 protein_molecule denotes Statl
T15 499-515 other_name denotes extrinsic asthma
T16 549-552 protein_family_or_group denotes IgE
T17 558-579 other_name denotes hyperimmunoglobulin E
T18 581-584 other_name denotes HIE
T19 607-610 protein_family_or_group denotes IgE
T20 653-661 protein_family_or_group denotes cytokine
T21 690-695 protein_molecule denotes Stat6
T22 706-711 cell_type denotes PBMCs
T23 716-720 tissue denotes sera
T24 728-736 multi_cell denotes patients
T25 742-758 other_name denotes extrinsic asthma
T26 765-768 protein_family_or_group denotes IgE
T27 790-798 multi_cell denotes patients
T28 804-807 other_name denotes HIE
T29 814-817 protein_family_or_group denotes IgE
T30 846-872 multi_cell denotes nonatopic control subjects
T31 879-882 protein_family_or_group denotes IgE
T32 933-937 protein_molecule denotes IL-4
T33 956-961 other_name denotes ELISA
T34 982-990 multi_cell denotes patients
T35 996-999 other_name denotes HIE
T36 1087-1091 protein_molecule denotes IL-4
T37 1105-1113 multi_cell denotes patients
T38 1135-1138 other_name denotes HIE
T39 1159-1168 other_name denotes increased
T40 1169-1172 protein_family_or_group denotes IgE
T41 1194-1199 protein_molecule denotes IL-13
T42 1236-1241 protein_molecule denotes Stat6
T43 1261-1266 cell_type denotes PBMCs
T44 1289-1297 multi_cell denotes patients
T45 1335-1340 protein_molecule denotes Stat6
T46 1392-1396 protein_molecule denotes IL-4
T47 1410-1418 multi_cell denotes patients
T48 1431-1434 other_name denotes HIE
T49 1496-1503 cell_type denotes B cells
T50 1534-1537 protein_family_or_group denotes IgE
T51 1550-1555 cell_type denotes PBMCs
T52 1567-1575 multi_cell denotes patients
T53 1591-1594 other_name denotes HIE
T54 1640-1643 protein_family_or_group denotes IgE
T55 1669-1672 other_name denotes HIE
T56 1719-1723 protein_molecule denotes IL-4
T57 1733-1738 protein_molecule denotes IL-13
T58 1788-1792 protein_molecule denotes IL-4
T59 1803-1809 other_name denotes asthma
T60 1814-1817 other_name denotes HIE
T61 1847-1852 protein_molecule denotes Stat6
T62 1867-1872 cell_type denotes PBMCs
T63 1918-1925 other_name denotes epsilon
T64 1972-1975 protein_family_or_group denotes IgE
T65 2010-2013 protein_family_or_group denotes IgE
T66 2023-2031 multi_cell denotes patients
T67 2052-2059 cell_type denotes B cells
T68 2088-2103 other_name denotes class switching
T69 2110-2128 other_name denotes Ig class switching
T70 2150-2164 tissue denotes target tissues