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PubMed:9765464 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-105 Sentence denotes Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection.
TextSentencer_T2 106-236 Sentence denotes Expression of many early viral genes during human cytomegalovirus (HCMV) infection is dependent on cellular transcription factors.
TextSentencer_T3 237-541 Sentence denotes Several immediate-early and early viral promoters contain DNA binding sites for cellular factors such as CREB, AP-1, serum response factor, and Elk-1, and these transcription factors can be activated by phosphorylation via the cellular mitogen-activated protein kinase (MAPK) signal transduction cascade.
TextSentencer_T4 542-730 Sentence denotes To determine if the extracellular signal-regulated MAPKs, ERK1 and ERK2, play a role in transcription factor activation during infection, we tested for ERK activity during viral infection.
TextSentencer_T5 731-916 Sentence denotes We found that HCMV infection resulted in the maintenance of previously activated ERK1 and ERK2 by a mechanism which appears to involve the inhibition of a cellular phosphatase activity.
TextSentencer_T6 917-1083 Sentence denotes ERK phosphorylation and activity were sustained for at least 8 h after infection, whereas in mock-infected cells, ERK activity steadily declined by 1 h postinfection.
TextSentencer_T7 1084-1209 Sentence denotes The activity of at least one cellular substrate of the ERKs, the protein kinase RSK1, was also maintained during this period.
TextSentencer_T8 1210-1315 Sentence denotes UV inactivation experiments suggested that viral gene expression was required for sustained ERK activity.
TextSentencer_T9 1316-1563 Sentence denotes In turn, activation of the ERKs appeared to be important for viral gene expression, as evidenced by the observed decrease in the transcriptional activity of the HCMV UL112-113 promoter during infection in the presence of the MEK inhibitor PD98059.
TextSentencer_T10 1564-1767 Sentence denotes These data suggest that HCMV utilizes cellular signal transduction pathways to activate viral or cellular transcription factors involved in the control of early viral gene expression and DNA replication.
T1 0-105 Sentence denotes Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection.
T2 106-236 Sentence denotes Expression of many early viral genes during human cytomegalovirus (HCMV) infection is dependent on cellular transcription factors.
T3 237-541 Sentence denotes Several immediate-early and early viral promoters contain DNA binding sites for cellular factors such as CREB, AP-1, serum response factor, and Elk-1, and these transcription factors can be activated by phosphorylation via the cellular mitogen-activated protein kinase (MAPK) signal transduction cascade.
T4 542-730 Sentence denotes To determine if the extracellular signal-regulated MAPKs, ERK1 and ERK2, play a role in transcription factor activation during infection, we tested for ERK activity during viral infection.
T5 731-916 Sentence denotes We found that HCMV infection resulted in the maintenance of previously activated ERK1 and ERK2 by a mechanism which appears to involve the inhibition of a cellular phosphatase activity.
T6 917-1083 Sentence denotes ERK phosphorylation and activity were sustained for at least 8 h after infection, whereas in mock-infected cells, ERK activity steadily declined by 1 h postinfection.
T7 1084-1209 Sentence denotes The activity of at least one cellular substrate of the ERKs, the protein kinase RSK1, was also maintained during this period.
T8 1210-1315 Sentence denotes UV inactivation experiments suggested that viral gene expression was required for sustained ERK activity.
T9 1316-1563 Sentence denotes In turn, activation of the ERKs appeared to be important for viral gene expression, as evidenced by the observed decrease in the transcriptional activity of the HCMV UL112-113 promoter during infection in the presence of the MEK inhibitor PD98059.
T10 1564-1767 Sentence denotes These data suggest that HCMV utilizes cellular signal transduction pathways to activate viral or cellular transcription factors involved in the control of early viral gene expression and DNA replication.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 609-613 gene:5594 denotes ERK2
T1 714-729 disease:C0042769 denotes viral infection
T2 694-697 gene:5594 denotes ERK
T3 714-729 disease:C0042769 denotes viral infection
T4 694-697 gene:2048 denotes ERK
T5 714-729 disease:C0042769 denotes viral infection
R1 T0 T1 associated_with ERK2,viral infection
R2 T2 T3 associated_with ERK,viral infection
R3 T4 T5 associated_with ERK,viral infection

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9765464-3#58#62#gene5595 600-604 gene5595 denotes ERK1
9765464-3#67#71#gene5594 609-613 gene5594 denotes ERK2
9765464-3#172#187#diseaseC0042769 714-729 diseaseC0042769 denotes viral infection
9765464-4#81#85#gene5595 812-816 gene5595 denotes ERK1
9765464-4#90#94#gene5594 821-825 gene5594 denotes ERK2
9765464-4#14#28#diseaseC0010823 745-759 diseaseC0010823 denotes HCMV infection
58#62#gene5595172#187#diseaseC0042769 9765464-3#58#62#gene5595 9765464-3#172#187#diseaseC0042769 associated_with ERK1,viral infection
67#71#gene5594172#187#diseaseC0042769 9765464-3#67#71#gene5594 9765464-3#172#187#diseaseC0042769 associated_with ERK2,viral infection
81#85#gene559514#28#diseaseC0010823 9765464-4#81#85#gene5595 9765464-4#14#28#diseaseC0010823 associated_with ERK1,HCMV infection
90#94#gene559414#28#diseaseC0010823 9765464-4#90#94#gene5594 9765464-4#14#28#diseaseC0010823 associated_with ERK2,HCMV infection

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 354-359 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1917 694-697 gene:2048 denotes ERK
T1918 714-729 disease:C0042769 denotes viral infection
R1 T1917 T1918 associated_with ERK,viral infection
R2 T1917 T1918 associated_with ERK,viral infection

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 354-359 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum