PubMed:9761241 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9761241","sourcedb":"PubMed","sourceid":"9761241","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9761241","text":"K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.\nMutant-enriched PCR and reverse dot blot hybridization in microplates were applied for examining K-ras status in stools and tissue samples from patients with pancreatic tumors and chronic pancreatitis. In tissue samples, K-ras mutations were found in 32 of 35 cases of ductal adenocarcinoma, in 5 of 7 periampullary cancers, in 1 cystadenocarcinoma, and in 3 of 5 patients with chronic pancreatitis. In stools, mutated K-ras was seen in 10 of 25 cases of ductal adenocarcinoma, in 1 case of cystadenocarcinoma, and in 2 of 6 cases of chronic pancreatitis. These data indicate that the K-ras status of stool samples may help identify pancreatic carcinoma and persons at risk for cancer development; however, it does not allow discrimination of malignant from nonmalignant diseases.","tracks":[{"project":"PennBioIE","denotations":[{"id":"T1","span":{"begin":0,"end":5},"obj":"protein"},{"id":"T2","span":{"begin":209,"end":214},"obj":"protein"},{"id":"T3","span":{"begin":333,"end":338},"obj":"protein"},{"id":"T4","span":{"begin":531,"end":536},"obj":"protein"},{"id":"T5","span":{"begin":697,"end":702},"obj":"protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"PennBioIE"},{"subj":"T2","pred":"source","obj":"PennBioIE"},{"subj":"T3","pred":"source","obj":"PennBioIE"},{"subj":"T4","pred":"source","obj":"PennBioIE"},{"subj":"T5","pred":"source","obj":"PennBioIE"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PennBioIE","color":"#a493ec","default":true}]}]}}