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PubMed:9759864 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-40 protein denotes Carboxyl-terminal 15-amino acid sequence
T2 44-50 protein denotes NFATx1
T3 148-155 cell_type denotes T cells
T4 157-161 protein denotes NFAT
T5 220-242 DNA denotes immunoregulatory genes
T6 261-266 protein denotes NFATx
T7 304-315 protein denotes NFAT family
T8 319-340 protein denotes transcription factors
T9 391-418 cell_type denotes peripheral blood leukocytes
T10 438-443 protein denotes NFATx
T11 445-451 protein denotes NFATx1
T12 513-534 protein denotes carboxyl-terminal end
T13 538-544 protein denotes NFATx1
T14 602-616 cell_line denotes Jurkat T cells
T15 664-687 protein denotes GAL4 DNA binding domain
T16 743-764 DNA denotes GAL4 DNA binding site
T17 786-824 protein denotes 15-amino acid transactivation sequence
T18 846-866 protein denotes NFAT family proteins
T19 909-934 protein denotes carboxyl-terminal regions
T20 942-953 protein denotes NFAT family
T21 1023-1028 protein denotes NFATx
T22 1041-1047 protein denotes NFATx2
T23 1049-1055 protein denotes NFATx3
T24 1061-1067 protein denotes NFATx4
T25 1168-1182 protein denotes NFATx isoforms
T26 1231-1245 cell_line denotes Jurkat T cells
T27 1247-1253 protein denotes NFATx1
T28 1299-1325 cell_type denotes peripheral blood leukocyte
T29 1373-1379 protein denotes NFATx2
T30 1384-1396 cell_line denotes Jurkat cells
T31 1421-1430 DNA denotes NFAT site
T32 1438-1451 DNA denotes IL-2 promoter
T33 1477-1483 protein denotes NFATx1
T34 1503-1509 protein denotes NFATx2
T35 1543-1565 protein denotes 15-amino acid sequence
T36 1569-1575 protein denotes NFATx1
T37 1581-1611 protein denotes major transactivation sequence
T38 1647-1653 protein denotes NFATx1
T39 1657-1664 cell_type denotes T cells
T40 1688-1692 protein denotes NFAT

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-40 protein_domain_or_region denotes Carboxyl-terminal 15-amino acid sequence
T2 44-50 protein_molecule denotes NFATx1
T3 120-144 other_name denotes transactivation activity
T4 148-155 cell_type denotes T cells
T5 157-161 protein_family_or_group denotes NFAT
T6 220-242 DNA_family_or_group denotes immunoregulatory genes
T7 261-266 protein_molecule denotes NFATx
T8 304-315 protein_family_or_group denotes NFAT family
T9 319-340 protein_family_or_group denotes transcription factors
T10 380-386 body_part denotes thymus
T11 391-418 cell_type denotes peripheral blood leukocytes
T12 438-443 protein_molecule denotes NFATx
T13 445-451 protein_molecule denotes NFATx1
T14 491-505 peptide denotes 15 amino acids
T15 513-534 protein_domain_or_region denotes carboxyl-terminal end
T16 538-544 protein_molecule denotes NFATx1
T17 574-598 other_name denotes transactivation activity
T18 602-616 cell_line denotes Jurkat T cells
T19 641-655 peptide denotes 15 amino acids
T20 664-687 protein_domain_or_region denotes GAL4 DNA binding domain
T21 743-764 DNA_domain_or_region denotes GAL4 DNA binding site
T22 786-824 protein_domain_or_region denotes 15-amino acid transactivation sequence
T23 846-857 protein_family_or_group denotes NFAT family
T24 909-934 protein_domain_or_region denotes carboxyl-terminal regions
T25 942-953 protein_family_or_group denotes NFAT family
T26 1023-1028 protein_molecule denotes NFATx
T27 1041-1047 protein_molecule denotes NFATx2
T28 1049-1055 protein_molecule denotes NFATx3
T29 1061-1067 protein_molecule denotes NFATx4
T30 1113-1149 other_name denotes tissue-specific alternative splicing
T31 1168-1173 protein_molecule denotes NFATx
T32 1203-1227 other_name denotes transactivation activity
T33 1231-1245 cell_line denotes Jurkat T cells
T34 1247-1253 protein_molecule denotes NFATx1
T35 1288-1294 body_part denotes thymus
T36 1299-1325 cell_type denotes peripheral blood leukocyte
T37 1373-1379 protein_molecule denotes NFATx2
T38 1384-1396 cell_line denotes Jurkat cells
T39 1421-1430 DNA_domain_or_region denotes NFAT site
T40 1438-1451 DNA_domain_or_region denotes IL-2 promoter
T41 1477-1483 protein_molecule denotes NFATx1
T42 1503-1509 protein_molecule denotes NFATx2
T43 1543-1565 protein_domain_or_region denotes 15-amino acid sequence
T44 1569-1575 protein_molecule denotes NFATx1
T45 1581-1611 protein_domain_or_region denotes major transactivation sequence
T46 1647-1653 protein_molecule denotes NFATx1
T47 1657-1664 cell_type denotes T cells
T48 1688-1692 protein_family_or_group denotes NFAT
T49 1710-1746 other_name denotes tissue-specific alternative splicing

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-156 Sentence denotes Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells.
S2 157-243 Sentence denotes NFAT regulates transcription of a number of cytokine and other immunoregulatory genes.
S3 244-452 Sentence denotes We have isolated NFATx, which is one of four members of the NFAT family of transcription factors and is preferentially expressed in the thymus and peripheral blood leukocytes, and an isoform of NFATx, NFATx1.
S4 453-617 Sentence denotes Here we provide evidence showing that 15 amino acids in the carboxyl-terminal end of NFATx1 are required for its maximum transactivation activity in Jurkat T cells.
S5 618-765 Sentence denotes A fusion between these 15 amino acids and the GAL4 DNA binding domain was capable of transactivating reporters driven by the GAL4 DNA binding site.
S6 766-978 Sentence denotes Interestingly, this 15-amino acid transactivation sequence is well conserved in NFAT family proteins, although the sequences contiguous to the carboxyl-terminal regions of the NFAT family are much less conserved.
S7 979-1068 Sentence denotes We also report three additional isoforms of NFATx, designated NFATx2, NFATx3, and NFATx4.
S8 1069-1246 Sentence denotes This transactivation sequence is altered by tissue-specific alternative splicing in newly isolated NFATx isoforms, resulting in lower transactivation activity in Jurkat T cells.
S9 1247-1380 Sentence denotes NFATx1 is expressed predominantly in the thymus and peripheral blood leukocyte, while the skeletal muscle expressed primarily NFATx2.
S10 1381-1510 Sentence denotes In Jurkat cells, transcription from the NFAT site of the IL-2 promoter is activated strongly by NFATx1 but only weakly by NFATx2.
S11 1511-1747 Sentence denotes These data demonstrate that the 15-amino acid sequence of NFATx1 is a major transactivation sequence required for induction of genes by NFATx1 in T cells and possibly regulates NFAT activity through tissue-specific alternative splicing.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 44-50 NP denotes NFATx1
C2 148-155 NP denotes T cells
C3 157-161 NP denotes NFAT
C4 261-266 NP denotes NFATx
C5 268-273 NP denotes which
C6 300-340 NP denotes the NFAT family of transcription factors
C7 376-418 NP denotes the thymus and peripheral blood leukocytes
C9 438-443 NP denotes NFATx
C8 424-443 NP denotes an isoform of NFATx
C10 445-451 NP denotes NFATx1
C12 538-544 NP denotes NFATx1
C11 491-544 NP denotes 15 amino acids in the carboxyl-terminal end of NFATx1
C13 562-565 NP denotes its
C14 602-616 NP denotes Jurkat T cells
C15 635-655 NP denotes these 15 amino acids
C16 846-866 NP denotes NFAT family proteins
C17 938-953 NP denotes the NFAT family
C19 1023-1028 NP denotes NFATx
C18 994-1028 NP denotes three additional isoforms of NFATx
C21 1041-1047 NP denotes NFATx2
C20 1041-1067 NP denotes NFATx2, NFATx3, and NFATx4
C22 1113-1149 NP denotes tissue-specific alternative splicing
C23 1231-1245 NP denotes Jurkat T cells
C24 1247-1253 NP denotes NFATx1
C25 1284-1325 NP denotes the thymus and peripheral blood leukocyte
C26 1384-1396 NP denotes Jurkat cells
C27 1477-1483 NP denotes NFATx1
C28 1503-1509 NP denotes NFATx2
C29 1569-1575 NP denotes NFATx1
C30 1647-1653 NP denotes NFATx1
C31 1657-1664 NP denotes T cells
C32 1710-1746 NP denotes tissue-specific alternative splicing
R1 C5 C4 coref-relat which,NFATx
R2 C6 C3 coref-ident the NFAT family of transcription factors,NFAT
R3 C9 C4 coref-ident NFATx,NFATx
R4 C8 C1 coref-ident an isoform of NFATx,NFATx1
R5 C10 C8 coref-appos NFATx1,an isoform of NFATx
R6 C12 C8 coref-ident NFATx1,an isoform of NFATx
R7 C13 C12 coref-pron its,NFATx1
R8 C14 C2 coref-ident Jurkat T cells,T cells
R9 C15 C11 coref-ident these 15 amino acids,15 amino acids in the carboxyl-terminal end of NFATx1
R10 C16 C6 coref-ident NFAT family proteins,the NFAT family of transcription factors
R11 C17 C16 coref-ident the NFAT family,NFAT family proteins
R12 C19 C9 coref-ident NFATx,NFATx
R13 C20 C18 coref-ident "NFATx2, NFATx3, and NFATx4",three additional isoforms of NFATx
R14 C23 C14 coref-ident Jurkat T cells,Jurkat T cells
R15 C24 C12 coref-ident NFATx1,NFATx1
R16 C25 C7 coref-ident the thymus and peripheral blood leukocyte,the thymus and peripheral blood leukocytes
R17 C26 C23 coref-ident Jurkat cells,Jurkat T cells
R18 C27 C24 coref-ident NFATx1,NFATx1
R19 C28 C21 coref-ident NFATx2,NFATx2
R20 C29 C27 coref-ident NFATx1,NFATx1
R21 C30 C29 coref-ident NFATx1,NFATx1
R22 C31 C26 coref-ident T cells,Jurkat cells
R23 C32 C22 coref-ident tissue-specific alternative splicing,tissue-specific alternative splicing