PubMed:9758264 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":85},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":86,"end":96},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":97,"end":311},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":312,"end":325},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":326,"end":411},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":412,"end":420},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":421,"end":606},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":607,"end":673},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":674,"end":786},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":787,"end":942},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":943,"end":1027},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1028,"end":1064},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1065,"end":1077},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1078,"end":1288},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1289,"end":1455},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":85},"obj":"Sentence"},{"id":"T2","span":{"begin":86,"end":96},"obj":"Sentence"},{"id":"T3","span":{"begin":97,"end":311},"obj":"Sentence"},{"id":"T4","span":{"begin":312,"end":325},"obj":"Sentence"},{"id":"T5","span":{"begin":326,"end":411},"obj":"Sentence"},{"id":"T6","span":{"begin":412,"end":420},"obj":"Sentence"},{"id":"T7","span":{"begin":421,"end":606},"obj":"Sentence"},{"id":"T8","span":{"begin":607,"end":673},"obj":"Sentence"},{"id":"T9","span":{"begin":674,"end":786},"obj":"Sentence"},{"id":"T10","span":{"begin":787,"end":942},"obj":"Sentence"},{"id":"T11","span":{"begin":943,"end":1027},"obj":"Sentence"},{"id":"T12","span":{"begin":1028,"end":1064},"obj":"Sentence"},{"id":"T13","span":{"begin":1065,"end":1077},"obj":"Sentence"},{"id":"T14","span":{"begin":1078,"end":1288},"obj":"Sentence"},{"id":"T15","span":{"begin":1289,"end":1455},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":652,"end":661},"obj":"HP:0410030"},{"id":"AB2","span":{"begin":718,"end":726},"obj":"HP:0001250"},{"id":"AB3","span":{"begin":957,"end":975},"obj":"HP:0002133"},{"id":"AB4","span":{"begin":1279,"end":1287},"obj":"HP:0001250"},{"id":"AB5","span":{"begin":1446,"end":1454},"obj":"HP:0001250"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":658,"end":661},"obj":"http://purl.obolibrary.org/obo/UBERON_0001833"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":1177,"end":1182},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1177,"end":1196},"obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":1183,"end":1188},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":652,"end":672},"obj":"ORDO:199306"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1177,"end":1182},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":1183,"end":1188},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1177,"end":1196},"obj":"http://purl.obolibrary.org/obo/UBERON_0000120"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":658,"end":661},"obj":"http://purl.obolibrary.org/obo/UBERON_0001833"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-experiment","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T4","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T5","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T6","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T7","span":{"begin":263,"end":276},"obj":"Disease"},{"id":"T8","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T9","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T10","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T11","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T12","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T13","span":{"begin":652,"end":657},"obj":"Disease"},{"id":"T14","span":{"begin":652,"end":661},"obj":"Disease"},{"id":"T15","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T16","span":{"begin":666,"end":672},"obj":"Disease"},{"id":"T17","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T18","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T19","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T20","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T21","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T22","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T23","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T24","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T25","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T26","span":{"begin":1153,"end":1158},"obj":"Disease"},{"id":"T27","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T28","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T29","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T30","span":{"begin":1353,"end":1362},"obj":"Disease"},{"id":"T31","span":{"begin":1386,"end":1404},"obj":"Disease"},{"id":"T32","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-deepseek-nr-ng","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T6","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T7","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T8","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T9","span":{"begin":998,"end":1026},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gemini-nr-ng","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T6","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T7","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T8","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T9","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T10","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T11","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T12","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T13","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T14","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T15","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T16","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gemini-r-ng","denotations":[{"id":"T1","span":{"begin":0,"end":22},"obj":"Disease"},{"id":"T2","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T3","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T4","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T5","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T6","span":{"begin":142,"end":154},"obj":"Chemical"},{"id":"T7","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T8","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T9","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T10","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T11","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T12","span":{"begin":496,"end":508},"obj":"Chemical"},{"id":"T13","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T14","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T15","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T16","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T17","span":{"begin":773,"end":785},"obj":"Chemical"},{"id":"T18","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T19","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T20","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T21","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T22","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T23","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T24","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T25","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T26","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T27","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T28","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gemini-r-g","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T7","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T8","span":{"begin":298,"end":310},"obj":"Disease"},{"id":"T9","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T10","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T11","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T12","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T13","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T14","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T15","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T16","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T17","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T18","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T19","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T20","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T21","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T22","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T23","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T24","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T25","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gemini-nr-g","denotations":[{"id":"T1","span":{"begin":0,"end":22},"obj":"Disease"},{"id":"T2","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T3","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T4","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T5","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T6","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T7","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T8","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T9","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T10","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T11","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T12","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T13","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T14","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T15","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T16","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T17","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T18","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T19","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T20","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T21","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T22","span":{"begin":1140,"end":1152},"obj":"Disease"},{"id":"T23","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T24","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T25","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T4","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T5","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T6","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T7","span":{"begin":263,"end":276},"obj":"Disease"},{"id":"T8","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T9","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T10","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T11","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T12","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T13","span":{"begin":652,"end":657},"obj":"Disease"},{"id":"T14","span":{"begin":652,"end":661},"obj":"Disease"},{"id":"T15","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T16","span":{"begin":666,"end":672},"obj":"Disease"},{"id":"T17","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T18","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T19","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T20","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T21","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T22","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T23","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T24","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T25","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T26","span":{"begin":1153,"end":1158},"obj":"Disease"},{"id":"T27","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T28","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T29","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T30","span":{"begin":1353,"end":1362},"obj":"Disease"},{"id":"T31","span":{"begin":1386,"end":1404},"obj":"Disease"},{"id":"T32","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gpt-nr-g","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T7","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T8","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T9","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T10","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T11","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T12","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T13","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T14","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T15","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T16","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T17","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T18","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T19","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T20","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T21","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T22","span":{"begin":1353,"end":1362},"obj":"Disease"},{"id":"T23","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gpt-r-ng","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T6","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T7","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T8","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T9","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T10","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T11","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T12","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T13","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T14","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T15","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T16","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T17","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T18","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T19","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T20","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gpt-nr-ng","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T6","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T7","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T8","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T9","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T10","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T11","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T12","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T13","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T14","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T15","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T16","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T17","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T18","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T19","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T20","span":{"begin":1446,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gpt-r-g","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":263,"end":276},"obj":"Disease"},{"id":"T7","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T8","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T9","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T10","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T11","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T12","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T13","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T14","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T15","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T16","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T17","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T18","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T19","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T20","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T21","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T22","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T23","span":{"begin":1353,"end":1362},"obj":"Disease"},{"id":"T24","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-deepseek-r-ng","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T6","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T7","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T8","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T9","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T10","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T11","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T12","span":{"begin":1153,"end":1158},"obj":"Disease"},{"id":"T13","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T14","span":{"begin":1319,"end":1329},"obj":"Chemical"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gemini-r-m","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T4","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T5","span":{"begin":142,"end":154},"obj":"Chemical"},{"id":"T6","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T7","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T8","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T9","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T10","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T11","span":{"begin":496,"end":508},"obj":"Chemical"},{"id":"T12","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T13","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T14","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T15","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T16","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T17","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T18","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T19","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T20","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T21","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T22","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gpt-r-m2","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T7","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T8","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T9","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T10","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T11","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T12","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T13","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T14","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T15","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T16","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T17","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T18","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T19","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T20","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T21","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T22","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T23","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T24","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T25","span":{"begin":1353,"end":1362},"obj":"Disease"},{"id":"T26","span":{"begin":1446,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-deepseek-r-g","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T7","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T8","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T9","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T10","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T11","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T12","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T13","span":{"begin":1140,"end":1158},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-deepseek-nr-g","denotations":[{"id":"T1","span":{"begin":0,"end":13},"obj":"Disease"},{"id":"T2","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"T3","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T4","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T5","span":{"begin":61,"end":71},"obj":"Chemical"},{"id":"T6","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T7","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T8","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T9","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T10","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T11","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T12","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T13","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T14","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T15","span":{"begin":964,"end":975},"obj":"Disease"},{"id":"T16","span":{"begin":998,"end":1026},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-deepseek-r-m","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T7","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T8","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T9","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T10","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T11","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T12","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T13","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T14","span":{"begin":1140,"end":1158},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}

{"project":"bc5cdr-valid-gpt-r-m","denotations":[{"id":"T1","span":{"begin":26,"end":36},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":120,"end":130},"obj":"Chemical"},{"id":"T5","span":{"begin":174,"end":183},"obj":"Disease"},{"id":"T6","span":{"begin":252,"end":276},"obj":"Disease"},{"id":"T7","span":{"begin":281,"end":289},"obj":"Disease"},{"id":"T8","span":{"begin":427,"end":436},"obj":"Disease"},{"id":"T9","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T10","span":{"begin":543,"end":551},"obj":"Disease"},{"id":"T11","span":{"begin":611,"end":620},"obj":"Disease"},{"id":"T12","span":{"begin":652,"end":672},"obj":"Disease"},{"id":"T13","span":{"begin":718,"end":726},"obj":"Disease"},{"id":"T14","span":{"begin":804,"end":813},"obj":"Disease"},{"id":"T15","span":{"begin":848,"end":861},"obj":"Chemical"},{"id":"T16","span":{"begin":868,"end":878},"obj":"Chemical"},{"id":"T17","span":{"begin":957,"end":975},"obj":"Disease"},{"id":"T18","span":{"begin":998,"end":1026},"obj":"Disease"},{"id":"T19","span":{"begin":1053,"end":1063},"obj":"Disease"},{"id":"T20","span":{"begin":1082,"end":1091},"obj":"Disease"},{"id":"T21","span":{"begin":1111,"end":1129},"obj":"Disease"},{"id":"T22","span":{"begin":1140,"end":1158},"obj":"Disease"},{"id":"T23","span":{"begin":1245,"end":1255},"obj":"Chemical"},{"id":"T24","span":{"begin":1279,"end":1287},"obj":"Disease"},{"id":"T25","span":{"begin":1319,"end":1329},"obj":"Chemical"},{"id":"T26","span":{"begin":1353,"end":1362},"obj":"Disease"},{"id":"T27","span":{"begin":1386,"end":1404},"obj":"Disease"},{"id":"T28","span":{"begin":1436,"end":1454},"obj":"Disease"}],"text":"Epileptogenic activity of folic acid after drug induces SLE (folic acid and epilepsy)\nOBJECTIVE: To study the effect of folic acid-containing multivitamin supplementation in epileptic women before and during pregnancy in order to determine the rate of structural birth defects and epilepsy-related side effects.\nSTUDY DESIGN: First a randomised trial, later periconception care including in total 12225 females.\nRESULTS: Of 60 epileptic women with periconceptional folic acid (0.8 mg)-containing multivitamin supplementation, no one developed epilepsy-related side effects during the periconception period. One epileptic woman delivered a newborn with cleft lip and palate. Another patient exhibited with a cluster of seizures after the periconception period using another multivitamin. This 22-year-old epileptic woman was treated continuously by carbamazepine and a folic acid (1 mg)-containing multivitamin from the 20th week of gestation. She developed status epilepticus and later symptoms of systemic lupus erythematodes. Her pregnancy ended with stillbirth.\nCONCLUSIONS: The epileptic pregnant patient's autoimmune disease (probably drug-induced lupus) could damage the blood-brain barrier, therefore the therapeutic dose (\u003e or =1 mg) of folic acid triggered a cluster of seizures. Physiological dose (\u003c1 mg) of folic acid both in healthy and 60 epileptic women, all without any autoimmune disease, did not increase the risk for epileptic seizures."}