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PubMed:9756417 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-20 protein denotes Transcription factor
T2 56-68 cell_type denotes killer cells
T3 73-84 cell_type denotes lymphocytes
T4 109-113 protein denotes IL-2
T5 151-173 protein denotes cytokine interleukin-2
T6 175-179 protein denotes IL-2
T7 347-356 protein denotes NF-kappaB
T8 362-412 protein denotes signal transducers and activators of transcription
T9 414-418 protein denotes STAT
T10 423-451 cell_type denotes cancer patients' lymphocytes
T11 469-473 protein denotes IL-2
T12 548-552 protein denotes IL-2
T13 588-628 cell_type denotes fresh peripheral blood mononuclear cells
T14 630-634 cell_type denotes PBMC
T15 664-668 protein denotes IL-2
T16 718-728 protein denotes lymphokine
T17 1014-1018 protein denotes IL-2
T18 1066-1087 protein denotes transcription factors
T19 1091-1095 cell_type denotes PBMC
T20 1139-1143 cell_type denotes PBMC
T21 1194-1198 protein denotes IL-2
T22 1249-1253 protein denotes AP-1
T23 1256-1259 protein denotes Sp1
T24 1265-1274 protein denotes NF-kappaB
T25 1318-1322 cell_type denotes PBMC
T26 1336-1340 protein denotes IL-2
T27 1384-1388 protein denotes IL-2
T28 1456-1476 protein denotes STAT binding factors
T29 1484-1493 protein denotes LAK cells
T30 1547-1551 protein denotes IL-2
T31 1588-1592 protein denotes STAT
T32 1700-1712 cell_type denotes immune cells
T33 1770-1774 protein denotes IL-2
T34 1844-1848 cell_type denotes PBMC
T35 1883-1887 protein denotes IL-2

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 protein_family_or_group denotes Transcription factor
T2 56-68 cell_type denotes killer cells
T3 73-84 cell_type denotes lymphocytes
T4 109-113 protein_molecule denotes IL-2
T5 151-173 protein_molecule denotes cytokine interleukin-2
T6 175-179 protein_molecule denotes IL-2
T7 237-257 tissue denotes renal cell carcinoma
T8 262-270 other_name denotes melanoma
T9 306-335 other_name denotes transcription factor families
T10 347-356 protein_complex denotes NF-kappaB
T11 362-412 protein_family_or_group denotes signal transducers and activators of transcription
T12 414-418 protein_family_or_group denotes STAT
T13 423-439 cell_type denotes cancer patients'
T14 440-451 cell_type denotes lymphocytes
T15 469-473 protein_molecule denotes IL-2
T16 506-521 other_name denotes gel-shift assay
T17 548-552 protein_molecule denotes IL-2
T18 588-628 cell_type denotes fresh peripheral blood mononuclear cells
T19 630-634 cell_type denotes PBMC
T20 641-660 multi_cell denotes healthy individuals
T21 664-668 protein_molecule denotes IL-2
T22 718-728 protein_family_or_group denotes lymphokine
T23 837-868 other_name denotes transcription factor activation
T24 958-980 other_name denotes functional differences
T25 1014-1018 protein_molecule denotes IL-2
T26 1066-1087 protein_family_or_group denotes transcription factors
T27 1091-1095 cell_type denotes PBMC
T28 1139-1143 cell_type denotes PBMC
T29 1149-1168 multi_cell denotes healthy individuals
T30 1194-1198 protein_molecule denotes IL-2
T31 1216-1224 multi_cell denotes patients
T32 1249-1253 protein_molecule denotes AP-1
T33 1256-1259 protein_molecule denotes Sp1
T34 1265-1274 protein_complex denotes NF-kappaB
T35 1318-1322 cell_type denotes PBMC
T36 1336-1340 protein_molecule denotes IL-2
T37 1384-1388 protein_molecule denotes IL-2
T38 1397-1405 multi_cell denotes patients
T39 1456-1476 protein_family_or_group denotes STAT binding factors
T40 1484-1493 protein_family_or_group denotes LAK cells
T41 1547-1551 protein_molecule denotes IL-2
T42 1588-1592 protein_family_or_group denotes STAT
T43 1700-1712 cell_type denotes immune cells
T44 1770-1774 protein_molecule denotes IL-2
T45 1844-1848 cell_type denotes PBMC
T46 1883-1887 protein_molecule denotes IL-2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-128 Sentence denotes Transcription factor activation in lymphokine activated killer cells and lymphocytes from patients receiving IL-2 immunotherapy.
S2 129-271 Sentence denotes Administration of the cytokine interleukin-2 (IL-2) can result in therapeutic benefits for individuals with renal cell carcinoma and melanoma.
S3 272-522 Sentence denotes Here we report an analysis of the transcription factor families AP-1, Sp1, NF-kappaB, and signal transducers and activators of transcription (STAT) in cancer patients' lymphocytes before and after IL-2 immunotherapy, as assessed by a gel-shift assay.
S4 523-779 Sentence denotes An in vitro surrogate of IL-2 immunotherapy is the incubation of fresh peripheral blood mononuclear cells (PBMC) from healthy individuals in IL-2 for several days, resulting in the production of lymphokine-activated killer (LAK) activity in these cultures.
S5 780-996 Sentence denotes One purpose of this study was to describe the profile of transcription factor activation in these different populations, and assess whether the patterns observed correlated with functional differences in these cells.
S6 997-1169 Sentence denotes Prior to in vivo IL-2 administration, the typical binding pattern of transcription factors in PBMC from patients resembled that seen in fresh PBMC from healthy individuals.
S7 1170-1350 Sentence denotes Over a 3-week course of IL-2 therapy, in most patients the binding patterns of AP-1 , Sp1, and NF-kappaB proteins changed to resemble those seen in PBMC activated by IL-2 in vitro.
S8 1351-1494 Sentence denotes However, the cells obtained from IL-2-treated patients did not have low-level constitutive expression of STAT binding factors as did LAK cells.
S9 1495-1623 Sentence denotes When these patient cells were further stimulated by IL-2 in vitro, additional differences in STAT induction patterns were noted.
S10 1624-1888 Sentence denotes These data provide further information on the molecular events occurring in immune cells generated through in vivo and in vitro administration of IL-2, and further document that there is not a precise congruence between PBMC activated in vivo and in vitro by IL-2.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 109-127 NP denotes IL-2 immunotherapy
C2 147-180 NP denotes the cytokine interleukin-2 (IL-2)
C3 469-487 NP denotes IL-2 immunotherapy
C4 548-566 NP denotes IL-2 immunotherapy
C5 588-660 NP denotes fresh peripheral blood mononuclear cells (PBMC) from healthy individuals
C6 664-668 NP denotes IL-2
C7 1035-1087 NP denotes the typical binding pattern of transcription factors
C8 1120-1124 NP denotes that
C9 1133-1168 NP denotes fresh PBMC from healthy individuals
C10 1225-1283 NP denotes the binding patterns of AP-1 , Sp1, and NF-kappaB proteins
C11 1304-1309 NP denotes those
C12 1336-1340 NP denotes IL-2
C13 1360-1405 NP denotes the cells obtained from IL-2-treated patients
C14 1500-1519 NP denotes these patient cells
C15 1547-1551 NP denotes IL-2
C16 1770-1774 NP denotes IL-2
C17 1780-1796 NP denotes further document
C18 1797-1801 NP denotes that
C19 1883-1887 NP denotes IL-2
R1 C3 C1 coref-ident IL-2 immunotherapy,IL-2 immunotherapy
R2 C4 C3 coref-ident IL-2 immunotherapy,IL-2 immunotherapy
R3 C6 C2 coref-ident IL-2,the cytokine interleukin-2 (IL-2)
R4 C8 C7 coref-pron that,the typical binding pattern of transcription factors
R5 C9 C5 coref-ident fresh PBMC from healthy individuals,fresh peripheral blood mononuclear cells (PBMC) from healthy individuals
R6 C11 C10 coref-pron those,"the binding patterns of AP-1 , Sp1, and NF-kappaB proteins"
R7 C12 C6 coref-ident IL-2,IL-2
R8 C14 C13 coref-ident these patient cells,the cells obtained from IL-2-treated patients
R9 C15 C12 coref-ident IL-2,IL-2
R10 C16 C15 coref-ident IL-2,IL-2
R11 C18 C17 coref-relat that,further document
R12 C19 C16 coref-ident IL-2,IL-2