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PubMed:9751756 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-18 protein denotes PEBP2betaMYH11
T2 37-53 DNA denotes Inv(16)(p13;q22)
T3 207-230 protein denotes alpha and beta subunits
T4 238-268 protein denotes Pebp2/Cbf transcription factor
T5 371-387 DNA denotes Inv(16)(p13;q22)
T6 416-428 protein denotes beta subunit
T7 432-437 protein denotes Pebp2
T8 445-455 DNA denotes MYH11 gene
T9 467-499 protein denotes smooth muscle myosin heavy chain
T10 501-506 protein denotes Smmhc
T11 538-554 DNA denotes inv(16)(p13;q22)
T12 584-606 DNA denotes hMRP8 promoter element
T13 650-659 protein denotes Pebp2beta
T14 659-688 protein denotes Smmhc chimeric fusion protein
T15 692-705 cell_type denotes myeloid cells
T16 745-759 protein denotes PEBP2betaMYH11
T17 828-851 cell_type denotes circulating neutrophils
T18 902-929 cell_type denotes immature neutrophilic cells
T19 986-1000 protein denotes PEBP2betaMYH11
T20 1065-1090 cell_type denotes hematopoietic progenitors
T21 1113-1127 protein denotes PEBP2betaMYH11
T22 1132-1146 protein denotes activated NRAS
T23 1286-1300 protein denotes PEBP2betaMYH11
T24 1376-1381 protein denotes Pebp2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-146 Sentence denotes The PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasia.
S2 147-370 Sentence denotes Chromosomal translocations involving the genes encoding the alpha and beta subunits of the Pebp2/Cbf transcription factor have been associated with human acute myeloid leukemia and the preleukemic condition, myelodysplasia.
S3 371-508 Sentence denotes Inv(16)(p13;q22) fuses the gene encoding the beta subunit of Pebp2 to the MYH11 gene encoding a smooth muscle myosin heavy chain (Smmhc).
S4 509-706 Sentence denotes To examine the effect of the inv(16)(p13;q22) on myelopoiesis, we used the hMRP8 promoter element to generate transgenic mice expressing the Pebp2betaSmmhc chimeric fusion protein in myeloid cells.
S5 707-776 Sentence denotes Neutrophil maturation was impaired in PEBP2betaMYH11 transgenic mice.
S6 777-972 Sentence denotes Although the transgenic mice had normal numbers of circulating neutrophils, their bone marrow contained increased numbers of immature neutrophilic cells, which exhibited abnormal characteristics.
S7 973-1091 Sentence denotes In addition, PEBP2betaMYH11 inhibited neutrophilic differentiation in colonies derived from hematopoietic progenitors.
S8 1092-1261 Sentence denotes Coexpression of both PEBP2betaMYH11 and activated NRAS induced a more severe phenotype characterized by abnormal nuclear morphology indicative of granulocytic dysplasia.
S9 1262-1430 Sentence denotes These results show that PEBP2betaMYH11 can impair neutrophil development and provide evidence that alterations of Pebp2 can contribute to the genesis of myelodysplasia.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 37-53 NP denotes Inv(16)(p13;q22)
C2 82-103 NP denotes neutrophil maturation
C3 123-145 NP denotes granulocytic dysplasia
C4 328-353 NP denotes the preleukemic condition
C5 355-369 NP denotes myelodysplasia
C6 371-387 NP denotes Inv(16)(p13;q22)
C7 432-437 NP denotes Pebp2
C8 534-554 NP denotes the inv(16)(p13;q22)
C9 707-728 NP denotes Neutrophil maturation
C10 745-775 NP denotes PEBP2betaMYH11 transgenic mice
C11 786-805 NP denotes the transgenic mice
C12 853-858 NP denotes their
C13 881-929 NP denotes increased numbers of immature neutrophilic cells
C14 931-936 NP denotes which
C15 986-1000 NP denotes PEBP2betaMYH11
C16 1238-1260 NP denotes granulocytic dysplasia
C17 1286-1300 NP denotes PEBP2betaMYH11
C18 1347-1355 NP denotes evidence
C19 1356-1360 NP denotes that
C20 1376-1381 NP denotes Pebp2
C21 1415-1429 NP denotes myelodysplasia
R1 C5 C4 coref-appos myelodysplasia,the preleukemic condition
R2 C6 C1 coref-ident Inv(16)(p13;q22),Inv(16)(p13;q22)
R3 C8 C6 coref-ident the inv(16)(p13;q22),Inv(16)(p13;q22)
R4 C9 C2 coref-ident Neutrophil maturation,neutrophil maturation
R5 C11 C10 coref-ident the transgenic mice,PEBP2betaMYH11 transgenic mice
R6 C12 C11 coref-pron their,the transgenic mice
R7 C14 C13 coref-relat which,increased numbers of immature neutrophilic cells
R8 C16 C3 coref-ident granulocytic dysplasia,granulocytic dysplasia
R9 C17 C15 coref-ident PEBP2betaMYH11,PEBP2betaMYH11
R10 C19 C18 coref-relat that,evidence
R11 C20 C7 coref-ident Pebp2,Pebp2
R12 C21 C4 coref-ident myelodysplasia,the preleukemic condition

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-18 protein_molecule denotes PEBP2betaMYH11
T2 37-53 DNA_domain_or_region denotes Inv(16)(p13;q22)
T3 57-73 other_name denotes myeloid leukemia
T4 123-145 other_name denotes granulocytic dysplasia
T5 147-173 other_name denotes Chromosomal translocations
T6 238-268 protein_molecule denotes Pebp2/Cbf transcription factor
T7 307-323 other_name denotes myeloid leukemia
T8 332-353 other_name denotes preleukemic condition
T9 355-369 other_name denotes myelodysplasia
T10 371-387 DNA_domain_or_region denotes Inv(16)(p13;q22)
T11 416-428 protein_subunit denotes beta subunit
T12 432-437 protein_molecule denotes Pebp2
T13 445-455 DNA_domain_or_region denotes MYH11 gene
T14 467-499 protein_molecule denotes smooth muscle myosin heavy chain
T15 501-506 protein_subunit denotes Smmhc
T16 538-554 DNA_domain_or_region denotes inv(16)(p13;q22)
T17 558-570 other_name denotes myelopoiesis
T18 584-606 DNA_domain_or_region denotes hMRP8 promoter element
T19 619-634 other_artificial_source denotes transgenic mice
T20 650-659 protein_molecule denotes Pebp2beta
T21 659-664 protein_subunit denotes Smmhc
T22 692-705 cell_type denotes myeloid cells
T23 707-728 other_name denotes Neutrophil maturation
T24 745-759 protein_molecule denotes PEBP2betaMYH11
T25 760-775 other_artificial_source denotes transgenic mice
T26 790-805 other_artificial_source denotes transgenic mice
T27 828-851 cell_type denotes circulating neutrophils
T28 859-870 tissue denotes bone marrow
T29 902-929 cell_type denotes immature neutrophilic cells
T30 986-1000 protein_molecule denotes PEBP2betaMYH11
T31 1011-1039 other_name denotes neutrophilic differentiation
T32 1065-1090 cell_type denotes hematopoietic progenitors
T33 1113-1127 protein_molecule denotes PEBP2betaMYH11
T34 1132-1146 protein_molecule denotes activated NRAS
T35 1196-1223 other_name denotes abnormal nuclear morphology
T36 1238-1260 other_name denotes granulocytic dysplasia
T37 1286-1300 protein_molecule denotes PEBP2betaMYH11
T38 1312-1334 other_name denotes neutrophil development
T39 1376-1381 protein_molecule denotes Pebp2
T40 1415-1429 other_name denotes myelodysplasia

bionlp-st-gro-2013-development

Id Subject Object Predicate Lexical cue
T1 4-18 FusionProtein denotes PEBP2betaMYH11
T2 37-53 MutantGene denotes Inv(16)(p13;q22)
T7 147-158 Chromosome denotes Chromosomal
T9 188-193 Gene denotes genes
T10 222-230 ProteinSubunit denotes subunits
T13 295-300 Eukaryote denotes human
T17 371-387 MutantGene denotes Inv(16)(p13;q22)
T18 398-402 Gene denotes gene
T19 416-428 ProteinSubunit denotes beta subunit
T20 432-437 Protein denotes Pebp2
T21 445-455 Gene denotes MYH11 gene
T24 538-554 MutantGene denotes inv(16)(p13;q22)
T25 584-598 Promoter denotes hMRP8 promoter
T26 630-634 Eukaryote denotes mice
T28 650-664 FusionProtein denotes Pebp2betaSmmhc
T29 674-688 FusionProtein denotes fusion protein
T30 692-705 Cell denotes myeloid cells
T33 745-759 FusionProtein denotes PEBP2betaMYH11
T34 771-775 Eukaryote denotes mice
T35 801-805 Eukaryote denotes mice
T36 828-851 Cell denotes circulating neutrophils
T37 859-870 Tissue denotes bone marrow
T38 911-929 Cell denotes neutrophilic cells
T39 986-1000 FusionProtein denotes PEBP2betaMYH11
T42 1065-1090 Cell denotes hematopoietic progenitors
T44 1113-1127 FusionProtein denotes PEBP2betaMYH11
T46 1142-1146 Protein denotes NRAS
T48 1169-1178 Phenotype denotes phenotype
T49 1205-1212 Nucleus denotes nuclear
T51 1286-1300 FusionProtein denotes PEBP2betaMYH11
T54 1376-1381 Protein denotes Pebp2
T11 238-268 TranscriptionFactor denotes Pebp2/Cbf transcription factor
T12 467-499 Protein denotes smooth muscle myosin heavy chain
T22 501-506 Protein denotes Smmhc
T23 1043-1051 Cell denotes colonies
E1 57-73 Disease denotes myeloid leukemia
E2 74-81 Decrease denotes impairs
E3 82-103 CellularProcess denotes neutrophil maturation
E4 123-145 Disease denotes granulocytic dysplasia
E5 159-173 Mutation denotes translocations
E6 301-323 Disease denotes acute myeloid leukemia
E7 332-343 Disease denotes preleukemic
E8 355-369 Disease denotes myelodysplasia
E9 635-645 GeneExpression denotes expressing
E10 707-728 CellularProcess denotes Neutrophil maturation
E11 733-741 NegativeRegulation denotes impaired
E12 1001-1010 NegativeRegulation denotes inhibited
E13 1011-1039 CellDifferentiation denotes neutrophilic differentiation
E14 1092-1104 GeneExpression denotes Coexpression
E15 1132-1141 PositiveRegulation denotes activated
E16 1147-1154 PositiveRegulation denotes induced
E17 1238-1260 Disease denotes granulocytic dysplasia
E18 1305-1311 NegativeRegulation denotes impair
E19 1312-1334 CellularDevelopmentalProcess denotes neutrophil development
E20 1415-1429 Disease denotes myelodysplasia
E21 1092-1104 GeneExpression denotes Coexpression
E22 1147-1154 PositiveRegulation denotes induced
R2 T7 T9 hasPart Chromosomal,genes
R6 T9 T10 encodes genes,subunits
R8 E6 T13 fromSpecies acute myeloid leukemia,human
R9 T18 T19 encodes gene,beta subunit
R10 T20 T19 hasPart Pebp2,beta subunit
R13 T25 T30 locatedIn hMRP8 promoter,myeloid cells
R14 E9 T30 locatedIn expressing,myeloid cells
R15 E9 T26 fromSpecies expressing,mice
R16 T33 T34 fromSpecies PEBP2betaMYH11,mice
R17 T36 T35 fromSpecies circulating neutrophils,mice
R1 T21 T22 encodes MYH11 gene,Smmhc
R3 E13 T23 locatedIn neutrophilic differentiation,colonies
R5 T1 E2 hasAgent PEBP2betaMYH11,impairs
R6 E3 E2 hasPatient neutrophil maturation,impairs
R7 T1 E4 hasAgent PEBP2betaMYH11,granulocytic dysplasia
R8 T9 E5 hasPatient genes,translocations
R9 E5 E6 hasAgent translocations,acute myeloid leukemia
R10 E5 E7 hasAgent translocations,preleukemic
R11 E5 E8 hasAgent translocations,myelodysplasia
R12 T28 E9 hasPatient Pebp2betaSmmhc,expressing
R13 T33 E11 hasAgent PEBP2betaMYH11,impaired
R14 E10 E11 hasPatient Neutrophil maturation,impaired
R15 T39 E12 hasAgent PEBP2betaMYH11,inhibited
R16 E13 E12 hasPatient neutrophilic differentiation,inhibited
R17 T44 E14 hasPatient PEBP2betaMYH11,Coexpression
R18 T46 E15 hasPatient NRAS,activated
R19 E14 E16 hasAgent Coexpression,induced
R20 T48 E16 hasPatient phenotype,induced
R21 T51 E18 hasAgent PEBP2betaMYH11,impair
R22 E19 E18 hasPatient neutrophil development,impair
R23 T46 E21 hasPatient NRAS,Coexpression
R24 E21 E22 hasAgent Coexpression,induced
R25 T48 E22 hasPatient phenotype,induced