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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-149 Sentence denotes Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells.
T2 150-161 Sentence denotes BACKGROUND:
T3 162-278 Sentence denotes Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.
T4 279-462 Sentence denotes The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.
T5 463-483 Sentence denotes METHODS AND RESULTS:
T6 484-725 Sentence denotes Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.
T7 726-897 Sentence denotes In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).
T8 898-1120 Sentence denotes Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.
T9 1121-1216 Sentence denotes In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.
T10 1217-1424 Sentence denotes Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).
T11 1425-1437 Sentence denotes CONCLUSIONS:
T12 1438-1611 Sentence denotes The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
T13 1612-1727 Sentence denotes Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.
T1 0-149 Sentence denotes Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells.
T2 150-161 Sentence denotes BACKGROUND:
T3 162-278 Sentence denotes Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.
T4 279-462 Sentence denotes The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.
T5 463-483 Sentence denotes METHODS AND RESULTS:
T6 484-725 Sentence denotes Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.
T7 726-897 Sentence denotes In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).
T8 898-1120 Sentence denotes Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.
T9 1121-1216 Sentence denotes In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.
T10 1217-1424 Sentence denotes Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).
T11 1425-1437 Sentence denotes CONCLUSIONS:
T12 1438-1611 Sentence denotes The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
T13 1612-1727 Sentence denotes Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-19 cell_type denotes Activated platelets
T2 27-57 protein denotes monocyte chemotactic protein-1
T3 94-127 cell_type denotes intercellular adhesion molecule-1
T4 131-148 cell_type denotes endothelial cells
T5 305-335 protein denotes monocyte chemotactic protein-1
T6 337-342 protein denotes MCP-1
T7 380-413 cell_type denotes intercellular adhesion molecule-1
T8 415-421 protein denotes ICAM-1
T9 426-443 cell_type denotes endothelial cells
T10 498-536 cell_type denotes human umbilical vein endothelial cells
T11 574-597 cell_type denotes ADP-activated platelets
T12 628-633 protein denotes MCP-1
T13 660-666 protein denotes ICAM-1
T14 745-768 cell_type denotes ADP-activated platelets
T15 775-780 protein denotes MCP-1
T16 795-801 protein denotes ICAM-1
T17 864-887 cell_type denotes nonstimulated platelets
T18 916-958 protein denotes transcription factor nuclear factor-kappaB
T19 960-969 protein denotes NF-kappaB
T20 1026-1032 protein denotes kappaB
T21 1100-1119 cell_type denotes activated platelets
T22 1134-1157 cell_type denotes ADP-activated platelets
T23 1341-1346 protein denotes MCP-1
T24 1383-1389 protein denotes ICAM-1
T25 1471-1490 cell_type denotes activated platelets
T26 1513-1518 protein denotes MCP-1
T27 1534-1540 protein denotes ICAM-1
T28 1556-1573 cell_type denotes endothelial cells
T29 1581-1590 protein denotes NF-kappaB
T30 1647-1656 protein denotes NF-kappaB

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-149 Sentence denotes Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells.
S2 150-278 Sentence denotes BACKGROUND: Platelet/endothelium interaction plays an important role in the pathophysiology of inflammation and atherosclerosis.
S3 279-462 Sentence denotes The role of platelets for monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells has been assessed.
S4 463-725 Sentence denotes METHODS AND RESULTS: Monolayers of human umbilical vein endothelial cells were incubated with nonstimulated or ADP-activated platelets for 6 hours, and secretion of MCP-1 and surface expression of ICAM-1 were determined by ELISA and flow cytometry, respectively.
S5 726-897 Sentence denotes In the presence of ADP-activated platelets, both MCP-1 secretion and ICAM-1 surface expression were significantly increased compared with nonstimulated platelets (P<0.02).
S6 898-1120 Sentence denotes Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) determined by electrophoretic mobility shift assay and kappaB-dependent transcriptional activity was enhanced in the presence of activated platelets.
S7 1121-1216 Sentence denotes In addition, ADP-activated platelets induced MCP-1 and ICAM-1 promoter-dependent transcription.
S8 1217-1424 Sentence denotes Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05).
S9 1425-1611 Sentence denotes CONCLUSIONS: The present study indicates that activated platelets modulate chemotactic (MCP-1) and adhesive (ICAM-1) properties of endothelial cells via an NF-kappaB-dependent mechanism.
S10 1612-1727 Sentence denotes Platelet-induced activation of the NF-kappaB system might contribute to early inflammatory events in atherogenesis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-19 NP denotes Activated platelets
C2 27-127 NP denotes monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1
C3 131-148 NP denotes endothelial cells
C4 305-422 NP denotes monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1)
C5 426-443 NP denotes endothelial cells
C6 615-666 NP denotes secretion of MCP-1 and surface expression of ICAM-1
C8 745-768 NP denotes ADP-activated platelets
C7 729-768 NP denotes the presence of ADP-activated platelets
C9 770-820 NP denotes both MCP-1 secretion and ICAM-1 surface expression
C11 1100-1119 NP denotes activated platelets
C10 1084-1119 NP denotes the presence of activated platelets
C12 1134-1157 NP denotes ADP-activated platelets
C13 1341-1389 NP denotes MCP-1 secretion and surface expression of ICAM-1
C14 1471-1490 NP denotes activated platelets
C15 1556-1573 NP denotes endothelial cells
R1 C4 C2 coref-ident monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1),monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1
R2 C5 C3 coref-ident endothelial cells,endothelial cells
R3 C6 C4 coref-ident secretion of MCP-1 and surface expression of ICAM-1,monocyte chemotactic protein-1 (MCP-1) secretion and surface expression of intercellular adhesion molecule-1 (ICAM-1)
R4 C8 C1 coref-ident ADP-activated platelets,Activated platelets
R5 C9 C6 coref-ident both MCP-1 secretion and ICAM-1 surface expression,secretion of MCP-1 and surface expression of ICAM-1
R6 C11 C8 coref-ident activated platelets,ADP-activated platelets
R7 C10 C7 coref-ident the presence of activated platelets,the presence of ADP-activated platelets
R8 C12 C11 coref-ident ADP-activated platelets,activated platelets
R9 C13 C9 coref-ident MCP-1 secretion and surface expression of ICAM-1,both MCP-1 secretion and ICAM-1 surface expression
R10 C14 C12 coref-ident activated platelets,ADP-activated platelets
R11 C15 C5 coref-ident endothelial cells,endothelial cells

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-19 cell_type denotes Activated platelets
T2 27-57 protein_molecule denotes monocyte chemotactic protein-1
T3 94-127 cell_type denotes intercellular adhesion molecule-1
T4 131-148 cell_type denotes endothelial cells
T5 162-194 other_name denotes Platelet/endothelium interaction
T6 245-257 other_name denotes inflammation
T7 262-277 other_name denotes atherosclerosis
T8 305-335 protein_molecule denotes monocyte chemotactic protein-1
T9 337-342 protein_molecule denotes MCP-1
T10 380-413 cell_type denotes intercellular adhesion molecule-1
T11 415-421 protein_molecule denotes ICAM-1
T12 426-443 cell_type denotes endothelial cells
T13 484-494 other_name denotes Monolayers
T14 498-518 cell_type denotes human umbilical vein
T15 519-536 cell_type denotes endothelial cells
T16 574-597 cell_type denotes ADP-activated platelets
T17 628-633 protein_molecule denotes MCP-1
T18 638-656 other_name denotes surface expression
T19 660-666 protein_molecule denotes ICAM-1
T20 686-691 other_name denotes ELISA
T21 696-710 other_name denotes flow cytometry
T22 745-768 cell_type denotes ADP-activated platelets
T23 775-780 protein_molecule denotes MCP-1
T24 795-801 protein_molecule denotes ICAM-1
T25 802-820 other_name denotes surface expression
T26 864-887 cell_type denotes nonstimulated platelets
T27 916-958 protein_complex denotes transcription factor nuclear factor-kappaB
T28 960-969 protein_complex denotes NF-kappaB
T29 985-1021 other_name denotes electrophoretic mobility shift assay
T30 1026-1032 protein_molecule denotes kappaB
T31 1100-1119 cell_type denotes activated platelets
T32 1134-1138 cell_type denotes ADP-
T33 1138-1157 cell_type denotes activated platelets
T34 1245-1300 polynucleotide denotes double-stranded kappaB phosphorothioate oligonucleotide
T35 1341-1346 protein_molecule denotes MCP-1
T36 1361-1379 other_name denotes surface expression
T37 1383-1389 protein_molecule denotes ICAM-1
T38 1393-1414 tissue denotes activated endothelium
T39 1471-1490 cell_type denotes activated platelets
T40 1513-1518 protein_molecule denotes MCP-1
T41 1524-1534 other_name denotes adhesive (
T42 1534-1540 protein_molecule denotes ICAM-1
T43 1556-1573 cell_type denotes endothelial cells
T44 1581-1590 protein_complex denotes NF-kappaB
T45 1612-1639 other_name denotes Platelet-induced activation
T46 1647-1656 protein_complex denotes NF-kappaB
T47 1684-1709 other_name denotes early inflammatory events
T48 1713-1726 other_name denotes atherogenesis