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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-142 Sentence denotes Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
TextSentencer_T2 143-345 Sentence denotes A new human leukemia cell line with an eosinophilic phenotype, designated YJ, was established from the peripheral blood cells of a patient with chronic myelomonocytic leukemia (CMMoL) with eosinophilia.
TextSentencer_T3 346-510 Sentence denotes When cultured in RPMI 1640 medium containing 10% fetal bovine serum, most YJ cells were myeloblastoid with a small number of the cells having eosinophilic granules.
TextSentencer_T4 511-613 Sentence denotes Cell surface markers in the YJ cells were positive for CD33 and were negative for CD34, CD16 and CD23.
TextSentencer_T5 614-984 Sentence denotes The eosinophilic characteristics of YJ cells were confirmed by histochemical staining with Fast-Green/Neutral-Red and by the expression of mRNAs for eosinophil-associated granule proteins, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), and for the Charcot-Leyden crystal (CLC) protein.
TextSentencer_T6 985-1107 Sentence denotes The YJ cells could be induced towards monocytic differentiation by stimulation with phorbol 12-myristate 13-acetate (PMA).
TextSentencer_T7 1108-1318 Sentence denotes The monocytic characteristics of YJ cells treated with PMA were confirmed by morphological analysis with alpha-naphthyl butyrate esterase staining, by CD14 expression, and by increased expression of Egr-1 mRNA.
TextSentencer_T8 1319-1445 Sentence denotes Furthermore, YJ cells could be differentiated towards the neutrophil lineage by stimulation with all-trans retinoic acid (RA).
TextSentencer_T9 1446-1656 Sentence denotes YJ cells treated in vitro with 2 microM RA differentiated into metamyelocytes and band neutrophils, and increased the number of nitroblue tetrazolium (NBT)-positive cells and increased gp91phox mRNA expression.
TextSentencer_T10 1657-1831 Sentence denotes Thus, the YJ cell line exhibited eosinophilic characteristics, but was able to differentiate to the monocytic or neutrophilic lineages in response to PMA or RA, respectively.
TextSentencer_T11 1832-1958 Sentence denotes The expression of genes for transcription factors involved in myeloid differentiation was evaluated by Northern blot analysis.
TextSentencer_T12 1959-2034 Sentence denotes Increased expression of Egr-1 was observed with macrophage differentiation.
TextSentencer_T13 2035-2141 Sentence denotes In contrast, increased expressions of C/EBPbeta and MZF-1 mRNA occurred with neutrophilic differentiation.
TextSentencer_T14 2142-2301 Sentence denotes The YJ cell line should be useful for elucidating the molecular mechanisms governing lineage switching from the eosinophil to monocytic or neutrophil lineages.
T1 0-142 Sentence denotes Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
T2 143-345 Sentence denotes A new human leukemia cell line with an eosinophilic phenotype, designated YJ, was established from the peripheral blood cells of a patient with chronic myelomonocytic leukemia (CMMoL) with eosinophilia.
T3 346-510 Sentence denotes When cultured in RPMI 1640 medium containing 10% fetal bovine serum, most YJ cells were myeloblastoid with a small number of the cells having eosinophilic granules.
T4 511-613 Sentence denotes Cell surface markers in the YJ cells were positive for CD33 and were negative for CD34, CD16 and CD23.
T5 614-984 Sentence denotes The eosinophilic characteristics of YJ cells were confirmed by histochemical staining with Fast-Green/Neutral-Red and by the expression of mRNAs for eosinophil-associated granule proteins, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), and for the Charcot-Leyden crystal (CLC) protein.
T6 985-1107 Sentence denotes The YJ cells could be induced towards monocytic differentiation by stimulation with phorbol 12-myristate 13-acetate (PMA).
T7 1108-1318 Sentence denotes The monocytic characteristics of YJ cells treated with PMA were confirmed by morphological analysis with alpha-naphthyl butyrate esterase staining, by CD14 expression, and by increased expression of Egr-1 mRNA.
T8 1319-1445 Sentence denotes Furthermore, YJ cells could be differentiated towards the neutrophil lineage by stimulation with all-trans retinoic acid (RA).
T9 1446-1656 Sentence denotes YJ cells treated in vitro with 2 microM RA differentiated into metamyelocytes and band neutrophils, and increased the number of nitroblue tetrazolium (NBT)-positive cells and increased gp91phox mRNA expression.
T10 1657-1831 Sentence denotes Thus, the YJ cell line exhibited eosinophilic characteristics, but was able to differentiate to the monocytic or neutrophilic lineages in response to PMA or RA, respectively.
T11 1832-1958 Sentence denotes The expression of genes for transcription factors involved in myeloid differentiation was evaluated by Northern blot analysis.
T12 1959-2034 Sentence denotes Increased expression of Egr-1 was observed with macrophage differentiation.
T13 2035-2141 Sentence denotes In contrast, increased expressions of C/EBPbeta and MZF-1 mRNA occurred with neutrophilic differentiation.
T14 2142-2301 Sentence denotes The YJ cell line should be useful for elucidating the molecular mechanisms governing lineage switching from the eosinophil to monocytic or neutrophil lineages.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 64-102 cell_line denotes myeloid-committed eosinophil cell line
T2 104-106 cell_line denotes YJ
T3 149-173 cell_line denotes human leukemia cell line
T4 217-219 cell_line denotes YJ
T5 246-268 cell_type denotes peripheral blood cells
T6 420-428 cell_line denotes YJ cells
T7 511-531 protein denotes Cell surface markers
T8 539-547 cell_line denotes YJ cells
T9 566-570 protein denotes CD33
T10 593-597 protein denotes CD34
T11 599-603 protein denotes CD16
T12 608-612 protein denotes CD23
T13 650-658 cell_line denotes YJ cells
T14 753-758 RNA denotes mRNAs
T15 763-801 protein denotes eosinophil-associated granule proteins
T16 803-830 protein denotes eosinophil cationic protein
T17 832-835 protein denotes ECP
T18 838-867 protein denotes eosinophil-derived neurotoxin
T19 869-872 protein denotes EDN
T20 875-896 protein denotes eosinophil peroxidase
T21 898-901 protein denotes EPO
T22 908-927 protein denotes major basic protein
T23 929-932 protein denotes MBP
T24 947-983 protein denotes Charcot-Leyden crystal (CLC) protein
T25 989-997 cell_line denotes YJ cells
T26 1141-1149 cell_line denotes YJ cells
T27 1259-1263 protein denotes CD14
T28 1307-1317 RNA denotes Egr-1 mRNA
T29 1332-1340 cell_line denotes YJ cells
T30 1377-1395 cell_type denotes neutrophil lineage
T31 1446-1454 cell_line denotes YJ cells
T32 1509-1523 cell_type denotes metamyelocytes
T33 1528-1544 cell_type denotes band neutrophils
T34 1574-1616 cell_line denotes nitroblue tetrazolium (NBT)-positive cells
T35 1631-1644 RNA denotes gp91phox mRNA
T36 1667-1679 cell_line denotes YJ cell line
T37 1757-1791 cell_type denotes monocytic or neutrophilic lineages
T38 1860-1881 protein denotes transcription factors
T39 1983-1988 protein denotes Egr-1
T40 2073-2082 protein denotes C/EBPbeta
T41 2087-2097 RNA denotes MZF-1 mRNA
T42 2146-2158 cell_line denotes YJ cell line
T43 2254-2264 cell_type denotes eosinophil
T44 2268-2300 cell_type denotes monocytic or neutrophil lineages

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-142 Sentence denotes Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
S2 143-345 Sentence denotes A new human leukemia cell line with an eosinophilic phenotype, designated YJ, was established from the peripheral blood cells of a patient with chronic myelomonocytic leukemia (CMMoL) with eosinophilia.
S3 346-510 Sentence denotes When cultured in RPMI 1640 medium containing 10% fetal bovine serum, most YJ cells were myeloblastoid with a small number of the cells having eosinophilic granules.
S4 511-613 Sentence denotes Cell surface markers in the YJ cells were positive for CD33 and were negative for CD34, CD16 and CD23.
S5 614-984 Sentence denotes The eosinophilic characteristics of YJ cells were confirmed by histochemical staining with Fast-Green/Neutral-Red and by the expression of mRNAs for eosinophil-associated granule proteins, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), and for the Charcot-Leyden crystal (CLC) protein.
S6 985-1107 Sentence denotes The YJ cells could be induced towards monocytic differentiation by stimulation with phorbol 12-myristate 13-acetate (PMA).
S7 1108-1318 Sentence denotes The monocytic characteristics of YJ cells treated with PMA were confirmed by morphological analysis with alpha-naphthyl butyrate esterase staining, by CD14 expression, and by increased expression of Egr-1 mRNA.
S8 1319-1445 Sentence denotes Furthermore, YJ cells could be differentiated towards the neutrophil lineage by stimulation with all-trans retinoic acid (RA).
S9 1446-1656 Sentence denotes YJ cells treated in vitro with 2 microM RA differentiated into metamyelocytes and band neutrophils, and increased the number of nitroblue tetrazolium (NBT)-positive cells and increased gp91phox mRNA expression.
S10 1657-1831 Sentence denotes Thus, the YJ cell line exhibited eosinophilic characteristics, but was able to differentiate to the monocytic or neutrophilic lineages in response to PMA or RA, respectively.
S11 1832-1958 Sentence denotes The expression of genes for transcription factors involved in myeloid differentiation was evaluated by Northern blot analysis.
S12 1959-2034 Sentence denotes Increased expression of Egr-1 was observed with macrophage differentiation.
S13 2035-2141 Sentence denotes In contrast, increased expressions of C/EBPbeta and MZF-1 mRNA occurred with neutrophilic differentiation.
S14 2142-2301 Sentence denotes The YJ cell line should be useful for elucidating the molecular mechanisms governing lineage switching from the eosinophil to monocytic or neutrophil lineages.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 58-107 NP denotes a new myeloid-committed eosinophil cell line (YJ)
C2 143-204 NP denotes A new human leukemia cell line with an eosinophilic phenotype
C3 217-219 NP denotes YJ
C4 415-428 NP denotes most YJ cells
C5 471-480 NP denotes the cells
C6 535-547 NP denotes the YJ cells
C8 650-658 NP denotes YJ cells
C7 614-658 NP denotes The eosinophilic characteristics of YJ cells
C9 985-997 NP denotes The YJ cells
C10 1069-1106 NP denotes phorbol 12-myristate 13-acetate (PMA)
C11 1141-1149 NP denotes YJ cells
C12 1163-1166 NP denotes PMA
C13 1332-1340 NP denotes YJ cells
C14 1416-1444 NP denotes all-trans retinoic acid (RA)
C15 1446-1454 NP denotes YJ cells
C16 1663-1679 NP denotes the YJ cell line
C17 1690-1718 NP denotes eosinophilic characteristics
C18 1753-1791 NP denotes the monocytic or neutrophilic lineages
C19 1807-1810 NP denotes PMA
C20 1814-1816 NP denotes RA
C21 2142-2158 NP denotes The YJ cell line
C22 2268-2300 NP denotes monocytic or neutrophil lineages
R1 C2 C1 coref-ident A new human leukemia cell line with an eosinophilic phenotype,a new myeloid-committed eosinophil cell line (YJ)
R2 C3 C2 coref-ident YJ,A new human leukemia cell line with an eosinophilic phenotype
R3 C5 C4 coref-ident the cells,most YJ cells
R4 C6 C5 coref-ident the YJ cells,the cells
R5 C9 C8 coref-ident The YJ cells,YJ cells
R6 C11 C9 coref-ident YJ cells,The YJ cells
R7 C12 C10 coref-ident PMA,phorbol 12-myristate 13-acetate (PMA)
R8 C13 C11 coref-ident YJ cells,YJ cells
R9 C15 C13 coref-ident YJ cells,YJ cells
R10 C16 C3 coref-ident the YJ cell line,YJ
R11 C17 C7 coref-ident eosinophilic characteristics,The eosinophilic characteristics of YJ cells
R12 C19 C12 coref-ident PMA,PMA
R13 C20 C14 coref-ident RA,all-trans retinoic acid (RA)
R14 C21 C16 coref-ident The YJ cell line,the YJ cell line
R15 C22 C18 coref-ident monocytic or neutrophil lineages,the monocytic or neutrophilic lineages

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 31-56 other_name denotes hematopoietic development
T2 64-102 cell_line denotes myeloid-committed eosinophil cell line
T3 104-106 cell_line denotes YJ
T4 121-141 other_name denotes trilineage potential
T5 149-173 cell_line denotes human leukemia cell line
T6 182-204 other_name denotes eosinophilic phenotype
T7 217-219 cell_line denotes YJ
T8 246-268 cell_type denotes peripheral blood cells
T9 274-281 multi_cell denotes patient
T10 287-318 other_name denotes chronic myelomonocytic leukemia
T11 320-325 other_name denotes CMMoL
T12 332-344 other_name denotes eosinophilia
T13 363-379 other_organic_compound denotes RPMI 1640 medium
T14 395-413 other_organic_compound denotes fetal bovine serum
T15 420-428 cell_line denotes YJ cells
T16 488-509 cell_component denotes eosinophilic granules
T17 511-531 protein_family_or_group denotes Cell surface markers
T18 539-547 cell_line denotes YJ cells
T19 566-570 protein_molecule denotes CD33
T20 593-597 protein_molecule denotes CD34
T21 599-603 protein_molecule denotes CD16
T22 608-612 protein_molecule denotes CD23
T23 650-658 cell_line denotes YJ cells
T24 705-727 other_organic_compound denotes Fast-Green/Neutral-Red
T25 753-758 RNA_family_or_group denotes mRNAs
T26 763-801 protein_family_or_group denotes eosinophil-associated granule proteins
T27 803-830 protein_molecule denotes eosinophil cationic protein
T28 832-835 protein_molecule denotes ECP
T29 838-867 protein_molecule denotes eosinophil-derived neurotoxin
T30 869-872 protein_molecule denotes EDN
T31 875-896 protein_molecule denotes eosinophil peroxidase
T32 898-901 protein_molecule denotes EPO
T33 908-927 protein_molecule denotes major basic protein
T34 929-932 protein_molecule denotes MBP
T35 947-983 protein_molecule denotes Charcot-Leyden crystal (CLC) protein
T36 989-997 cell_line denotes YJ cells
T37 1023-1048 other_name denotes monocytic differentiation
T38 1069-1100 other_organic_compound denotes phorbol 12-myristate 13-acetate
T39 1102-1105 other_organic_compound denotes PMA
T40 1141-1149 cell_line denotes YJ cells
T41 1163-1166 other_organic_compound denotes PMA
T42 1213-1245 other_organic_compound denotes alpha-naphthyl butyrate esterase
T43 1259-1263 protein_molecule denotes CD14
T44 1307-1317 RNA_molecule denotes Egr-1 mRNA
T45 1332-1340 cell_line denotes YJ cells
T46 1377-1395 cell_type denotes neutrophil lineage
T47 1416-1439 other_organic_compound denotes all-trans retinoic acid
T48 1441-1443 other_organic_compound denotes RA
T49 1446-1454 cell_line denotes YJ cells
T50 1486-1488 other_organic_compound denotes RA
T51 1509-1523 cell_type denotes metamyelocytes
T52 1528-1544 cell_type denotes band neutrophils
T53 1574-1616 cell_line denotes nitroblue tetrazolium (NBT)-positive cells
T54 1631-1644 RNA_molecule denotes gp91phox mRNA
T55 1667-1679 cell_line denotes YJ cell line
T56 1690-1718 other_name denotes eosinophilic characteristics
T57 1807-1810 other_organic_compound denotes PMA
T58 1814-1816 other_organic_compound denotes RA
T59 1860-1881 protein_family_or_group denotes transcription factors
T60 1935-1957 other_name denotes Northern blot analysis
T61 1983-1988 protein_molecule denotes Egr-1
T62 2007-2033 other_name denotes macrophage differentiation
T63 2073-2082 protein_molecule denotes C/EBPbeta
T64 2087-2092 protein_molecule denotes MZF-1
T65 2146-2158 cell_line denotes YJ cell line
T66 2254-2264 cell_type denotes eosinophil

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 257-262 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 408-413 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 155-163 HP:0001909 denotes leukemia
AB2 287-318 HP:0012325 denotes chronic myelomonocytic leukemia
AB3 332-344 HP:0001880 denotes eosinophilia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 257-262 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 408-413 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 287-318 ORDO:98823 denotes chronic myelomonocytic leukemia