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PubMed:9722600 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.
T2 129-223 Sentence denotes The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia.
T3 224-381 Sentence denotes Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process.
T4 382-463 Sentence denotes This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A).
T5 464-628 Sentence denotes Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression.
T6 629-741 Sentence denotes In this paper, we demonstrate that Tax can also activate E2F-mediated transcription independently of p16(INK4A).
T7 742-990 Sentence denotes Indeed, when Tax is coexpressed with the E2F-1 transcription factor in CEM T-cells, which lack expression of p16(INK4A), it strongly potentiates the E2F-dependent activation of a reporter construct driven by a promoter containing E2F binding sites.
T8 991-1066 Sentence denotes This stimulation is abrogated by mutations affecting the E2F-binding sites.
T9 1067-1143 Sentence denotes In addition, Tax also stimulates the transcription of the E2F-1 gene itself.
T10 1144-1439 Sentence denotes Using Tax mutants that fail to activate either ATF- or NF-kappaB-dependent promoters and different 5' truncation mutants of the E2F-1 promoter, we show that the Tax-dependent transcriptional control of the E2F1 gene involves, at least in part, the ATF binding site located in the E2F-1 promoter.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 321-324 gene:6900 denotes Tax
T1 284-298 disease:C0598766 denotes leukemogenesis
R1 T0 T1 associated_with Tax,leukemogenesis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-17 protein denotes E2F
T2 44-90 protein denotes human T-cell leukemia virus type I Tax protein
T3 96-127 cell_line denotes p16(INK4A)-negative T-cell line
T4 321-332 protein denotes Tax protein
T5 435-451 protein denotes tumor suppressor
T6 452-462 protein denotes p16(INK4A)
T7 478-481 protein denotes Tax
T8 545-548 protein denotes E2F
T9 664-667 protein denotes Tax
T10 686-689 protein denotes E2F
T11 730-740 protein denotes p16(INK4A)
T12 755-758 protein denotes Tax
T13 783-788 protein denotes E2F-1
T14 789-809 protein denotes transcription factor
T15 813-824 cell_line denotes CEM T-cells
T16 851-861 protein denotes p16(INK4A)
T17 891-894 protein denotes E2F
T18 972-989 DNA denotes E2F binding sites
T19 1048-1065 DNA denotes E2F-binding sites
T20 1080-1083 protein denotes Tax
T21 1125-1135 DNA denotes E2F-1 gene
T22 1150-1153 protein denotes Tax
T23 1191-1194 protein denotes ATF
T24 1199-1228 DNA denotes NF-kappaB-dependent promoters
T25 1243-1264 DNA denotes 5' truncation mutants
T26 1272-1286 DNA denotes E2F-1 promoter
T27 1305-1308 protein denotes Tax
T28 1350-1359 DNA denotes E2F1 gene
T29 1392-1408 DNA denotes ATF binding site
T30 1424-1438 DNA denotes E2F-1 promoter

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9722600-0#79#82#gene6900 79-82 gene6900 denotes Tax
9722600-0#100#105#gene1029 100-105 gene1029 denotes INK4A
9722600-0#44#65#diseaseC0023493 44-65 diseaseC0023493 denotes human T-cell leukemia
9722600-2#97#100#gene6900 321-324 gene6900 denotes Tax
9722600-2#60#74#diseaseC0598766 284-298 diseaseC0598766 denotes leukemogenesis
79#82#gene690044#65#diseaseC0023493 9722600-0#79#82#gene6900 9722600-0#44#65#diseaseC0023493 associated_with Tax,human T-cell leukemia
100#105#gene102944#65#diseaseC0023493 9722600-0#100#105#gene1029 9722600-0#44#65#diseaseC0023493 associated_with INK4A,human T-cell leukemia
97#100#gene690060#74#diseaseC0598766 9722600-2#97#100#gene6900 9722600-2#60#74#diseaseC0598766 associated_with Tax,leukemogenesis

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-128 Sentence denotes Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line.
S2 129-223 Sentence denotes The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia.
S3 224-381 Sentence denotes Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process.
S4 382-463 Sentence denotes This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A).
S5 464-628 Sentence denotes Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression.
S6 629-741 Sentence denotes In this paper, we demonstrate that Tax can also activate E2F-mediated transcription independently of p16(INK4A).
S7 742-990 Sentence denotes Indeed, when Tax is coexpressed with the E2F-1 transcription factor in CEM T-cells, which lack expression of p16(INK4A), it strongly potentiates the E2F-dependent activation of a reporter construct driven by a promoter containing E2F binding sites.
S8 991-1066 Sentence denotes This stimulation is abrogated by mutations affecting the E2F-binding sites.
S9 1067-1143 Sentence denotes In addition, Tax also stimulates the transcription of the E2F-1 gene itself.
S10 1144-1439 Sentence denotes Using Tax mutants that fail to activate either ATF- or NF-kappaB-dependent promoters and different 5' truncation mutants of the E2F-1 promoter, we show that the Tax-dependent transcriptional control of the E2F1 gene involves, at least in part, the ATF binding site located in the E2F-1 promoter.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 129-176 NP denotes The human T-cell leukemia virus type I (HTLV-I)
C2 233-252 NP denotes the exact mechanism
C3 256-261 NP denotes which
C4 262-268 NP denotes HTLV-I
C5 284-298 NP denotes leukemogenesis
C6 317-332 NP denotes the Tax protein
C7 368-380 NP denotes this process
C8 382-405 NP denotes This 40-kDa polypeptide
C9 431-462 NP denotes the tumor suppressor p16(INK4A)
C10 478-481 NP denotes Tax
C11 495-516 NP denotes the signaling pathway
C12 517-521 NP denotes that
C13 545-548 NP denotes E2F
C14 549-553 NP denotes that
C15 664-667 NP denotes Tax
C16 730-740 NP denotes p16(INK4A)
C17 755-758 NP denotes Tax
C18 813-824 NP denotes CEM T-cells
C19 826-831 NP denotes which
C20 851-861 NP denotes p16(INK4A)
C21 863-865 NP denotes it
C22 972-989 NP denotes E2F binding sites
C23 1044-1065 NP denotes the E2F-binding sites
C24 1080-1083 NP denotes Tax
C25 1121-1142 NP denotes the E2F-1 gene itself
C26 1150-1161 NP denotes Tax mutants
C27 1162-1166 NP denotes that
C28 1268-1286 NP denotes the E2F-1 promoter
C29 1346-1359 NP denotes the E2F1 gene
C30 1420-1438 NP denotes the E2F-1 promoter
R1 C3 C2 coref-relat which,the exact mechanism
R2 C4 C1 coref-ident HTLV-I,The human T-cell leukemia virus type I (HTLV-I)
R3 C7 C5 coref-ident this process,leukemogenesis
R4 C8 C6 coref-ident This 40-kDa polypeptide,the Tax protein
R5 C12 C11 coref-relat that,the signaling pathway
R6 C14 C13 coref-relat that,E2F
R7 C15 C10 coref-ident Tax,Tax
R8 C16 C9 coref-ident p16(INK4A),the tumor suppressor p16(INK4A)
R9 C17 C15 coref-ident Tax,Tax
R10 C19 C18 coref-relat which,CEM T-cells
R11 C20 C16 coref-ident p16(INK4A),p16(INK4A)
R12 C21 C17 coref-pron it,Tax
R13 C23 C22 coref-ident the E2F-binding sites,E2F binding sites
R14 C24 C21 coref-ident Tax,it
R15 C27 C26 coref-relat that,Tax mutants
R16 C29 C25 coref-ident the E2F1 gene,the E2F-1 gene itself
R17 C30 C28 coref-ident the E2F-1 promoter,the E2F-1 promoter

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-17 protein_molecule denotes E2F
T2 44-71 virus denotes human T-cell leukemia virus
T3 96-127 cell_line denotes p16(INK4A)-negative T-cell line
T4 133-167 virus denotes human T-cell leukemia virus type I
T5 169-175 virus denotes HTLV-I
T6 201-222 other_name denotes adult T-cell leukemia
T7 262-268 virus denotes HTLV-I
T8 284-298 other_name denotes leukemogenesis
T9 321-332 protein_molecule denotes Tax protein
T10 387-405 peptide denotes 40-kDa polypeptide
T11 435-451 protein_family_or_group denotes tumor suppressor
T12 452-462 protein_molecule denotes p16(INK4A)
T13 478-481 protein_molecule denotes Tax
T14 545-548 protein_molecule denotes E2F
T15 605-627 other_name denotes cell cycle progression
T16 664-667 protein_molecule denotes Tax
T17 686-689 protein_molecule denotes E2F
T18 730-740 protein_molecule denotes p16(INK4A)
T19 755-758 protein_molecule denotes Tax
T20 783-788 protein_molecule denotes E2F-1
T21 789-809 protein_family_or_group denotes transcription factor
T22 813-824 cell_line denotes CEM T-cells
T23 851-861 protein_molecule denotes p16(INK4A)
T24 891-894 protein_molecule denotes E2F
T25 972-975 protein_molecule denotes E2F
T26 1048-1051 protein_molecule denotes E2F
T27 1080-1083 protein_molecule denotes Tax
T28 1125-1130 protein_molecule denotes E2F-1
T29 1150-1153 protein_molecule denotes Tax
T30 1191-1194 protein_family_or_group denotes ATF
T31 1199-1228 DNA_family_or_group denotes NF-kappaB-dependent promoters
T32 1243-1264 DNA_family_or_group denotes 5' truncation mutants
T33 1272-1277 protein_molecule denotes E2F-1
T34 1305-1308 protein_molecule denotes Tax
T35 1350-1359 DNA_domain_or_region denotes E2F1 gene
T36 1392-1408 DNA_domain_or_region denotes ATF binding site
T37 1424-1429 protein_molecule denotes E2F-1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 50-65 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T2 139-154 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T3 201-222 Disease denotes adult T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0019471
T4 435-440 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 57-65 Phenotype denotes leukemia HP:0001909
T2 146-154 Phenotype denotes leukemia HP:0001909
T3 214-222 Phenotype denotes leukemia HP:0001909
T4 435-440 Phenotype denotes tumor HP:0002664

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 44-49 OrganismTaxon denotes human 9606
T2 133-138 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 50-56 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 116-122 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T3 139-145 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T4 207-213 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T5 605-615 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 50-56 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 72-78 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T4 116-122 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T5 139-145 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T6 161-167 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T8 207-213 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T9 817-824 Cell denotes T-cells http://purl.obolibrary.org/obo/CL:0000084