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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-135 Sentence denotes In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation.
TextSentencer_T2 136-295 Sentence denotes The primary role of protooncogene c-kit in mast cell differentiation is supported by the development of mast cells from CD34+/CD117+(c-kit) myeloid precursors.
TextSentencer_T3 296-502 Sentence denotes Growth factor independence, neoplastic transformation and differentiation of mast cells were found in association with c-kit activating mutations in both murine and human mastocytoma and mast cell diseases.
TextSentencer_T4 503-704 Sentence denotes We have identified a novel c-kit mutation (D816Y) in peripheral blood mononuclear cells from a patient with AML (M2), massive presence of mast cells in bone marrow and rapid progression of the disease.
TextSentencer_T5 705-964 Sentence denotes The mutation, a G-->T transversion at nt 2467 of the c-kit gene resulting in Asp816-->Tyr substitution, corresponds to the D814Y and D817Y mutations identified and characterized in the murine P815 mastocytoma and the rat RBL-2H3 mast cell leukemia cell lines.
TextSentencer_T6 965-1132 Sentence denotes The absence of SCF transcripts that we found by RTPCR in the patient's blasts indicates that, also in humans, this activating mutation leads to SCF independent growth.
TextSentencer_T7 1133-1287 Sentence denotes The expression of the mutant allele on Kit signaling may be further enhanced by trisomy of chromosome 4 (carrying the c-kit gene) in the patient's blasts.
TextSentencer_T8 1288-1564 Sentence denotes From these findings it is concluded that mast cells could be generated from a leukemic CD34/CD117-positive clone, that combines the antigenic expression of mast cell precursor to the growth and differentiation factor-independence which was derived by the c-kit D816Y mutation.
T1 0-135 Sentence denotes In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation.
T2 136-295 Sentence denotes The primary role of protooncogene c-kit in mast cell differentiation is supported by the development of mast cells from CD34+/CD117+(c-kit) myeloid precursors.
T3 296-502 Sentence denotes Growth factor independence, neoplastic transformation and differentiation of mast cells were found in association with c-kit activating mutations in both murine and human mastocytoma and mast cell diseases.
T4 503-704 Sentence denotes We have identified a novel c-kit mutation (D816Y) in peripheral blood mononuclear cells from a patient with AML (M2), massive presence of mast cells in bone marrow and rapid progression of the disease.
T5 705-964 Sentence denotes The mutation, a G-->T transversion at nt 2467 of the c-kit gene resulting in Asp816-->Tyr substitution, corresponds to the D814Y and D817Y mutations identified and characterized in the murine P815 mastocytoma and the rat RBL-2H3 mast cell leukemia cell lines.
T6 965-1132 Sentence denotes The absence of SCF transcripts that we found by RTPCR in the patient's blasts indicates that, also in humans, this activating mutation leads to SCF independent growth.
T7 1133-1287 Sentence denotes The expression of the mutant allele on Kit signaling may be further enhanced by trisomy of chromosome 4 (carrying the c-kit gene) in the patient's blasts.
T8 1288-1564 Sentence denotes From these findings it is concluded that mast cells could be generated from a leukemic CD34/CD117-positive clone, that combines the antigenic expression of mast cell precursor to the growth and differentiation factor-independence which was derived by the c-kit D816Y mutation.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1251-1256 gene:3815 denotes c-kit
T1 1213-1220 disease:C0041107 denotes trisomy
R1 T0 T1 associated_with c-kit,trisomy

PennBioIE

Id Subject Object Predicate Lexical cue
T1 120-125 protein denotes C-kit
T2 170-175 protein denotes c-kit
T3 256-260 protein denotes CD34
T4 262-267 protein denotes CD117
T5 269-274 protein denotes c-kit
T6 296-309 protein denotes Growth factor
T7 415-420 protein denotes c-kit
T8 530-535 protein denotes c-kit
T9 536-544 protein denotes mutation
T10 546-547 protein denotes D
T11 547-550 protein denotes 816
T12 550-551 protein denotes Y
T13 709-717 protein denotes mutation
T14 721-722 protein denotes G
T15 725-726 protein denotes T
T16 727-739 protein denotes transversion
T17 743-750 protein denotes nt 2467
T18 758-763 protein denotes c-kit
T19 782-785 protein denotes Asp
T20 785-788 protein denotes 816
T21 791-794 protein denotes Tyr
T22 795-807 protein denotes substitution
T23 828-829 protein denotes D
T24 829-832 protein denotes 814
T25 832-833 protein denotes Y
T26 838-839 protein denotes D
T27 839-842 protein denotes 817
T28 842-843 protein denotes Y
T29 844-853 protein denotes mutations
T30 980-983 protein denotes SCF
T31 1091-1099 protein denotes mutation
T32 1109-1112 protein denotes SCF
T33 1172-1175 protein denotes Kit
T34 1213-1220 protein denotes trisomy
T35 1224-1236 protein denotes chromosome 4
T36 1251-1256 protein denotes c-kit
T37 1375-1379 protein denotes CD34
T38 1380-1385 protein denotes CD117
T39 1471-1504 protein denotes growth and differentiation factor
T40 1543-1548 protein denotes c-kit
T41 1549-1550 protein denotes D
T42 1550-1553 protein denotes 816
T43 1553-1554 protein denotes Y
T44 1555-1563 protein denotes mutation

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
9714703-3#43#48#geners121913506 546-551 geners121913506 denotes D816Y
9714703-3#113#115#diseaseC0023467 616-618 diseaseC0023467 denotes M2
9714703-4#133#138#geners121913506 838-843 geners121913506 denotes D817Y
9714703-4#197#208#diseaseC0024897 902-913 diseaseC0024897 denotes mastocytoma
9714703-4#197#208#diseaseC0334664 902-913 diseaseC0334664 denotes mastocytoma
9714703-4#197#208#diseaseC2242987 902-913 diseaseC2242987 denotes mastocytoma
9714703-4#229#247#diseaseC0023461 934-952 diseaseC0023461 denotes mast cell leukemia
43#48#geners121913506113#115#diseaseC0023467 9714703-3#43#48#geners121913506 9714703-3#113#115#diseaseC0023467 associated_with D816Y,M2
133#138#geners121913506197#208#diseaseC0024897 9714703-4#133#138#geners121913506 9714703-4#197#208#diseaseC0024897 associated_with D817Y,mastocytoma
133#138#geners121913506197#208#diseaseC0334664 9714703-4#133#138#geners121913506 9714703-4#197#208#diseaseC0334664 associated_with D817Y,mastocytoma
133#138#geners121913506197#208#diseaseC2242987 9714703-4#133#138#geners121913506 9714703-4#197#208#diseaseC2242987 associated_with D817Y,mastocytoma
133#138#geners121913506229#247#diseaseC0023461 9714703-4#133#138#geners121913506 9714703-4#229#247#diseaseC0023461 associated_with D817Y,mast cell leukemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9714703-6#118#123#gene3815 1251-1256 gene3815 denotes c-kit
9714703-6#80#87#diseaseC0041107 1213-1220 diseaseC0041107 denotes trisomy
118#123#gene381580#87#diseaseC0041107 9714703-6#118#123#gene3815 9714703-6#80#87#diseaseC0041107 associated_with c-kit,trisomy

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 567-572 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 655-666 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 43-65 HP:0004808 denotes acute myeloid leukemia
AB1 944-952 HP:0001909 denotes leukemia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 567-572 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 655-666 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 611-618 ORDO:98834 denotes AML (M2