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PubMed:9712883 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-156 Sentence denotes Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.
T2 157-212 Sentence denotes Both BTG1 and BTG2 are involved in cell-growth control.
T3 213-364 Sentence denotes BTG2 expression is regulated by p53, and its inactivation in embryonic stem cells leads to the disruption of DNA damage-induced G2/M cell-cycle arrest.
T4 365-498 Sentence denotes In order to investigate the mechanism underlying Btg-mediated functions, we looked for possible functional partners of Btg1 and Btg2.
T5 499-998 Sentence denotes Using yeast two-hybrid screening, protein-binding assays, and transient transfection assays in HeLa cells, we demonstrated the physical in vitro and in vivo interaction of both Btg1 and Btg2 with the mouse protein mCaf1 (i.e. mouse CCR4-associated factor 1). mCaf1 was identified through its interaction with the CCR4 protein, a component of a general transcription multisubunit complex, which, in yeast, regulates the expression of different genes involved in cell-cycle regulation and progression.
T6 999-1212 Sentence denotes These data suggest that Btg proteins, through their association with mCaf1, may participate, either directly or indirectly, in the transcriptional regulation of the genes involved in the control of the cell cycle.
T7 1213-1383 Sentence denotes Finally, we found that box B, one of two conserved domains which define the Btg family, plays a functional role, namely that it is essential to the Btg-mCaf1 interaction.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 284-294 http://purl.obolibrary.org/obo/MAT_0000185 denotes stem cells
T2 284-288 http://purl.obolibrary.org/obo/MAT_0000239 denotes stem
T3 1240-1246 http://purl.obolibrary.org/obo/MAT_0000299 denotes B, one

relna

Id Subject Object Predicate Lexical cue
T1 15-19 Protein denotes BTG1
T2 24-27 DNA denotes p53
T3 38-42 DNA denotes BTG2
T4 62-67 DNA denotes mCaf1
T5 116-120 Protein denotes CCR4
T6 162-166 Protein denotes BTG1
T7 171-175 DNA denotes BTG2
T8 213-217 DNA denotes BTG2
T9 245-248 DNA denotes p53
T10 484-488 Protein denotes Btg1
T11 493-497 DNA denotes Btg2
T12 676-680 Protein denotes Btg1
T13 685-689 DNA denotes Btg2
T14 713-718 DNA denotes mCaf1
T15 725-755 DNA denotes mouse CCR4-associated factor 1
T16 758-763 DNA denotes mCaf1
T17 812-816 Protein denotes CCR4
T18 1068-1073 DNA denotes mCaf1
T19 1365-1370 DNA denotes mCaf1
R0 T1 T4 linked BTG1,mCaf1
R1 T12 T14 linked Btg1,mCaf1
R2 T16 T17 linked mCaf1,CCR4

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 284-294 Body_part denotes stem cells http://purl.obolibrary.org/obo/MAT_0000185
T2 1240-1246 Body_part denotes B, one http://purl.obolibrary.org/obo/MAT_0000299

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 699-704 OrganismTaxon denotes mouse 10088|10090
T3 725-730 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 284-294 Body_part denotes stem cells http://purl.obolibrary.org/obo/CL_0000034
T2 346-356 Body_part denotes cell-cycle http://purl.obolibrary.org/obo/UBERON_2000098
T3 960-970 Body_part denotes cell-cycle http://purl.obolibrary.org/obo/UBERON_2000098
T4 1201-1211 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T5 1240-1246 Body_part denotes B, one http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 274-294 Cell denotes embryonic stem cells http://purl.obolibrary.org/obo/CL:0002322
T2 344-350 Cell denotes M cell http://purl.obolibrary.org/obo/CL:0000682|http://purl.obolibrary.org/obo/CL:4023189