PubMed:9712870
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 13-20 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T3 | 103-110 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T5 | 163-182 | Glycan_Motif | denotes | N-acetylglucosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP |
| T6 | 186-193 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T8 | 404-411 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T10 | 462-469 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T12 | 793-800 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T14 | 975-982 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T16 | 1286-1293 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T18 | 1871-1878 | Glycan_Motif | denotes | heparin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-127 | Sentence | denotes | The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells. |
| T2 | 128-435 | Sentence | denotes | N-Deacetylation and N-sulfation of N-acetylglucosamine of heparin and heparan sulfate are hypothesized to be mediated by different tissue-specific N-acetylglucosaminyl N-deacetylases/N-sulfotransferases, which in turn lead to the higher L-iduronic acid and sulfate content of heparin versus heparan sulfate. |
| T3 | 436-690 | Sentence | denotes | Furthermore, the putative heparin-specific N-acetylglucosaminyl N-deacetylase/N-sulfotransferase has been reported to require auxiliary proteins for its N-acetylglucosaminyl N-deacetylase activity in vivo based on its requirement of polycations in vitro. |
| T4 | 691-983 | Sentence | denotes | We have now found that cells derived from embryonic bovine trachea, a tissue that does not synthesize heparin, has a N-acetylglucosaminyl N-deacetylase/N-sulfotransferase, which has 95% amino acid sequence identity to the above enzyme postulated to be involved in the biosynthesis of heparin. |
| T5 | 984-1050 | Sentence | denotes | Both enzymes also have very similar affinity for their substrates. |
| T6 | 1051-1322 | Sentence | denotes | The trachea enzyme does not require additional effectors for its N-acetylglucosaminyl N-deacetylase activity in vitro even though its biochemical characteristics are virtually the same as the enzyme previously isolated from cells of a heparin-producing mastocytoma tumor. |
| T7 | 1323-1565 | Sentence | denotes | The trachea enzyme, which is encoded by an abundant 4.6-kilobase mRNA, like mastocytoma cells, has 70% amino acid sequence identity with the corresponding enzyme from rat liver postulated to participate in the biosynthesis of heparan sulfate. |
| T8 | 1566-1682 | Sentence | denotes | Heparan sulfate synthesized by trachea cells has a higher content of sulfated iduronic acid than from other tissues. |
| T9 | 1683-2082 | Sentence | denotes | Together, the above results strongly suggest that the above enzymes from mastocytoma, liver, and trachea, per se, are not solely responsible for the selective tissue-specific synthesis of heparin or heparan sulfate; more likely cellular factors, additional enzymes, and availability of substrates in the Golgi lumen also play important roles in the differential synthesis of the above proteoglycans. |
| T1 | 0-127 | Sentence | denotes | The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells. |
| T2 | 128-435 | Sentence | denotes | N-Deacetylation and N-sulfation of N-acetylglucosamine of heparin and heparan sulfate are hypothesized to be mediated by different tissue-specific N-acetylglucosaminyl N-deacetylases/N-sulfotransferases, which in turn lead to the higher L-iduronic acid and sulfate content of heparin versus heparan sulfate. |
| T3 | 436-690 | Sentence | denotes | Furthermore, the putative heparin-specific N-acetylglucosaminyl N-deacetylase/N-sulfotransferase has been reported to require auxiliary proteins for its N-acetylglucosaminyl N-deacetylase activity in vivo based on its requirement of polycations in vitro. |
| T4 | 691-983 | Sentence | denotes | We have now found that cells derived from embryonic bovine trachea, a tissue that does not synthesize heparin, has a N-acetylglucosaminyl N-deacetylase/N-sulfotransferase, which has 95% amino acid sequence identity to the above enzyme postulated to be involved in the biosynthesis of heparin. |
| T5 | 984-1050 | Sentence | denotes | Both enzymes also have very similar affinity for their substrates. |
| T6 | 1051-1322 | Sentence | denotes | The trachea enzyme does not require additional effectors for its N-acetylglucosaminyl N-deacetylase activity in vitro even though its biochemical characteristics are virtually the same as the enzyme previously isolated from cells of a heparin-producing mastocytoma tumor. |
| T7 | 1323-1565 | Sentence | denotes | The trachea enzyme, which is encoded by an abundant 4.6-kilobase mRNA, like mastocytoma cells, has 70% amino acid sequence identity with the corresponding enzyme from rat liver postulated to participate in the biosynthesis of heparan sulfate. |
| T8 | 1566-1682 | Sentence | denotes | Heparan sulfate synthesized by trachea cells has a higher content of sulfated iduronic acid than from other tissues. |
| T9 | 1683-2082 | Sentence | denotes | Together, the above results strongly suggest that the above enzymes from mastocytoma, liver, and trachea, per se, are not solely responsible for the selective tissue-specific synthesis of heparin or heparan sulfate; more likely cellular factors, additional enzymes, and availability of substrates in the Golgi lumen also play important roles in the differential synthesis of the above proteoglycans. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 13-20 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T2 | 13-20 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T3 | 103-110 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T4 | 103-110 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T5 | 163-182 | https://glytoucan.org/Structures/Glycans/G64581RP | denotes | N-acetylglucosamine |
| T6 | 186-193 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T7 | 186-193 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T8 | 404-411 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T9 | 404-411 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T10 | 462-469 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T11 | 462-469 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T12 | 793-800 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T13 | 793-800 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T14 | 975-982 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T15 | 975-982 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T16 | 1286-1293 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T17 | 1286-1293 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
| T18 | 1871-1878 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T19 | 1871-1878 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 198-213 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T2 | 419-434 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T3 | 1549-1564 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
| T4 | 1566-1581 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | Heparan sulfate |
| T5 | 1882-1897 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 750-757 | http://purl.obolibrary.org/obo/MAT_0000137 | denotes | trachea |
| T2 | 1055-1062 | http://purl.obolibrary.org/obo/MAT_0000137 | denotes | trachea |
| T3 | 1327-1334 | http://purl.obolibrary.org/obo/MAT_0000137 | denotes | trachea |
| T4 | 1494-1499 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T5 | 1597-1604 | http://purl.obolibrary.org/obo/MAT_0000137 | denotes | trachea |
| T6 | 1769-1774 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T7 | 1780-1787 | http://purl.obolibrary.org/obo/MAT_0000137 | denotes | trachea |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1304-1315 | Disease | denotes | mastocytoma | http://purl.obolibrary.org/obo/MONDO_0002724|http://purl.obolibrary.org/obo/MONDO_0003079 |
| T3 | 1316-1321 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T4 | 1399-1410 | Disease | denotes | mastocytoma | http://purl.obolibrary.org/obo/MONDO_0002724|http://purl.obolibrary.org/obo/MONDO_0003079 |
| T6 | 1756-1767 | Disease | denotes | mastocytoma | http://purl.obolibrary.org/obo/MONDO_0002724|http://purl.obolibrary.org/obo/MONDO_0003079 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1316-1321 | Phenotype | denotes | tumor | HP:0002664 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 743-749 | OrganismTaxon | denotes | bovine | 9913 |
| T2 | 750-757 | OrganismTaxon | denotes | trachea | 988164 |
| T3 | 1055-1062 | OrganismTaxon | denotes | trachea | 988164 |
| T4 | 1327-1334 | OrganismTaxon | denotes | trachea | 988164 |
| T5 | 1490-1493 | OrganismTaxon | denotes | rat | 10114|10116 |
| T7 | 1597-1604 | OrganismTaxon | denotes | trachea | 988164 |
| T8 | 1780-1787 | OrganismTaxon | denotes | trachea | 988164 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 259-265 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T2 | 750-757 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T5 | 761-767 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T6 | 1055-1062 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T9 | 1327-1334 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T12 | 1494-1499 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T13 | 1597-1604 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T16 | 1769-1774 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T17 | 1780-1787 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/UBERON_0003126|http://purl.obolibrary.org/obo/UBERON_0003127|http://purl.obolibrary.org/obo/UBERON_6005043 |
| T20 | 1842-1848 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T21 | 1987-1992 | Body_part | denotes | Golgi | http://purl.obolibrary.org/obo/GO_0005794 |
| T22 | 1993-1998 | Body_part | denotes | lumen | http://purl.obolibrary.org/obo/UBERON_0000464 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 750-757 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |
| T2 | 1055-1062 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |
| T3 | 1327-1334 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |
| T4 | 1494-1499 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T5 | 1597-1604 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |
| T6 | 1769-1774 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T7 | 1780-1787 | Body_part | denotes | trachea | http://purl.obolibrary.org/obo/MAT_0000137 |