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PubMed:9712703 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells.
T2 175-293 Sentence denotes Peroxisome proliferator-activated receptors (PPAR) control discrete genes involved in fatty acid and lipid metabolism.
T3 294-532 Sentence denotes Recently, it was suggested that activation of the alpha isoform of PPAR by the potent proinflammatory mediator leukotriene B4 (LTB4) enhanced degradation of this eicosanoid, offersuggesting a new aspect of down-regulation of inflammation.
T4 533-778 Sentence denotes Here, we studied whether PPARalpha activation (by means of the selective agonist WY 14,643) of endothelial cells, pivotal in the regulation of inflammatory responses, interfered with LTB4 induced adhesion of PMN neutrophil granulocytes in vitro.
T5 779-996 Sentence denotes When endothelial cells were treated with WY 14,643 prior to activation with LTB4 (or fMLP, IL-1beta or TNFalpha, as controls) we could not document any effect on the number of adhering PMN or duration of the response.
T6 997-1161 Sentence denotes Thus, this study provides no evidence indicating a regulatory function of PPARalpha in LTB4 induced adhesive interactions between endothelial cells and neutrophils.
T1 0-174 Sentence denotes The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells.
T2 175-293 Sentence denotes Peroxisome proliferator-activated receptors (PPAR) control discrete genes involved in fatty acid and lipid metabolism.
T3 294-532 Sentence denotes Recently, it was suggested that activation of the alpha isoform of PPAR by the potent proinflammatory mediator leukotriene B4 (LTB4) enhanced degradation of this eicosanoid, offersuggesting a new aspect of down-regulation of inflammation.
T4 533-778 Sentence denotes Here, we studied whether PPARalpha activation (by means of the selective agonist WY 14,643) of endothelial cells, pivotal in the regulation of inflammatory responses, interfered with LTB4 induced adhesion of PMN neutrophil granulocytes in vitro.
T5 779-996 Sentence denotes When endothelial cells were treated with WY 14,643 prior to activation with LTB4 (or fMLP, IL-1beta or TNFalpha, as controls) we could not document any effect on the number of adhering PMN or duration of the response.
T6 997-1161 Sentence denotes Thus, this study provides no evidence indicating a regulatory function of PPARalpha in LTB4 induced adhesive interactions between endothelial cells and neutrophils.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-52 protein denotes peroxisome proliferator-activated receptor alpha
T2 54-63 protein denotes PPARalpha
T3 141-152 cell_type denotes neutrophils
T4 156-173 cell_type denotes endothelial cells
T5 175-218 protein denotes Peroxisome proliferator-activated receptors
T6 220-224 protein denotes PPAR
T7 344-357 protein denotes alpha isoform
T8 361-365 protein denotes PPAR
T9 558-567 protein denotes PPARalpha
T10 628-645 cell_type denotes endothelial cells
T11 741-768 cell_type denotes PMN neutrophil granulocytes
T12 784-801 cell_type denotes endothelial cells
T13 864-868 protein denotes fMLP
T14 870-878 protein denotes IL-1beta
T15 882-890 protein denotes TNFalpha
T16 955-967 cell_type denotes adhering PMN
T17 1071-1080 protein denotes PPARalpha
T18 1127-1144 cell_type denotes endothelial cells
T19 1149-1160 cell_type denotes neutrophils

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-174 Sentence denotes The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643 does not interfere with leukotriene B4 induced adhesion of neutrophils to endothelial cells.
S2 175-293 Sentence denotes Peroxisome proliferator-activated receptors (PPAR) control discrete genes involved in fatty acid and lipid metabolism.
S3 294-532 Sentence denotes Recently, it was suggested that activation of the alpha isoform of PPAR by the potent proinflammatory mediator leukotriene B4 (LTB4) enhanced degradation of this eicosanoid, offersuggesting a new aspect of down-regulation of inflammation.
S4 533-778 Sentence denotes Here, we studied whether PPARalpha activation (by means of the selective agonist WY 14,643) of endothelial cells, pivotal in the regulation of inflammatory responses, interfered with LTB4 induced adhesion of PMN neutrophil granulocytes in vitro.
S5 779-996 Sentence denotes When endothelial cells were treated with WY 14,643 prior to activation with LTB4 (or fMLP, IL-1beta or TNFalpha, as controls) we could not document any effect on the number of adhering PMN or duration of the response.
S6 997-1161 Sentence denotes Thus, this study provides no evidence indicating a regulatory function of PPARalpha in LTB4 induced adhesive interactions between endothelial cells and neutrophils.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-81 NP denotes The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643
C2 141-152 NP denotes neutrophils
C3 156-173 NP denotes endothelial cells
C4 175-225 NP denotes Peroxisome proliferator-activated receptors (PPAR)
C5 361-365 NP denotes PPAR
C6 369-426 NP denotes the potent proinflammatory mediator leukotriene B4 (LTB4)
C7 628-645 NP denotes endothelial cells
C8 716-720 NP denotes LTB4
C9 784-801 NP denotes endothelial cells
C10 820-829 NP denotes WY 14,643
C11 855-859 NP denotes LTB4
C12 1084-1088 NP denotes LTB4
C13 1127-1144 NP denotes endothelial cells
C14 1149-1160 NP denotes neutrophils
R1 C5 C4 coref-ident PPAR,Peroxisome proliferator-activated receptors (PPAR)
R2 C7 C3 coref-ident endothelial cells,endothelial cells
R3 C8 C6 coref-ident LTB4,the potent proinflammatory mediator leukotriene B4 (LTB4)
R4 C9 C7 coref-ident endothelial cells,endothelial cells
R5 C10 C1 coref-ident "WY 14,643","The peroxisome proliferator-activated receptor alpha (PPARalpha) ligand WY 14,643"
R6 C11 C8 coref-ident LTB4,LTB4
R7 C12 C11 coref-ident LTB4,LTB4
R8 C13 C9 coref-ident endothelial cells,endothelial cells
R9 C14 C2 coref-ident neutrophils,neutrophils

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-52 protein_molecule denotes peroxisome proliferator-activated receptor alpha
T2 54-63 protein_molecule denotes PPARalpha
T3 72-81 other_organic_compound denotes WY 14,643
T4 106-120 other_organic_compound denotes leukotriene B4
T5 141-152 cell_type denotes neutrophils
T6 156-173 cell_type denotes endothelial cells
T7 175-218 protein_family_or_group denotes Peroxisome proliferator-activated receptors
T8 220-224 protein_family_or_group denotes PPAR
T9 344-357 protein_family_or_group denotes alpha isoform
T10 361-365 protein_family_or_group denotes PPAR
T11 405-419 other_organic_compound denotes leukotriene B4
T12 421-425 other_organic_compound denotes LTB4
T13 500-531 other_name denotes down-regulation of inflammation
T14 558-567 protein_molecule denotes PPARalpha
T15 614-623 other_organic_compound denotes WY 14,643
T16 628-645 cell_type denotes endothelial cells
T17 716-720 other_organic_compound denotes LTB4
T18 741-768 cell_type denotes PMN neutrophil granulocytes
T19 784-801 cell_type denotes endothelial cells
T20 820-829 other_organic_compound denotes WY 14,643
T21 855-859 other_organic_compound denotes LTB4
T22 864-868 protein_molecule denotes fMLP
T23 870-878 protein_molecule denotes IL-1beta
T24 882-890 protein_molecule denotes TNFalpha
T25 955-967 cell_type denotes adhering PMN
T26 1048-1067 other_name denotes regulatory function
T27 1071-1080 protein_molecule denotes PPARalpha
T28 1084-1088 other_organic_compound denotes LTB4
T29 1127-1144 cell_type denotes endothelial cells
T30 1149-1160 cell_type denotes neutrophils