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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
T2 87-265 Sentence denotes Inducible nitric oxide (iNO) is produced at sites of vascular inflammation by resident and nonresident vascular wall cells, but its role in the inflammatory process is not known.
T3 266-357 Sentence denotes In this study, we show that a novel function of iNO is to terminate inflammatory processes.
T4 358-547 Sentence denotes We find that iNO produced by murine macrophage-like cells, RAW264.7, can inhibit cytokine-induced endothelial cell activation in a separated and mixed endothelial-RAW264.7 coculture system.
T5 548-679 Sentence denotes Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma.
T6 680-1028 Sentence denotes Inhibition of iNO synthase (iNOS) activity with N omega-monomethyl-L-arginine in endothelial-RAW264.7 cocultures, stimulated with murine-specific IFN-gamma and LPS, decreased iNO production by 86%, augmented VCAM-1 and iNOS expression in endothelial and RAW264.7 cells, respectively, and increased monocyte adhesion to the endothelial cell surface.
T7 1029-1258 Sentence denotes Transient transfection studies using various VCAM-1 promoter constructs demonstrated that inhibitory effects of iNO on VCAM-1 gene transcription were mediated, in part, by inhibitory effects of iNO on kappa B cis-acting elements.
T8 1259-1419 Sentence denotes Immunofluorescence studies using an Ab to the RelA (p65) subunit of nuclear factor-kappa B revealed that iNO inhibited the activation of nuclear factor-kappa B.
T9 1420-1659 Sentence denotes These studies indicate that iNO attenuates iNOS expression in macrophages and inhibits monocyte adhesion to endothelial cells, and suggest that endogenously derived iNO may be an important autoregulatory inhibitor of vascular inflammation.
T1 0-86 Sentence denotes Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
T2 87-265 Sentence denotes Inducible nitric oxide (iNO) is produced at sites of vascular inflammation by resident and nonresident vascular wall cells, but its role in the inflammatory process is not known.
T3 266-357 Sentence denotes In this study, we show that a novel function of iNO is to terminate inflammatory processes.
T4 358-547 Sentence denotes We find that iNO produced by murine macrophage-like cells, RAW264.7, can inhibit cytokine-induced endothelial cell activation in a separated and mixed endothelial-RAW264.7 coculture system.
T5 548-679 Sentence denotes Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma.
T6 680-1028 Sentence denotes Inhibition of iNO synthase (iNOS) activity with N omega-monomethyl-L-arginine in endothelial-RAW264.7 cocultures, stimulated with murine-specific IFN-gamma and LPS, decreased iNO production by 86%, augmented VCAM-1 and iNOS expression in endothelial and RAW264.7 cells, respectively, and increased monocyte adhesion to the endothelial cell surface.
T7 1029-1258 Sentence denotes Transient transfection studies using various VCAM-1 promoter constructs demonstrated that inhibitory effects of iNO on VCAM-1 gene transcription were mediated, in part, by inhibitory effects of iNO on kappa B cis-acting elements.
T8 1259-1419 Sentence denotes Immunofluorescence studies using an Ab to the RelA (p65) subunit of nuclear factor-kappa B revealed that iNO inhibited the activation of nuclear factor-kappa B.
T9 1420-1659 Sentence denotes These studies indicate that iNO attenuates iNOS expression in macrophages and inhibits monocyte adhesion to endothelial cells, and suggest that endogenously derived iNO may be an important autoregulatory inhibitor of vascular inflammation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 190-209 cell_type denotes vascular wall cells
T2 387-415 cell_line denotes murine macrophage-like cells
T3 417-425 cell_line denotes RAW264.7
T4 439-447 protein denotes cytokine
T5 509-546 cell_line denotes endothelial-RAW264.7 coculture system
T6 584-590 protein denotes VCAM-1
T7 653-678 protein denotes murine-specific IFN-gamma
T8 694-706 protein denotes iNO synthase
T9 708-712 protein denotes iNOS
T10 761-792 cell_line denotes endothelial-RAW264.7 cocultures
T11 810-835 protein denotes murine-specific IFN-gamma
T12 888-894 protein denotes VCAM-1
T13 899-903 protein denotes iNOS
T14 934-948 cell_line denotes RAW264.7 cells
T15 1074-1089 DNA denotes VCAM-1 promoter
T16 1148-1154 protein denotes VCAM-1
T17 1230-1257 DNA denotes kappa B cis-acting elements
T18 1305-1323 protein denotes RelA (p65) subunit
T19 1335-1349 protein denotes factor-kappa B
T20 1396-1418 protein denotes nuclear factor-kappa B
T21 1463-1467 protein denotes iNOS
T22 1482-1493 cell_type denotes macrophages
T23 1528-1545 cell_type denotes endothelial cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-86 Sentence denotes Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation.
S2 87-265 Sentence denotes Inducible nitric oxide (iNO) is produced at sites of vascular inflammation by resident and nonresident vascular wall cells, but its role in the inflammatory process is not known.
S3 266-357 Sentence denotes In this study, we show that a novel function of iNO is to terminate inflammatory processes.
S4 358-547 Sentence denotes We find that iNO produced by murine macrophage-like cells, RAW264.7, can inhibit cytokine-induced endothelial cell activation in a separated and mixed endothelial-RAW264.7 coculture system.
S5 548-679 Sentence denotes Both iNO production and endothelial VCAM-1 expression were induced simultaneously with bacterial LPS and murine-specific IFN-gamma.
S6 680-1028 Sentence denotes Inhibition of iNO synthase (iNOS) activity with N omega-monomethyl-L-arginine in endothelial-RAW264.7 cocultures, stimulated with murine-specific IFN-gamma and LPS, decreased iNO production by 86%, augmented VCAM-1 and iNOS expression in endothelial and RAW264.7 cells, respectively, and increased monocyte adhesion to the endothelial cell surface.
S7 1029-1258 Sentence denotes Transient transfection studies using various VCAM-1 promoter constructs demonstrated that inhibitory effects of iNO on VCAM-1 gene transcription were mediated, in part, by inhibitory effects of iNO on kappa B cis-acting elements.
S8 1259-1419 Sentence denotes Immunofluorescence studies using an Ab to the RelA (p65) subunit of nuclear factor-kappa B revealed that iNO inhibited the activation of nuclear factor-kappa B.
S9 1420-1659 Sentence denotes These studies indicate that iNO attenuates iNOS expression in macrophages and inhibits monocyte adhesion to endothelial cells, and suggest that endogenously derived iNO may be an important autoregulatory inhibitor of vascular inflammation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-22 NP denotes Inducible nitric oxide
C3 64-85 NP denotes vascular inflammation
C2 24-85 NP denotes an autoregulatory feedback inhibitor of vascular inflammation
C4 87-115 NP denotes Inducible nitric oxide (iNO)
C5 140-161 NP denotes vascular inflammation
C6 215-218 NP denotes its
C7 314-317 NP denotes iNO
C8 371-374 NP denotes iNO
C9 387-415 NP denotes murine macrophage-like cells
C10 417-425 NP denotes RAW264.7
C11 635-678 NP denotes bacterial LPS and murine-specific IFN-gamma
C12 810-843 NP denotes murine-specific IFN-gamma and LPS
C13 1141-1144 NP denotes iNO
C14 1223-1226 NP denotes iNO
C15 1327-1349 NP denotes nuclear factor-kappa B
C16 1364-1367 NP denotes iNO
C17 1396-1418 NP denotes nuclear factor-kappa B
C18 1448-1451 NP denotes iNO
C19 1564-1588 NP denotes endogenously derived iNO
C20 1637-1658 NP denotes vascular inflammation
R1 C2 C1 coref-appos an autoregulatory feedback inhibitor of vascular inflammation,Inducible nitric oxide
R2 C4 C1 coref-ident Inducible nitric oxide (iNO),Inducible nitric oxide
R3 C5 C3 coref-ident vascular inflammation,vascular inflammation
R4 C6 C4 coref-pron its,Inducible nitric oxide (iNO)
R5 C7 C4 coref-ident iNO,Inducible nitric oxide (iNO)
R6 C8 C7 coref-ident iNO,iNO
R7 C10 C9 coref-appos RAW264.7,murine macrophage-like cells
R8 C12 C11 coref-ident murine-specific IFN-gamma and LPS,bacterial LPS and murine-specific IFN-gamma
R9 C13 C8 coref-ident iNO,iNO
R10 C14 C13 coref-ident iNO,iNO
R11 C16 C14 coref-ident iNO,iNO
R12 C17 C15 coref-ident nuclear factor-kappa B,nuclear factor-kappa B
R13 C18 C16 coref-ident iNO,iNO
R14 C19 C18 coref-ident endogenously derived iNO,iNO
R15 C20 C5 coref-ident vascular inflammation,vascular inflammation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-9 inorganic denotes Inducible
T2 10-22 inorganic denotes nitric oxide
T3 27-60 inorganic denotes autoregulatory feedback inhibitor
T4 64-85 other_name denotes vascular inflammation
T5 87-96 inorganic denotes Inducible
T6 97-109 inorganic denotes nitric oxide
T7 111-114 inorganic denotes iNO
T8 140-161 other_name denotes vascular inflammation
T9 190-209 cell_type denotes vascular wall cells
T10 231-251 other_name denotes inflammatory process
T11 314-317 inorganic denotes iNO
T12 334-356 other_name denotes inflammatory processes
T13 371-374 inorganic denotes iNO
T14 387-415 cell_line denotes murine macrophage-like cells
T15 417-425 cell_line denotes RAW264.7
T16 439-447 protein_family_or_group denotes cytokine
T17 509-529 cell_line denotes endothelial-RAW264.7
T18 553-556 inorganic denotes iNO
T19 572-583 other_name denotes endothelial
T20 584-590 protein_molecule denotes VCAM-1
T21 635-648 lipid denotes bacterial LPS
T22 653-668 protein_molecule denotes murine-specific
T23 669-678 protein_molecule denotes IFN-gamma
T24 694-697 inorganic denotes iNO
T25 708-712 protein_molecule denotes iNOS
T26 728-757 amino_acid_monomer denotes N omega-monomethyl-L-arginine
T27 761-792 cell_line denotes endothelial-RAW264.7 cocultures
T28 810-825 protein_molecule denotes murine-specific
T29 826-835 protein_molecule denotes IFN-gamma
T30 840-843 lipid denotes LPS
T31 855-858 inorganic denotes iNO
T32 888-894 protein_molecule denotes VCAM-1
T33 899-903 protein_molecule denotes iNOS
T34 934-948 cell_line denotes RAW264.7 cells
T35 978-995 other_name denotes monocyte adhesion
T36 1003-1027 cell_component denotes endothelial cell surface
T37 1074-1080 protein_molecule denotes VCAM-1
T38 1119-1137 other_name denotes inhibitory effects
T39 1141-1144 inorganic denotes iNO
T40 1148-1154 protein_molecule denotes VCAM-1
T41 1155-1173 other_name denotes gene transcription
T42 1223-1226 inorganic denotes iNO
T43 1230-1257 DNA_family_or_group denotes kappa B cis-acting elements
T44 1259-1285 other_name denotes Immunofluorescence studies
T45 1305-1309 protein_subunit denotes RelA
T46 1311-1314 protein_subunit denotes p65
T47 1335-1349 protein_complex denotes factor-kappa B
T48 1364-1367 inorganic denotes iNO
T49 1396-1418 protein_complex denotes nuclear factor-kappa B
T50 1448-1451 inorganic denotes iNO
T51 1463-1467 protein_molecule denotes iNOS
T52 1482-1493 cell_type denotes macrophages
T53 1507-1524 other_name denotes monocyte adhesion
T54 1528-1545 cell_type denotes endothelial cells
T55 1585-1588 inorganic denotes iNO
T56 1609-1633 other_name denotes autoregulatory inhibitor
T57 1637-1658 other_name denotes vascular inflammation