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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-103 Sentence denotes Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.
T2 104-281 Sentence denotes The high concentration of foreign antigen in the lumen of the gastrointestinal tract is separated from the underlying lymphocytes by a single cell layer of polarized epithelium.
T3 282-436 Sentence denotes Intestinal epithelial cells can express HLA class II antigens and may function as antigen-presenting cells to CD4(+) T cells within the intestinal mucosa.
T4 437-697 Sentence denotes Using tetanus toxoid specific and HLA-DR-restricted T lymphocytes, we show that polarized intestinal epithelial cells directed to express HLA-DR molecules are able to initiate class II processing only after internalization of antigen from their apical surface.
T5 698-1015 Sentence denotes Coexpression of the class II transactivator CIITA in these cells, which stimulates highly efficient class II processing without the characteristic decline in barrier function seen in polarized monolayers treated with the proinflammatory cytokine gamma-IFN, facilitates antigen processing from the basolateral surface.
T6 1016-1128 Sentence denotes In both cases, peptide presentation to T cells via class II molecules was restricted to the basolateral surface.
T7 1129-1495 Sentence denotes These data indicate a highly polarized functional architecture for antigen processing and presentation by intestinal epithelial cells, and suggest that the functional outcome of antigen processing by the intestinal epithelium is both dependent on the cellular surface at which the foreign antigen is internalized and by the underlying degree of mucosal inflammation.
T1 0-103 Sentence denotes Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.
T2 104-281 Sentence denotes The high concentration of foreign antigen in the lumen of the gastrointestinal tract is separated from the underlying lymphocytes by a single cell layer of polarized epithelium.
T3 282-436 Sentence denotes Intestinal epithelial cells can express HLA class II antigens and may function as antigen-presenting cells to CD4(+) T cells within the intestinal mucosa.
T4 437-697 Sentence denotes Using tetanus toxoid specific and HLA-DR-restricted T lymphocytes, we show that polarized intestinal epithelial cells directed to express HLA-DR molecules are able to initiate class II processing only after internalization of antigen from their apical surface.
T5 698-1015 Sentence denotes Coexpression of the class II transactivator CIITA in these cells, which stimulates highly efficient class II processing without the characteristic decline in barrier function seen in polarized monolayers treated with the proinflammatory cytokine gamma-IFN, facilitates antigen processing from the basolateral surface.
T6 1016-1128 Sentence denotes In both cases, peptide presentation to T cells via class II molecules was restricted to the basolateral surface.
T7 1129-1495 Sentence denotes These data indicate a highly polarized functional architecture for antigen processing and presentation by intestinal epithelial cells, and suggest that the functional outcome of antigen processing by the intestinal epithelium is both dependent on the cellular surface at which the foreign antigen is internalized and by the underlying degree of mucosal inflammation.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 17-37 protein denotes HLA class II antigen
T2 69-102 cell_type denotes human intestinal epithelial cells
T3 130-145 protein denotes foreign antigen
T4 153-158 cell_type denotes lumen
T5 222-233 cell_type denotes lymphocytes
T6 282-309 cell_type denotes Intestinal epithelial cells
T7 322-343 protein denotes HLA class II antigens
T8 364-406 cell_type denotes antigen-presenting cells to CD4(+) T cells
T9 443-502 cell_type denotes tetanus toxoid specific and HLA-DR-restricted T lymphocytes
T10 517-554 cell_type denotes polarized intestinal epithelial cells
T11 575-591 protein denotes HLA-DR molecules
T12 718-747 protein denotes class II transactivator CIITA
T13 919-953 protein denotes proinflammatory cytokine gamma-IFN
T14 1055-1062 cell_type denotes T cells
T15 1067-1085 protein denotes class II molecules
T16 1235-1262 cell_type denotes intestinal epithelial cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 69-102 NP denotes human intestinal epithelial cells
C2 130-145 NP denotes foreign antigen
C3 282-309 NP denotes Intestinal epithelial cells
C4 517-591 NP denotes polarized intestinal epithelial cells directed to express HLA-DR molecules
C5 676-681 NP denotes their
C7 751-762 NP denotes these cells
C6 698-762 NP denotes Coexpression of the class II transactivator CIITA in these cells
C8 764-769 NP denotes which
C9 991-1014 NP denotes the basolateral surface
C10 1104-1127 NP denotes the basolateral surface
C11 1235-1262 NP denotes intestinal epithelial cells
C12 1376-1396 NP denotes the cellular surface
C13 1400-1405 NP denotes which
C14 1406-1425 NP denotes the foreign antigen
R1 C3 C1 coref-ident Intestinal epithelial cells,human intestinal epithelial cells
R2 C5 C4 coref-pron their,polarized intestinal epithelial cells directed to express HLA-DR molecules
R3 C7 C4 coref-ident these cells,polarized intestinal epithelial cells directed to express HLA-DR molecules
R4 C8 C6 coref-relat which,Coexpression of the class II transactivator CIITA in these cells
R5 C10 C9 coref-ident the basolateral surface,the basolateral surface
R6 C11 C3 coref-ident intestinal epithelial cells,Intestinal epithelial cells
R7 C13 C12 coref-relat which,the cellular surface
R8 C14 C2 coref-ident the foreign antigen,foreign antigen

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-103 Sentence denotes Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells.
S2 104-281 Sentence denotes The high concentration of foreign antigen in the lumen of the gastrointestinal tract is separated from the underlying lymphocytes by a single cell layer of polarized epithelium.
S3 282-436 Sentence denotes Intestinal epithelial cells can express HLA class II antigens and may function as antigen-presenting cells to CD4(+) T cells within the intestinal mucosa.
S4 437-697 Sentence denotes Using tetanus toxoid specific and HLA-DR-restricted T lymphocytes, we show that polarized intestinal epithelial cells directed to express HLA-DR molecules are able to initiate class II processing only after internalization of antigen from their apical surface.
S5 698-1015 Sentence denotes Coexpression of the class II transactivator CIITA in these cells, which stimulates highly efficient class II processing without the characteristic decline in barrier function seen in polarized monolayers treated with the proinflammatory cytokine gamma-IFN, facilitates antigen processing from the basolateral surface.
S6 1016-1128 Sentence denotes In both cases, peptide presentation to T cells via class II molecules was restricted to the basolateral surface.
S7 1129-1495 Sentence denotes These data indicate a highly polarized functional architecture for antigen processing and presentation by intestinal epithelial cells, and suggest that the functional outcome of antigen processing by the intestinal epithelium is both dependent on the cellular surface at which the foreign antigen is internalized and by the underlying degree of mucosal inflammation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 17-37 protein_family_or_group denotes HLA class II antigen
T2 69-102 cell_type denotes human intestinal epithelial cells
T3 130-145 protein_family_or_group denotes foreign antigen
T4 153-158 cell_type denotes lumen
T5 166-188 body_part denotes gastrointestinal tract
T6 222-233 cell_type denotes lymphocytes
T7 260-280 tissue denotes polarized epithelium
T8 282-309 cell_type denotes Intestinal epithelial cells
T9 322-343 protein_family_or_group denotes HLA class II antigens
T10 364-406 cell_type denotes antigen-presenting cells to CD4(+) T cells
T11 418-435 tissue denotes intestinal mucosa
T12 517-554 cell_type denotes polarized intestinal epithelial cells
T13 575-591 protein_family_or_group denotes HLA-DR molecules
T14 613-632 other_name denotes class II processing
T15 718-747 protein_molecule denotes class II transactivator CIITA
T16 781-817 other_name denotes highly efficient class II processing
T17 856-872 other_name denotes barrier function
T18 919-953 protein_molecule denotes proinflammatory cytokine gamma-IFN
T19 995-1014 tissue denotes basolateral surface
T20 1031-1051 other_name denotes peptide presentation
T21 1055-1062 cell_type denotes T cells
T22 1067-1085 protein_family_or_group denotes class II molecules
T23 1151-1191 other_name denotes highly polarized functional architecture
T24 1235-1262 cell_type denotes intestinal epithelial cells
T25 1307-1325 other_name denotes antigen processing
T26 1333-1354 tissue denotes intestinal epithelium
T27 1380-1396 cell_component denotes cellular surface
T28 1410-1425 other_name denotes foreign antigen
T29 1474-1494 other_name denotes mucosal inflammation