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PubMed:9697819 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-197 Sentence denotes Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.
TextSentencer_T2 198-209 Sentence denotes BACKGROUND:
TextSentencer_T3 210-375 Sentence denotes Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD).
TextSentencer_T4 376-412 Sentence denotes More prospective studies are needed.
TextSentencer_T5 413-433 Sentence denotes METHODS AND RESULTS:
TextSentencer_T6 434-646 Sentence denotes We used a prospective case-cohort design to determine whether tHcy-related factors are associated with incidence of CHD over an average of 3.3 years of follow-up in a biracial sample of middle-aged men and women.
TextSentencer_T7 647-928 Sentence denotes Age-, race-, and field center-adjusted CHD incidence was associated positively (P<0.05) with tHcy in women but not men, and CHD was associated negatively (P<0.05) with plasma folate (women only), plasma pyridoxal 5'-phosphate (both sexes), and vitamin supplementation (women only).
TextSentencer_T8 929-1161 Sentence denotes However, after accounting for other risk factors, only plasma pyridoxal 5'-phosphate was associated with CHD incidence; the relative risk for the highest versus lowest quintile of pyridoxal 5'-phosphate was 0.28 (95% CI=0.1 to 0.7).
TextSentencer_T9 1162-1326 Sentence denotes There was no association of CHD with the C677T mutation of the methylenetetrahydrofolate reductase gene or with 3 mutations of the cystathionine beta-synthase gene.
TextSentencer_T10 1327-1339 Sentence denotes CONCLUSIONS:
TextSentencer_T11 1340-1505 Sentence denotes Our prospective findings add uncertainty to conclusions derived mostly from cross-sectional studies that tHcy is a major, independent, causative risk factor for CHD.
TextSentencer_T12 1506-1604 Sentence denotes Our findings point more strongly to the possibility that vitamin B6 offers independent protection.
TextSentencer_T13 1605-1753 Sentence denotes Randomized trials, some of which are under way, are needed to better clarify the interrelationships of tHcy, B vitamins, and cardiovascular disease.
T1 0-197 Sentence denotes Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study.
T2 198-209 Sentence denotes BACKGROUND:
T3 210-375 Sentence denotes Elevated plasma total homocysteine (tHcy), low B-vitamin intake, and genetic polymorphisms related to tHcy metabolism may play roles in coronary heart disease (CHD).
T4 376-412 Sentence denotes More prospective studies are needed.
T5 413-433 Sentence denotes METHODS AND RESULTS:
T6 434-646 Sentence denotes We used a prospective case-cohort design to determine whether tHcy-related factors are associated with incidence of CHD over an average of 3.3 years of follow-up in a biracial sample of middle-aged men and women.
T7 647-928 Sentence denotes Age-, race-, and field center-adjusted CHD incidence was associated positively (P<0.05) with tHcy in women but not men, and CHD was associated negatively (P<0.05) with plasma folate (women only), plasma pyridoxal 5'-phosphate (both sexes), and vitamin supplementation (women only).
T8 929-1161 Sentence denotes However, after accounting for other risk factors, only plasma pyridoxal 5'-phosphate was associated with CHD incidence; the relative risk for the highest versus lowest quintile of pyridoxal 5'-phosphate was 0.28 (95% CI=0.1 to 0.7).
T9 1162-1326 Sentence denotes There was no association of CHD with the C677T mutation of the methylenetetrahydrofolate reductase gene or with 3 mutations of the cystathionine beta-synthase gene.
T10 1327-1339 Sentence denotes CONCLUSIONS:
T11 1340-1505 Sentence denotes Our prospective findings add uncertainty to conclusions derived mostly from cross-sectional studies that tHcy is a major, independent, causative risk factor for CHD.
T12 1506-1604 Sentence denotes Our findings point more strongly to the possibility that vitamin B6 offers independent protection.
T13 1605-1753 Sentence denotes Randomized trials, some of which are under way, are needed to better clarify the interrelationships of tHcy, B vitamins, and cardiovascular disease.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1225-1260 gene:4524 denotes methylenetetrahydrofolate reductase
T1 1190-1193 disease:C0010068 denotes CHD
R1 T0 T1 associated_with methylenetetrahydrofolate reductase,CHD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9697819-5#63#98#gene4524 1225-1260 gene4524 denotes methylenetetrahydrofolate reductase
9697819-5#28#31#diseaseC0010068 1190-1193 diseaseC0010068 denotes CHD
63#98#gene452428#31#diseaseC0010068 9697819-5#63#98#gene4524 9697819-5#28#31#diseaseC0010068 associated_with methylenetetrahydrofolate reductase,CHD

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 30-35 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T2 355-360 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T582 1293-1320 gene:102724560 denotes cystathionine beta-synthase
T583 1190-1193 disease:C0010068 denotes CHD
R1 T582 T583 associated_with cystathionine beta-synthase,CHD
R2 T582 T583 associated_with cystathionine beta-synthase,CHD

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 30-35 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
PD-UBERON-AE-B_T2 355-360 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart