| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-46 |
Enzyme |
denotes |
Mitogen- and stress-activated protein kinase-1 |
| T2 |
48-52 |
Enzyme |
denotes |
MSK1 |
| T4 |
79-83 |
Enzyme |
denotes |
MAPK |
| T5 |
88-97 |
Enzyme |
denotes |
SAPK2/p38 |
| T8 |
129-133 |
Protein |
denotes |
CREB |
| T9 |
162-206 |
Enzyme |
denotes |
mitogen- and stress-activated protein kinase |
| T10 |
208-212 |
Enzyme |
denotes |
MSK1 |
| T11 |
232-254 |
ProteinDomain |
denotes |
protein kinase domains |
| T12 |
267-278 |
Peptide |
denotes |
polypeptide |
| T13 |
280-284 |
Enzyme |
denotes |
MSK1 |
| T15 |
310-320 |
Enzyme |
denotes |
MAPK2/ERK2 |
| T16 |
324-333 |
Enzyme |
denotes |
SAPK2/p38 |
| T17 |
346-350 |
Enzyme |
denotes |
MSK1 |
| T19 |
367-376 |
Cell |
denotes |
293 cells |
| T20 |
387-414 |
Chemical |
denotes |
growth factor/phorbol ester |
| T21 |
464-493 |
Stress |
denotes |
oxidative and chemical stress |
| T23 |
513-517 |
Enzyme |
denotes |
MSK1 |
| T24 |
521-550 |
Chemical |
denotes |
growth factors/phorbol esters |
| T26 |
567-575 |
Agonist |
denotes |
PD 98059 |
| T29 |
612-616 |
Enzyme |
denotes |
MAPK |
| T31 |
650-654 |
Enzyme |
denotes |
MSK1 |
| T32 |
658-672 |
Stress |
denotes |
stress stimuli |
| T34 |
689-698 |
Agonist |
denotes |
SB 203580 |
| T36 |
724-733 |
Enzyme |
denotes |
SAPK2/p38 |
| T37 |
738-742 |
Cell |
denotes |
HeLa |
| T38 |
744-748 |
Cell |
denotes |
PC12 |
| T39 |
753-766 |
Cell |
denotes |
SK-N-MC cells |
| T40 |
768-776 |
Agonist |
denotes |
PD 98059 |
| T41 |
781-790 |
Agonist |
denotes |
SB 203580 |
| T44 |
839-843 |
Enzyme |
denotes |
MSK1 |
| T45 |
847-850 |
Protein |
denotes |
TNF |
| T46 |
852-855 |
Protein |
denotes |
NGF |
| T47 |
860-863 |
Protein |
denotes |
FGF |
| T48 |
887-901 |
Agonist |
denotes |
these agonists |
| T50 |
920-928 |
Enzyme |
denotes |
MAPK/ERK |
| T51 |
933-942 |
Enzyme |
denotes |
SAPK2/p38 |
| T52 |
953-957 |
Enzyme |
denotes |
MSK1 |
| T54 |
978-985 |
Nucleus |
denotes |
nucleus |
| T55 |
1016-1021 |
Cell |
denotes |
cells |
| T57 |
1042-1046 |
Protein |
denotes |
CREB |
| T58 |
1050-1056 |
AminoAcid |
denotes |
Ser133 |
| T59 |
1088-1091 |
Enzyme |
denotes |
PKA |
| T60 |
1093-1109 |
Enzyme |
denotes |
MAPKAP-K1(p90Rsk |
| T61 |
1115-1124 |
Enzyme |
denotes |
MAPKAP-K2 |
| T62 |
1141-1150 |
Agonist |
denotes |
SB 203580 |
| T63 |
1152-1160 |
Agonist |
denotes |
PD 98059 |
| T64 |
1165-1174 |
Agonist |
denotes |
Ro 318220 |
| T65 |
1178-1185 |
Agonist |
denotes |
agonist |
| T68 |
1208-1212 |
Protein |
denotes |
CREB |
| T69 |
1217-1221 |
Protein |
denotes |
ATF1 |
| T70 |
1230-1240 |
Cell |
denotes |
cell-lines |
| T71 |
1263-1279 |
Protein |
denotes |
these inhibitors |
| T72 |
1283-1287 |
Enzyme |
denotes |
MSK1 |
| T74 |
1323-1332 |
Enzyme |
denotes |
MAPKAP-K1 |
| T75 |
1337-1348 |
Enzyme |
denotes |
MAPKAP-K2/3 |
| T76 |
1429-1433 |
Enzyme |
denotes |
MSK1 |
| T78 |
1450-1463 |
Protein |
denotes |
growth-factor |
| T79 |
1468-1474 |
Stress |
denotes |
stress |
| T82 |
1497-1501 |
Protein |
denotes |
CREB |
| E1 |
66-75 |
PositiveRegulation |
denotes |
activated |
| E2 |
107-114 |
RegulatoryProcess |
denotes |
mediate |
| E3 |
115-125 |
PositiveRegulation |
denotes |
activation |
| E4 |
288-297 |
PositiveRegulation |
denotes |
activated |
| E5 |
354-363 |
PositiveRegulation |
denotes |
activated |
| E6 |
499-509 |
PositiveRegulation |
denotes |
activation |
| E7 |
554-563 |
NegativeRegulation |
denotes |
prevented |
| E8 |
583-593 |
NegativeRegulation |
denotes |
suppresses |
| E9 |
594-604 |
PositiveRegulation |
denotes |
activation |
| E10 |
636-646 |
PositiveRegulation |
denotes |
activation |
| E11 |
676-685 |
NegativeRegulation |
denotes |
prevented |
| E12 |
711-720 |
NegativeRegulation |
denotes |
inhibitor |
| E13 |
812-820 |
NegativeRegulation |
denotes |
suppress |
| E14 |
825-835 |
PositiveRegulation |
denotes |
activation |
| E15 |
902-910 |
PositiveRegulation |
denotes |
activate |
| E16 |
961-970 |
Localization |
denotes |
localized |
| E17 |
1027-1041 |
Phosphorylation |
denotes |
phosphorylates |
| E18 |
1186-1193 |
PositiveRegulation |
denotes |
induced |
| E19 |
1194-1204 |
PositiveRegulation |
denotes |
activation |
| E20 |
1288-1298 |
PositiveRegulation |
denotes |
activation |
| E21 |
1438-1445 |
RegulatoryProcess |
denotes |
mediate |
| E22 |
1475-1482 |
PositiveRegulation |
denotes |
induced |
| E23 |
1483-1493 |
PositiveRegulation |
denotes |
activation |
| E24 |
617-624 |
SignalingPathway |
denotes |
cascade |
| E25 |
943-951 |
SignalingPathway |
denotes |
cascades |
| E26 |
66-75 |
PositiveRegulation |
denotes |
activated |
| E27 |
288-297 |
PositiveRegulation |
denotes |
activated |
| E28 |
812-820 |
NegativeRegulation |
denotes |
suppress |
| E29 |
825-835 |
PositiveRegulation |
denotes |
activation |
| E30 |
825-835 |
PositiveRegulation |
denotes |
activation |
| E31 |
812-820 |
NegativeRegulation |
denotes |
suppress |
| E32 |
812-820 |
NegativeRegulation |
denotes |
suppress |
| E33 |
812-820 |
NegativeRegulation |
denotes |
suppress |
| E34 |
812-820 |
NegativeRegulation |
denotes |
suppress |
| E35 |
1194-1204 |
PositiveRegulation |
denotes |
activation |
| E36 |
1475-1482 |
PositiveRegulation |
denotes |
induced |
| E37 |
1186-1193 |
PositiveRegulation |
denotes |
induced |
| R1 |
T9 |
T12 |
hasPart |
mitogen- and stress-activated protein kinase,polypeptide |
| R2 |
T12 |
T11 |
hasPart |
polypeptide,protein kinase domains |
| R3 |
E5 |
T19 |
locatedIn |
activated,293 cells |
| R7 |
E16 |
T54 |
locatedIn |
localized,nucleus |
| R8 |
T54 |
T55 |
locatedIn |
nucleus,cells |
| R9 |
T57 |
T58 |
hasPart |
CREB,Ser133 |
| R10 |
E19 |
T70 |
locatedIn |
activation,cell-lines |
| R4 |
E13 |
T37 |
locatedIn |
suppress,HeLa |
| R5 |
E13 |
T38 |
locatedIn |
suppress,PC12 |
| R6 |
E13 |
T39 |
locatedIn |
suppress,SK-N-MC cells |
| R11 |
E28 |
T39 |
locatedIn |
suppress,SK-N-MC cells |
| R12 |
E28 |
T38 |
locatedIn |
suppress,PC12 |
| R13 |
E28 |
T37 |
locatedIn |
suppress,HeLa |
| R15 |
T4 |
E1 |
hasAgent |
MAPK,activated |
| R16 |
T1 |
E1 |
hasPatient |
Mitogen- and stress-activated protein kinase-1,activated |
| R17 |
T1 |
E2 |
hasAgent |
Mitogen- and stress-activated protein kinase-1,mediate |
| R18 |
E3 |
E2 |
hasPatient |
activation,mediate |
| R19 |
T8 |
E3 |
hasPatient |
CREB,activation |
| R20 |
T15 |
E4 |
hasAgent |
MAPK2/ERK2,activated |
| R21 |
T13 |
E4 |
hasPatient |
MSK1,activated |
| R22 |
T17 |
E5 |
hasPatient |
MSK1,activated |
| R23 |
T24 |
E6 |
hasAgent |
growth factors/phorbol esters,activation |
| R24 |
T23 |
E6 |
hasPatient |
MSK1,activation |
| R25 |
T26 |
E7 |
hasAgent |
PD 98059,prevented |
| R26 |
E6 |
E7 |
hasPatient |
activation,prevented |
| R27 |
T26 |
E8 |
hasAgent |
PD 98059,suppresses |
| R28 |
E9 |
E8 |
hasPatient |
activation,suppresses |
| R29 |
E24 |
E9 |
hasPatient |
cascade,activation |
| R30 |
T32 |
E10 |
hasAgent |
stress stimuli,activation |
| R31 |
T31 |
E10 |
hasPatient |
MSK1,activation |
| R32 |
T34 |
E11 |
hasAgent |
SB 203580,prevented |
| R33 |
E10 |
E11 |
hasPatient |
activation,prevented |
| R34 |
T34 |
E12 |
hasAgent |
SB 203580,inhibitor |
| R35 |
T36 |
E12 |
hasPatient |
SAPK2/p38,inhibitor |
| R36 |
T40 |
E13 |
hasAgent |
PD 98059,suppress |
| R37 |
E14 |
E13 |
hasPatient |
activation,suppress |
| R38 |
T45 |
E14 |
hasAgent |
TNF,activation |
| R39 |
T44 |
E14 |
hasPatient |
MSK1,activation |
| R40 |
T48 |
E15 |
hasAgent |
these agonists,activate |
| R41 |
E25 |
E15 |
hasPatient |
cascades,activate |
| R42 |
T52 |
E16 |
hasPatient |
MSK1,localized |
| R43 |
T52 |
E17 |
hasAgent |
MSK1,phosphorylates |
| R44 |
T58 |
E17 |
hasPatient |
Ser133,phosphorylates |
| R45 |
T65 |
E18 |
hasAgent |
agonist,induced |
| R46 |
E19 |
E18 |
hasPatient |
activation,induced |
| R47 |
T68 |
E19 |
hasPatient |
CREB,activation |
| R48 |
T72 |
E20 |
hasPatient |
MSK1,activation |
| R49 |
T76 |
E21 |
hasAgent |
MSK1,mediate |
| R50 |
E23 |
E21 |
hasPatient |
activation,mediate |
| R51 |
T78 |
E22 |
hasAgent |
growth-factor,induced |
| R52 |
E23 |
E22 |
hasPatient |
activation,induced |
| R53 |
T82 |
E23 |
hasPatient |
CREB,activation |
| R54 |
T5 |
E26 |
hasAgent |
SAPK2/p38,activated |
| R55 |
T1 |
E26 |
hasPatient |
Mitogen- and stress-activated protein kinase-1,activated |
| R56 |
T16 |
E27 |
hasAgent |
SAPK2/p38,activated |
| R57 |
T13 |
E27 |
hasPatient |
MSK1,activated |
| R58 |
T41 |
E28 |
hasAgent |
SB 203580,suppress |
| R59 |
E14 |
E28 |
hasPatient |
activation,suppress |
| R60 |
T46 |
E29 |
hasAgent |
NGF,activation |
| R61 |
T44 |
E29 |
hasPatient |
MSK1,activation |
| R62 |
T47 |
E30 |
hasAgent |
FGF,activation |
| R63 |
T44 |
E30 |
hasPatient |
MSK1,activation |
| R64 |
T40 |
E31 |
hasAgent |
PD 98059,suppress |
| R65 |
E29 |
E31 |
hasPatient |
activation,suppress |
| R66 |
T40 |
E32 |
hasAgent |
PD 98059,suppress |
| R67 |
E30 |
E32 |
hasPatient |
activation,suppress |
| R68 |
T41 |
E33 |
hasAgent |
SB 203580,suppress |
| R69 |
E29 |
E33 |
hasPatient |
activation,suppress |
| R70 |
T41 |
E34 |
hasAgent |
SB 203580,suppress |
| R71 |
E30 |
E34 |
hasPatient |
activation,suppress |
| R72 |
T69 |
E35 |
hasPatient |
ATF1,activation |
| R73 |
T79 |
E36 |
hasAgent |
stress,induced |
| R74 |
E23 |
E36 |
hasPatient |
activation,induced |
| R75 |
T65 |
E37 |
hasAgent |
agonist,induced |
| R76 |
E35 |
E37 |
hasPatient |
activation,induced |
