> top > docs > PubMed:9658370 > annotations

PubMed:9658370 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes Predictive value of aminotransferase and hepatitis B virus DNA levels on response to interferon therapy for chronic hepatitis B.
TextSentencer_T2 129-375 Sentence denotes In a previously reported randomized controlled trial of interferon-alpha (IFN-alpha) for chronic hepatitis B, we found a significant difference in response between Chinese adults with elevated vs normal pretreatment aminotransferase (ALT) levels.
TextSentencer_T3 376-508 Sentence denotes The aim of this study was to determine the correlation between serum hepatitis B virus (HBV) DNA levels and response to IFN therapy.
TextSentencer_T4 509-645 Sentence denotes HBV DNA levels in residual stored sera from patients who participated in the above trial were quantified by a branched DNA (bDNA) assay.
TextSentencer_T5 646-796 Sentence denotes Nominal logistic regression was used to estimate the probability of response to IFN treatment as a function of pretreatment ALT and/or HBV DNA levels.
TextSentencer_T6 797-914 Sentence denotes We found a significant (P < 0.01) correlation between the HBV DNA levels at midtreatment and response to IFN therapy.
TextSentencer_T7 915-1074 Sentence denotes Response was achieved in 53% of patients who had undetectable HBV DNA levels at midtreatment but in only 17% of those who remained HBV DNA positive (P < 0.01).
TextSentencer_T8 1075-1240 Sentence denotes In contrast, the probabilities of response for patients with baseline HBV DNA levels over the range 10 to 10000 million equivalents (MEq) ml-1 were almost identical.
TextSentencer_T9 1241-1345 Sentence denotes We also found a significant correlation between the pretreatment ALT levels and response to IFN therapy.
TextSentencer_T10 1346-1526 Sentence denotes The probabilities of response for patients with pretreatment ALT levels of 500 and 100 IU l-1 were higher than for patients with normal ALT levels by two and onefold, respectively.
TextSentencer_T11 1527-1742 Sentence denotes Our findings may help to improve the cost-effectiveness of IFN therapy for chronic hepatitis B by guiding the selection of patients for therapy and in optimizing the duration of treatment for the individual patient.
T1 0-128 Sentence denotes Predictive value of aminotransferase and hepatitis B virus DNA levels on response to interferon therapy for chronic hepatitis B.
T2 129-375 Sentence denotes In a previously reported randomized controlled trial of interferon-alpha (IFN-alpha) for chronic hepatitis B, we found a significant difference in response between Chinese adults with elevated vs normal pretreatment aminotransferase (ALT) levels.
T3 376-508 Sentence denotes The aim of this study was to determine the correlation between serum hepatitis B virus (HBV) DNA levels and response to IFN therapy.
T4 509-645 Sentence denotes HBV DNA levels in residual stored sera from patients who participated in the above trial were quantified by a branched DNA (bDNA) assay.
T5 646-796 Sentence denotes Nominal logistic regression was used to estimate the probability of response to IFN treatment as a function of pretreatment ALT and/or HBV DNA levels.
T6 797-914 Sentence denotes We found a significant (P < 0.01) correlation between the HBV DNA levels at midtreatment and response to IFN therapy.
T7 915-1074 Sentence denotes Response was achieved in 53% of patients who had undetectable HBV DNA levels at midtreatment but in only 17% of those who remained HBV DNA positive (P < 0.01).
T8 1075-1240 Sentence denotes In contrast, the probabilities of response for patients with baseline HBV DNA levels over the range 10 to 10000 million equivalents (MEq) ml-1 were almost identical.
T9 1241-1345 Sentence denotes We also found a significant correlation between the pretreatment ALT levels and response to IFN therapy.
T10 1346-1526 Sentence denotes The probabilities of response for patients with pretreatment ALT levels of 500 and 100 IU l-1 were higher than for patients with normal ALT levels by two and onefold, respectively.
T11 1527-1742 Sentence denotes Our findings may help to improve the cost-effectiveness of IFN therapy for chronic hepatitis B by guiding the selection of patients for therapy and in optimizing the duration of treatment for the individual patient.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 496-499 gene:3439 denotes IFN
T1 445-456 disease:C0019163 denotes hepatitis B
T2 496-499 gene:3447 denotes IFN
T3 445-456 disease:C0019163 denotes hepatitis B
R1 T0 T1 associated_with IFN,hepatitis B
R2 T2 T3 associated_with IFN,hepatitis B

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 439-444 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1411 1586-1589 gene:3439 denotes IFN
T1412 1602-1621 disease:C0524909 denotes chronic hepatitis B
R1 T1411 T1412 associated_with IFN,chronic hepatitis B
R2 T1411 T1412 associated_with IFN,chronic hepatitis B

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 439-444 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum