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PubMed:9649010 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Relatively low expression of multidrug resistance-1 (MDR-1) and its possible clinical implication in gastric cancers.
TextSentencer_T2 118-204 Sentence denotes The mechanism of drug resistance of gastric cancer cells has rarely been investigated.
TextSentencer_T3 205-342 Sentence denotes We specifically examine the magnitude and the biologic significance of multidrug resistance-1 (MDR-1) expression in human gastric cancer.
TextSentencer_T4 343-462 Sentence denotes All patients had previously been treated in prospective clinical trials for advanced gastric cancer in our institution.
TextSentencer_T5 463-655 Sentence denotes Patients with adequate prechemotherapy gastric cancer tissues for immunohistochemical studies by a C219 monoclonal antibody were selected for the determination of the expression rate of MDR-1.
TextSentencer_T6 656-762 Sentence denotes The results were designated as negative or positive by the independent interpretation of two pathologists.
TextSentencer_T7 763-918 Sentence denotes A subgroup of patients who had been treated with doxorubicin- or etoposide-containing regimens were selected for further correlation with drug sensitivity.
TextSentencer_T8 919-1030 Sentence denotes Between 1990 and 1996, a total of 60 patients, 38 men and 22 women with a median age of 55 years, were studied.
TextSentencer_T9 1031-1107 Sentence denotes Eight (13.3%; 95% confidence interval, 6%-25%) of them had MDR-1 expression.
TextSentencer_T10 1108-1280 Sentence denotes None of the pertinent clinicopathologic features, including the histopathologic types of the tumors and the extent of the diseases, correlated with the expression of MDR-1.
TextSentencer_T11 1281-1470 Sentence denotes Among the 30 patients who had received doxorubicin- or etoposide-containing combination chemotherapy, 3 (10%; 95% confidence interval, 3%-27%) were designated positive for MDR-1 expression.
TextSentencer_T12 1471-1632 Sentence denotes None of the 3 patients responded to chemotherapy, whereas 19 (70.4%) of the 27 patients who had not expressed MDR-1 did respond (p=0.041 by Fisher's exact test).
TextSentencer_T13 1633-1710 Sentence denotes We conclude that the expression of MDR-1 in gastric cancer is relatively low.
TextSentencer_T14 1711-1911 Sentence denotes Its expression, however, is clinically relevant and is useful in predicting the chemoresistance of patients with gastric cancer receiving doxorubicin- or etoposide-containing combination chemotherapy.
T1 0-117 Sentence denotes Relatively low expression of multidrug resistance-1 (MDR-1) and its possible clinical implication in gastric cancers.
T2 118-204 Sentence denotes The mechanism of drug resistance of gastric cancer cells has rarely been investigated.
T3 205-342 Sentence denotes We specifically examine the magnitude and the biologic significance of multidrug resistance-1 (MDR-1) expression in human gastric cancer.
T4 343-462 Sentence denotes All patients had previously been treated in prospective clinical trials for advanced gastric cancer in our institution.
T5 463-655 Sentence denotes Patients with adequate prechemotherapy gastric cancer tissues for immunohistochemical studies by a C219 monoclonal antibody were selected for the determination of the expression rate of MDR-1.
T6 656-762 Sentence denotes The results were designated as negative or positive by the independent interpretation of two pathologists.
T7 763-918 Sentence denotes A subgroup of patients who had been treated with doxorubicin- or etoposide-containing regimens were selected for further correlation with drug sensitivity.
T8 919-1030 Sentence denotes Between 1990 and 1996, a total of 60 patients, 38 men and 22 women with a median age of 55 years, were studied.
T9 1031-1107 Sentence denotes Eight (13.3%; 95% confidence interval, 6%-25%) of them had MDR-1 expression.
T10 1108-1280 Sentence denotes None of the pertinent clinicopathologic features, including the histopathologic types of the tumors and the extent of the diseases, correlated with the expression of MDR-1.
T11 1281-1470 Sentence denotes Among the 30 patients who had received doxorubicin- or etoposide-containing combination chemotherapy, 3 (10%; 95% confidence interval, 3%-27%) were designated positive for MDR-1 expression.
T12 1471-1632 Sentence denotes None of the 3 patients responded to chemotherapy, whereas 19 (70.4%) of the 27 patients who had not expressed MDR-1 did respond (p=0.041 by Fisher's exact test).
T13 1633-1710 Sentence denotes We conclude that the expression of MDR-1 in gastric cancer is relatively low.
T14 1711-1911 Sentence denotes Its expression, however, is clinically relevant and is useful in predicting the chemoresistance of patients with gastric cancer receiving doxorubicin- or etoposide-containing combination chemotherapy.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 300-305 gene:23158 denotes MDR-1
T1 327-341 disease:C0024623 denotes gastric cancer
T2 300-305 gene:23158 denotes MDR-1
T3 327-341 disease:C0699791 denotes gastric cancer
T4 300-305 gene:5243 denotes MDR-1
T5 327-341 disease:C0024623 denotes gastric cancer
T6 300-305 gene:5243 denotes MDR-1
T7 327-341 disease:C0699791 denotes gastric cancer
R1 T0 T1 associated_with MDR-1,gastric cancer
R2 T2 T3 associated_with MDR-1,gastric cancer
R3 T4 T5 associated_with MDR-1,gastric cancer
R4 T6 T7 associated_with MDR-1,gastric cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 517-524 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 517-524 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T101 1668-1673 gene:5243 denotes MDR-1
T102 1677-1691 disease:C0699791 denotes gastric cancer
R1 T101 T102 associated_with MDR-1,gastric cancer
R2 T101 T102 associated_with MDR-1,gastric cancer