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PubMed:9619918 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes IL-2
T2 23-64 cell_type denotes CD8+ T cell prolymphocytic leukemia cells
T3 77-86 protein denotes NF-kappaB
T4 101-120 protein denotes IL-2 receptor alpha
T5 148-161 protein denotes interleukin-2
T6 163-167 protein denotes IL-2
T7 195-202 cell_type denotes T cells
T8 233-254 protein denotes nuclear factor kappaB
T9 256-265 protein denotes NF-kappaB
T10 286-324 DNA denotes IL-2 receptor (IL-2R) alpha chain gene
T11 384-389 protein denotes IL-2R
T12 417-466 cell_line denotes CD8+ T cell prolymphocytic leukemia (T-PLL) cells
T13 519-541 cell_type denotes primary leukemia cells
T14 583-609 protein denotes IL-2Ralpha and beta chains
T15 676-686 protein denotes IL-2Ralpha
T16 725-729 protein denotes IL-2
T17 771-780 RNA denotes IL-2 mRNA
T18 798-802 protein denotes IL-2
T19 906-910 protein denotes IL-2
T20 921-930 protein denotes NF-kappaB
T21 975-989 cell_type denotes leukemia cells
T22 1030-1034 protein denotes IL-2
T23 1081-1090 protein denotes NF-kappaB
T24 1102-1107 protein denotes c-Rel
T25 1112-1116 protein denotes KBF1
T26 1133-1137 protein denotes IL-2
T27 1173-1177 protein denotes IL-2
T28 1224-1230 protein denotes IL-2Rs
T29 1238-1252 cell_type denotes leukemia cells
T30 1289-1309 protein denotes high-affinity IL-2Rs
T31 1335-1339 protein denotes IL-2
T32 1389-1398 protein denotes NF-kappaB
T33 1402-1426 cell_line denotes primary CD8+ T-PLL cells

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 23-64 NP denotes CD8+ T cell prolymphocytic leukemia cells
C2 101-131 NP denotes IL-2 receptor alpha expression
C3 148-168 NP denotes interleukin-2 (IL-2)
C4 172-175 NP denotes its
C5 211-266 NP denotes nuclear expression of nuclear factor kappaB (NF-kappaB)
C6 417-466 NP denotes CD8+ T cell prolymphocytic leukemia (T-PLL) cells
C7 519-572 NP denotes primary leukemia cells from a patient with CD8+ T-PLL
C8 615-624 NP denotes the cells
C9 676-697 NP denotes IL-2Ralpha expression
C10 731-753 NP denotes Northern blot analysis
C11 798-802 NP denotes IL-2
C12 971-989 NP denotes the leukemia cells
C13 995-1017 NP denotes Northern blot analysis
C14 1030-1034 NP denotes IL-2
C15 1120-1131 NP denotes these cells
C16 1173-1177 NP denotes IL-2
C17 1234-1252 NP denotes the leukemia cells
C18 1335-1339 NP denotes IL-2
C19 1363-1398 NP denotes the nuclear expression of NF-kappaB
C20 1402-1426 NP denotes primary CD8+ T-PLL cells
R1 C4 C3 coref-pron its,interleukin-2 (IL-2)
R2 C6 C1 coref-ident CD8+ T cell prolymphocytic leukemia (T-PLL) cells,CD8+ T cell prolymphocytic leukemia cells
R3 C8 C7 coref-ident the cells,primary leukemia cells from a patient with CD8+ T-PLL
R4 C9 C2 coref-ident IL-2Ralpha expression,IL-2 receptor alpha expression
R5 C11 C3 coref-ident IL-2,interleukin-2 (IL-2)
R6 C12 C8 coref-ident the leukemia cells,the cells
R7 C13 C10 coref-ident Northern blot analysis,Northern blot analysis
R8 C14 C11 coref-ident IL-2,IL-2
R9 C15 C12 coref-ident these cells,the leukemia cells
R10 C16 C14 coref-ident IL-2,IL-2
R11 C17 C15 coref-ident the leukemia cells,these cells
R12 C18 C16 coref-ident IL-2,IL-2
R13 C19 C5 coref-ident the nuclear expression of NF-kappaB,nuclear expression of nuclear factor kappaB (NF-kappaB)
R14 C20 C6 coref-ident primary CD8+ T-PLL cells,CD8+ T cell prolymphocytic leukemia (T-PLL) cells

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-132 Sentence denotes IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression.
S2 133-349 Sentence denotes The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor kappaB (NF-kappaB), activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation.
S3 350-489 Sentence denotes In the present study, the role of IL-2R signaling in the growth of CD8+ T cell prolymphocytic leukemia (T-PLL) cells has been investigated.
S4 490-730 Sentence denotes Flow cytometry revealed that primary leukemia cells from a patient with CD8+ T-PLL expressed IL-2Ralpha and beta chains, and the cells showed a proliferative response and an increase in IL-2Ralpha expression on culture with exogeneous IL-2.
S5 731-841 Sentence denotes Northern blot analysis failed to detect IL-2 mRNA, suggesting that IL-2 may act in a paracrine manner in vivo.
S6 842-1132 Sentence denotes Electrophoretic mobility-shift assays revealed that recombinant IL-2 increased NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells.
S7 1133-1310 Sentence denotes IL-2 binding analysis demonstrated that IL-2 markedly increased the number of low affinity IL-2Rs on the leukemia cells, without an effect on the number of high-affinity IL-2Rs.
S8 1311-1508 Sentence denotes These results show that IL-2 is capable of inducing the nuclear expression of NF-kappaB in primary CD8+ T-PLL cells, and that this effect is mediated, at least in part, at a pretranslational level.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-4 protein_molecule denotes IL-2
T2 23-64 cell_type denotes CD8+ T cell prolymphocytic leukemia cells
T3 77-86 protein_complex denotes NF-kappaB
T4 101-105 protein_molecule denotes IL-2
T5 148-161 protein_molecule denotes interleukin-2
T6 163-167 protein_molecule denotes IL-2
T7 195-202 cell_type denotes T cells
T8 211-229 other_name denotes nuclear expression
T9 233-254 protein_complex denotes nuclear factor kappaB
T10 256-265 protein_complex denotes NF-kappaB
T11 286-290 protein_molecule denotes IL-2
T12 330-348 other_name denotes cell proliferation
T13 384-389 protein_family_or_group denotes IL-2R
T14 417-466 cell_line denotes CD8+ T cell prolymphocytic leukemia (T-PLL) cells
T15 519-541 cell_type denotes primary leukemia cells
T16 562-572 other_name denotes CD8+ T-PLL
T17 676-686 protein_subunit denotes IL-2Ralpha
T18 725-729 protein_molecule denotes IL-2
T19 731-753 other_name denotes Northern blot analysis
T20 771-780 RNA_molecule denotes IL-2 mRNA
T21 798-802 protein_molecule denotes IL-2
T22 842-879 other_name denotes Electrophoretic mobility-shift assays
T23 906-910 protein_molecule denotes IL-2
T24 921-930 protein_complex denotes NF-kappaB
T25 951-967 cell_component denotes nuclear extracts
T26 975-989 cell_type denotes leukemia cells
T27 995-1017 other_name denotes Northern blot analysis
T28 1030-1034 protein_molecule denotes IL-2
T29 1081-1090 protein_complex denotes NF-kappaB
T30 1102-1107 protein_molecule denotes c-Rel
T31 1112-1116 protein_molecule denotes KBF1
T32 1133-1137 protein_molecule denotes IL-2
T33 1173-1177 protein_molecule denotes IL-2
T34 1224-1230 protein_family_or_group denotes IL-2Rs
T35 1238-1252 cell_type denotes leukemia cells
T36 1289-1309 protein_family_or_group denotes high-affinity IL-2Rs
T37 1335-1339 protein_molecule denotes IL-2
T38 1367-1385 other_name denotes nuclear expression
T39 1389-1398 protein_complex denotes NF-kappaB
T40 1402-1426 cell_line denotes primary CD8+ T-PLL cells
T41 1485-1507 other_name denotes pretranslational level

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-132 Sentence denotes IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression.
TextSentencer_T2 133-349 Sentence denotes The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor kappaB (NF-kappaB), activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation.
TextSentencer_T3 350-489 Sentence denotes In the present study, the role of IL-2R signaling in the growth of CD8+ T cell prolymphocytic leukemia (T-PLL) cells has been investigated.
TextSentencer_T4 490-730 Sentence denotes Flow cytometry revealed that primary leukemia cells from a patient with CD8+ T-PLL expressed IL-2Ralpha and beta chains, and the cells showed a proliferative response and an increase in IL-2Ralpha expression on culture with exogeneous IL-2.
TextSentencer_T5 731-841 Sentence denotes Northern blot analysis failed to detect IL-2 mRNA, suggesting that IL-2 may act in a paracrine manner in vivo.
TextSentencer_T6 842-1132 Sentence denotes Electrophoretic mobility-shift assays revealed that recombinant IL-2 increased NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells.
TextSentencer_T7 1133-1310 Sentence denotes IL-2 binding analysis demonstrated that IL-2 markedly increased the number of low affinity IL-2Rs on the leukemia cells, without an effect on the number of high-affinity IL-2Rs.
TextSentencer_T8 1311-1508 Sentence denotes These results show that IL-2 is capable of inducing the nuclear expression of NF-kappaB in primary CD8+ T-PLL cells, and that this effect is mediated, at least in part, at a pretranslational level.
T1 0-132 Sentence denotes IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression.
T2 133-349 Sentence denotes The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor kappaB (NF-kappaB), activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation.
T3 350-489 Sentence denotes In the present study, the role of IL-2R signaling in the growth of CD8+ T cell prolymphocytic leukemia (T-PLL) cells has been investigated.
T4 490-730 Sentence denotes Flow cytometry revealed that primary leukemia cells from a patient with CD8+ T-PLL expressed IL-2Ralpha and beta chains, and the cells showed a proliferative response and an increase in IL-2Ralpha expression on culture with exogeneous IL-2.
T5 731-841 Sentence denotes Northern blot analysis failed to detect IL-2 mRNA, suggesting that IL-2 may act in a paracrine manner in vivo.
T6 842-1132 Sentence denotes Electrophoretic mobility-shift assays revealed that recombinant IL-2 increased NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells.
T7 1133-1310 Sentence denotes IL-2 binding analysis demonstrated that IL-2 markedly increased the number of low affinity IL-2Rs on the leukemia cells, without an effect on the number of high-affinity IL-2Rs.
T8 1311-1508 Sentence denotes These results show that IL-2 is capable of inducing the nuclear expression of NF-kappaB in primary CD8+ T-PLL cells, and that this effect is mediated, at least in part, at a pretranslational level.

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 50-58 HP:0001909 denotes leukemia
AB1 444-452 HP:0001909 denotes leukemia
AB2 527-535 HP:0001909 denotes leukemia
AB3 975-983 HP:0001909 denotes leukemia
AB4 1238-1246 HP:0001909 denotes leukemia

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 28-58 ORDO:86871 denotes T cell prolymphocytic leukemia
AB1 422-452 ORDO:86871 denotes T cell prolymphocytic leukemia
AB2 454-459 ORDO:86871 denotes T-PLL
AB3 567-572 ORDO:86871 denotes T-PLL
AB4 1415-1420 ORDO:86871 denotes T-PLL