PubMed:9600235 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9600235","sourcedb":"PubMed","sourceid":"9600235","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9600235","text":"Mutations of the ATM gene detected in Japanese ataxia-telangiectasia patients: possible preponderance of the two founder mutations 4612del165 and 7883del5.\nThe ATM (A-T, mutated) gene on human chromosome 11q22.3 has recently been identified as the gene responsible for the human recessive disease ataxia-telangiectasia (A-T). In order to define the types of disease-causing ATM mutations in Japanese A-T patients as well as to look for possible mutational hotspots, reverse-transcribed RNA derived from ten patients belonging to eight unrelated Japanese A-T families was analyzed for mutations by the restriction endonuclease fingerprinting method. As has been reported by others, mutations that lead to exon skipping or premature protein truncation were also predominant in our mutants. Six different mutations were identified on 12 of the 16 alleles examined. Four were deletions involving a loss of a single exon: exon 7, exon 16, exon 33 or exon 35. The others were minute deletions, 4649delA in exon 33 and 7883del5 in exon 55. The mutations 4612del165 and 7883del5 were found in more than two unrelated families; 44% (7 of 16) of the mutant alleles had one of the two mutations. The 4612del165 mutations in three different families were all ascribed to the same T--\u003eA substitution at the splice donor site in intron 33. Microsatellite genotyping around the ATM locus also indicated that a common haplotype was shared by the mutant alleles in both mutations. This suggests that these two founder mutations may be predominant among Japanese ATM mutant alleles.","tracks":[{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier:D001260"},{"id":"T2","span":{"begin":279,"end":296},"obj":"DiseaseClass:D030342"},{"id":"T3","span":{"begin":297,"end":318},"obj":"SpecificDisease:D001260"},{"id":"T4","span":{"begin":320,"end":323},"obj":"SpecificDisease:D001260"},{"id":"T5","span":{"begin":400,"end":403},"obj":"Modifier:D001260"},{"id":"T6","span":{"begin":554,"end":557},"obj":"Modifier:D001260"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T2","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T3","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T4","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T5","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T6","pred":"source","obj":"NCBIDiseaseCorpus"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":160,"end":163},"obj":"gene:472"},{"id":"T1","span":{"begin":165,"end":168},"obj":"disease:C0004135"},{"id":"T2","span":{"begin":160,"end":163},"obj":"gene:472"},{"id":"T3","span":{"begin":297,"end":318},"obj":"disease:C0004135"},{"id":"T4","span":{"begin":160,"end":163},"obj":"gene:472"},{"id":"T5","span":{"begin":320,"end":323},"obj":"disease:C0004135"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"9600235-0#17#20#gene472","span":{"begin":17,"end":20},"obj":"gene472"},{"id":"9600235-0#47#68#diseaseC0004135","span":{"begin":47,"end":68},"obj":"diseaseC0004135"}],"relations":[{"id":"17#20#gene47247#68#diseaseC0004135","pred":"associated_with","subj":"9600235-0#17#20#gene472","obj":"9600235-0#47#68#diseaseC0004135"}],"attributes":[{"subj":"9600235-0#17#20#gene472","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"9600235-0#47#68#diseaseC0004135","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"NCBI-Disease-Test","denotations":[{"id":"T441","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T442","span":{"begin":279,"end":296},"obj":"DiseaseClass"},{"id":"T443","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T444","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T445","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T446","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"id":"A441","pred":"database_id","subj":"T441","obj":"D001260"},{"id":"A442","pred":"database_id","subj":"T442","obj":"D030342"},{"id":"A443","pred":"database_id","subj":"T443","obj":"D001260"},{"id":"A444","pred":"database_id","subj":"T444","obj":"D001260"},{"id":"A445","pred":"database_id","subj":"T445","obj":"D001260"},{"id":"A446","pred":"database_id","subj":"T446","obj":"D001260"},{"subj":"T441","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T442","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T443","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T444","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T445","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T446","pred":"source","obj":"NCBI-Disease-Test"}]},{"project":"NCBI-Disease-Test-Assistant-Knowledge","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":297,"end":324},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"}]},{"project":"NCBI-Disease-Test-4o-NoGuidelineInPrompt","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":297,"end":324},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":358,"end":373},"obj":"Modifier"},{"id":"T4","span":{"begin":400,"end":403},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":554,"end":557},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"}]},{"project":"NCBI-Disease-Test-4o-GuidelineInPrompt","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":400,"end":403},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":554,"end":557},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"}]},{"project":"NCBI-Disease-Corpus-UpdatedGuideline","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":279,"end":296},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":297,"end":318},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"}]},{"project":"NCBI-Disease-Corpus-humanintheloop","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T5","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"}]},{"project":"NCBI-Disease-Corpus-rezarta1","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":400,"end":403},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"}]},{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T441","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T442","span":{"begin":279,"end":296},"obj":"DiseaseClass"},{"id":"T443","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T444","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T445","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T446","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"id":"A441","pred":"database_id","subj":"T441","obj":"D001260"},{"id":"A442","pred":"database_id","subj":"T442","obj":"D030342"},{"id":"A443","pred":"database_id","subj":"T443","obj":"D001260"},{"id":"A444","pred":"database_id","subj":"T444","obj":"D001260"},{"id":"A445","pred":"database_id","subj":"T445","obj":"D001260"},{"id":"A446","pred":"database_id","subj":"T446","obj":"D001260"},{"subj":"T441","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T442","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T443","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T444","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T445","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T446","pred":"source","obj":"NCBI-Disease-Corpus-All"}]},{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T5","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"}]},{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T4","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"}]},{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"}]},{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":297,"end":324},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":400,"end":403},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":554,"end":557},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"}]},{"project":"NCBI-Disease-Corpus-o3-2","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":165,"end":168},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":400,"end":403},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":554,"end":557},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"}]},{"project":"NCBI-Disease-Corpus-high-o3-1","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T5","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"}]},{"project":"NCBI-Disease-Corpus-high-o3-2","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T5","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"}]},{"project":"12345","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T5","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"12345"},{"subj":"T2","pred":"source","obj":"12345"},{"subj":"T3","pred":"source","obj":"12345"},{"subj":"T4","pred":"source","obj":"12345"},{"subj":"T5","pred":"source","obj":"12345"}]},{"project":"123456","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T5","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"123456"},{"subj":"T2","pred":"source","obj":"123456"},{"subj":"T3","pred":"source","obj":"123456"},{"subj":"T4","pred":"source","obj":"123456"},{"subj":"T5","pred":"source","obj":"123456"}]},{"project":"NCBI-Disease-Corpus-GPT5-withguidelines","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":165,"end":168},"obj":"Modifier"},{"id":"T3","span":{"begin":279,"end":296},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T7","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"}]},{"project":"NCBI-Disease-Corpus-GPT5-noguidelines","denotations":[{"id":"T1","span":{"begin":38,"end":77},"obj":"CompositeMention"},{"id":"T2","span":{"begin":165,"end":168},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":279,"end":296},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":297,"end":324},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":391,"end":412},"obj":"CompositeMention"},{"id":"T6","span":{"begin":545,"end":566},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"}]},{"project":"NCBI-Disease-Corpus-GPT5-guidelineprompt","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":165,"end":168},"obj":"Modifier"},{"id":"T3","span":{"begin":279,"end":296},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T7","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"}]},{"project":"NCBI-Disease-Corpus-Moderated1","denotations":[{"id":"T1","span":{"begin":47,"end":68},"obj":"Modifier"},{"id":"T2","span":{"begin":165,"end":168},"obj":"Modifier"},{"id":"T3","span":{"begin":273,"end":296},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":297,"end":318},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":320,"end":323},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":400,"end":403},"obj":"Modifier"},{"id":"T7","span":{"begin":554,"end":557},"obj":"Modifier"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NCBIDiseaseCorpus","color":"#dfec93","default":true},{"id":"DisGeNET","color":"#de93ec"},{"id":"DisGeNET5_gene_disease","color":"#93ecc4"},{"id":"NCBI-Disease-Test","color":"#ecaa93"},{"id":"NCBI-Disease-Test-Assistant-Knowledge","color":"#9395ec"},{"id":"NCBI-Disease-Test-4o-NoGuidelineInPrompt","color":"#afec93"},{"id":"NCBI-Disease-Test-4o-GuidelineInPrompt","color":"#ec93c9"},{"id":"NCBI-Disease-Corpus-UpdatedGuideline","color":"#93e3ec"},{"id":"NCBI-Disease-Corpus-humanintheloop","color":"#ecda93"},{"id":"NCBI-Disease-Corpus-rezarta1","color":"#c093ec"},{"id":"NCBI-Disease-Corpus-All","color":"#93eca6"},{"id":"NCBI-Disease-Corpus-2stage-All","color":"#ec9399"},{"id":"NCBI-Disease-Corpus-rezarta-All","color":"#93b3ec"},{"id":"NCBI-Disease-Corpus-4oGuideline-All","color":"#cdec93"},{"id":"NCBI-Disease-Corpus-Simple-All","color":"#ec93e7"},{"id":"NCBI-Disease-Corpus-o3-2","color":"#93ecd7"},{"id":"NCBI-Disease-Corpus-high-o3-1","color":"#ecbd93"},{"id":"NCBI-Disease-Corpus-high-o3-2","color":"#a393ec"},{"id":"12345","color":"#9dec93"},{"id":"123456","color":"#ec93b7"},{"id":"NCBI-Disease-Corpus-GPT5-withguidelines","color":"#93d1ec"},{"id":"NCBI-Disease-Corpus-GPT5-noguidelines","color":"#ebec93"},{"id":"NCBI-Disease-Corpus-GPT5-guidelineprompt","color":"#d393ec"},{"id":"NCBI-Disease-Corpus-Moderated1","color":"#93ecb9"}]}]}}