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PubMed:9593714 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-26 Sentence denotes Cloning of human PEX cDNA.
TextSentencer_T2 27-92 Sentence denotes Expression, subcellular localization, and endopeptidase activity.
TextSentencer_T3 93-173 Sentence denotes Mutations in the PEX gene are responsible for X-linked hypophosphatemic rickets.
TextSentencer_T4 174-358 Sentence denotes To gain insight into the role of PEX in normal physiology we have cloned the human full-length cDNA and studied its tissue expression, subcellular localization, and peptidase activity.
TextSentencer_T5 359-510 Sentence denotes We show that the cDNA encodes a 749-amino acid protein structurally related to a family of neutral endopeptidases that include neprilysin as prototype.
TextSentencer_T6 511-598 Sentence denotes By Northern blot analysis, the size of the full-length PEX transcript is 6.5 kilobases.
TextSentencer_T7 599-784 Sentence denotes PEX expression, as determined by semi-quantitative polymerase chain reaction, is high in bone and in tumor tissue associated with the paraneoplastic syndrome of renal phosphate wasting.
TextSentencer_T8 785-969 Sentence denotes PEX is glycosylated in the presence of canine microsomal membranes and partitions exclusively in the detergent phase from Triton X-114 extractions of transiently transfected COS cells.
TextSentencer_T9 970-1315 Sentence denotes Immunofluorescence studies in A293 cells expressing PEX tagged with a c-myc epitope show a predominant cell-surface location for the protein with its COOH-terminal domain in the extracellular compartment, substantiating the assumption that PEX, like other members of the neutral endopeptidase family, is a type II integral membrane glycoprotein.
TextSentencer_T10 1316-1545 Sentence denotes Cell membranes from cultured COS cells transiently expressing PEX efficiently degrade exogenously added parathyroid hormone-derived peptides, demonstrating for the first time that recombinant PEX can function as an endopeptidase.
TextSentencer_T11 1546-1708 Sentence denotes PEX peptidase activity may provide a convenient target for pharmacological intervention in states of altered phosphate homeostasis and in metabolic bone diseases.
T1 0-26 Sentence denotes Cloning of human PEX cDNA.
T2 27-92 Sentence denotes Expression, subcellular localization, and endopeptidase activity.
T3 93-173 Sentence denotes Mutations in the PEX gene are responsible for X-linked hypophosphatemic rickets.
T4 174-358 Sentence denotes To gain insight into the role of PEX in normal physiology we have cloned the human full-length cDNA and studied its tissue expression, subcellular localization, and peptidase activity.
T5 359-510 Sentence denotes We show that the cDNA encodes a 749-amino acid protein structurally related to a family of neutral endopeptidases that include neprilysin as prototype.
T6 511-598 Sentence denotes By Northern blot analysis, the size of the full-length PEX transcript is 6.5 kilobases.
T7 599-784 Sentence denotes PEX expression, as determined by semi-quantitative polymerase chain reaction, is high in bone and in tumor tissue associated with the paraneoplastic syndrome of renal phosphate wasting.
T8 785-969 Sentence denotes PEX is glycosylated in the presence of canine microsomal membranes and partitions exclusively in the detergent phase from Triton X-114 extractions of transiently transfected COS cells.
T9 970-1315 Sentence denotes Immunofluorescence studies in A293 cells expressing PEX tagged with a c-myc epitope show a predominant cell-surface location for the protein with its COOH-terminal domain in the extracellular compartment, substantiating the assumption that PEX, like other members of the neutral endopeptidase family, is a type II integral membrane glycoprotein.
T10 1316-1545 Sentence denotes Cell membranes from cultured COS cells transiently expressing PEX efficiently degrade exogenously added parathyroid hormone-derived peptides, demonstrating for the first time that recombinant PEX can function as an endopeptidase.
T11 1546-1708 Sentence denotes PEX peptidase activity may provide a convenient target for pharmacological intervention in states of altered phosphate homeostasis and in metabolic bone diseases.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 688-692 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 1420-1431 http://purl.obolibrary.org/obo/MAT_0000082 denotes parathyroid
T3 1694-1698 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

DisGeNET

Id Subject Object Predicate Lexical cue
T0 599-602 gene:5251 denotes PEX
T1 733-756 disease:C0030472 denotes paraneoplastic syndrome
T2 1546-1549 gene:5251 denotes PEX
T3 1684-1707 disease:C0005944 denotes metabolic bone diseases
R1 T0 T1 associated_with PEX,paraneoplastic syndrome
R2 T2 T3 associated_with PEX,metabolic bone diseases

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9593714-5#0#3#gene5251 599-602 gene5251 denotes PEX
9593714-5#134#157#diseaseC0030472 733-756 diseaseC0030472 denotes paraneoplastic syndrome
9593714-9#138#161#diseaseC0005944 1684-1707 diseaseC0005944 denotes metabolic bone diseases
0#3#gene5251134#157#diseaseC0030472 9593714-5#0#3#gene5251 9593714-5#134#157#diseaseC0030472 associated_with PEX,paraneoplastic syndrome

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 148-172 HP:0004912 denotes hypophosphatemic rickets
AB2 760-783 HP:0000117 denotes renal phosphate wasting

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 290-296 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 706-712 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 290-296 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 706-712 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 139-172 ORDO:89936 denotes X-linked hypophosphatemic rickets

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 139-172 Disease denotes X-linked hypophosphatemic rickets http://purl.obolibrary.org/obo/MONDO_0010619
T2 700-705 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 733-756 Disease denotes paraneoplastic syndrome http://purl.obolibrary.org/obo/MONDO_0021073
T4 1684-1707 Disease denotes metabolic bone diseases http://purl.obolibrary.org/obo/MONDO_0016370

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 688-692 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 1420-1431 Body_part denotes parathyroid http://purl.obolibrary.org/obo/MAT_0000082
T3 1694-1698 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 11-16 OrganismTaxon denotes human 9606
T2 251-256 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 290-296 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 688-692 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T4 706-712 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T5 824-830 Body_part denotes canine http://purl.obolibrary.org/obo/UBERON_0003674
T6 842-851 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T9 1148-1161 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T10 1293-1301 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T13 1316-1330 Body_part denotes Cell membranes http://purl.obolibrary.org/obo/GO_0005886
T14 1420-1431 Body_part denotes parathyroid http://purl.obolibrary.org/obo/UBERON_0001132
T15 1694-1698 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 148-172 Phenotype denotes hypophosphatemic rickets HP:0004912
T2 700-705 Phenotype denotes tumor HP:0002664
T3 760-783 Phenotype denotes renal phosphate wasting HP:0000117