PubMed:9563950 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9563950","sourcedb":"PubMed","sourceid":"9563950","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9563950","text":"Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy.\nMyotonic dystrophy (DM) is caused by a CTG expansion in the 3' untranslated region of the DM gene. One model of DM pathogenesis suggests that RNAs from the expanded allele create a gain-of-function mutation by the inappropriate binding of proteins to the CUG repeats. Data presented here indicate that the conserved heterogeneous nuclear ribonucleoprotein, CUG-binding protein (CUG-BP), may mediate the trans-dominant effect of the RNA. CUG-BP was found to bind to the human cardiac troponin T (cTNT) pre-messenger RNA and regulate its alternative splicing. Splicing of cTNT was disrupted in DM striated muscle and in normal cells expressing transcripts that contain CUG repeats. Altered expression of genes regulated posttranscriptionally by CUG-BP therefore may contribute to DM 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