| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-141 |
Sentence |
denotes |
PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants. |
| TextSentencer_T2 |
142-273 |
Sentence |
denotes |
Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. |
| TextSentencer_T3 |
274-358 |
Sentence |
denotes |
The renin-angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. |
| TextSentencer_T4 |
359-501 |
Sentence |
denotes |
An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been related to plasma and cellular ACE levels. |
| TextSentencer_T5 |
502-711 |
Sentence |
denotes |
In 1032 employees (446 men and 586 women; 22 to 66 years old) of a hospital in southern Italy, we investigated the association between PAI-1 4G/5G and the ACE I/D gene variants and plasma PAI-1 antigen levels. |
| TextSentencer_T6 |
712-786 |
Sentence |
denotes |
None of the individuals enrolled had clinical evidence of atherosclerosis. |
| TextSentencer_T7 |
787-980 |
Sentence |
denotes |
In univariate analysis, PAI-1 levels were significantly higher in men (P<.001), alcohol drinkers (P<.001), smokers (P=.009), and homozygotes for the PAI-1 gene deletion allele (4G/4G) (P=.012). |
| TextSentencer_T8 |
981-1216 |
Sentence |
denotes |
Multivariate analysis documented the independent effect on PAI-1 plasma levels of body mass index (P<.001), triglycerides (P<.001), sex (P<.001), PAI-1 4G/5G polymorphism (P=.019), smoking habit (P=.041), and ACE I/D genotype (P=.042). |
| TextSentencer_T9 |
1217-1507 |
Sentence |
denotes |
Thus, in addition to the markers of insulin resistance and smoking habit, gene variants of PAI-1 and ACE account for a significant portion of the between-individual variability of circulating PAI-1 antigen concentrations in a general population without clinical evidence of atherosclerosis. |
| T1 |
0-141 |
Sentence |
denotes |
PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants. |
| T2 |
142-273 |
Sentence |
denotes |
Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. |
| T3 |
274-358 |
Sentence |
denotes |
The renin-angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. |
| T4 |
359-501 |
Sentence |
denotes |
An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been related to plasma and cellular ACE levels. |
| T5 |
502-711 |
Sentence |
denotes |
In 1032 employees (446 men and 586 women; 22 to 66 years old) of a hospital in southern Italy, we investigated the association between PAI-1 4G/5G and the ACE I/D gene variants and plasma PAI-1 antigen levels. |
| T6 |
712-786 |
Sentence |
denotes |
None of the individuals enrolled had clinical evidence of atherosclerosis. |
| T7 |
787-980 |
Sentence |
denotes |
In univariate analysis, PAI-1 levels were significantly higher in men (P<.001), alcohol drinkers (P<.001), smokers (P=.009), and homozygotes for the PAI-1 gene deletion allele (4G/4G) (P=.012). |
| T8 |
981-1216 |
Sentence |
denotes |
Multivariate analysis documented the independent effect on PAI-1 plasma levels of body mass index (P<.001), triglycerides (P<.001), sex (P<.001), PAI-1 4G/5G polymorphism (P=.019), smoking habit (P=.041), and ACE I/D genotype (P=.042). |
| T9 |
1217-1507 |
Sentence |
denotes |
Thus, in addition to the markers of insulin resistance and smoking habit, gene variants of PAI-1 and ACE account for a significant portion of the between-individual variability of circulating PAI-1 antigen concentrations in a general population without clinical evidence of atherosclerosis. |
