PubMed:9548490
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-48 | protein | denotes | DNA-binding activities |
| T2 | 59-63 | protein | denotes | CD19 |
| T3 | 81-102 | cell_type | denotes | human B lineage cells |
| T4 | 108-145 | protein | denotes | B cell-specific cell surface molecule |
| T5 | 146-150 | protein | denotes | CD19 |
| T6 | 286-315 | protein | denotes | cytoplasmic effector proteins |
| T7 | 331-335 | protein | denotes | CD19 |
| T8 | 345-366 | cell_type | denotes | human B lineage cells |
| T9 | 394-440 | protein | denotes | CD19/Vav/phosphatidylinositol-3 kinase complex |
| T10 | 470-474 | protein | denotes | CD19 |
| T11 | 479-482 | protein | denotes | Vav |
| T12 | 506-509 | protein | denotes | Ras |
| T13 | 559-563 | protein | denotes | CD19 |
| T14 | 629-634 | protein | denotes | Elk-1 |
| T15 | 650-669 | protein | denotes | activator protein-1 |
| T16 | 671-675 | protein | denotes | AP-1 |
| T17 | 718-727 | protein | denotes | NF-kappaB |
| T18 | 729-750 | protein | denotes | transcription factors |
| T19 | 770-774 | protein | denotes | CD19 |
| T20 | 814-836 | cell_line | denotes | BLIN-1 pre-B cell line |
| T21 | 862-889 | protein | denotes | cell surface mu heavy chain |
| T22 | 906-927 | protein | denotes | surrogate light chain |
| T23 | 972-993 | protein | denotes | cell surface mu/kappa |
| T24 | 1008-1012 | protein | denotes | CD19 |
| T25 | 1026-1035 | cell_line | denotes | 1E8 cells |
| T26 | 1073-1093 | protein | denotes | Elk-1 fusion protein |
| T27 | 1134-1154 | protein | denotes | Elk-1 fusion protein |
| T28 | 1183-1213 | cell_line | denotes | CD19 cross-linked BLIN-1 cells |
| T29 | 1265-1269 | protein | denotes | AP-1 |
| T30 | 1274-1283 | protein | denotes | NF-kappaB |
| T31 | 1340-1344 | protein | denotes | AP-1 |
| T32 | 1393-1402 | protein | denotes | NF-kappaB |
| T33 | 1455-1459 | protein | denotes | CD19 |
| T34 | 1477-1486 | cell_line | denotes | 1E8 cells |
| T35 | 1525-1529 | protein | denotes | JunD |
| T36 | 1534-1548 | protein | denotes | c-Fos proteins |
| T37 | 1563-1567 | protein | denotes | CD19 |
| T38 | 1576-1580 | protein | denotes | AP-1 |
| T39 | 1601-1610 | cell_line | denotes | 1E8 cells |
| T40 | 1625-1629 | protein | denotes | CD19 |
| T41 | 1647-1659 | cell_line | denotes | BLIN-1 cells |
| T42 | 1689-1698 | protein | denotes | NF-kappaB |
| T43 | 1730-1734 | protein | denotes | AP-1 |
| T44 | 1777-1781 | protein | denotes | CD19 |
| T45 | 1831-1852 | protein | denotes | transcription factors |
| T46 | 1968-1973 | DNA | denotes | genes |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 59-77 | NP | denotes | CD19 cross-linking |
| C2 | 104-150 | NP | denotes | The B cell-specific cell surface molecule CD19 |
| C3 | 331-335 | NP | denotes | CD19 |
| C4 | 470-474 | NP | denotes | CD19 |
| C5 | 695-750 | NP | denotes | nuclear factor-kappaB (NF-kappaB) transcription factors |
| C6 | 770-788 | NP | denotes | CD19 cross-linking |
| C7 | 1008-1035 | NP | denotes | CD19 cross-linked 1E8 cells |
| C8 | 1070-1093 | NP | denotes | an Elk-1 fusion protein |
| C9 | 1134-1154 | NP | denotes | Elk-1 fusion protein |
| C10 | 1183-1213 | NP | denotes | CD19 cross-linked BLIN-1 cells |
| C11 | 1455-1473 | NP | denotes | CD19 cross-linking |
| C12 | 1477-1486 | NP | denotes | 1E8 cells |
| C13 | 1601-1610 | NP | denotes | 1E8 cells |
| C14 | 1647-1659 | NP | denotes | BLIN-1 cells |
| C15 | 1689-1698 | NP | denotes | NF-kappaB |
| C16 | 1856-1895 | NP | denotes | juxtaposed stages of B cell development |
| C17 | 1896-1900 | NP | denotes | that |
| R1 | C3 | C2 | coref-ident | CD19,The B cell-specific cell surface molecule CD19 |
| R2 | C4 | C3 | coref-ident | CD19,CD19 |
| R3 | C6 | C1 | coref-ident | CD19 cross-linking,CD19 cross-linking |
| R4 | C9 | C8 | coref-ident | Elk-1 fusion protein,an Elk-1 fusion protein |
| R5 | C11 | C6 | coref-ident | CD19 cross-linking,CD19 cross-linking |
| R6 | C12 | C7 | coref-ident | 1E8 cells,CD19 cross-linked 1E8 cells |
| R7 | C13 | C12 | coref-ident | 1E8 cells,1E8 cells |
| R8 | C14 | C10 | coref-ident | BLIN-1 cells,CD19 cross-linked BLIN-1 cells |
| R9 | C15 | C5 | coref-ident | NF-kappaB,nuclear factor-kappaB (NF-kappaB) transcription factors |
| R10 | C17 | C16 | coref-relat | that,juxtaposed stages of B cell development |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-103 | Sentence | denotes | Differential induction of DNA-binding activities following CD19 cross-linking in human B lineage cells. |
| S2 | 104-316 | Sentence | denotes | The B cell-specific cell surface molecule CD19 is expressed at all stages of B cell development, including normal plasma cells, and mediates signal transduction via interaction with cytoplasmic effector proteins. |
| S3 | 317-518 | Sentence | denotes | Cross-linking CD19 on early human B lineage cells induces the formation of a CD19/Vav/phosphatidylinositol-3 kinase complex, tyrosine phosphorylation of CD19 and Vav, and activation of the Ras pathway. |
| S4 | 519-789 | Sentence | denotes | To further explore the ramifications of CD19 signaling, the current study examined whether phosphorylation of Elk-1, activation of activator protein-1 (AP-1), or activation of nuclear factor-kappaB (NF-kappaB) transcription factors occurred following CD19 cross-linking. |
| S5 | 790-994 | Sentence | denotes | The cells used were the BLIN-1 pre-B cell line expressing low levels of cell surface mu heavy chain associated with surrogate light chain and the 1E8 immature B cell line expressing cell surface mu/kappa. |
| S6 | 995-1214 | Sentence | denotes | Lysates from CD19 cross-linked 1E8 cells induced robust phosphorylation of an Elk-1 fusion protein in vitro, whereas no phosphorylation of Elk-1 fusion protein occurred using lysates from CD19 cross-linked BLIN-1 cells. |
| S7 | 1215-1487 | Sentence | denotes | An electrophoretic mobility shift assay employing AP-1 and NF-kappaB consensus oligonucleotides was used to demonstrate that AP-1 -binding activity increased, while constitutive NF-kappaB-binding activity was not enhanced, following 2 h of CD19 cross-linking in 1E8 cells. |
| S8 | 1488-1611 | Sentence | denotes | Supershift experiments revealed that JunD and c-Fos proteins mediated anti-CD19 induced AP-1-binding activity in 1E8 cells. |
| S9 | 1612-1752 | Sentence | denotes | In contrast, CD19 cross-linking in BLIN-1 cells resulted in the induction of NF-kappaB, but had no apparent effect on AP-1-binding activity. |
| S10 | 1753-1974 | Sentence | denotes | These data suggest that CD19-mediated signal transduction activates different transcription factors at juxtaposed stages of B cell development that may culminate in the activation or suppression of distinct sets of genes. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 26-48 | protein_family_or_group | denotes | DNA-binding activities |
| T2 | 59-63 | protein_molecule | denotes | CD19 |
| T3 | 81-102 | cell_type | denotes | human B lineage cells |
| T4 | 108-145 | protein_family_or_group | denotes | B cell-specific cell surface molecule |
| T5 | 146-150 | protein_molecule | denotes | CD19 |
| T6 | 181-199 | other_name | denotes | B cell development |
| T7 | 286-315 | protein_family_or_group | denotes | cytoplasmic effector proteins |
| T8 | 331-335 | protein_molecule | denotes | CD19 |
| T9 | 345-366 | cell_type | denotes | human B lineage cells |
| T10 | 394-398 | protein_molecule | denotes | CD19 |
| T11 | 442-450 | amino_acid_monomer | denotes | tyrosine |
| T12 | 470-474 | protein_molecule | denotes | CD19 |
| T13 | 479-482 | protein_molecule | denotes | Vav |
| T14 | 506-509 | protein_molecule | denotes | Ras |
| T15 | 559-563 | protein_molecule | denotes | CD19 |
| T16 | 629-634 | protein_molecule | denotes | Elk-1 |
| T17 | 650-669 | protein_molecule | denotes | activator protein-1 |
| T18 | 671-675 | protein_molecule | denotes | AP-1 |
| T19 | 718-727 | protein_complex | denotes | NF-kappaB |
| T20 | 729-750 | protein_family_or_group | denotes | transcription factors |
| T21 | 770-774 | protein_molecule | denotes | CD19 |
| T22 | 814-836 | cell_line | denotes | BLIN-1 pre-B cell line |
| T23 | 862-889 | protein_subunit | denotes | cell surface mu heavy chain |
| T24 | 906-927 | protein_subunit | denotes | surrogate light chain |
| T25 | 972-993 | protein_molecule | denotes | cell surface mu/kappa |
| T26 | 1008-1012 | protein_molecule | denotes | CD19 |
| T27 | 1026-1035 | cell_line | denotes | 1E8 cells |
| T28 | 1073-1078 | protein_molecule | denotes | Elk-1 |
| T29 | 1134-1139 | protein_molecule | denotes | Elk-1 |
| T30 | 1183-1187 | protein_molecule | denotes | CD19 |
| T31 | 1218-1254 | other_name | denotes | electrophoretic mobility shift assay |
| T32 | 1265-1269 | protein_molecule | denotes | AP-1 |
| T33 | 1274-1283 | protein_complex | denotes | NF-kappaB |
| T34 | 1294-1310 | polynucleotide | denotes | oligonucleotides |
| T35 | 1340-1344 | protein_molecule | denotes | AP-1 |
| T36 | 1393-1402 | protein_complex | denotes | NF-kappaB |
| T37 | 1455-1459 | protein_molecule | denotes | CD19 |
| T38 | 1477-1486 | cell_line | denotes | 1E8 cells |
| T39 | 1488-1510 | other_name | denotes | Supershift experiments |
| T40 | 1525-1529 | protein_molecule | denotes | JunD |
| T41 | 1534-1548 | protein_molecule | denotes | c-Fos proteins |
| T42 | 1563-1567 | protein_molecule | denotes | CD19 |
| T43 | 1576-1580 | protein_molecule | denotes | AP-1 |
| T44 | 1601-1610 | cell_line | denotes | 1E8 cells |
| T45 | 1625-1629 | protein_molecule | denotes | CD19 |
| T46 | 1647-1659 | cell_line | denotes | BLIN-1 cells |
| T47 | 1689-1698 | protein_complex | denotes | NF-kappaB |
| T48 | 1730-1734 | protein_molecule | denotes | AP-1 |
| T49 | 1777-1781 | protein_molecule | denotes | CD19 |
| T50 | 1831-1852 | protein_family_or_group | denotes | transcription factors |
| T51 | 1877-1895 | other_name | denotes | B cell development |
| T52 | 1968-1973 | DNA_domain_or_region | denotes | genes |