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PubMed:9548485 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 8-51 protein denotes cyclic AMP response element-binding protein
T2 80-89 protein denotes NF-kappaB
T3 118-127 protein denotes NF-kappaB
T4 290-299 protein denotes NF-kappaB
T5 326-341 cell_type denotes human monocytes
T6 346-363 cell_type denotes endothelial cells
T7 408-427 protein denotes NF-kappaB complexes
T8 539-555 protein denotes protein kinase A
T9 586-595 protein denotes NF-kappaB
T10 656-693 protein denotes cAMP response element-binding protein
T11 695-699 protein denotes CREB
T12 756-759 protein denotes CBP
T13 784-805 protein denotes amino-terminal region
T14 807-824 protein denotes amino acids 1-450
T15 829-832 protein denotes CBP
T16 865-889 protein denotes carboxyl-terminal region
T17 891-910 protein denotes amino acids 286-551
T18 915-924 protein denotes NF-kappaB
T19 925-928 protein denotes p65
T20 930-934 protein denotes RelA
T21 994-1011 cell_type denotes endothelial cells
T22 1048-1051 protein denotes CBP
T23 1079-1088 protein denotes NF-kappaB
T24 1144-1160 protein denotes chimeric protein
T25 1162-1179 protein denotes GAL4-p65(286-551)
T26 1201-1224 protein denotes GAL4 DNA binding domain
T27 1238-1262 protein denotes carboxyl-terminal region
T28 1266-1269 protein denotes p65
T29 1271-1290 protein denotes amino acids 286-551
T30 1324-1328 protein denotes CREB
T31 1339-1343 protein denotes GAL4
T32 1426-1442 protein denotes protein kinase A
T33 1460-1469 protein denotes NF-kappaB
T34 1503-1507 protein denotes CREB
T35 1529-1532 protein denotes p65
T36 1557-1560 protein denotes CBP

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 80-112 NP denotes NF-kappaB-mediated transcription
C1 55-112 NP denotes cyclic AMP inhibition of NF-kappaB-mediated transcription
C3 290-322 NP denotes NF-kappaB-mediated transcription
C4 483-498 NP denotes this inhibition
C6 535-573 NP denotes the protein kinase A signaling pathway
C5 521-573 NP denotes activation of the protein kinase A signaling pathway
C7 586-618 NP denotes NF-kappaB-mediated transcription
C8 656-700 NP denotes cAMP response element-binding protein (CREB)
C9 702-707 NP denotes which
C10 740-759 NP denotes the coactivator CBP
C11 829-832 NP denotes CBP
C12 861-935 NP denotes the carboxyl-terminal region (amino acids 286-551) of NF-kappaB p65 (RelA)
C13 1048-1051 NP denotes CBP
C14 1079-1111 NP denotes NF-kappaB-mediated transcription
C15 1142-1160 NP denotes a chimeric protein
C16 1162-1179 NP denotes GAL4-p65(286-551)
C17 1181-1186 NP denotes which
C19 1266-1269 NP denotes p65
C18 1234-1291 NP denotes the carboxyl-terminal region of p65 (amino acids 286-551)
C20 1324-1328 NP denotes CREB
C22 1422-1450 NP denotes the protein kinase A pathway
C21 1408-1450 NP denotes activation of the protein kinase A pathway
C23 1460-1483 NP denotes NF-kappaB transcription
C24 1503-1507 NP denotes CREB
C25 1509-1514 NP denotes which
C26 1529-1532 NP denotes p65
C27 1557-1560 NP denotes CBP
R1 C3 C2 coref-ident NF-kappaB-mediated transcription,NF-kappaB-mediated transcription
R2 C4 C1 coref-ident this inhibition,cyclic AMP inhibition of NF-kappaB-mediated transcription
R3 C9 C8 coref-relat which,cAMP response element-binding protein (CREB)
R4 C11 C10 coref-ident CBP,the coactivator CBP
R5 C13 C11 coref-ident CBP,CBP
R6 C14 C7 coref-ident NF-kappaB-mediated transcription,NF-kappaB-mediated transcription
R7 C16 C15 coref-appos GAL4-p65(286-551),a chimeric protein
R8 C17 C16 coref-relat which,GAL4-p65(286-551)
R9 C18 C12 coref-ident the carboxyl-terminal region of p65 (amino acids 286-551),the carboxyl-terminal region (amino acids 286-551) of NF-kappaB p65 (RelA)
R10 C20 C8 coref-ident CREB,cAMP response element-binding protein (CREB)
R11 C22 C6 coref-ident the protein kinase A pathway,the protein kinase A signaling pathway
R12 C21 C5 coref-ident activation of the protein kinase A pathway,activation of the protein kinase A signaling pathway
R13 C23 C14 coref-ident NF-kappaB transcription,NF-kappaB-mediated transcription
R14 C24 C20 coref-ident CREB,CREB
R15 C25 C24 coref-relat which,CREB
R16 C26 C19 coref-ident p65,p65
R17 C27 C13 coref-ident CBP,CBP

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-113 Sentence denotes Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription.
S2 114-217 Sentence denotes The NF-kappaB family of transcription factors regulates the inducible expression of a variety of genes.
S3 218-428 Sentence denotes Recently, we showed that elevation of intracellular cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytes and endothelial cells without preventing nuclear translocation of NF-kappaB complexes.
S4 429-499 Sentence denotes The present study examined the molecular mechanism of this inhibition.
S5 500-760 Sentence denotes We hypothesized that activation of the protein kinase A signaling pathway may inhibit NF-kappaB-mediated transcription by phosphorylating proteins, such as cAMP response element-binding protein (CREB), which compete for limiting amounts of the coactivator CBP.
S6 761-962 Sentence denotes Here, we show that the amino-terminal region (amino acids 1-450) of CBP specifically interacts with the carboxyl-terminal region (amino acids 286-551) of NF-kappaB p65 (RelA) both in vitro and in vivo.
S7 963-1292 Sentence denotes Functional studies using human endothelial cells demonstrated that overexpression of CBP rescued cAMP inhibition of NF-kappaB-mediated transcription and transcription mediated by a chimeric protein, GAL4-p65(286-551), which contained the GAL4 DNA binding domain fused to the carboxyl-terminal region of p65 (amino acids 286-551).
S8 1293-1380 Sentence denotes In contrast, overexpression of CREB inhibited GAL4-p65(286-551)-mediated transcription.
S9 1381-1561 Sentence denotes These results suggest that activation of the protein kinase A pathway inhibits NF-kappaB transcription by phosphorylating CREB, which competes with p65 for limiting amounts of CBP.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 8-18 nucleotide denotes cyclic AMP
T2 55-65 nucleotide denotes cyclic AMP
T3 80-89 protein_complex denotes NF-kappaB
T4 118-127 protein_complex denotes NF-kappaB
T5 270-280 nucleotide denotes cyclic AMP
T6 290-299 protein_complex denotes NF-kappaB
T7 326-341 cell_type denotes human monocytes
T8 346-363 cell_type denotes endothelial cells
T9 408-417 protein_complex denotes NF-kappaB
T10 539-555 protein_molecule denotes protein kinase A
T11 586-595 protein_complex denotes NF-kappaB
T12 656-693 protein_molecule denotes cAMP response element-binding protein
T13 695-699 protein_molecule denotes CREB
T14 756-759 protein_molecule denotes CBP
T15 784-805 protein_domain_or_region denotes amino-terminal region
T16 807-824 protein_domain_or_region denotes amino acids 1-450
T17 829-832 protein_molecule denotes CBP
T18 865-889 protein_domain_or_region denotes carboxyl-terminal region
T19 891-910 protein_domain_or_region denotes amino acids 286-551
T20 915-924 protein_complex denotes NF-kappaB
T21 925-928 protein_subunit denotes p65
T22 930-934 protein_subunit denotes RelA
T23 994-1011 cell_type denotes endothelial cells
T24 1048-1051 protein_molecule denotes CBP
T25 1060-1064 nucleotide denotes cAMP
T26 1079-1088 protein_complex denotes NF-kappaB
T27 1144-1160 protein_family_or_group denotes chimeric protein
T28 1162-1179 protein_molecule denotes GAL4-p65(286-551)
T29 1201-1224 protein_domain_or_region denotes GAL4 DNA binding domain
T30 1238-1262 protein_domain_or_region denotes carboxyl-terminal region
T31 1266-1269 protein_subunit denotes p65
T32 1271-1290 protein_domain_or_region denotes amino acids 286-551
T33 1324-1328 protein_molecule denotes CREB
T34 1339-1343 protein_molecule denotes GAL4
T35 1426-1442 protein_molecule denotes protein kinase A
T36 1460-1469 protein_complex denotes NF-kappaB
T37 1503-1507 protein_molecule denotes CREB
T38 1529-1532 protein_subunit denotes p65
T39 1557-1560 protein_molecule denotes CBP