PubMed:9545554
Annnotations
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 54-67 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
| T2 | 614-627 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 639-643 | Glycan | denotes | SM-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T2 | 835-839 | Glycan | denotes | SM-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T3 | 924-927 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
| T4 | 1008-1012 | Glycan | denotes | SM-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 924-927 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 924-927 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 45-73 | Body_part | denotes | vascular smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000359 |
| T2 | 605-632 | Body_part | denotes | vascular smooth muscle cell | http://purl.obolibrary.org/obo/CL_0000359 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 45-73 | Cell | denotes | vascular smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000359 |
| T2 | 54-73 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
| T3 | 605-632 | Cell | denotes | vascular smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000359 |
| T4 | 614-632 | Cell | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000192 |
| T5 | 621-632 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
| T6 | 1195-1210 | Cell | denotes | fraction, and a | http://purl.obolibrary.org/obo/CL:0002045 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-108 | Sentence | denotes | Inhibition of migration and proliferation of vascular smooth muscle cells by dehydroepiandrosterone sulfate. |
| T2 | 109-269 | Sentence | denotes | Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroids in humans, and their serum concentrations progressively decrease with age. |
| T3 | 270-480 | Sentence | denotes | Although relationships between DHEA(-S) and many age-related illnesses have been postulated, the mechanisms for their effects remain unknown, and specific receptors for these molecules have not been identified. |
| T4 | 481-673 | Sentence | denotes | In this paper, to investigate the role of DHEA(-S) in atherogenesis, we studied the proliferation and migration of a rabbit vascular smooth muscle cell line, SM-3, in the presence of DHEA(-S). |
| T5 | 674-753 | Sentence | denotes | Cellular proliferation was inhibited by DHEA-S, and to a lesser extent by DHEA. |
| T6 | 754-861 | Sentence | denotes | Modified Boyden's chamber assays revealed that DHEA-S inhibited the migration of SM-3 cells toward PDGF-BB. |
| T7 | 862-949 | Sentence | denotes | In cell attachment assays, DHEA-S inhibited the attachment of SM3 cells to fibronectin. |
| T8 | 950-1095 | Sentence | denotes | It was suggested that the inhibitory effect of DHEA-S for SM-3 proliferation and migration was due to the decreased interaction with fibronectin. |
| T9 | 1096-1252 | Sentence | denotes | Scatchard analysis revealed the presence of two populations of DHEA-S binding sites in the nuclear fraction, and a smaller number in the cytosolic fraction. |
| T10 | 1253-1455 | Sentence | denotes | Since the dissociation constant of the higher affinity site was similar to the serum DHEA-S concentration in humans (Kd = 5.8 microM), this binding site could be functional under physiologic conditions. |
| T11 | 1456-1550 | Sentence | denotes | These findings suggest that there may be receptor-mediated anti-atherogenic actions of DHEA-S. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 924-927 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 45-73 | Body_part | denotes | vascular smooth muscle cells | FMA:284560 |
| T2 | 216-221 | Body_part | denotes | serum | FMA:63083 |
| T3 | 605-632 | Body_part | denotes | vascular smooth muscle cell | FMA:284560 |
| T4 | 1233-1242 | Body_part | denotes | cytosolic | FMA:66836 |
| T5 | 1332-1337 | Body_part | denotes | serum | FMA:63083 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 54-67 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
| T2 | 614-627 | Body_part | denotes | smooth muscle | http://purl.obolibrary.org/obo/MAT_0000303 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 45-73 | Body_part | denotes | vascular smooth muscle cells | http://purl.obolibrary.org/obo/CL_0000359 |
| T2 | 605-632 | Body_part | denotes | vascular smooth muscle cell | http://purl.obolibrary.org/obo/CL_0000359 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 45-73 | Cell | denotes | vascular smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000359 |
| T2 | 54-73 | Cell | denotes | smooth muscle cells | http://purl.obolibrary.org/obo/CL:0000192 |
| T3 | 605-632 | Cell | denotes | vascular smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000359 |
| T4 | 614-632 | Cell | denotes | smooth muscle cell | http://purl.obolibrary.org/obo/CL:0000192 |
| T5 | 621-632 | Cell | denotes | muscle cell | http://purl.obolibrary.org/obo/CL:0000187 |
| T6 | 1195-1210 | Cell | denotes | fraction, and a | http://purl.obolibrary.org/obo/CL:0002045 |