| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-54 |
Sentence |
denotes |
Apolipoprotein E allelic frequency in elderly smokers. |
| TextSentencer_T2 |
55-267 |
Sentence |
denotes |
Susceptibility genes for human diseases (e.g., cancer and atherosclerosis) increase disease risk by altering the metabolic activation of exogenous (e.g., carcinogens) and endogenous (e.g., cholesterol) compounds. |
| TextSentencer_T3 |
268-361 |
Sentence |
denotes |
The function of these genes, and subsequent risk, can be adversely affected by polymorphisms. |
| TextSentencer_T4 |
362-625 |
Sentence |
denotes |
This study tests the hypothesis that if specific genetic polymorphisms are related to mortality, then in elderly heavy smokers, there should be a decreased frequency of "at risk" alleles and an increased frequency of "protective" alleles, i.e., a survival effect. |
| TextSentencer_T5 |
626-881 |
Sentence |
denotes |
One such potential polymorphism is in the apolipoprotein E (apoE) gene, which is involved in cholesterol metabolism, where the epsilon4 allele is associated with an increased risk of coronary artery disease and is under represented in elderly populations. |
| TextSentencer_T6 |
882-982 |
Sentence |
denotes |
In this study, ApoE variant alleles were determined in 81 living, elderly current smokers (mean age: |
| TextSentencer_T7 |
983-995 |
Sentence |
denotes |
72.5; range: |
| TextSentencer_T8 |
996-1019 |
Sentence |
denotes |
65-94; mean pack-years: |
| TextSentencer_T9 |
1020-1030 |
Sentence |
denotes |
78; range: |
| TextSentencer_T10 |
1031-1082 |
Sentence |
denotes |
13-192) and in 82 younger autopsy donors (mean age: |
| TextSentencer_T11 |
1083-1093 |
Sentence |
denotes |
33; range: |
| TextSentencer_T12 |
1094-1100 |
Sentence |
denotes |
1-58). |
| TextSentencer_T13 |
1101-1281 |
Sentence |
denotes |
There was a borderline difference in the apoE 4 allelic frequencies among the groups (11% in the elderly and 18% in the comparable younger group [df = 1; chi(2) = 4.02; P = 0.05]). |
| TextSentencer_T14 |
1282-1492 |
Sentence |
denotes |
A significant difference was found for age when stratified as a continuous variable by genotype in the elderly smokers (P = 0.03; mean age for persons with and without epsilon4 was 69.9 and 73.2, respectively). |
| TextSentencer_T15 |
1493-1584 |
Sentence |
denotes |
Pack-years of cigarette smokers did not differ by genotype, indicating no selective effect. |
| TextSentencer_T16 |
1585-1772 |
Sentence |
denotes |
These results confirm earlier associations for differences in the apoE allelic frequencies in the elderly and extend it to smokers, who generally have increased mortality at younger ages. |
| T1 |
0-54 |
Sentence |
denotes |
Apolipoprotein E allelic frequency in elderly smokers. |
| T2 |
55-267 |
Sentence |
denotes |
Susceptibility genes for human diseases (e.g., cancer and atherosclerosis) increase disease risk by altering the metabolic activation of exogenous (e.g., carcinogens) and endogenous (e.g., cholesterol) compounds. |
| T3 |
268-361 |
Sentence |
denotes |
The function of these genes, and subsequent risk, can be adversely affected by polymorphisms. |
| T4 |
362-625 |
Sentence |
denotes |
This study tests the hypothesis that if specific genetic polymorphisms are related to mortality, then in elderly heavy smokers, there should be a decreased frequency of "at risk" alleles and an increased frequency of "protective" alleles, i.e., a survival effect. |
| T5 |
626-881 |
Sentence |
denotes |
One such potential polymorphism is in the apolipoprotein E (apoE) gene, which is involved in cholesterol metabolism, where the epsilon4 allele is associated with an increased risk of coronary artery disease and is under represented in elderly populations. |
| T6 |
882-982 |
Sentence |
denotes |
In this study, ApoE variant alleles were determined in 81 living, elderly current smokers (mean age: |
| T7 |
983-995 |
Sentence |
denotes |
72.5; range: |
| T8 |
996-1019 |
Sentence |
denotes |
65-94; mean pack-years: |
| T9 |
1020-1030 |
Sentence |
denotes |
78; range: |
| T10 |
1031-1082 |
Sentence |
denotes |
13-192) and in 82 younger autopsy donors (mean age: |
| T11 |
1083-1093 |
Sentence |
denotes |
33; range: |
| T12 |
1094-1100 |
Sentence |
denotes |
1-58). |
| T13 |
1101-1281 |
Sentence |
denotes |
There was a borderline difference in the apoE 4 allelic frequencies among the groups (11% in the elderly and 18% in the comparable younger group [df = 1; chi(2) = 4.02; P = 0.05]). |
| T14 |
1282-1492 |
Sentence |
denotes |
A significant difference was found for age when stratified as a continuous variable by genotype in the elderly smokers (P = 0.03; mean age for persons with and without epsilon4 was 69.9 and 73.2, respectively). |
| T15 |
1493-1584 |
Sentence |
denotes |
Pack-years of cigarette smokers did not differ by genotype, indicating no selective effect. |
| T16 |
1585-1772 |
Sentence |
denotes |
These results confirm earlier associations for differences in the apoE allelic frequencies in the elderly and extend it to smokers, who generally have increased mortality at younger ages. |
