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PubMed:9499378 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 95-99 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T2 301-305 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T3 718-722 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000
T4 1094-1098 Body_part denotes cell http://purl.obolibrary.org/obo/CL_0000000

Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 12-26 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis x
T2 195-199 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T3 227-231 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T4 573-577 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T5 649-653 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T6 670-674 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T7 768-772 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T8 898-902 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T9 928-932 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T10 974-978 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T11 1199-1203 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T12 1226-1230 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T13 1263-1267 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T14 1321-1325 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 12-26 Glycan_Motif denotes sialyl Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T2 19-26 Glycan_Motif denotes Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T4 195-199 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T5 227-231 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T6 573-577 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T7 649-653 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T8 670-674 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T9 768-772 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T10 898-902 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T11 928-932 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T12 974-978 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T13 1199-1203 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T14 1226-1230 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T15 1263-1267 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T16 1321-1325 Glycan_Motif denotes sLex https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 12-26 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis x
T2 19-26 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis x

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Multivalent sialyl Lewis x ligands of definite structures as inhibitors of E-selectin mediated cell adhesion.
TextSentencer_T2 110-314 Sentence denotes We report on the efficiencies of structurally different but well defined multivalent sLex-ligands (di- and trivalent sLex-peptides and sLexbearing liposomes) to block receptor mediated HepG2-cell binding.
TextSentencer_T3 315-586 Sentence denotes Using three types of binding assays with distinct receptor accommodations (soluble anti-sLexmonoclonal antibody CSLEX1, immobilized E-selectin, activated HUVECs), we quantified considerable differences of the inhibition efficiencies for the same multivalent sLex-ligands.
TextSentencer_T4 587-808 Sentence denotes Compared to the monovalent sLexthe inhibition powers of both (sLex)2-peptides and (sLex)3-peptides were enhanced up to 50-fold for cell binding to the soluble antibody, and that of sLex-liposomes by 7 orders of magnitude.
TextSentencer_T5 809-1003 Sentence denotes Directed to immobilized E-selectin the inhibition activity was enhanced only 3-fold for (sLex)2-peptides, 10-fold for (sLex)3-peptides but 5 orders of magnitude for sLex-liposomes, respectively.
TextSentencer_T6 1004-1127 Sentence denotes Further decrease of the inhibition efficiencies of glycoligands prepared was observed for cell binding to activated HUVECs.
TextSentencer_T7 1128-1278 Sentence denotes Compared to monovalent sLexwe measured relative efficiencies of 1 for (sLex)2-peptides, of 2 for (sLex)3-peptides but about 20,000 for sLex-liposomes.
TextSentencer_T8 1279-1421 Sentence denotes We concluded that the multivalency of the sLex-ligands prepared is an essential but not sufficient precondition for a high inhibition potency.
TextSentencer_T9 1422-1582 Sentence denotes Additionally, structural properties of the inhibitors determine their binding behavior, which must be considered for the design of potential therapeutic probes.
T1 0-109 Sentence denotes Multivalent sialyl Lewis x ligands of definite structures as inhibitors of E-selectin mediated cell adhesion.
T2 110-314 Sentence denotes We report on the efficiencies of structurally different but well defined multivalent sLex-ligands (di- and trivalent sLex-peptides and sLexbearing liposomes) to block receptor mediated HepG2-cell binding.
T3 315-586 Sentence denotes Using three types of binding assays with distinct receptor accommodations (soluble anti-sLexmonoclonal antibody CSLEX1, immobilized E-selectin, activated HUVECs), we quantified considerable differences of the inhibition efficiencies for the same multivalent sLex-ligands.
T4 587-808 Sentence denotes Compared to the monovalent sLexthe inhibition powers of both (sLex)2-peptides and (sLex)3-peptides were enhanced up to 50-fold for cell binding to the soluble antibody, and that of sLex-liposomes by 7 orders of magnitude.
T5 809-1003 Sentence denotes Directed to immobilized E-selectin the inhibition activity was enhanced only 3-fold for (sLex)2-peptides, 10-fold for (sLex)3-peptides but 5 orders of magnitude for sLex-liposomes, respectively.
T6 1004-1127 Sentence denotes Further decrease of the inhibition efficiencies of glycoligands prepared was observed for cell binding to activated HUVECs.
T7 1128-1278 Sentence denotes Compared to monovalent sLexwe measured relative efficiencies of 1 for (sLex)2-peptides, of 2 for (sLex)3-peptides but about 20,000 for sLex-liposomes.
T8 1279-1421 Sentence denotes We concluded that the multivalency of the sLex-ligands prepared is an essential but not sufficient precondition for a high inhibition potency.
T9 1422-1582 Sentence denotes Additionally, structural properties of the inhibitors determine their binding behavior, which must be considered for the design of potential therapeutic probes.
T1 0-109 Sentence denotes Multivalent sialyl Lewis x ligands of definite structures as inhibitors of E-selectin mediated cell adhesion.
T2 110-314 Sentence denotes We report on the efficiencies of structurally different but well defined multivalent sLex-ligands (di- and trivalent sLex-peptides and sLexbearing liposomes) to block receptor mediated HepG2-cell binding.
T3 315-586 Sentence denotes Using three types of binding assays with distinct receptor accommodations (soluble anti-sLexmonoclonal antibody CSLEX1, immobilized E-selectin, activated HUVECs), we quantified considerable differences of the inhibition efficiencies for the same multivalent sLex-ligands.
T4 587-808 Sentence denotes Compared to the monovalent sLexthe inhibition powers of both (sLex)2-peptides and (sLex)3-peptides were enhanced up to 50-fold for cell binding to the soluble antibody, and that of sLex-liposomes by 7 orders of magnitude.
T5 809-1003 Sentence denotes Directed to immobilized E-selectin the inhibition activity was enhanced only 3-fold for (sLex)2-peptides, 10-fold for (sLex)3-peptides but 5 orders of magnitude for sLex-liposomes, respectively.
T6 1004-1127 Sentence denotes Further decrease of the inhibition efficiencies of glycoligands prepared was observed for cell binding to activated HUVECs.
T7 1128-1278 Sentence denotes Compared to monovalent sLexwe measured relative efficiencies of 1 for (sLex)2-peptides, of 2 for (sLex)3-peptides but about 20,000 for sLex-liposomes.
T8 1279-1421 Sentence denotes We concluded that the multivalency of the sLex-ligands prepared is an essential but not sufficient precondition for a high inhibition potency.
T9 1422-1582 Sentence denotes Additionally, structural properties of the inhibitors determine their binding behavior, which must be considered for the design of potential therapeutic probes.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 12-26 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis x
T2 19-26 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis x
T3 19-26 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis x
T4 195-199 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T5 227-231 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T6 573-577 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T7 649-653 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T8 670-674 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T9 768-772 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T10 898-902 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T11 928-932 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T12 974-978 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T13 1199-1203 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T14 1226-1230 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T15 1263-1267 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex
T16 1321-1325 https://glytoucan.org/Structures/Glycans/G00054MO denotes sLex

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 95-99 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 295-305 http://purl.obolibrary.org/obo/CLO_0051862 denotes HepG2-cell
T3 301-305 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 459-468 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T5 469-475 http://purl.obolibrary.org/obo/CLO_0004307 denotes HUVECs
T6 718-722 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7 859-867 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T8 1094-1098 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9 1110-1119 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T10 1120-1126 http://purl.obolibrary.org/obo/CLO_0004307 denotes HUVECs

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 75-85 FMAID:62933 denotes E-selectin
_T2 75-85 FMAID:167265 denotes E-selectin
_T3 75-85 FMAID:167267 denotes E-selectin
_T4 75-85 FMAID:62932 denotes E-selectin
_T5 75-85 FMAID:62931 denotes E-selectin
_T6 75-85 FMAID:167268 denotes E-selectin
_T7 77-85 FMAID:165243 denotes selectin
_T8 77-85 FMAID:61795 denotes selectin
_T9 418-426 FMAID:167180 denotes antibody
_T10 447-457 FMAID:62932 denotes E-selectin
_T11 447-457 FMAID:62931 denotes E-selectin
_T12 447-457 FMAID:167267 denotes E-selectin
_T13 447-457 FMAID:167268 denotes E-selectin
_T14 447-457 FMAID:62933 denotes E-selectin
_T15 447-457 FMAID:167265 denotes E-selectin
_T16 449-457 FMAID:61795 denotes selectin
_T17 449-457 FMAID:165243 denotes selectin
_T18 746-754 FMAID:167180 denotes antibody
_T19 833-843 FMAID:62932 denotes E-selectin
_T20 833-843 FMAID:167265 denotes E-selectin
_T21 833-843 FMAID:167268 denotes E-selectin
_T22 833-843 FMAID:167267 denotes E-selectin
_T23 833-843 FMAID:62933 denotes E-selectin
_T24 833-843 FMAID:62931 denotes E-selectin
_T25 835-843 FMAID:61795 denotes selectin
_T26 835-843 FMAID:165243 denotes selectin

uniprot-human

Id Subject Object Predicate Lexical cue
T1 75-85 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T2 447-457 http://www.uniprot.org/uniprot/P16581 denotes E-selectin
T3 833-843 http://www.uniprot.org/uniprot/P16581 denotes E-selectin

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 75-85 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T2 447-457 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin
T3 833-843 http://www.uniprot.org/uniprot/Q00690 denotes E-selectin

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1500-1508 http://purl.bioontology.org/ontology/STY/T053 denotes behavior

GO-BP

Id Subject Object Predicate Lexical cue
T1 12-18 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T2 86-108 http://purl.obolibrary.org/obo/GO_0033627 denotes mediated cell adhesion
T3 95-108 http://purl.obolibrary.org/obo/GO_0007155 denotes cell adhesion
T4 1099-1119 http://purl.obolibrary.org/obo/GO_0051099 denotes binding to activated
T5 1500-1508 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior

GO-MF

Id Subject Object Predicate Lexical cue
T1 27-34 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T2 200-207 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T3 578-585 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T4 1326-1333 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T5 77-85 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T6 449-457 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T7 835-843 http://purl.obolibrary.org/obo/GO_0030246 denotes selectin
T8 306-313 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T9 336-343 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T10 723-730 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T11 1099-1106 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T12 1492-1499 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T13 306-313 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T14 336-343 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T15 723-730 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T16 1099-1106 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T17 1492-1499 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T18 306-313 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T19 336-343 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T20 723-730 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T21 1099-1106 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T22 1492-1499 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T23 306-313 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T24 336-343 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T25 723-730 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T26 1099-1106 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T27 1492-1499 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T28 418-426 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T29 746-754 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-CC

Id Subject Object Predicate Lexical cue
T1 95-99 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 301-305 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 718-722 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 1094-1098 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 12-24 http://rdf.glycoinfo.org/glycan/G00053MO denotes sialyl Lewis
T2 12-26 http://rdf.glycoinfo.org/glycan/G00054MO denotes sialyl Lewis x
T3 19-24 http://rdf.glycoinfo.org/glycan/G00047MO denotes Lewis
T4 19-26 http://rdf.glycoinfo.org/glycan/G00051MO denotes Lewis x
T5 195-199 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T6 227-231 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T7 573-577 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T8 649-653 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T9 670-674 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T10 768-772 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T11 898-902 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T12 928-932 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T13 974-978 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T14 1199-1203 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T15 1226-1230 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T16 1263-1267 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex
T17 1321-1325 http://rdf.glycoinfo.org/glycan/G00054MO denotes sLex

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 75-85 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T2 447-457 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T3 833-843 https://acgg.asia/db/lfdb/LfDB0043 denotes E-selectin
Lectin_T4 77-85 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T5 449-457 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T6 835-843 https://acgg.asia/db/lfdb/LfDB0013 denotes selectin
Lectin_T7 77-85 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin
Lectin_T8 449-457 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin
Lectin_T9 835-843 https://acgg.asia/db/lfdb/LfDB0142 denotes selectin

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 19-26 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis x
PD-GlycoEpitope-B_T2 12-24 http://www.glycoepitope.jp/epitopes/EP0008 denotes sialyl Lewis
PD-GlycoEpitope-B_T3 12-26 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis x