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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 26-31 protein denotes MCP-1
T2 201-210 protein denotes cytokines
T3 221-237 protein denotes interferon-gamma
T4 239-248 protein denotes IFN-gamma
T5 269-290 protein denotes chemokine superfamily
T6 385-394 protein denotes IFN-gamma
T7 405-425 protein denotes class II MHC antigen
T8 457-490 protein denotes intercellular adhesion molecule-1
T9 495-521 cell_line denotes cultured endothelial cells
T10 634-643 protein denotes IFN-gamma
T11 899-929 protein denotes monocyte chemotactic peptide-1
T12 931-936 protein denotes MCP-1
T13 941-950 protein denotes chemokine
T14 1070-1079 protein denotes IFN-gamma
T15 1169-1175 protein denotes STAT-1
T16 1210-1227 cell_type denotes endothelial cells
T17 1233-1242 protein denotes IFN-gamma
T18 1261-1266 protein denotes MCP-1
T19 1334-1343 protein denotes IFN-gamma
T20 1458-1463 protein denotes MCP-1
T21 1512-1541 protein denotes phosphatidylinositol 3-kinase
T22 1585-1607 cell_type denotes mononuclear leucocytes
T23 1618-1627 protein denotes chemokine
T24 1767-1772 protein denotes MCP-1
T25 1849-1858 protein denotes IFN-gamma
T26 1886-1891 protein denotes MCP-1
T27 1906-1932 cell_line denotes cultured endothelial cells
T28 2034-2039 protein denotes MCP-1

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 26-31 NP denotes MCP-1
C2 47-54 NP denotes heparin
C3 105-112 NP denotes Heparin
C5 116-153 NP denotes a polyanionic glycosaminoglycan (GAG)
C6 154-158 NP denotes that
C7 221-249 NP denotes interferon-gamma (IFN-gamma)
C4 116-290 NP denotes a polyanionic glycosaminoglycan (GAG) that can bind with high affinity to a range of cytokines including interferon-gamma (IFN-gamma) and members of the chemokine superfamily
C8 292-300 NP denotes This GAG
C9 385-394 NP denotes IFN-gamma
C10 495-521 NP denotes cultured endothelial cells
C11 556-596 NP denotes binding to cell-surface heparan sulphate
C12 634-643 NP denotes IFN-gamma
C13 653-665 NP denotes free heparin
C14 689-715 NP denotes this sequestration process
C15 816-823 NP denotes heparin
C16 899-937 NP denotes monocyte chemotactic peptide-1 (MCP-1)
C17 939-1026 NP denotes a chemokine important for mononuclear leucocyte recruitment across vascular endothelium
C18 1057-1064 NP denotes heparin
C19 1070-1079 NP denotes IFN-gamma
C20 1233-1242 NP denotes IFN-gamma
C22 1261-1277 NP denotes MCP-1 production
C21 1244-1277 NP denotes An inhibition of MCP-1 production
C23 1291-1295 NP denotes that
C24 1334-1343 NP denotes IFN-gamma
C25 1349-1399 NP denotes heparin-like, and therefore cytokine-binding, GAGs
C26 1435-1452 NP denotes heparin-like GAGs
C27 1458-1463 NP denotes MCP-1
C28 1474-1541 NP denotes the rapid tyrosine phosphorylation of phosphatidylinositol 3-kinase
C29 1542-1547 NP denotes which
C30 1613-1627 NP denotes this chemokine
C31 1767-1772 NP denotes MCP-1
C32 1812-1838 NP denotes soluble, heparin-like GAGs
C33 1886-1902 NP denotes MCP-1 production
C34 1906-1932 NP denotes cultured endothelial cells
C35 2021-2039 NP denotes pre-existing MCP-1
C36 2111-2118 NP denotes heparin
R1 C3 C2 coref-ident Heparin,heparin
R2 C6 C5 coref-relat that,a polyanionic glycosaminoglycan (GAG)
R3 C8 C4 coref-ident This GAG,a polyanionic glycosaminoglycan (GAG) that can bind with high affinity to a range of cytokines including interferon-gamma (IFN-gamma) and members of the chemokine superfamily
R4 C9 C7 coref-ident IFN-gamma,interferon-gamma (IFN-gamma)
R5 C12 C9 coref-ident IFN-gamma,IFN-gamma
R6 C13 C3 coref-ident free heparin,Heparin
R7 C14 C11 coref-ident this sequestration process,binding to cell-surface heparan sulphate
R8 C15 C13 coref-ident heparin,free heparin
R9 C16 C1 coref-ident monocyte chemotactic peptide-1 (MCP-1),MCP-1
R10 C17 C16 coref-appos a chemokine important for mononuclear leucocyte recruitment across vascular endothelium,monocyte chemotactic peptide-1 (MCP-1)
R11 C18 C15 coref-ident heparin,heparin
R12 C19 C12 coref-ident IFN-gamma,IFN-gamma
R13 C20 C19 coref-ident IFN-gamma,IFN-gamma
R14 C23 C21 coref-relat that,An inhibition of MCP-1 production
R15 C24 C20 coref-ident IFN-gamma,IFN-gamma
R16 C26 C25 coref-ident heparin-like GAGs,"heparin-like, and therefore cytokine-binding, GAGs"
R17 C27 C16 coref-ident MCP-1,monocyte chemotactic peptide-1 (MCP-1)
R18 C29 C28 coref-relat which,the rapid tyrosine phosphorylation of phosphatidylinositol 3-kinase
R19 C30 C27 coref-ident this chemokine,MCP-1
R20 C31 C30 coref-ident MCP-1,this chemokine
R21 C32 C26 coref-ident "soluble, heparin-like GAGs",heparin-like GAGs
R22 C33 C22 coref-ident MCP-1 production,MCP-1 production
R23 C34 C10 coref-ident cultured endothelial cells,cultured endothelial cells
R24 C35 C31 coref-ident pre-existing MCP-1,MCP-1
R25 C36 C18 coref-ident heparin,heparin

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-104 Sentence denotes Endothelial production of MCP-1: modulation by heparin and consequences for mononuclear cell activation.
S2 105-291 Sentence denotes Heparin is a polyanionic glycosaminoglycan (GAG) that can bind with high affinity to a range of cytokines including interferon-gamma (IFN-gamma) and members of the chemokine superfamily.
S3 292-522 Sentence denotes This GAG also possesses immunomodulatory activity in vivo and can antagonize the capacity of IFN-gamma to induce class II MHC antigen expression, and to up-regulate intercellular adhesion molecule-1, by cultured endothelial cells.
S4 523-716 Sentence denotes Previous studies have shown that binding to cell-surface heparan sulphate is essential for optimal activity of IFN-gamma and that free heparin competitively inhibits this sequestration process.
S5 717-1027 Sentence denotes The present study was performed to increase our understanding of the immunosuppressive activity of heparin by investigation of potential antagonism of the production and function of monocyte chemotactic peptide-1 (MCP-1), a chemokine important for mononuclear leucocyte recruitment across vascular endothelium.
S6 1028-1243 Sentence denotes It was found that mixture of heparin with IFN-gamma inhibited up-regulation of the signal transducer and activator of transcription protein, STAT-1 produced normally by treatment of endothelial cells with IFN-gamma.
S7 1244-1400 Sentence denotes An inhibition of MCP-1 production was observed that was specifically caused by mixture of IFN-gamma with heparin-like, and therefore cytokine-binding, GAGs.
S8 1401-1628 Sentence denotes It was also shown that mixture of heparin-like GAGs with MCP-1 inhibited the rapid tyrosine phosphorylation of phosphatidylinositol 3-kinase which is normally produced by treatment of mononuclear leucocytes with this chemokine.
S9 1629-1773 Sentence denotes Blockade of this intracellular signalling event was associated with a reduction in the normal transendothelial migration response towards MCP-1.
S10 1774-2040 Sentence denotes Results from this study indicate that soluble, heparin-like GAGs can block IFN-gamma-dependent up-regulation of MCP-1 production by cultured endothelial cells, and can also antagonize the leucocyte-activating and migration-promoting properties of pre-existing MCP-1.
S11 2041-2119 Sentence denotes These activities may contribute to the immunomodulatory properties of heparin.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-22 other_name denotes Endothelial production
T2 26-31 protein_molecule denotes MCP-1
T3 47-54 other_organic_compound denotes heparin
T4 76-103 other_name denotes mononuclear cell activation
T5 105-112 other_organic_compound denotes Heparin
T6 118-147 other_organic_compound denotes polyanionic glycosaminoglycan
T7 149-152 other_organic_compound denotes GAG
T8 201-210 protein_family_or_group denotes cytokines
T9 221-237 protein_molecule denotes interferon-gamma
T10 239-248 protein_molecule denotes IFN-gamma
T11 269-290 protein_family_or_group denotes chemokine superfamily
T12 297-300 other_organic_compound denotes GAG
T13 316-341 other_name denotes immunomodulatory activity
T14 385-394 protein_molecule denotes IFN-gamma
T15 405-425 protein_family_or_group denotes class II MHC antigen
T16 457-490 protein_molecule denotes intercellular adhesion molecule-1
T17 495-521 cell_line denotes cultured endothelial cells
T18 567-596 other_organic_compound denotes cell-surface heparan sulphate
T19 614-630 other_name denotes optimal activity
T20 634-643 protein_molecule denotes IFN-gamma
T21 658-665 other_organic_compound denotes heparin
T22 694-715 other_name denotes sequestration process
T23 786-812 other_name denotes immunosuppressive activity
T24 816-823 other_organic_compound denotes heparin
T25 899-929 protein_molecule denotes monocyte chemotactic peptide-1
T26 931-936 protein_molecule denotes MCP-1
T27 941-950 protein_family_or_group denotes chemokine
T28 965-998 other_name denotes mononuclear leucocyte recruitment
T29 1006-1026 tissue denotes vascular endothelium
T30 1057-1064 other_organic_compound denotes heparin
T31 1070-1079 protein_molecule denotes IFN-gamma
T32 1169-1175 protein_molecule denotes STAT-1
T33 1210-1227 cell_type denotes endothelial cells
T34 1233-1242 protein_molecule denotes IFN-gamma
T35 1261-1266 protein_molecule denotes MCP-1
T36 1334-1343 protein_molecule denotes IFN-gamma
T37 1435-1442 other_organic_compound denotes heparin
T38 1458-1463 protein_molecule denotes MCP-1
T39 1484-1492 amino_acid_monomer denotes tyrosine
T40 1512-1541 protein_molecule denotes phosphatidylinositol 3-kinase
T41 1585-1607 cell_type denotes mononuclear leucocytes
T42 1618-1627 protein_family_or_group denotes chemokine
T43 1646-1676 other_name denotes intracellular signalling event
T44 1716-1749 other_name denotes normal transendothelial migration
T45 1767-1772 protein_molecule denotes MCP-1
T46 1821-1828 other_organic_compound denotes heparin
T47 1849-1858 protein_molecule denotes IFN-gamma
T48 1886-1891 protein_molecule denotes MCP-1
T49 1906-1914 cell_line denotes cultured
T50 1915-1932 cell_type denotes endothelial cells
T51 1962-2017 other_name denotes leucocyte-activating and migration-promoting properties
T52 2034-2039 protein_molecule denotes MCP-1
T53 2080-2107 other_name denotes immunomodulatory properties
T54 2111-2118 other_organic_compound denotes heparin