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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-153 Sentence denotes Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate.
T2 154-340 Sentence denotes Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
T3 341-439 Sentence denotes The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.
T4 440-661 Sentence denotes Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
T5 662-827 Sentence denotes Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently.
T6 828-1090 Sentence denotes Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
T7 1091-1174 Sentence denotes However, the nature of the subunit involved in this mechanism has not been defined.
T8 1175-1417 Sentence denotes To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.
T9 1418-1638 Sentence denotes High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
T10 1639-1829 Sentence denotes The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.
T1 0-153 Sentence denotes Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate.
T2 154-340 Sentence denotes Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
T3 341-439 Sentence denotes The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.
T4 440-661 Sentence denotes Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
T5 662-827 Sentence denotes Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently.
T6 828-1090 Sentence denotes Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
T7 1091-1174 Sentence denotes However, the nature of the subunit involved in this mechanism has not been defined.
T8 1175-1417 Sentence denotes To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.
T9 1418-1638 Sentence denotes High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
T10 1639-1829 Sentence denotes The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-53 RNA denotes nuclear factor kappa B subunit p65 mRNA
T2 70-121 cell_line denotes lipopolysaccharide-stimulated human monocytic cells
T3 269-291 protein denotes inflammatory mediators
T4 300-321 protein denotes tumor necrosis factor
T5 326-339 protein denotes interleukin-1
T6 407-421 DNA denotes cytokine genes
T7 440-512 protein denotes Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins
T8 584-606 protein denotes inflammatory mediators
T9 612-621 cell_type denotes monocytes
T10 931-941 protein denotes NF-kappa B
T11 986-1006 protein denotes NF-kappa B inhibitor
T12 1008-1017 protein denotes I kappa B
T13 1050-1060 protein denotes NF-kappa B
T14 1229-1237 protein denotes cytokine
T15 1292-1302 protein denotes NF-kappa B
T16 1307-1322 RNA denotes NF-kappa B mRNA
T17 1352-1403 cell_line denotes lipopolysaccharide-stimulated human monocytic cells
T18 1461-1471 protein denotes NF-kappa B
T19 1472-1480 RNA denotes p65 mRNA
T20 1529-1539 protein denotes NF-kappa B
T21 1541-1544 protein denotes p50
T22 1616-1626 protein denotes NF-kappa B
T23 1669-1672 protein denotes p65
T24 1684-1694 protein denotes NF-kappa B
T25 1806-1828 protein denotes inflammatory mediators

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 70-89 NP denotes lipopolysaccharide-
C2 154-172 NP denotes Lipopolysaccharide
C6 222-231 NP denotes monocytes
C4 269-339 NP denotes inflammatory mediators such as tumor necrosis factor and interleukin-1
C3 440-512 NP denotes Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins
C5 584-606 NP denotes inflammatory mediators
C7 612-621 NP denotes monocytes
C8 642-660 NP denotes lipopolysaccharide
C13 828-839 NP denotes Salicylates
C9 867-886 NP denotes lipopolysaccharide-
C10 1050-1060 NP denotes NF-kappa B
C11 1186-1200 NP denotes the mechanisms
C12 1204-1209 NP denotes which
C14 1210-1221 NP denotes salicylates
C15 1352-1370 NP denotes lipopolysaccharide
C17 1589-1608 NP denotes lipopolysaccharide-
C18 1684-1694 NP denotes NF-kappa B
C19 1806-1828 NP denotes inflammatory mediators
R1 C2 C1 coref-ident Lipopolysaccharide,lipopolysaccharide-
R2 C5 C4 coref-ident inflammatory mediators,inflammatory mediators such as tumor necrosis factor and interleukin-1
R3 C7 C6 coref-ident monocytes,monocytes
R4 C8 C2 coref-ident lipopolysaccharide,Lipopolysaccharide
R5 C9 C8 coref-ident lipopolysaccharide-,lipopolysaccharide
R6 C10 C3 coref-ident NF-kappa B,Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins
R7 C12 C11 coref-relat which,the mechanisms
R8 C14 C13 coref-ident salicylates,Salicylates
R9 C15 C9 coref-ident lipopolysaccharide,lipopolysaccharide-
R10 C17 C15 coref-ident lipopolysaccharide-,lipopolysaccharide
R11 C18 C10 coref-ident NF-kappa B,NF-kappa B
R12 C19 C5 coref-ident inflammatory mediators,inflammatory mediators

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-153 Sentence denotes Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate.
S2 154-340 Sentence denotes Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
S3 341-439 Sentence denotes The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.
S4 440-661 Sentence denotes Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
S5 662-827 Sentence denotes Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently.
S6 828-1090 Sentence denotes Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
S7 1091-1174 Sentence denotes However, the nature of the subunit involved in this mechanism has not been defined.
S8 1175-1417 Sentence denotes To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.
S9 1418-1638 Sentence denotes High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
S10 1639-1829 Sentence denotes The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-36 protein_molecule denotes nuclear factor kappa B
T2 70-88 lipid denotes lipopolysaccharide
T3 135-152 other_organic_compound denotes sodium salicylate
T4 269-291 protein_family_or_group denotes inflammatory mediators
T5 300-321 protein_family_or_group denotes tumor necrosis factor
T6 326-339 protein_molecule denotes interleukin-1
T7 407-415 protein_family_or_group denotes cytokine
T8 440-462 protein_family_or_group denotes Nuclear factor kappa B
T9 464-474 protein_complex denotes NF-kappa B
T10 491-494 protein_subunit denotes p50
T11 499-502 protein_subunit denotes p65
T12 562-580 other_name denotes gene transcription
T13 584-606 protein_family_or_group denotes inflammatory mediators
T14 612-621 cell_type denotes monocytes
T15 642-660 lipid denotes lipopolysaccharide
T16 662-674 other_organic_compound denotes Nonsteroidal
T17 675-698 other_organic_compound denotes anti-inflammatory drugs
T18 755-767 other_name denotes inflammation
T19 828-839 other_organic_compound denotes Salicylates
T20 867-885 lipid denotes lipopolysaccharide
T21 894-912 other_name denotes gene transcription
T22 931-941 protein_complex denotes NF-kappa B
T23 986-996 protein_molecule denotes NF-kappa B
T24 1008-1017 protein_molecule denotes I kappa B
T25 1050-1060 protein_complex denotes NF-kappa B
T26 1070-1089 cell_component denotes nuclear compartment
T27 1210-1221 other_organic_compound denotes salicylates
T28 1229-1237 protein_family_or_group denotes cytokine
T29 1238-1256 other_name denotes gene transcription
T30 1292-1302 protein_complex denotes NF-kappa B
T31 1307-1317 protein_complex denotes NF-kappa B
T32 1352-1370 lipid denotes lipopolysaccharide
T33 1432-1449 other_organic_compound denotes sodium salicylate
T34 1461-1471 protein_complex denotes NF-kappa B
T35 1472-1475 protein_subunit denotes p65
T36 1529-1539 protein_complex denotes NF-kappa B
T37 1541-1544 protein_subunit denotes p50
T38 1548-1570 polynucleotide denotes tissue oligonucleotide
T39 1589-1607 lipid denotes lipopolysaccharide
T40 1616-1626 protein_complex denotes NF-kappa B
T41 1669-1672 protein_subunit denotes p65
T42 1684-1694 protein_complex denotes NF-kappa B
T43 1711-1721 other_organic_compound denotes salicylate
T44 1787-1802 other_name denotes gene expression
T45 1806-1828 protein_family_or_group denotes inflammatory mediators