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PubMed:9465822 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-169 Sentence denotes Plasma glutathione S-transferase alpha 1-1: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy.
TextSentencer_T2 170-180 Sentence denotes OBJECTIVE:
TextSentencer_T3 181-363 Sentence denotes Our purpose was to investigate the value of plasma glutathione S-transferase Alpha 1-1 measurements in the assessment of hepatocellular damage in hypertensive disorders of pregnancy.
TextSentencer_T4 364-377 Sentence denotes STUDY DESIGN:
TextSentencer_T5 378-503 Sentence denotes Patients were recruited at the Department of Obstetrics and Gynecology of the University Hospital, Nijmegen, The Netherlands.
TextSentencer_T6 504-771 Sentence denotes Five groups of patients were studied: normotensive pregnancy (n = 87), pregnancy-induced hypertension (n = 48), preeclampsia (n = 79), the syndrome of hemolysis, elevated liver enzymes, and low platelets (n = 39), and serially studied normotensive pregnancy (n = 21).
TextSentencer_T7 772-904 Sentence denotes Blood was collected for assessment of plasma glutathione S-transferase Alpha 1-1 levels and serum alanine aminotransferase activity.
TextSentencer_T8 905-1019 Sentence denotes Levels in hypertensive pregnancies were compared with levels in normotensive pregnancy by the Mann-Whitney U test.
TextSentencer_T9 1020-1155 Sentence denotes Patients were categorized according as to whether their values are below (normal) or above (elevated) the upper normal reference level.
TextSentencer_T10 1156-1292 Sentence denotes The difference in relative magnitude of elevation between the two factors was determined by the Wilcoxon matched-pairs signed-rank test.
TextSentencer_T11 1293-1301 Sentence denotes RESULTS:
TextSentencer_T12 1302-1497 Sentence denotes Plasma levels in the longitudinally studied normotensive pregnancy group did not differ between gestational ages and were not significantly different from those of the normotensive control group.
TextSentencer_T13 1498-1730 Sentence denotes Median levels of glutathione S-transferase Alpha 1-1 and alanine aminotransferase were significantly increased (p < 0.01, p < 0.0001, respectively) in all subgroups of hypertensive pregnancies compared with normotensive pregnancies.
TextSentencer_T14 1731-2033 Sentence denotes When both levels were elevated, the relative magnitude of the increase of glutathione S-transferase Alpha 1-1 levels was significantly higher than that of alanine aminotransferase activity in preeclampsia (p < 0.01) and the syndrome of hemolysis, elevated liver enzymes, and low platelets (p < 0.0001).
TextSentencer_T15 2034-2171 Sentence denotes Almost half the patients with preeclampsia showed elevated levels of alanine aminotransferase and/or glutathione S-transferase Alpha 1-1.
TextSentencer_T16 2172-2183 Sentence denotes CONCLUSION:
TextSentencer_T17 2184-2513 Sentence denotes Plasma glutathione S-transferase Alpha 1-1 measurements may provide a more sensitive indicator of acute hepatic damage in preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelets compared with the assessment of aminotransferase activity and therefore may allow earlier recognition of these syndromes.
TextSentencer_T18 2514-2712 Sentence denotes The clinical benefits of plasma measurements of glutathione S-transferase Alpha 1-1 for monitoring the hepatic condition in the management of these patients need to be elucidated in further studies.
T1 0-169 Sentence denotes Plasma glutathione S-transferase alpha 1-1: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy.
T2 170-180 Sentence denotes OBJECTIVE:
T3 181-363 Sentence denotes Our purpose was to investigate the value of plasma glutathione S-transferase Alpha 1-1 measurements in the assessment of hepatocellular damage in hypertensive disorders of pregnancy.
T4 364-377 Sentence denotes STUDY DESIGN:
T5 378-503 Sentence denotes Patients were recruited at the Department of Obstetrics and Gynecology of the University Hospital, Nijmegen, The Netherlands.
T6 504-771 Sentence denotes Five groups of patients were studied: normotensive pregnancy (n = 87), pregnancy-induced hypertension (n = 48), preeclampsia (n = 79), the syndrome of hemolysis, elevated liver enzymes, and low platelets (n = 39), and serially studied normotensive pregnancy (n = 21).
T7 772-904 Sentence denotes Blood was collected for assessment of plasma glutathione S-transferase Alpha 1-1 levels and serum alanine aminotransferase activity.
T8 905-1019 Sentence denotes Levels in hypertensive pregnancies were compared with levels in normotensive pregnancy by the Mann-Whitney U test.
T9 1020-1155 Sentence denotes Patients were categorized according as to whether their values are below (normal) or above (elevated) the upper normal reference level.
T10 1156-1292 Sentence denotes The difference in relative magnitude of elevation between the two factors was determined by the Wilcoxon matched-pairs signed-rank test.
T11 1293-1301 Sentence denotes RESULTS:
T12 1302-1497 Sentence denotes Plasma levels in the longitudinally studied normotensive pregnancy group did not differ between gestational ages and were not significantly different from those of the normotensive control group.
T13 1498-1730 Sentence denotes Median levels of glutathione S-transferase Alpha 1-1 and alanine aminotransferase were significantly increased (p < 0.01, p < 0.0001, respectively) in all subgroups of hypertensive pregnancies compared with normotensive pregnancies.
T14 1731-2033 Sentence denotes When both levels were elevated, the relative magnitude of the increase of glutathione S-transferase Alpha 1-1 levels was significantly higher than that of alanine aminotransferase activity in preeclampsia (p < 0.01) and the syndrome of hemolysis, elevated liver enzymes, and low platelets (p < 0.0001).
T15 2034-2171 Sentence denotes Almost half the patients with preeclampsia showed elevated levels of alanine aminotransferase and/or glutathione S-transferase Alpha 1-1.
T16 2172-2183 Sentence denotes CONCLUSION:
T17 2184-2513 Sentence denotes Plasma glutathione S-transferase Alpha 1-1 measurements may provide a more sensitive indicator of acute hepatic damage in preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelets compared with the assessment of aminotransferase activity and therefore may allow earlier recognition of these syndromes.
T18 2514-2712 Sentence denotes The clinical benefits of plasma measurements of glutathione S-transferase Alpha 1-1 for monitoring the hepatic condition in the management of these patients need to be elucidated in further studies.

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 133-168 ORPHA:275555 denotes hypertensive disorders of pregnancy
PD-Preeclampsia-B_T2 327-362 ORPHA:275555 denotes hypertensive disorders of pregnancy
PD-Preeclampsia-B_T3 616-628 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1923-1935 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 2064-2076 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T6 2306-2318 ORPHA:275555 denotes preeclampsia

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 133-168 ORPHA:275555 denotes hypertensive disorders of pregnancy
PD-Preeclampsia-B_T2 327-362 ORPHA:275555 denotes hypertensive disorders of pregnancy
PD-Preeclampsia-B_T3 616-628 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T4 1923-1935 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 2064-2076 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T6 2306-2318 ORPHA:275555 denotes preeclampsia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 99-104 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 864-869 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 675-680 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 1987-1992 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T5 2359-2364 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver

preeclampsia_genes

Id Subject Object Predicate Lexical cue
PD-PreeclampsiaGenes-B_T1 7-38 HGNC:GSTA5 denotes glutathione S-transferase alpha
PD-PreeclampsiaGenes-B_T2 232-263 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T3 817-848 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T4 1515-1546 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T5 1805-1836 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T6 2135-2166 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T7 2191-2222 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T8 2562-2593 HGNC:GSTA5 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T9 7-38 HGNC:GSTA2 denotes glutathione S-transferase alpha
PD-PreeclampsiaGenes-B_T10 232-263 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T11 817-848 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T12 1515-1546 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T13 1805-1836 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T14 2135-2166 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T15 2191-2222 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T16 2562-2593 HGNC:GSTA2 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T17 7-40 HGNC:GSTA1 denotes glutathione S-transferase alpha 1
PD-PreeclampsiaGenes-B_T18 232-265 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T19 817-850 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T20 1515-1548 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T21 1805-1838 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T22 2135-2168 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T23 2191-2224 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T24 2562-2595 HGNC:GSTA1 denotes glutathione S-transferase Alpha 1
PD-PreeclampsiaGenes-B_T25 7-38 HGNC:GSTA4 denotes glutathione S-transferase alpha
PD-PreeclampsiaGenes-B_T26 232-263 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T27 817-848 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T28 1515-1546 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T29 1805-1836 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T30 2135-2166 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T31 2191-2222 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T32 2562-2593 HGNC:GSTA4 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T33 7-38 HGNC:GSTA3 denotes glutathione S-transferase alpha
PD-PreeclampsiaGenes-B_T34 232-263 HGNC:GSTA3 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T35 817-848 HGNC:GSTA3 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T36 1515-1546 HGNC:GSTA3 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T37 1805-1836 HGNC:GSTA3 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T38 2135-2166 HGNC:GSTA3 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T39 2191-2222 HGNC:GSTA3 denotes glutathione S-transferase Alpha
PD-PreeclampsiaGenes-B_T40 2562-2593 HGNC:GSTA3 denotes glutathione S-transferase Alpha

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 772-777 http://purl.obolibrary.org/obo/UBERON_0000178 denotes Blood
PD-UBERON-AE-B_T2 675-680 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 1987-1992 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 2359-2364 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T5 99-104 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 864-869 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum