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PubMed:9446624 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-57 Sentence denotes Human small intestinal maltase-glucoamylase cDNA cloning.
T2 58-89 Sentence denotes Homology to sucrase-isomaltase.
T3 90-157 Sentence denotes It has been hypothesized that human mucosal glucoamylase (EC 3.2.1.
T4 158-449 Sentence denotes 20 and 3.2.1.3) activity serves as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition and that maltase-glucoamylase plays a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
T5 450-719 Sentence denotes As a first step toward the testing of this hypothesis, we have cloned human small intestinal maltase-glucoamylase cDNA to permit study of the individual catalytic and binding sites for maltose and starch enzyme hydrolase activities in subsequent expression experiments.
T6 720-803 Sentence denotes Human maltase-glucoamylase was purified by immunoisolation and partially sequenced.
T7 804-970 Sentence denotes Maltase-glucoamylase cDNA was amplified from human intestinal RNA using degenerate and gene-specific primers with the reverse transcription-polymerase chain reaction.
T8 971-1095 Sentence denotes The 6,513-base pair cDNA contains an open reading frame that encodes a 1,857-amino acid protein (molecular mass 209,702 Da).
T9 1096-1224 Sentence denotes Maltase-glucoamylase has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous.
T10 1225-1322 Sentence denotes Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities.
T11 1323-1521 Sentence denotes Our findings suggest that divergences in the carbohydrate binding sequences must determine the substrate specificities for the four different enzyme activities that share a conserved catalytic site.
T1 0-57 Sentence denotes Human small intestinal maltase-glucoamylase cDNA cloning.
T2 58-89 Sentence denotes Homology to sucrase-isomaltase.
T3 90-157 Sentence denotes It has been hypothesized that human mucosal glucoamylase (EC 3.2.1.
T4 158-449 Sentence denotes 20 and 3.2.1.3) activity serves as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition and that maltase-glucoamylase plays a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
T5 450-719 Sentence denotes As a first step toward the testing of this hypothesis, we have cloned human small intestinal maltase-glucoamylase cDNA to permit study of the individual catalytic and binding sites for maltose and starch enzyme hydrolase activities in subsequent expression experiments.
T6 720-803 Sentence denotes Human maltase-glucoamylase was purified by immunoisolation and partially sequenced.
T7 804-970 Sentence denotes Maltase-glucoamylase cDNA was amplified from human intestinal RNA using degenerate and gene-specific primers with the reverse transcription-polymerase chain reaction.
T8 971-1095 Sentence denotes The 6,513-base pair cDNA contains an open reading frame that encodes a 1,857-amino acid protein (molecular mass 209,702 Da).
T9 1096-1224 Sentence denotes Maltase-glucoamylase has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous.
T10 1225-1322 Sentence denotes Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities.
T11 1323-1521 Sentence denotes Our findings suggest that divergences in the carbohydrate binding sequences must determine the substrate specificities for the four different enzyme activities that share a conserved catalytic site.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 6-22 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestinal
T2 526-542 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestinal
T3 855-865 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 635-642 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 307-319 Disease denotes malnutrition http://purl.obolibrary.org/obo/MONDO_0006873

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 6-22 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T2 526-542 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T3 855-865 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 307-319 Phenotype denotes malnutrition HP:0004395

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 635-642 Glycan denotes maltose https://api.glycosmos.org/wurcs2image/latest/png/binary/G44653LT

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 307-319 Phenotype denotes malnutrition HP:0004395

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 307-319 Disease denotes malnutrition MONDO:0006873

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 6-22 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108
T2 526-542 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 0-5 Organism denotes Human 9606
T2 120-125 Organism denotes human 9606
T3 520-525 Organism denotes human 9606
T4 720-725 Organism denotes Human 9606
T5 849-854 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-57 Sentence denotes Human small intestinal maltase-glucoamylase cDNA cloning.
T2 58-89 Sentence denotes Homology to sucrase-isomaltase.
T3 90-157 Sentence denotes It has been hypothesized that human mucosal glucoamylase (EC 3.2.1.
T4 158-449 Sentence denotes 20 and 3.2.1.3) activity serves as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition and that maltase-glucoamylase plays a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
T5 450-719 Sentence denotes As a first step toward the testing of this hypothesis, we have cloned human small intestinal maltase-glucoamylase cDNA to permit study of the individual catalytic and binding sites for maltose and starch enzyme hydrolase activities in subsequent expression experiments.
T6 720-803 Sentence denotes Human maltase-glucoamylase was purified by immunoisolation and partially sequenced.
T7 804-970 Sentence denotes Maltase-glucoamylase cDNA was amplified from human intestinal RNA using degenerate and gene-specific primers with the reverse transcription-polymerase chain reaction.
T8 971-1095 Sentence denotes The 6,513-base pair cDNA contains an open reading frame that encodes a 1,857-amino acid protein (molecular mass 209,702 Da).
T9 1096-1224 Sentence denotes Maltase-glucoamylase has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous.
T10 1225-1322 Sentence denotes Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities.
T11 1323-1521 Sentence denotes Our findings suggest that divergences in the carbohydrate binding sequences must determine the substrate specificities for the four different enzyme activities that share a conserved catalytic site.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 6-22 Body_part denotes small intestinal FMA:7200
T2 526-542 Body_part denotes small intestinal FMA:7200
T3 855-865 Body_part denotes intestinal FMA:7199

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 6-22 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T2 526-542 Body_part denotes small intestinal http://purl.obolibrary.org/obo/MAT_0000047
T3 855-865 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Human 9606
T2 120-125 OrganismTaxon denotes human 9606
T3 520-525 OrganismTaxon denotes human 9606
T4 720-725 OrganismTaxon denotes Human 9606
T5 849-854 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 6-22 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108
T2 526-542 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108