PubMed:9446552
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 0-9 | Glycan_Motif | denotes | Globoside | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T2 | 335-344 | Glycan_Motif | denotes | globoside | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T3 | 346-349 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T4 | 456-462 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T7 | 456-460 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T8 | 772-775 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T9 | 778-781 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T10 | 905-908 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T11 | 930-933 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T12 | 967-973 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T15 | 967-971 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T16 | 1137-1140 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T17 | 1206-1212 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T20 | 1206-1210 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T21 | 1260-1263 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T22 | 1430-1436 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T25 | 1430-1434 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T26 | 1670-1673 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T27 | 2046-2049 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T28 | 2193-2196 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-211 | Sentence | denotes | Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. |
| T2 | 212-471 | Sentence | denotes | Undifferentiated human embryonal carcinoma cells are characterized by high expression of lactoneotetraosylceramide (nLc4), globoside (Gb4), and extended globo-series glycosphingolipids (GSLs) termed "stage-specific embryonic antigens 3 and 4" (SSEA-3 and -4). |
| T3 | 472-593 | Sentence | denotes | Expression of these GSLs declines in association with a decline of homotypic adhesion during the differentiation process. |
| T4 | 594-673 | Sentence | denotes | Therefore, these GSLs may play an essential role in adhesion among these cells. |
| T5 | 674-808 | Sentence | denotes | As an example, human embryonal carcinoma 2102 cells display strong adhesion to plates coated with Gb4 ("Gb4-dependent cell adhesion"). |
| T6 | 809-1465 | Sentence | denotes | This adhesion, which simulates homotypic 2102 cell aggregation, is based on interaction between Gb4 and nLc4, or between Gb4 and GalGb4 (IV3GalGb4; the major SSEA-3 epitope), as indicated by the following observations: (i) adhesion of 2102 cells or GSL-liposomes to GSL-coated plates in various combinations; (ii) inhibition of Gb4-dependent 2102 cell adhesion by preincubation of cells with anti-SSEA-3 or anti-nLc4 antibodies, or by pretreatment of Gb4-coated plates with aqueous micellar solution of nLc4 or GalGb4; (iii) decline of the cell adhesion in association with retinoic acid-induced differentiation, whereby SSEA-3 and nLc4 levels are reduced. |
| T7 | 1466-1781 | Sentence | denotes | Since cell adhesion is an essential prerequisite for induction of differentiation, as observed at each step of embryogenesis, expression of seven transcription factors following adhesion of 2102 cells to Gb4-coated plates, and to detergent-insoluble substrate adhesion matrix prepared from 2102 cells, were studied. |
| T8 | 1782-1943 | Sentence | denotes | In both types of adhesion, a strong enhancement of AP1 and CREB site binding activity was observed during the early stage (15-60 min following initial adhesion). |
| T9 | 1944-2127 | Sentence | denotes | Although 2102 cells showed strong adhesion to Gg3-coated plates, based on interaction between Gg3 and Gb4, adhesion of the cells to Gg3 did not cause changes of AP1 and CREB activity. |
| T10 | 2128-2216 | Sentence | denotes | No other transcription factors showed changes induced by Gg3- or Gb4-dependent adhesion. |
| T1 | 0-211 | Sentence | denotes | Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. |
| T2 | 212-471 | Sentence | denotes | Undifferentiated human embryonal carcinoma cells are characterized by high expression of lactoneotetraosylceramide (nLc4), globoside (Gb4), and extended globo-series glycosphingolipids (GSLs) termed "stage-specific embryonic antigens 3 and 4" (SSEA-3 and -4). |
| T3 | 472-593 | Sentence | denotes | Expression of these GSLs declines in association with a decline of homotypic adhesion during the differentiation process. |
| T4 | 594-673 | Sentence | denotes | Therefore, these GSLs may play an essential role in adhesion among these cells. |
| T5 | 674-808 | Sentence | denotes | As an example, human embryonal carcinoma 2102 cells display strong adhesion to plates coated with Gb4 ("Gb4-dependent cell adhesion"). |
| T6 | 809-1465 | Sentence | denotes | This adhesion, which simulates homotypic 2102 cell aggregation, is based on interaction between Gb4 and nLc4, or between Gb4 and GalGb4 (IV3GalGb4; the major SSEA-3 epitope), as indicated by the following observations: (i) adhesion of 2102 cells or GSL-liposomes to GSL-coated plates in various combinations; (ii) inhibition of Gb4-dependent 2102 cell adhesion by preincubation of cells with anti-SSEA-3 or anti-nLc4 antibodies, or by pretreatment of Gb4-coated plates with aqueous micellar solution of nLc4 or GalGb4; (iii) decline of the cell adhesion in association with retinoic acid-induced differentiation, whereby SSEA-3 and nLc4 levels are reduced. |
| T7 | 1466-1781 | Sentence | denotes | Since cell adhesion is an essential prerequisite for induction of differentiation, as observed at each step of embryogenesis, expression of seven transcription factors following adhesion of 2102 cells to Gb4-coated plates, and to detergent-insoluble substrate adhesion matrix prepared from 2102 cells, were studied. |
| T8 | 1782-1943 | Sentence | denotes | In both types of adhesion, a strong enhancement of AP1 and CREB site binding activity was observed during the early stage (15-60 min following initial adhesion). |
| T9 | 1944-2127 | Sentence | denotes | Although 2102 cells showed strong adhesion to Gg3-coated plates, based on interaction between Gg3 and Gb4, adhesion of the cells to Gg3 did not cause changes of AP1 and CREB activity. |
| T10 | 2128-2216 | Sentence | denotes | No other transcription factors showed changes induced by Gg3- or Gb4-dependent adhesion. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-9 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Globoside |
| T2 | 335-344 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | globoside |
| T3 | 346-349 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T4 | 456-462 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T5 | 456-462 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T6 | 456-462 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T7 | 456-460 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T8 | 772-775 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T9 | 778-781 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T10 | 905-908 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T11 | 930-933 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T12 | 967-973 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T13 | 967-973 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T14 | 967-973 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T15 | 967-971 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T16 | 1137-1140 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T17 | 1206-1212 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T18 | 1206-1212 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T19 | 1206-1212 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T20 | 1206-1210 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T21 | 1260-1263 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T22 | 1430-1436 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T23 | 1430-1436 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T24 | 1430-1436 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T25 | 1430-1434 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T26 | 1670-1673 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T27 | 2046-2049 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T28 | 2193-2196 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-9 | http://www.glycoepitope.jp/epitopes/EP0073 | denotes | Globoside |
| T2 | 335-344 | http://www.glycoepitope.jp/epitopes/EP0073 | denotes | globoside |
| T3 | 456-462 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T4 | 967-973 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T5 | 1206-1212 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T6 | 1430-1436 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 38-57 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
| T2 | 235-254 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
| T3 | 695-714 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 48-57 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 245-254 | Phenotype | denotes | carcinoma | HP:0030731 |
| T3 | 705-714 | Phenotype | denotes | carcinoma | HP:0030731 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 0-9 | Glycan | denotes | Globoside | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T2 | 328-332 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T3 | 335-344 | Glycan | denotes | globoside | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T4 | 346-349 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T5 | 456-462 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T6 | 772-775 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T7 | 778-781 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T8 | 905-908 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T9 | 913-917 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T10 | 930-933 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T11 | 967-973 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T12 | 1137-1140 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T13 | 1206-1212 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T14 | 1221-1225 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T15 | 1260-1263 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T16 | 1312-1316 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T17 | 1430-1436 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T18 | 1441-1445 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T19 | 1670-1673 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T20 | 1990-1993 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T21 | 2038-2041 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T22 | 2046-2049 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T23 | 2076-2079 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T24 | 2185-2188 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T25 | 2193-2196 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 48-57 | Phenotype | denotes | carcinoma | HP:0030731 |
| T2 | 245-254 | Phenotype | denotes | carcinoma | HP:0030731 |
| T3 | 705-714 | Phenotype | denotes | carcinoma | HP:0030731 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 38-57 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
| T2 | 235-254 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
| T3 | 695-714 | Disease | denotes | embryonal carcinoma | http://purl.obolibrary.org/obo/MONDO_0005440 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 32-37 | OrganismTaxon | denotes | human | 9606 |
| T2 | 229-234 | OrganismTaxon | denotes | human | 9606 |
| T3 | 689-694 | OrganismTaxon | denotes | human | 9606 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-211 | Sentence | denotes | Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. |
| T2 | 212-471 | Sentence | denotes | Undifferentiated human embryonal carcinoma cells are characterized by high expression of lactoneotetraosylceramide (nLc4), globoside (Gb4), and extended globo-series glycosphingolipids (GSLs) termed "stage-specific embryonic antigens 3 and 4" (SSEA-3 and -4). |
| T3 | 472-593 | Sentence | denotes | Expression of these GSLs declines in association with a decline of homotypic adhesion during the differentiation process. |
| T4 | 594-673 | Sentence | denotes | Therefore, these GSLs may play an essential role in adhesion among these cells. |
| T5 | 674-808 | Sentence | denotes | As an example, human embryonal carcinoma 2102 cells display strong adhesion to plates coated with Gb4 ("Gb4-dependent cell adhesion"). |
| T6 | 809-1465 | Sentence | denotes | This adhesion, which simulates homotypic 2102 cell aggregation, is based on interaction between Gb4 and nLc4, or between Gb4 and GalGb4 (IV3GalGb4; the major SSEA-3 epitope), as indicated by the following observations: (i) adhesion of 2102 cells or GSL-liposomes to GSL-coated plates in various combinations; (ii) inhibition of Gb4-dependent 2102 cell adhesion by preincubation of cells with anti-SSEA-3 or anti-nLc4 antibodies, or by pretreatment of Gb4-coated plates with aqueous micellar solution of nLc4 or GalGb4; (iii) decline of the cell adhesion in association with retinoic acid-induced differentiation, whereby SSEA-3 and nLc4 levels are reduced. |
| T7 | 1466-1781 | Sentence | denotes | Since cell adhesion is an essential prerequisite for induction of differentiation, as observed at each step of embryogenesis, expression of seven transcription factors following adhesion of 2102 cells to Gb4-coated plates, and to detergent-insoluble substrate adhesion matrix prepared from 2102 cells, were studied. |
| T8 | 1782-1943 | Sentence | denotes | In both types of adhesion, a strong enhancement of AP1 and CREB site binding activity was observed during the early stage (15-60 min following initial adhesion). |
| T9 | 1944-2127 | Sentence | denotes | Although 2102 cells showed strong adhesion to Gg3-coated plates, based on interaction between Gg3 and Gb4, adhesion of the cells to Gg3 did not cause changes of AP1 and CREB activity. |
| T10 | 2128-2216 | Sentence | denotes | No other transcription factors showed changes induced by Gg3- or Gb4-dependent adhesion. |
| T1 | 0-211 | Sentence | denotes | Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. |
| T2 | 212-471 | Sentence | denotes | Undifferentiated human embryonal carcinoma cells are characterized by high expression of lactoneotetraosylceramide (nLc4), globoside (Gb4), and extended globo-series glycosphingolipids (GSLs) termed "stage-specific embryonic antigens 3 and 4" (SSEA-3 and -4). |
| T3 | 472-593 | Sentence | denotes | Expression of these GSLs declines in association with a decline of homotypic adhesion during the differentiation process. |
| T4 | 594-673 | Sentence | denotes | Therefore, these GSLs may play an essential role in adhesion among these cells. |
| T5 | 674-808 | Sentence | denotes | As an example, human embryonal carcinoma 2102 cells display strong adhesion to plates coated with Gb4 ("Gb4-dependent cell adhesion"). |
| T6 | 809-1465 | Sentence | denotes | This adhesion, which simulates homotypic 2102 cell aggregation, is based on interaction between Gb4 and nLc4, or between Gb4 and GalGb4 (IV3GalGb4; the major SSEA-3 epitope), as indicated by the following observations: (i) adhesion of 2102 cells or GSL-liposomes to GSL-coated plates in various combinations; (ii) inhibition of Gb4-dependent 2102 cell adhesion by preincubation of cells with anti-SSEA-3 or anti-nLc4 antibodies, or by pretreatment of Gb4-coated plates with aqueous micellar solution of nLc4 or GalGb4; (iii) decline of the cell adhesion in association with retinoic acid-induced differentiation, whereby SSEA-3 and nLc4 levels are reduced. |
| T7 | 1466-1781 | Sentence | denotes | Since cell adhesion is an essential prerequisite for induction of differentiation, as observed at each step of embryogenesis, expression of seven transcription factors following adhesion of 2102 cells to Gb4-coated plates, and to detergent-insoluble substrate adhesion matrix prepared from 2102 cells, were studied. |
| T8 | 1782-1943 | Sentence | denotes | In both types of adhesion, a strong enhancement of AP1 and CREB site binding activity was observed during the early stage (15-60 min following initial adhesion). |
| T9 | 1944-2127 | Sentence | denotes | Although 2102 cells showed strong adhesion to Gg3-coated plates, based on interaction between Gg3 and Gb4, adhesion of the cells to Gg3 did not cause changes of AP1 and CREB activity. |
| T10 | 2128-2216 | Sentence | denotes | No other transcription factors showed changes induced by Gg3- or Gb4-dependent adhesion. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-211 | Sentence | denotes | Globoside-dependent adhesion of human embryonal carcinoma cells, based on carbohydrate-carbohydrate interaction, initiates signal transduction and induces enhanced activity of transcription factors AP1 and CREB. |
| T2 | 212-471 | Sentence | denotes | Undifferentiated human embryonal carcinoma cells are characterized by high expression of lactoneotetraosylceramide (nLc4), globoside (Gb4), and extended globo-series glycosphingolipids (GSLs) termed "stage-specific embryonic antigens 3 and 4" (SSEA-3 and -4). |
| T3 | 472-593 | Sentence | denotes | Expression of these GSLs declines in association with a decline of homotypic adhesion during the differentiation process. |
| T4 | 594-673 | Sentence | denotes | Therefore, these GSLs may play an essential role in adhesion among these cells. |
| T5 | 674-808 | Sentence | denotes | As an example, human embryonal carcinoma 2102 cells display strong adhesion to plates coated with Gb4 ("Gb4-dependent cell adhesion"). |
| T6 | 809-1465 | Sentence | denotes | This adhesion, which simulates homotypic 2102 cell aggregation, is based on interaction between Gb4 and nLc4, or between Gb4 and GalGb4 (IV3GalGb4; the major SSEA-3 epitope), as indicated by the following observations: (i) adhesion of 2102 cells or GSL-liposomes to GSL-coated plates in various combinations; (ii) inhibition of Gb4-dependent 2102 cell adhesion by preincubation of cells with anti-SSEA-3 or anti-nLc4 antibodies, or by pretreatment of Gb4-coated plates with aqueous micellar solution of nLc4 or GalGb4; (iii) decline of the cell adhesion in association with retinoic acid-induced differentiation, whereby SSEA-3 and nLc4 levels are reduced. |
| T7 | 1466-1781 | Sentence | denotes | Since cell adhesion is an essential prerequisite for induction of differentiation, as observed at each step of embryogenesis, expression of seven transcription factors following adhesion of 2102 cells to Gb4-coated plates, and to detergent-insoluble substrate adhesion matrix prepared from 2102 cells, were studied. |
| T8 | 1782-1943 | Sentence | denotes | In both types of adhesion, a strong enhancement of AP1 and CREB site binding activity was observed during the early stage (15-60 min following initial adhesion). |
| T9 | 1944-2127 | Sentence | denotes | Although 2102 cells showed strong adhesion to Gg3-coated plates, based on interaction between Gg3 and Gb4, adhesion of the cells to Gg3 did not cause changes of AP1 and CREB activity. |
| T10 | 2128-2216 | Sentence | denotes | No other transcription factors showed changes induced by Gg3- or Gb4-dependent adhesion. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 0-9 | Glycan | denotes | Globoside | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T2 | 328-332 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T3 | 335-344 | Glycan | denotes | globoside | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T4 | 346-349 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T5 | 456-462 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T6 | 772-775 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T7 | 778-781 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T8 | 905-908 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T9 | 913-917 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T10 | 930-933 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T11 | 967-973 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T12 | 1137-1140 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T13 | 1206-1212 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T14 | 1221-1225 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T15 | 1260-1263 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T16 | 1312-1316 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T17 | 1430-1436 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T18 | 1441-1445 | Glycan | denotes | nLc4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G58896AZ |
| T19 | 1670-1673 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T20 | 1990-1993 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T21 | 2038-2041 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T22 | 2046-2049 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T23 | 2076-2079 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T24 | 2185-2188 | Glycan | denotes | Gg3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB |
| T25 | 2193-2196 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 0-9 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Globoside | http://www.glycoepitope.jp/epitopes/EP0073 |
| T2 | 335-344 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | globoside | http://www.glycoepitope.jp/epitopes/EP0073 |
| T3 | 456-462 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T4 | 967-973 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T5 | 1206-1212 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T6 | 1430-1436 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 32-37 | OrganismTaxon | denotes | human | 9606 |
| T2 | 229-234 | OrganismTaxon | denotes | human | 9606 |
| T3 | 689-694 | OrganismTaxon | denotes | human | 9606 |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 0-9 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Globoside | http://www.glycoepitope.jp/epitopes/EP0073 |
| T2 | 335-344 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | globoside | http://www.glycoepitope.jp/epitopes/EP0073 |
| T3 | 456-462 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T4 | 967-973 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T5 | 1206-1212 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T6 | 1430-1436 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |