> top > docs > PubMed:9394832 > annotations

PubMed:9394832 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 30-48 protein denotes interleukin (IL)-1
T2 75-114 protein denotes IL-1 receptor-associated protein kinase
T3 119-129 protein denotes NF-kappa B
T4 135-164 protein denotes interleukin-1 receptor type I
T5 166-172 protein denotes IL-1RI
T6 223-237 protein denotes complex system
T7 247-251 protein denotes IL-1
T8 360-394 protein denotes receptor-associated protein kinase
T9 486-490 protein denotes IL-1
T10 654-686 protein denotes IL-1RI-associated protein kinase
T11 788-792 protein denotes IL-1
T12 802-812 protein denotes NF-kappa B
T13 827-845 cell_line denotes murine T cell line
T14 847-850 cell_line denotes EL4
T15 872-876 protein denotes IL-1
T16 1122-1126 protein denotes IL-1
T17 1153-1185 protein denotes IL-1RI-associated protein kinase
T18 1468-1492 protein denotes IL-1RI-associated kinase
T19 1530-1540 protein denotes NF-kappa B
T20 1544-1553 cell_line denotes EL4 cells
T21 1615-1629 protein denotes IL-1RI complex
T22 1670-1702 protein denotes IL-1RI-associated protein kinase
T23 1742-1746 protein denotes IL-1
T24 1768-1778 protein denotes NF-kappa B

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-130 Sentence denotes Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B.
S2 131-279 Sentence denotes The interleukin-1 receptor type I (IL-1RI) is associated with other proteins thus forming a complex system by which IL-1 exerts its various signals.
S3 280-485 Sentence denotes The initiating event is still uncertain, but activation of a recently described receptor-associated protein kinase is one of the earliest events detectable (Martin et al., Eur. J. Immunol. 1994. 24: 1566).
S4 486-597 Sentence denotes IL-1 signaling is commonly accompanied by oxidative processes and is thought to be subject to redox regulation.
S5 598-824 Sentence denotes We therefore investigated whether the activation of the IL-1RI-associated protein kinase could be a target for redox regulation and whether an altered activity of the kinase could influence IL-1-mediated NF-kappa B activation.
S6 825-977 Sentence denotes A murine T cell line, EL4, was stimulated with IL-1 with and without pretreatment with different compounds known to influence the cellular redox status.
S7 978-1186 Sentence denotes Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase.
S8 1187-1285 Sentence denotes N-Acetylcysteine, alpha,alpha'-dipyridyl, aminotriazole or nitrofurantoin did not show any effect.
S9 1286-1391 Sentence denotes The inhibition by PDTC was reversible unless glutathione synthesis was blocked by buthionine sulfoximine.
S10 1392-1554 Sentence denotes The described conditions which inhibited or prevented the activation of the IL-1RI-associated kinase similarly impaired the activation of NF-kappa B in EL4 cells.
S11 1555-1790 Sentence denotes From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 72-114 NP denotes an IL-1 receptor-associated protein kinase
C2 221-237 NP denotes a complex system
C3 241-246 NP denotes which
C4 247-251 NP denotes IL-1
C5 259-262 NP denotes its
C6 580-596 NP denotes redox regulation
C8 650-686 NP denotes the IL-1RI-associated protein kinase
C7 632-686 NP denotes the activation of the IL-1RI-associated protein kinase
C9 709-725 NP denotes redox regulation
C10 761-771 NP denotes the kinase
C11 825-845 NP denotes A murine T cell line
C12 847-850 NP denotes EL4
C13 872-876 NP denotes IL-1
C14 1026-1060 NP denotes pyrrolidine dithiocarbamate (PDTC)
C15 1149-1185 NP denotes the IL-1RI-associated protein kinase
C16 1304-1308 NP denotes PDTC
C17 1392-1416 NP denotes The described conditions
C18 1417-1422 NP denotes which
C20 1464-1492 NP denotes the IL-1RI-associated kinase
C19 1446-1492 NP denotes the activation of the IL-1RI-associated kinase
C22 1666-1702 NP denotes the IL-1RI-associated protein kinase
C21 1648-1702 NP denotes the activation of the IL-1RI-associated protein kinase
R1 C3 C2 coref-relat which,a complex system
R2 C5 C4 coref-pron its,IL-1
R3 C8 C1 coref-ident the IL-1RI-associated protein kinase,an IL-1 receptor-associated protein kinase
R4 C9 C6 coref-ident redox regulation,redox regulation
R5 C10 C8 coref-ident the kinase,the IL-1RI-associated protein kinase
R6 C12 C11 coref-appos EL4,A murine T cell line
R7 C13 C4 coref-ident IL-1,IL-1
R8 C15 C8 coref-ident the IL-1RI-associated protein kinase,the IL-1RI-associated protein kinase
R9 C16 C14 coref-ident PDTC,pyrrolidine dithiocarbamate (PDTC)
R10 C18 C17 coref-relat which,The described conditions
R11 C20 C15 coref-ident the IL-1RI-associated kinase,the IL-1RI-associated protein kinase
R12 C19 C7 coref-ident the activation of the IL-1RI-associated kinase,the activation of the IL-1RI-associated protein kinase
R13 C22 C20 coref-ident the IL-1RI-associated protein kinase,the IL-1RI-associated kinase
R14 C21 C19 coref-ident the activation of the IL-1RI-associated protein kinase,the activation of the IL-1RI-associated kinase

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-16 other_name denotes Thiol modulation
T2 30-48 protein_molecule denotes interleukin (IL)-1
T3 75-114 protein_family_or_group denotes IL-1 receptor-associated protein kinase
T4 119-129 protein_complex denotes NF-kappa B
T5 135-164 protein_molecule denotes interleukin-1 receptor type I
T6 166-172 protein_molecule denotes IL-1RI
T7 223-237 protein_complex denotes complex system
T8 247-251 protein_molecule denotes IL-1
T9 284-300 other_name denotes initiating event
T10 360-394 protein_family_or_group denotes receptor-associated protein kinase
T11 486-490 protein_molecule denotes IL-1
T12 528-547 other_name denotes oxidative processes
T13 654-660 protein_molecule denotes IL-1RI
T14 709-725 other_name denotes redox regulation
T15 788-792 protein_molecule denotes IL-1
T16 802-812 protein_complex denotes NF-kappa B
T17 827-845 cell_line denotes murine T cell line
T18 847-850 cell_line denotes EL4
T19 872-876 protein_molecule denotes IL-1
T20 955-976 other_name denotes cellular redox status
T21 978-1000 other_organic_compound denotes Thiol modifying agents
T22 1006-1013 other_organic_compound denotes diamide
T23 1015-1024 other_organic_compound denotes menadione
T24 1026-1053 other_organic_compound denotes pyrrolidine dithiocarbamate
T25 1055-1059 other_organic_compound denotes PDTC
T26 1062-1085 other_organic_compound denotes diethyl dithiocarbamate
T27 1089-1107 other_organic_compound denotes phenylarsine oxide
T28 1122-1126 protein_molecule denotes IL-1
T29 1153-1185 protein_molecule denotes IL-1RI-associated protein kinase
T30 1187-1203 amino_acid_monomer denotes N-Acetylcysteine
T31 1205-1227 other_organic_compound denotes alpha,alpha'-dipyridyl
T32 1229-1242 other_organic_compound denotes aminotriazole
T33 1246-1260 other_organic_compound denotes nitrofurantoin
T34 1304-1308 other_organic_compound denotes PDTC
T35 1331-1342 peptide denotes glutathione
T36 1368-1390 other_organic_compound denotes buthionine sulfoximine
T37 1468-1474 protein_molecule denotes IL-1RI
T38 1530-1540 protein_complex denotes NF-kappa B
T39 1544-1553 cell_line denotes EL4 cells
T40 1615-1621 protein_molecule denotes IL-1RI
T41 1670-1676 protein_molecule denotes IL-1RI
T42 1742-1746 protein_molecule denotes IL-1
T43 1768-1778 protein_complex denotes NF-kappa B