> top > docs > PubMed:9376579 > annotations

PubMed:9376579 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 35-100 DNA denotes novel human myeloid-selective CCAAT/enhancer binding protein gene
T2 102-115 DNA denotes C/EBP epsilon
T3 124-137 DNA denotes C/EBP epsilon
T4 174-204 protein denotes CCAAT/enhancer binding protein
T5 306-324 RNA denotes C/EBP epsilon mRNA
T6 352-361 cell_line denotes NB4 cells
T7 363-390 cell_line denotes promyelocytic leukemia line
T8 478-490 cell_type denotes granulocytes
T9 508-526 RNA denotes C/EBP epsilon mRNA
T10 573-582 cell_line denotes NB4 cells
T11 771-789 RNA denotes C/EBP epsilon mRNA
T12 862-871 cell_line denotes NB4 cells
T13 1076-1094 RNA denotes C/EBP epsilon mRNA
T14 1298-1301 cell_line denotes NB4
T15 1320-1338 RNA denotes C/EBP epsilon mRNA
T16 1413-1431 RNA denotes C/EBP epsilon mRNA
T17 1497-1515 RNA denotes C/EBP epsilon mRNA
T18 1562-1577 protein denotes protein factors
T19 1603-1621 RNA denotes C/EBP epsilon mRNA
T20 1708-1729 protein denotes C/EBP epsilon protein
T21 1733-1742 cell_line denotes NB4 cells
T22 1906-1917 cell_line denotes HL-60 cells
T23 1992-2010 RNA denotes C/EBP epsilon mRNA
T24 2069-2087 RNA denotes C/EBP epsilon mRNA
T25 2116-2133 cell_line denotes NB4 promyelocytes
T26 2184-2196 cell_type denotes granulocytes
T27 2216-2234 RNA denotes C/EBP epsilon mRNA
T28 2329-2344 protein denotes protein factors
T29 2366-2397 DNA denotes C/EBP epsilon promoter/enhancer
T30 2409-2439 DNA denotes retinoic acid-response element

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-117 Sentence denotes Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).
S2 118-271 Sentence denotes Human C/EBP epsilon is a newly cloned gene coding for a CCAAT/enhancer binding protein that may be involved in the regulation of myeloid differentiation.
S3 272-491 Sentence denotes Our studies showed that levels of C/EBP epsilon mRNA were markedly increased in NB4 cells (promyelocytic leukemia line), because they were induced by 9-cis retinoic acid (9-cis RA) to differentiate towards granulocytes.
S4 492-666 Sentence denotes Accumulation of C/EBP epsilon mRNA occurred as early as 1 hour after exposure of NB4 cells to 9-cis RA (5 x 10(-7) mol/L); and at 48 hours, levels were increased by 5.1-fold.
S5 667-861 Sentence denotes Dose-response studies showed that 10(-7) to 10(-6) mol/L 9-cis RA (12 hours) resulted in peak levels of C/EBP epsilon mRNA; but even 10(-10) mol/L 9-cis RA increased levels of these transcripts.
S6 862-1267 Sentence denotes NB4 cells pulse-exposed (30 minutes) to all-trans retinoic acid (ATRA), washed, and cultured (3 days) with either dimethylsulfoxide (DMSO) or hexamethylene bisacetamide (HMBA) had a prominent increase in levels of C/EBP epsilon mRNA and an increase in granulocytic differentiation, but exposure to either DMSO or HMBA alone had no effect on base levels of C/EBP epsilon and did not induce differentiation.
S7 1268-1339 Sentence denotes Macrophage-differentiation of NB4 reduced levels of C/EBP epsilon mRNA.
S8 1340-1478 Sentence denotes Nuclear run-off assays and half-life studies showed that accumulation of C/EBP epsilon mRNA by 9-cis RA was due to enhanced transcription.
S9 1479-1675 Sentence denotes Furthermore, this C/EBP epsilon mRNA accumulation did not require synthesis of new protein factors because 9-cis RA induced C/EBP epsilon mRNA accumulation in the absence of new protein synthesis.
S10 1676-1773 Sentence denotes ATRA also induced expression of C/EBP epsilon protein in NB4 cells, as shown by Western blotting.
S11 1774-2018 Sentence denotes In contrast to the increase of C/EBP epsilon in 9-cis RA-mediated granulocytic differentiation, the DMSO-induced differentiation of HL-60 cells down the granulocytic pathway was associated with an initial reduction of C/EBP epsilon mRNA levels.
S12 2019-2197 Sentence denotes In summary, we have discovered that expression of C/EBP epsilon mRNA is markedly enhanced as the NB4 promyelocytes are induced by retinoids to differentiate towards granulocytes.
S13 2198-2345 Sentence denotes This induction of C/EBP epsilon mRNA expression is transcriptionally mediated and occurs in the absence of synthesis of additional protein factors.
S14 2346-2481 Sentence denotes We suspect that the C/EBP epsilon promoter/enhancer contains a retinoic acid-response element that is directly stimulated by retinoids.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 33-116 NP denotes a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon)
C1 14-116 NP denotes mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon)
C3 118-137 NP denotes Human C/EBP epsilon
C4 172-204 NP denotes a CCAAT/enhancer binding protein
C5 205-209 NP denotes that
C7 306-324 NP denotes C/EBP epsilon mRNA
C6 296-324 NP denotes levels of C/EBP epsilon mRNA
C8 352-391 NP denotes NB4 cells (promyelocytic leukemia line)
C9 401-405 NP denotes they
C10 422-452 NP denotes 9-cis retinoic acid (9-cis RA)
C11 478-490 NP denotes granulocytes
C13 508-526 NP denotes C/EBP epsilon mRNA
C12 492-526 NP denotes Accumulation of C/EBP epsilon mRNA
C14 573-582 NP denotes NB4 cells
C15 771-790 NP denotes C/EBP epsilon mRNA;
C17 843-860 NP denotes these transcripts
C16 833-860 NP denotes levels of these transcripts
C18 902-932 NP denotes all-trans retinoic acid (ATRA)
C19 976-1000 NP denotes dimethylsulfoxide (DMSO)
C20 1004-1037 NP denotes hexamethylene bisacetamide (HMBA)
C22 1076-1094 NP denotes C/EBP epsilon mRNA
C21 1066-1094 NP denotes levels of C/EBP epsilon mRNA
C23 1167-1171 NP denotes DMSO
C24 1175-1179 NP denotes HMBA
C25 1218-1231 NP denotes C/EBP epsilon
C26 1320-1338 NP denotes C/EBP epsilon mRNA
C28 1413-1431 NP denotes C/EBP epsilon mRNA
C29 1435-1443 NP denotes 9-cis RA
C27 1397-1443 NP denotes accumulation of C/EBP epsilon mRNA by 9-cis RA
C30 1492-1528 NP denotes this C/EBP epsilon mRNA accumulation
C31 1586-1594 NP denotes 9-cis RA
C32 1603-1634 NP denotes C/EBP epsilon mRNA accumulation
C33 1676-1680 NP denotes ATRA
C34 1733-1742 NP denotes NB4 cells
C35 1992-2017 NP denotes C/EBP epsilon mRNA levels
C37 2069-2087 NP denotes C/EBP epsilon mRNA
C36 2055-2087 NP denotes expression of C/EBP epsilon mRNA
C38 2149-2158 NP denotes retinoids
C39 2184-2196 NP denotes granulocytes
C40 2216-2245 NP denotes C/EBP epsilon mRNA expression
C41 2407-2439 NP denotes a retinoic acid-response element
C42 2440-2444 NP denotes that
C43 2471-2480 NP denotes retinoids
R1 C3 C2 coref-ident Human C/EBP epsilon,a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon)
R2 C5 C4 coref-relat that,a CCAAT/enhancer binding protein
R3 C9 C7 coref-pron they,C/EBP epsilon mRNA
R4 C13 C7 coref-ident C/EBP epsilon mRNA,C/EBP epsilon mRNA
R5 C14 C8 coref-ident NB4 cells,NB4 cells (promyelocytic leukemia line)
R6 C15 C13 coref-ident C/EBP epsilon mRNA;,C/EBP epsilon mRNA
R7 C17 C15 coref-ident these transcripts,C/EBP epsilon mRNA;
R8 C16 C6 coref-ident levels of these transcripts,levels of C/EBP epsilon mRNA
R9 C22 C15 coref-ident C/EBP epsilon mRNA,C/EBP epsilon mRNA;
R10 C21 C16 coref-ident levels of C/EBP epsilon mRNA,levels of these transcripts
R11 C23 C19 coref-ident DMSO,dimethylsulfoxide (DMSO)
R12 C24 C20 coref-ident HMBA,hexamethylene bisacetamide (HMBA)
R13 C25 C3 coref-ident C/EBP epsilon,Human C/EBP epsilon
R14 C26 C22 coref-ident C/EBP epsilon mRNA,C/EBP epsilon mRNA
R15 C28 C26 coref-ident C/EBP epsilon mRNA,C/EBP epsilon mRNA
R16 C29 C10 coref-ident 9-cis RA,9-cis retinoic acid (9-cis RA)
R17 C27 C12 coref-ident accumulation of C/EBP epsilon mRNA by 9-cis RA,Accumulation of C/EBP epsilon mRNA
R18 C30 C27 coref-ident this C/EBP epsilon mRNA accumulation,accumulation of C/EBP epsilon mRNA by 9-cis RA
R19 C31 C29 coref-ident 9-cis RA,9-cis RA
R20 C32 C30 coref-ident C/EBP epsilon mRNA accumulation,this C/EBP epsilon mRNA accumulation
R21 C33 C18 coref-ident ATRA,all-trans retinoic acid (ATRA)
R22 C34 C14 coref-ident NB4 cells,NB4 cells
R23 C35 C21 coref-ident C/EBP epsilon mRNA levels,levels of C/EBP epsilon mRNA
R24 C37 C28 coref-ident C/EBP epsilon mRNA,C/EBP epsilon mRNA
R25 C36 C1 coref-ident expression of C/EBP epsilon mRNA,mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon)
R26 C39 C11 coref-ident granulocytes,granulocytes
R27 C40 C36 coref-ident C/EBP epsilon mRNA expression,expression of C/EBP epsilon mRNA
R28 C42 C41 coref-relat that,a retinoic acid-response element
R29 C43 C38 coref-ident retinoids,retinoids

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-29 other_name denotes mRNA expression
T2 35-100 DNA_domain_or_region denotes novel human myeloid-selective CCAAT/enhancer binding protein gene
T3 102-115 DNA_domain_or_region denotes C/EBP epsilon
T4 124-137 DNA_domain_or_region denotes C/EBP epsilon
T5 174-204 protein_family_or_group denotes CCAAT/enhancer binding protein
T6 247-270 other_name denotes myeloid differentiation
T7 306-324 RNA_molecule denotes C/EBP epsilon mRNA
T8 352-361 cell_line denotes NB4 cells
T9 363-390 cell_line denotes promyelocytic leukemia line
T10 422-441 other_organic_compound denotes 9-cis retinoic acid
T11 443-451 other_organic_compound denotes 9-cis RA
T12 478-490 cell_type denotes granulocytes
T13 508-526 RNA_molecule denotes C/EBP epsilon mRNA
T14 573-582 cell_line denotes NB4 cells
T15 586-594 other_organic_compound denotes 9-cis RA
T16 724-732 other_organic_compound denotes 9-cis RA
T17 771-789 RNA_molecule denotes C/EBP epsilon mRNA
T18 814-822 other_organic_compound denotes 9-cis RA
T19 862-871 cell_line denotes NB4 cells
T20 902-925 other_organic_compound denotes all-trans retinoic acid
T21 927-931 other_organic_compound denotes ATRA
T22 976-993 other_organic_compound denotes dimethylsulfoxide
T23 995-999 other_organic_compound denotes DMSO
T24 1004-1030 other_organic_compound denotes hexamethylene bisacetamide
T25 1032-1036 other_organic_compound denotes HMBA
T26 1076-1094 RNA_molecule denotes C/EBP epsilon mRNA
T27 1114-1142 other_name denotes granulocytic differentiation
T28 1167-1171 other_organic_compound denotes DMSO
T29 1175-1179 other_organic_compound denotes HMBA
T30 1268-1294 other_name denotes Macrophage-differentiation
T31 1298-1301 cell_line denotes NB4
T32 1320-1338 RNA_molecule denotes C/EBP epsilon mRNA
T33 1340-1362 other_name denotes Nuclear run-off assays
T34 1367-1384 other_name denotes half-life studies
T35 1413-1431 RNA_molecule denotes C/EBP epsilon mRNA
T36 1435-1443 other_organic_compound denotes 9-cis RA
T37 1497-1515 RNA_molecule denotes C/EBP epsilon mRNA
T38 1562-1577 protein_family_or_group denotes protein factors
T39 1586-1594 other_organic_compound denotes 9-cis RA
T40 1603-1621 RNA_molecule denotes C/EBP epsilon mRNA
T41 1657-1674 other_name denotes protein synthesis
T42 1676-1680 other_organic_compound denotes ATRA
T43 1708-1729 protein_molecule denotes C/EBP epsilon protein
T44 1733-1742 cell_line denotes NB4 cells
T45 1756-1772 other_name denotes Western blotting
T46 1822-1830 other_organic_compound denotes 9-cis RA
T47 1840-1868 other_name denotes granulocytic differentiation
T48 1874-1878 other_organic_compound denotes DMSO
T49 1906-1917 cell_line denotes HL-60 cells
T50 1927-1947 other_name denotes granulocytic pathway
T51 1992-2010 RNA_molecule denotes C/EBP epsilon mRNA
T52 2069-2087 RNA_molecule denotes C/EBP epsilon mRNA
T53 2116-2133 cell_line denotes NB4 promyelocytes
T54 2184-2196 cell_type denotes granulocytes
T55 2216-2234 RNA_molecule denotes C/EBP epsilon mRNA
T56 2329-2344 protein_family_or_group denotes protein factors
T57 2366-2397 DNA_domain_or_region denotes C/EBP epsilon promoter/enhancer
T58 2409-2439 DNA_domain_or_region denotes retinoic acid-response element
T59 2471-2480 other_organic_compound denotes retinoids