PubMed:9375804
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 96-104 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T2 | 257-265 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T3 | 597-605 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T4 | 773-776 | Disease | denotes | LAD | http://purl.obolibrary.org/obo/MONDO_0017570 |
| T5 | 876-884 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T6 | 967-970 | Disease | denotes | LAD | http://purl.obolibrary.org/obo/MONDO_0017570 |
| T7 | 1067-1070 | Disease | denotes | LAD | http://purl.obolibrary.org/obo/MONDO_0017570 |
| T8 | 1163-1171 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
| T9 | 1358-1366 | Disease | denotes | ischemia | http://purl.obolibrary.org/obo/MONDO_0005053 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1242-1245 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1304-1312 | Cell | denotes | myocytes | http://purl.obolibrary.org/obo/CL:0000187 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 124-130 | Body_part | denotes | canine | http://purl.obolibrary.org/obo/UBERON_0003674 |
| T2 | 131-141 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/UBERON_0002349 |
| T3 | 248-253 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T7 | 548-554 | Body_part | denotes | canine | http://purl.obolibrary.org/obo/UBERON_0003674 |
| T8 | 555-565 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/UBERON_0002349 |
| T9 | 756-771 | Body_part | denotes | coronary artery | http://purl.obolibrary.org/obo/UBERON_0001621 |
| T10 | 1322-1340 | Body_part | denotes | interstitial fluid | http://purl.obolibrary.org/obo/UBERON_0000913 |
| T11 | 1594-1607 | Body_part | denotes | cell membrane | http://purl.obolibrary.org/obo/GO_0005886 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 131-141 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/MAT_0000453 |
| T2 | 248-253 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T3 | 555-565 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/MAT_0000453 |
| T4 | 765-771 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/MAT_0000034 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-142 | Sentence | denotes | Metabolic and antioxidant effects of R(+/-)-N6-(2-phenylisopropyl)-adenosine following regional ischemia and reperfusion in canine myocardium. |
| T2 | 143-285 | Sentence | denotes | Recent studies have indicated that activation of A1/A2-receptors may mediate metabolic adaptation of the heart to ischemia/reperfusion stress. |
| T3 | 286-622 | Sentence | denotes | This study tests whether pretreatment with A1-selective agonist R(-)-N6-(2-phenylisopropyl) adenosine (R-PIA) might mimic effects of a brief period of coronary occlusion (ischemic preconditioning, IP) on energy metabolism and hydroxyl radical (OH.) formation in canine myocardium following subsequent prolonged ischemia and reperfusion. |
| T4 | 623-1184 | Sentence | denotes | Anaesthetized dogs were randomized to a control group subjected to 40-min occlusion of a diagonal branch of left anterior descending coronary artery (LAD) followed by 1-h reperfusion, or a preconditioned group (PC) in which the same period of sustained ischemia and reperfusion was preceded by a single cycle of IP (5-min occlusion of the same LAD branch and 10-min reperfusion), or to PIA group in which R-PIA infusion into the same branch of LAD (0.4 microg/kg per min during 5 min) was followed by 10 min of perfusion prior to sustained ischemia-reperfusion. |
| T5 | 1185-1404 | Sentence | denotes | Pretreatment with R-PIA similarly to IP reduced lactate (Lac), creatine (Cr) and inorganic phosphate (Pi) release from myocytes into the interstitial fluid during sustained ischemia compared to these indices in control. |
| T6 | 1405-1615 | Sentence | denotes | By the end of reperfusion, both IP and R-PIA infusion enhanced recovery of myocardial ATP and phosphocreatine (PCr) and attenuated the total creatine (sigmaCr = PCr + Cr) loss, an index of cell membrane damage. |
| T7 | 1616-1828 | Sentence | denotes | A1-receptor activation by R-PIA, as IP, led to a significant reduction in OH. radical generation following reperfusion assessed by a spin trap 5,5'-dimethyl-1-pyrroline-N-oxide (DMPO) using cardiac microdialysis. |
| T8 | 1829-1907 | Sentence | denotes | R-PIA pretreatment did not affect systemic and cardiac hemodynamic parameters. |
| T9 | 1908-2124 | Sentence | denotes | We conclude that (1) adaptive mechanisms of IP involve A1-receptor activation that contributes to the overall metabolic response and (2) R-PIA acts as a useful preconditioning-mimetic and anti-ischemic agent in dogs. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 1242-1245 | Glycan | denotes | Lac | https://api.glycosmos.org/wurcs2image/latest/png/binary/G84224TW |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 96-104 | Disease | denotes | ischemia | MONDO:0005053 |
| T2 | 257-265 | Disease | denotes | ischemia | MONDO:0005053 |
| T3 | 597-605 | Disease | denotes | ischemia | MONDO:0005053 |
| T4 | 876-884 | Disease | denotes | ischemia | MONDO:0005053 |
| T5 | 1163-1171 | Disease | denotes | ischemia | MONDO:0005053 |
| T6 | 1358-1366 | Disease | denotes | ischemia | MONDO:0005053 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 637-641 | OrganismTaxon | denotes | dogs | 9615 |
| T2 | 2119-2123 | OrganismTaxon | denotes | dogs | 9615 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 637-641 | OrganismTaxon | denotes | dogs | 9615 |
| T2 | 2119-2123 | OrganismTaxon | denotes | dogs | 9615 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 131-141 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/MAT_0000453 |
| T2 | 248-253 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T3 | 555-565 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/MAT_0000453 |
| T4 | 765-771 | Body_part | denotes | artery | http://purl.obolibrary.org/obo/MAT_0000034 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 124-130 | Body_part | denotes | canine | http://purl.obolibrary.org/obo/UBERON_0003674 |
| T2 | 131-141 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/UBERON_0002349 |
| T3 | 248-253 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T7 | 548-554 | Body_part | denotes | canine | http://purl.obolibrary.org/obo/UBERON_0003674 |
| T8 | 555-565 | Body_part | denotes | myocardium | http://purl.obolibrary.org/obo/UBERON_0002349 |
| T9 | 756-771 | Body_part | denotes | coronary artery | http://purl.obolibrary.org/obo/UBERON_0001621 |
| T10 | 1322-1340 | Body_part | denotes | interstitial fluid | http://purl.obolibrary.org/obo/UBERON_0000913 |
| T11 | 1594-1607 | Body_part | denotes | cell membrane | http://purl.obolibrary.org/obo/GO_0005886 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1304-1312 | Cell | denotes | myocytes | http://purl.obolibrary.org/obo/CL:0000187 |