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PubMed:9374642 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.
T2 95-255 Sentence denotes Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.
T3 256-317 Sentence denotes Coincident with many inflammatory diseases is tissue hypoxia.
T4 318-454 Sentence denotes Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.
T5 455-613 Sentence denotes Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.
T6 614-753 Sentence denotes Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 +/- 0.4-fold over normoxia) ICAM-1 expression.
T7 754-932 Sentence denotes Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.
T8 933-1201 Sentence denotes Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.
T9 1202-1313 Sentence denotes Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.
T10 1314-1439 Sentence denotes We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.
T1 0-94 Sentence denotes Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.
T2 95-255 Sentence denotes Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.
T3 256-317 Sentence denotes Coincident with many inflammatory diseases is tissue hypoxia.
T4 318-454 Sentence denotes Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.
T5 455-613 Sentence denotes Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.
T6 614-753 Sentence denotes Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 +/- 0.4-fold over normoxia) ICAM-1 expression.
T7 754-932 Sentence denotes Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.
T8 933-1201 Sentence denotes Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.
T9 1202-1313 Sentence denotes Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.
T10 1314-1439 Sentence denotes We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 30-48 protein denotes endothelial ICAM-1
T2 82-93 protein denotes proteasomes
T3 95-128 protein denotes Intercellular adhesion molecule 1
T4 130-136 protein denotes ICAM-1
T5 435-453 protein denotes endothelial ICAM-1
T6 455-478 cell_type denotes Human endothelial cells
T7 606-612 protein denotes ICAM-1
T8 652-658 protein denotes ICAM-1
T9 735-741 protein denotes ICAM-1
T10 879-901 protein denotes anti-ICAM-1 antibodies
T11 1012-1022 protein denotes proteasome
T12 1080-1090 protein denotes proteasome
T13 1144-1200 protein denotes nuclear transcription factor-kappa B p65 (Rel A) subunit
T14 1207-1217 protein denotes proteasome
T15 1388-1398 protein denotes proteasome
T16 1422-1428 protein denotes ICAM-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-94 Sentence denotes Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.
S2 95-255 Sentence denotes Intercellular adhesion molecule 1 (ICAM-1) is an important molecule in promotion of polymorphonuclear neutrophil transendothelial migration during inflammation.
S3 256-317 Sentence denotes Coincident with many inflammatory diseases is tissue hypoxia.
S4 318-454 Sentence denotes Thus we hypothesized that combinations of hypoxia and inflammatory stimuli may differentially regulate expression of endothelial ICAM-1.
S5 455-613 Sentence denotes Human endothelial cells were exposed to hypoxia in the presence or absence of added lipopolysaccharide (LPS) and examined for expression of functional ICAM-1.
S6 614-753 Sentence denotes Although hypoxia alone did not induce ICAM-1, the combination of LPS and hypoxia enhanced (3 +/- 0.4-fold over normoxia) ICAM-1 expression.
S7 754-932 Sentence denotes Combinations of hypoxia and LPS significantly increased lymphocyte binding, and such increases were inhibited by addition of anti-ICAM-1 antibodies or antisense oligonucleotides.
S8 933-1201 Sentence denotes Hypoxic endothelia showed a > 10-fold increase in sensitivity to inhibitors of proteasome activation, and combinations of hypoxia and LPS enhanced proteasome-dependent cytoplasmic-to-nuclear localization of the nuclear transcription factor-kappa B p65 (Rel A) subunit.
S9 1202-1313 Sentence denotes Such proteasome activation correlated with hypoxia-evoked decreases in both extracellular and intracellular pH.
S10 1314-1439 Sentence denotes We conclude from these studies that endothelial hypoxia provides a novel, proteasome-dependent stimulus for ICAM-1 induction.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-7 NP denotes Hypoxia
C2 30-48 NP denotes endothelial ICAM-1
C3 95-137 NP denotes Intercellular adhesion molecule 1 (ICAM-1)
C4 360-367 NP denotes hypoxia
C5 435-453 NP denotes endothelial ICAM-1
C6 495-502 NP denotes hypoxia
C7 623-630 NP denotes hypoxia
C8 652-658 NP denotes ICAM-1
C10 679-682 NP denotes LPS
C11 687-694 NP denotes hypoxia
C9 660-694 NP denotes the combination of LPS and hypoxia
C13 770-777 NP denotes hypoxia
C14 782-785 NP denotes LPS
C12 754-785 NP denotes Combinations of hypoxia and LPS
C15 1012-1033 NP denotes proteasome activation
C17 1055-1062 NP denotes hypoxia
C18 1067-1070 NP denotes LPS
C16 1039-1070 NP denotes combinations of hypoxia and LPS
C19 1202-1228 NP denotes Such proteasome activation
R1 C4 C1 coref-ident hypoxia,Hypoxia
R2 C5 C2 coref-ident endothelial ICAM-1,endothelial ICAM-1
R3 C6 C4 coref-ident hypoxia,hypoxia
R4 C7 C6 coref-ident hypoxia,hypoxia
R5 C8 C3 coref-ident ICAM-1,Intercellular adhesion molecule 1 (ICAM-1)
R6 C11 C7 coref-ident hypoxia,hypoxia
R7 C13 C11 coref-ident hypoxia,hypoxia
R8 C14 C10 coref-ident LPS,LPS
R9 C12 C9 coref-ident Combinations of hypoxia and LPS,the combination of LPS and hypoxia
R10 C17 C13 coref-ident hypoxia,hypoxia
R11 C18 C14 coref-ident LPS,LPS
R12 C16 C12 coref-ident combinations of hypoxia and LPS,Combinations of hypoxia and LPS
R13 C19 C15 coref-ident Such proteasome activation,proteasome activation

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 30-48 protein_molecule denotes endothelial ICAM-1
T2 59-77 other_name denotes metabolic acidosis
T3 82-93 protein_complex denotes proteasomes
T4 95-128 protein_molecule denotes Intercellular adhesion molecule 1
T5 130-136 protein_molecule denotes ICAM-1
T6 179-234 other_name denotes polymorphonuclear neutrophil transendothelial migration
T7 242-254 other_name denotes inflammation
T8 277-298 other_name denotes inflammatory diseases
T9 302-316 other_name denotes tissue hypoxia
T10 360-367 other_name denotes hypoxia
T11 372-392 other_name denotes inflammatory stimuli
T12 435-446 protein_molecule denotes endothelial
T13 447-453 protein_molecule denotes ICAM-1
T14 455-478 cell_type denotes Human endothelial cells
T15 495-502 other_name denotes hypoxia
T16 539-557 lipid denotes lipopolysaccharide
T17 559-562 lipid denotes LPS
T18 606-612 protein_molecule denotes ICAM-1
T19 623-630 other_name denotes hypoxia
T20 652-658 protein_molecule denotes ICAM-1
T21 679-682 lipid denotes LPS
T22 687-694 other_name denotes hypoxia
T23 735-741 protein_molecule denotes ICAM-1
T24 770-777 other_name denotes hypoxia
T25 782-785 lipid denotes LPS
T26 879-884 protein_family_or_group denotes anti-
T27 884-890 protein_molecule denotes ICAM-1
T28 905-931 polynucleotide denotes antisense oligonucleotides
T29 933-951 tissue denotes Hypoxic endothelia
T30 1012-1022 protein_complex denotes proteasome
T31 1055-1062 other_name denotes hypoxia
T32 1067-1070 lipid denotes LPS
T33 1080-1090 protein_complex denotes proteasome
T34 1144-1200 protein_subunit denotes nuclear transcription factor-kappa B p65 (Rel A) subunit
T35 1207-1217 protein_complex denotes proteasome
T36 1245-1252 other_name denotes hypoxia
T37 1350-1361 other_name denotes endothelial
T38 1362-1369 other_name denotes hypoxia
T39 1388-1398 protein_complex denotes proteasome
T40 1422-1428 protein_molecule denotes ICAM-1