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PubMed:9372912 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-17 protein denotes Id3
T2 91-142 protein denotes basic helix-loop-helix (bHLH) transcription factors
T3 276-301 protein denotes Id family of HLH proteins
T4 309-325 protein denotes bHLH antagonists
T5 418-430 protein denotes bHLH targets
T6 434-455 protein denotes inactive heterodimers
T7 492-525 DNA denotes gene regulatory (E box) sequences
T8 643-646 protein denotes Id2
T9 764-767 protein denotes Id2
T10 782-802 protein denotes E-box-dependent bHLH
T11 982-985 protein denotes Id3
T12 1012-1015 protein denotes Id3
T13 1036-1056 protein denotes E-box-dependent bHLH
T14 1125-1138 DNA denotes reporter gene
T15 1184-1197 protein denotes wild-type Id3
T16 1202-1217 protein denotes Id3 Asp5 mutant
T17 1295-1318 cell_line denotes transfected fibroblasts
T18 1331-1346 protein denotes Id3 Ala5 mutant
T19 1430-1451 protein denotes wild-type Id3 protein
T20 1604-1607 protein denotes Id3
T21 1633-1637 protein denotes bHLH
T22 1699-1702 protein denotes Id3
T23 1791-1795 protein denotes bHLH

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-73 Sentence denotes Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation.
S2 74-302 Sentence denotes The functions of basic helix-loop-helix (bHLH) transcription factors in activating differentiation-linked gene expression and in inducing G1 cell cycle arrest are negatively regulated by members of the Id family of HLH proteins.
S3 303-526 Sentence denotes These bHLH antagonists are induced during a mitogenic signalling response, and they function by sequestering their bHLH targets in inactive heterodimers that are unable to bind to specific gene regulatory (E box) sequences.
S4 527-911 Sentence denotes Recently, cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2 has been shown to occur during late G1-to-S phase transition of the cell cycle, and this neutralizes the function of Id2 in abrogating E-box-dependent bHLH homo- or heterodimer complex formation in vitro (E. Hara, M. Hall, and G. Peters, EMBO J. 16:332-342, 1997).
S5 912-1156 Sentence denotes We now show that an analogous cell-cycle-regulated phosphorylation of Id3 alters the specificity of Id3 for abrogating both E-box-dependent bHLH homo- or heterodimer complex formation in vitro and E-box-dependent reporter gene function in vivo.
S6 1157-1452 Sentence denotes Furthermore, compared with wild-type Id3, an Id3 Asp5 mutant (mimicking phosphorylation) is unable to promote cell cycle S phase entry in transfected fibroblasts, whereas an Id3 Ala5 mutant (ablating phosphorylation) displays an activity significantly greater than that of wild-type Id3 protein.
S7 1453-1650 Sentence denotes Cdk2-dependent phosphorylation therefore provides a switch during late G1-to-S phase that both nullifies an early G1 cell cycle regulatory function of Id3 and modulates its target bHLH specificity.
S8 1651-2001 Sentence denotes These data also demonstrate that the ability of Id3 to promote cell cycle S phase entry is not simply a function of its ability to modulate bHLH heterodimer-dependent gene expression and establish a biologically important mechanism through which Cdk2 and Id-bHLH functions are integrated in the coordination of cell proliferation and differentiation.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 41-72 NP denotes Cdk-2-dependent phosphorylation
C2 261-301 NP denotes members of the Id family of HLH proteins
C3 303-325 NP denotes These bHLH antagonists
C4 382-386 NP denotes they
C5 412-417 NP denotes their
C6 434-455 NP denotes inactive heterodimers
C7 456-460 NP denotes that
C9 643-646 NP denotes Id2
C8 537-646 NP denotes cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2
C10 731-735 NP denotes this
C11 764-767 NP denotes Id2
C12 782-850 NP denotes E-box-dependent bHLH homo- or heterodimer complex formation in vitro
C13 982-985 NP denotes Id3
C14 1012-1015 NP denotes Id3
C15 1036-1104 NP denotes E-box-dependent bHLH homo- or heterodimer complex formation in vitro
C16 1184-1197 NP denotes wild-type Id3
C17 1267-1291 NP denotes cell cycle S phase entry
C18 1383-1394 NP denotes an activity
C19 1422-1426 NP denotes that
C20 1430-1451 NP denotes wild-type Id3 protein
C21 1453-1483 NP denotes Cdk2-dependent phosphorylation
C22 1519-1537 NP denotes late G1-to-S phase
C23 1538-1542 NP denotes that
C24 1604-1607 NP denotes Id3
C25 1622-1625 NP denotes its
C26 1699-1702 NP denotes Id3
C27 1714-1738 NP denotes cell cycle S phase entry
C28 1767-1770 NP denotes its
C29 1848-1882 NP denotes a biologically important mechanism
C30 1891-1896 NP denotes which
R1 C3 C2 coref-ident These bHLH antagonists,members of the Id family of HLH proteins
R2 C4 C2 coref-pron they,members of the Id family of HLH proteins
R3 C5 C2 coref-pron their,members of the Id family of HLH proteins
R4 C7 C6 coref-relat that,inactive heterodimers
R5 C10 C8 coref-pron this,cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2
R6 C11 C9 coref-ident Id2,Id2
R7 C14 C13 coref-ident Id3,Id3
R8 C15 C12 coref-ident E-box-dependent bHLH homo- or heterodimer complex formation in vitro,E-box-dependent bHLH homo- or heterodimer complex formation in vitro
R9 C19 C18 coref-pron that,an activity
R10 C20 C16 coref-ident wild-type Id3 protein,wild-type Id3
R11 C21 C1 coref-ident Cdk2-dependent phosphorylation,Cdk-2-dependent phosphorylation
R12 C23 C22 coref-relat that,late G1-to-S phase
R13 C24 C14 coref-ident Id3,Id3
R14 C25 C22 coref-pron its,late G1-to-S phase
R15 C26 C24 coref-ident Id3,Id3
R16 C27 C17 coref-ident cell cycle S phase entry,cell cycle S phase entry
R17 C28 C26 coref-pron its,Id3
R18 C30 C29 coref-relat which,a biologically important mechanism

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-17 protein_molecule denotes Id3
T2 41-72 other_name denotes Cdk-2-dependent phosphorylation
T3 91-120 protein_family_or_group denotes basic helix-loop-helix (bHLH)
T4 121-142 protein_family_or_group denotes transcription factors
T5 157-195 other_name denotes differentiation-linked gene expression
T6 212-232 other_name denotes G1 cell cycle arrest
T7 276-301 protein_family_or_group denotes Id family of HLH proteins
T8 309-325 protein_family_or_group denotes bHLH antagonists
T9 347-376 other_name denotes mitogenic signalling response
T10 418-430 protein_family_or_group denotes bHLH targets
T11 434-455 protein_family_or_group denotes inactive heterodimers
T12 492-525 DNA_family_or_group denotes gene regulatory (E box) sequences
T13 618-632 amino_acid_monomer denotes serine residue
T14 634-638 amino_acid_monomer denotes Ser5
T15 643-646 protein_molecule denotes Id2
T16 683-707 other_name denotes G1-to-S phase transition
T17 764-767 protein_molecule denotes Id2
T18 782-802 protein_molecule denotes E-box-dependent bHLH
T19 932-978 other_name denotes analogous cell-cycle-regulated phosphorylation
T20 982-985 protein_molecule denotes Id3
T21 1012-1015 protein_molecule denotes Id3
T22 1036-1056 protein_molecule denotes E-box-dependent bHLH
T23 1109-1124 other_name denotes E-box-dependent
T24 1125-1138 DNA_family_or_group denotes reporter gene
T25 1184-1193 protein_molecule denotes wild-type
T26 1194-1197 protein_molecule denotes Id3
T27 1202-1205 protein_molecule denotes Id3
T28 1206-1210 amino_acid_monomer denotes Asp5
T29 1267-1291 other_name denotes cell cycle S phase entry
T30 1295-1318 cell_line denotes transfected fibroblasts
T31 1331-1334 protein_molecule denotes Id3
T32 1335-1339 amino_acid_monomer denotes Ala5
T33 1430-1439 protein_molecule denotes wild-type
T34 1440-1443 protein_molecule denotes Id3
T35 1524-1537 other_name denotes G1-to-S phase
T36 1561-1600 other_name denotes early G1 cell cycle regulatory function
T37 1604-1607 protein_molecule denotes Id3
T38 1626-1632 other_name denotes target
T39 1633-1637 protein_substructure denotes bHLH
T40 1699-1702 protein_molecule denotes Id3
T41 1714-1738 other_name denotes cell cycle S phase entry
T42 1791-1795 protein_substructure denotes bHLH
T43 1962-1980 other_name denotes cell proliferation
T44 1985-2000 other_name denotes differentiation