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PubMed:9372447 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-33 DNA denotes immunoglobulin gene
T2 48-55 cell_type denotes B cells
T3 73-83 cell_line denotes HeLa cells
T4 126-157 protein denotes essential transcription factors
T5 257-295 cell_type denotes immunoglobulin (Ig) expressing B cells
T6 311-322 cell_type denotes non-B cells
T7 458-468 cell_line denotes HeLa cells
T8 481-510 cell_type denotes diploid or tetraploid B cells
T9 512-517 cell_line denotes Daudi
T10 569-589 DNA denotes B cell-encoded genes
T11 665-687 DNA denotes B cell-expressed genes
T12 803-810 DNA denotes Ig gene
T13 871-892 protein denotes transcription factors
T14 916-923 DNA denotes Ig gene
T15 945-966 protein denotes transcription factors
T16 1048-1053 DNA denotes Oct-2
T17 1055-1060 DNA denotes OBF-1
T18 1062-1066 protein denotes PU.1
T19 1115-1125 protein denotes NF-kappa B
T20 1127-1130 DNA denotes E47
T21 1146-1172 cell_line denotes Daudi x HeLa heterokaryons
T22 1239-1276 protein denotes B cell-specific transcription factors
T23 1289-1296 DNA denotes Ig gene
T24 1312-1317 DNA denotes Oct-2
T25 1322-1332 protein denotes NF-kappa B
T26 1401-1411 cell_line denotes HeLa cells
T27 1437-1475 protein denotes B cell-expressed transcription factors
T28 1562-1569 DNA denotes Ig gene
T29 1684-1692 DNA denotes Ig genes
T30 1782-1796 cell_line denotes HeLa phenotype

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-251 Sentence denotes Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner.
S2 252-422 Sentence denotes When immunoglobulin (Ig) expressing B cells are fused with non-B cells, Ig expression is rapidly suppressed at the level of transcription, a phenomenon termed extinction.
S3 423-637 Sentence denotes Here we demonstrate that fusion of HeLa cells with either diploid or tetraploid B cells (Daudi) results in widespread extinction of several other B cell-encoded genes that are expressed in a B cell-specific manner.
S4 638-751 Sentence denotes In contrast, expression of B cell-expressed genes that are not dependent on cell-specific controls is unaffected.
S5 752-938 Sentence denotes We show that the molecular mechanism(s) underlying Ig gene extinction can be explained, at least in part, by a lack of transcription factors that are essential for Ig gene transcription.
S6 939-1132 Sentence denotes These transcription factors are either not produced due to block of transcription of their respective genes (Oct-2, OBF-1, PU.1), or are rendered inactive posttranslationally (NF-kappa B, E47).
S7 1133-1333 Sentence denotes By isolating Daudi x HeLa heterokaryons a few hours after fusion, we have studied the initial fate of two B cell-specific transcription factors involved in Ig gene transcription, Oct-2 and NF-kappa B.
S8 1334-1581 Sentence denotes This report provides the first demonstration that upon fusion with HeLa cells, the nuclear contents of B cell-expressed transcription factors are depleted within a few hours with kinetics that are as fast or faster than that of Ig gene extinction.
S9 1582-1653 Sentence denotes Thus, the extinguishing mechanism is effective very early after fusion.
S10 1654-1797 Sentence denotes We suggest that extinction of Ig genes is part of a global mechanism that suppresses the differentiation program foreign to the HeLa phenotype.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 73-83 NP denotes HeLa cells
C1 61-83 NP denotes fusion with HeLa cells
C3 226-250 NP denotes a B cell-specific manner
C4 458-468 NP denotes HeLa cells
C5 555-589 NP denotes several other B cell-encoded genes
C6 590-594 NP denotes that
C7 612-636 NP denotes a B cell-specific manner
C8 665-687 NP denotes B cell-expressed genes
C9 688-692 NP denotes that
C10 803-821 NP denotes Ig gene extinction
C12 871-892 NP denotes transcription factors
C13 893-897 NP denotes that
C14 916-937 NP denotes Ig gene transcription
C11 871-937 NP denotes transcription factors that are essential for Ig gene transcription
C15 939-966 NP denotes These transcription factors
C16 1024-1029 NP denotes their
C17 1191-1197 NP denotes fusion
C19 1289-1310 NP denotes Ig gene transcription
C18 1235-1310 NP denotes two B cell-specific transcription factors involved in Ig gene transcription
C20 1312-1332 NP denotes Oct-2 and NF-kappa B
C21 1355-1378 NP denotes the first demonstration
C22 1379-1383 NP denotes that
C24 1401-1411 NP denotes HeLa cells
C23 1389-1411 NP denotes fusion with HeLa cells
C25 1513-1521 NP denotes kinetics
C26 1522-1526 NP denotes that
C27 1562-1580 NP denotes Ig gene extinction
C28 1646-1652 NP denotes fusion
C29 1670-1692 NP denotes extinction of Ig genes
C30 1704-1722 NP denotes a global mechanism
C31 1723-1727 NP denotes that
R1 C4 C2 coref-ident HeLa cells,HeLa cells
R2 C6 C5 coref-relat that,several other B cell-encoded genes
R3 C7 C3 coref-ident a B cell-specific manner,a B cell-specific manner
R4 C9 C8 coref-relat that,B cell-expressed genes
R5 C13 C12 coref-relat that,transcription factors
R6 C15 C11 coref-ident These transcription factors,transcription factors that are essential for Ig gene transcription
R7 C16 C11 coref-pron their,transcription factors that are essential for Ig gene transcription
R8 C19 C14 coref-ident Ig gene transcription,Ig gene transcription
R9 C20 C18 coref-appos Oct-2 and NF-kappa B,two B cell-specific transcription factors involved in Ig gene transcription
R10 C22 C21 coref-relat that,the first demonstration
R11 C24 C4 coref-ident HeLa cells,HeLa cells
R12 C23 C1 coref-ident fusion with HeLa cells,fusion with HeLa cells
R13 C26 C25 coref-relat that,kinetics
R14 C27 C10 coref-ident Ig gene extinction,Ig gene extinction
R15 C28 C17 coref-ident fusion,fusion
R16 C29 C27 coref-ident extinction of Ig genes,Ig gene extinction
R17 C31 C30 coref-relat that,a global mechanism

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-33 DNA_family_or_group denotes immunoglobulin gene
T2 48-55 cell_type denotes B cells
T3 73-83 cell_line denotes HeLa cells
T4 105-122 other_name denotes nuclear depletion
T5 126-157 protein_family_or_group denotes essential transcription factors
T6 228-250 other_name denotes B cell-specific manner
T7 257-271 protein_family_or_group denotes immunoglobulin
T8 273-275 protein_family_or_group denotes Ig
T9 288-295 cell_type denotes B cells
T10 311-322 cell_type denotes non-B cells
T11 411-421 other_name denotes extinction
T12 458-468 cell_line denotes HeLa cells
T13 512-517 cell_line denotes Daudi
T14 569-589 DNA_family_or_group denotes B cell-encoded genes
T15 614-636 other_name denotes B cell-specific manner
T16 665-687 DNA_family_or_group denotes B cell-expressed genes
T17 769-788 other_name denotes molecular mechanism
T18 803-810 DNA_domain_or_region denotes Ig gene
T19 871-892 protein_family_or_group denotes transcription factors
T20 916-923 DNA_domain_or_region denotes Ig gene
T21 945-966 protein_family_or_group denotes transcription factors
T22 1048-1053 DNA_domain_or_region denotes Oct-2
T23 1055-1060 DNA_domain_or_region denotes OBF-1
T24 1062-1066 protein_molecule denotes PU.1
T25 1115-1125 protein_complex denotes NF-kappa B
T26 1127-1130 DNA_domain_or_region denotes E47
T27 1146-1172 cell_line denotes Daudi x HeLa heterokaryons
T28 1239-1254 protein_family_or_group denotes B cell-specific
T29 1255-1276 protein_family_or_group denotes transcription factors
T30 1289-1296 DNA_domain_or_region denotes Ig gene
T31 1312-1317 DNA_domain_or_region denotes Oct-2
T32 1322-1332 protein_complex denotes NF-kappa B
T33 1401-1411 cell_line denotes HeLa cells
T34 1437-1453 protein_family_or_group denotes B cell-expressed
T35 1454-1475 protein_family_or_group denotes transcription factors
T36 1562-1569 DNA_domain_or_region denotes Ig gene
T37 1684-1692 DNA_family_or_group denotes Ig genes
T38 1706-1722 other_name denotes global mechanism
T39 1743-1766 other_name denotes differentiation program
T40 1782-1796 cell_line denotes HeLa phenotype