> top > docs > PubMed:9368761 > annotations

PubMed:9368761 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T2 15-18 CHEBI:16768 denotes MSH
T6 15-18 D009074 denotes MSH
T7 15-18 D009074 denotes MSH
T8 15-19 PR:000010666 denotes MSH2
T9 15-19 PR:P25847 denotes MSH2
T10 15-19 PR:P43246 denotes MSH2
T11 15-19 P22711 denotes MSH2
T12 15-19 PR:P22711 denotes MSH2
T13 15-19 PR:P54275 denotes MSH2
T14 15-19 PR:O74773 denotes MSH2
T15 15-19 PR:P43247 denotes MSH2
T16 15-19 PR:Q553L4 denotes MSH2
T17 15-19 PR:O24617 denotes MSH2
T19 20-23 CHEBI:16768 denotes MSH
T23 20-23 D009074 denotes MSH
T24 20-23 D009074 denotes MSH
T25 20-24 PR:O65607 denotes MSH3
T26 20-24 PR:000010667 denotes MSH3
T27 20-24 PR:Q59Y41 denotes MSH3
T28 20-24 PR:P25336 denotes MSH3
T29 20-24 PR:P20585 denotes MSH3
T30 20-24 PR:P26359 denotes MSH3
T31 20-24 PR:P13705 denotes MSH3
T32 20-24 PR:Q1ZXH0 denotes MSH3
T34 62-67 214355 denotes yeast
T33 62-67 D015003 denotes yeast
T38 68-72 CVCL_G669 denotes MLH1
T35 68-72 PR:Q9ZRV4 denotes MLH1
T36 68-72 PR:P38920 denotes MLH1
T37 68-72 PR:Q54KD8 denotes MLH1
T39 68-72 PR:Q9JK91 denotes MLH1
T40 68-72 PR:P97679 denotes MLH1
T41 68-72 PR:Q9P7W6 denotes MLH1
T42 68-72 PR:000010442 denotes MLH1
T43 68-72 PR:P40692 denotes MLH1
T44 68-85 GO:0032390 denotes MLH1-PMS1 complex
T51 73-77 PR:P14242 denotes PMS1
T52 73-77 PR:000012913 denotes PMS1
T55 73-77 PR:Q941I6 denotes PMS1
T56 73-77 PR:P54280 denotes PMS1
T57 73-77 PR:Q5NC83 denotes PMS1
T58 73-77 PR:P54277 denotes PMS1
T59 73-77 PR:Q54QA0 denotes PMS1
T53 73-77 C102203 denotes PMS1
T54 73-77 C102203 denotes PMS1
T60 91-106 GO:0006298 denotes mismatch repair
T61 137-154 D042822 denotes genomic stability
T62 137-154 D042822 denotes genomic stability
T63 167-182 GO:0006298 denotes mismatch repair
T64 210-218 SO:0000109 denotes mutation
T65 302-307 D006801 denotes human
T66 308-323 GO:0006298 denotes mismatch repair
T67 364-382 D015179 denotes colorectal cancers
T68 364-382 D015179 denotes colorectal cancers
T71 443-458 GO:0006298 denotes mismatch repair
T73 495-500 214355 denotes yeast
T72 495-500 D015003 denotes yeast
T75 545-548 CHEBI:16768 denotes MSH
T79 545-548 D009074 denotes MSH
T80 545-548 D009074 denotes MSH
T81 545-549 PR:000010666 denotes MSH2
T82 545-549 PR:P25847 denotes MSH2
T83 545-549 PR:P43246 denotes MSH2
T84 545-549 P22711 denotes MSH2
T85 545-549 PR:P22711 denotes MSH2
T86 545-549 PR:P54275 denotes MSH2
T87 545-549 PR:O74773 denotes MSH2
T88 545-549 PR:P43247 denotes MSH2
T89 545-549 PR:Q553L4 denotes MSH2
T90 545-549 PR:O24617 denotes MSH2
T92 550-553 CHEBI:16768 denotes MSH
T96 550-553 D009074 denotes MSH
T97 550-553 D009074 denotes MSH
T98 550-554 PR:O65607 denotes MSH3
T99 550-554 PR:000010667 denotes MSH3
T100 550-554 PR:Q59Y41 denotes MSH3
T101 550-554 PR:P25336 denotes MSH3
T102 550-554 PR:P20585 denotes MSH3
T103 550-554 PR:P26359 denotes MSH3
T104 550-554 PR:P13705 denotes MSH3
T105 550-554 PR:Q1ZXH0 denotes MSH3
T107 559-562 CHEBI:16768 denotes MSH
T111 559-562 D009074 denotes MSH
T112 559-562 D009074 denotes MSH
T113 559-563 PR:000010666 denotes MSH2
T114 559-563 PR:P25847 denotes MSH2
T115 559-563 PR:P43246 denotes MSH2
T116 559-563 P22711 denotes MSH2
T117 559-563 PR:P22711 denotes MSH2
T118 559-563 PR:P54275 denotes MSH2
T119 559-563 PR:O74773 denotes MSH2
T120 559-563 PR:P43247 denotes MSH2
T121 559-563 PR:Q553L4 denotes MSH2
T122 559-563 PR:O24617 denotes MSH2
T124 564-567 CHEBI:16768 denotes MSH
T128 564-567 D009074 denotes MSH
T129 564-567 D009074 denotes MSH
T130 564-568 PR:P52701 denotes MSH6
T131 564-568 PR:P54276 denotes MSH6
T132 564-568 PR:Q9VUM0 denotes MSH6
T133 564-568 PR:Q55GU9 denotes MSH6
T134 564-568 PR:O04716 denotes MSH6
T135 564-568 PR:Q03834 denotes MSH6
T136 564-568 PR:O74502 denotes MSH6
T137 564-568 PR:000010670 denotes MSH6
T138 645-656 SO:0000068 denotes overlapping
T139 666-673 SO:0100018 denotes binding
T140 666-673 SO:0001091 denotes binding
T141 666-673 GO:0005488 denotes binding
T142 689-693 PR:Q9ZRV4 denotes MLH1
T143 689-693 PR:P38920 denotes MLH1
T144 689-693 PR:Q54KD8 denotes MLH1
T146 689-693 PR:Q9JK91 denotes MLH1
T147 689-693 PR:P97679 denotes MLH1
T148 689-693 PR:Q9P7W6 denotes MLH1
T149 689-693 PR:000010442 denotes MLH1
T150 689-693 PR:P40692 denotes MLH1
T145 689-693 CVCL_G669 denotes MLH1
T157 698-702 PR:P14242 denotes PMS1
T158 698-702 PR:000012913 denotes PMS1
T161 698-702 PR:Q941I6 denotes PMS1
T162 698-702 PR:P54280 denotes PMS1
T163 698-702 PR:Q5NC83 denotes PMS1
T164 698-702 PR:P54277 denotes PMS1
T165 698-702 PR:Q54QA0 denotes PMS1
T159 698-702 C102203 denotes PMS1
T160 698-702 C102203 denotes PMS1
T166 741-756 GO:0006298 denotes mismatch repair
T168 831-836 214355 denotes yeast
T167 831-836 D015003 denotes yeast
T172 837-841 CVCL_G669 denotes MLH1
T169 837-841 PR:Q9ZRV4 denotes MLH1
T170 837-841 PR:P38920 denotes MLH1
T171 837-841 PR:Q54KD8 denotes MLH1
T173 837-841 PR:Q9JK91 denotes MLH1
T174 837-841 PR:P97679 denotes MLH1
T175 837-841 PR:Q9P7W6 denotes MLH1
T176 837-841 PR:000010442 denotes MLH1
T177 837-841 PR:P40692 denotes MLH1
T184 842-846 PR:P14242 denotes PMS1
T185 842-846 PR:000012913 denotes PMS1
T188 842-846 PR:Q941I6 denotes PMS1
T189 842-846 PR:P54280 denotes PMS1
T190 842-846 PR:Q5NC83 denotes PMS1
T191 842-846 PR:P54277 denotes PMS1
T192 842-846 PR:Q54QA0 denotes PMS1
T186 842-846 C102203 denotes PMS1
T187 842-846 C102203 denotes PMS1
T194 907-910 CHEBI:16768 denotes MSH
T198 907-910 D009074 denotes MSH
T199 907-910 D009074 denotes MSH
T200 907-911 PR:000010666 denotes MSH2
T201 907-911 PR:P25847 denotes MSH2
T202 907-911 PR:P43246 denotes MSH2
T203 907-911 P22711 denotes MSH2
T204 907-911 PR:P22711 denotes MSH2
T205 907-911 PR:P54275 denotes MSH2
T206 907-911 PR:O74773 denotes MSH2
T207 907-911 PR:P43247 denotes MSH2
T208 907-911 PR:Q553L4 denotes MSH2
T209 907-911 PR:O24617 denotes MSH2
T211 912-915 CHEBI:16768 denotes MSH
T215 912-915 D009074 denotes MSH
T216 912-915 D009074 denotes MSH
T217 912-916 PR:O65607 denotes MSH3
T218 912-916 PR:000010667 denotes MSH3
T219 912-916 PR:Q59Y41 denotes MSH3
T220 912-916 PR:P25336 denotes MSH3
T221 912-916 PR:P20585 denotes MSH3
T222 912-916 PR:P26359 denotes MSH3
T223 912-916 PR:P13705 denotes MSH3
T224 912-916 PR:Q1ZXH0 denotes MSH3
T225 917-924 SO:0100018 denotes binding
T226 917-924 SO:0001091 denotes binding
T227 917-924 GO:0005488 denotes binding
T230 928-931 SO:0000352 denotes DNA
T228 928-931 GO:0005574 denotes DNA
T229 928-931 CHEBI:16991 denotes DNA
T231 928-931 D004247 denotes DNA
T232 959-963 PR:Q9ZRV4 denotes MLH1
T233 959-963 PR:P38920 denotes MLH1
T234 959-963 PR:Q54KD8 denotes MLH1
T236 959-963 PR:Q9JK91 denotes MLH1
T237 959-963 PR:P97679 denotes MLH1
T238 959-963 PR:Q9P7W6 denotes MLH1
T239 959-963 PR:000010442 denotes MLH1
T240 959-963 PR:P40692 denotes MLH1
T235 959-963 CVCL_G669 denotes MLH1
T241 959-976 GO:0032390 denotes MLH1-PMS1 complex
T250 964-968 C102203 denotes PMS1
T251 964-968 C102203 denotes PMS1
T248 964-968 PR:P14242 denotes PMS1
T249 964-968 PR:000012913 denotes PMS1
T252 964-968 PR:Q941I6 denotes PMS1
T253 964-968 PR:P54280 denotes PMS1
T254 964-968 PR:Q5NC83 denotes PMS1
T255 964-968 PR:P54277 denotes PMS1
T256 964-968 PR:Q54QA0 denotes PMS1
T259 1010-1013 SO:0000352 denotes DNA
T258 1010-1013 CHEBI:16991 denotes DNA
T260 1010-1013 D004247 denotes DNA
T257 1010-1013 GO:0005574 denotes DNA
T261 1052-1059 SO:0100018 denotes binding
T262 1052-1059 SO:0001091 denotes binding
T263 1052-1059 GO:0005488 denotes binding
T265 1071-1074 CHEBI:16768 denotes MSH
T269 1071-1074 D009074 denotes MSH
T270 1071-1074 D009074 denotes MSH
T271 1071-1075 PR:000010666 denotes MSH2
T272 1071-1075 PR:P25847 denotes MSH2
T273 1071-1075 PR:P43246 denotes MSH2
T274 1071-1075 P22711 denotes MSH2
T275 1071-1075 PR:P22711 denotes MSH2
T276 1071-1075 PR:P54275 denotes MSH2
T277 1071-1075 PR:O74773 denotes MSH2
T278 1071-1075 PR:P43247 denotes MSH2
T279 1071-1075 PR:Q553L4 denotes MSH2
T280 1071-1075 PR:O24617 denotes MSH2
T282 1076-1079 CHEBI:16768 denotes MSH
T286 1076-1079 D009074 denotes MSH
T287 1076-1079 D009074 denotes MSH
T288 1076-1080 PR:O65607 denotes MSH3
T289 1076-1080 PR:000010667 denotes MSH3
T290 1076-1080 PR:Q59Y41 denotes MSH3
T291 1076-1080 PR:P25336 denotes MSH3
T292 1076-1080 PR:P20585 denotes MSH3
T293 1076-1080 PR:P26359 denotes MSH3
T294 1076-1080 PR:P13705 denotes MSH3
T295 1076-1080 PR:Q1ZXH0 denotes MSH3

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-86 DRI_Approach denotes Enhancement of MSH2-MSH3-mediated mismatch recognition by the yeast MLH1-PMS1 complex.
T2 87-155 DRI_Approach denotes DNA mismatch repair has a key role in maintaining genomic stability.
T3 156-383 DRI_Background denotes Defects in mismatch repair cause elevated spontaneous mutation rates and increased instability of simple repetitive sequences, while mutations in human mismatch repair genes result in hereditary nonpolyposis colorectal cancers.
T4 384-459 DRI_Approach denotes Mismatch recognition represents the first critical step of mismatch repair.
T5 460-606 DRI_Background denotes Genetic and biochemical studies in yeast and humans have indicated a requirement for MSH2-MSH3 and MSH2-MSH6 heterodimers in mismatch recognition.
T6 607-688 DRI_Background denotes These complexes have, to some extent, overlapping mismatch binding specificities.
T7 689-809 DRI_Background denotes MLH1 and PMS1 are the other essential components of mismatch repair, but how they function in this process is not known.
T8 810-943 DRI_Approach denotes We have purified the yeast MLH1-PMS1 heterodimer to near homogeneity, and examined its effect on MSH2-MSH3 binding to DNA mismatches.
T9 944-1081 DRI_Outcome denotes By itself, the MLH1-PMS1 complex shows no affinity for mismatched DNA, but it greatly enhances the mismatch binding ability of MSH2-MSH3.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 87-155 DRI_Approach denotes DNA mismatch repair has a key role in maintaining genomic stability.
T2 156-383 DRI_Background denotes Defects in mismatch repair cause elevated spontaneous mutation rates and increased instability of simple repetitive sequences, while mutations in human mismatch repair genes result in hereditary nonpolyposis colorectal cancers.
T3 384-459 DRI_Approach denotes Mismatch recognition represents the first critical step of mismatch repair.
T4 460-606 DRI_Background denotes Genetic and biochemical studies in yeast and humans have indicated a requirement for MSH2-MSH3 and MSH2-MSH6 heterodimers in mismatch recognition.
T5 607-688 DRI_Background denotes These complexes have, to some extent, overlapping mismatch binding specificities.
T6 689-809 DRI_Background denotes MLH1 and PMS1 are the other essential components of mismatch repair, but how they function in this process is not known.
T7 810-943 DRI_Approach denotes We have purified the yeast MLH1-PMS1 heterodimer to near homogeneity, and examined its effect on MSH2-MSH3 binding to DNA mismatches.
T8 944-1081 DRI_Outcome denotes By itself, the MLH1-PMS1 complex shows no affinity for mismatched DNA, but it greatly enhances the mismatch binding ability of MSH2-MSH3.