PubMed:9366415
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-24 | protein | denotes | CD40 |
| T2 | 59-81 | protein | denotes | nuclear factor-kappa B |
| T3 | 96-109 | cell_type | denotes | B lymphocytes |
| T4 | 111-115 | protein | denotes | CD40 |
| T5 | 129-136 | cell_type | denotes | B cells |
| T6 | 203-207 | protein | denotes | CD40 |
| T7 | 328-350 | protein | denotes | cell surface molecules |
| T8 | 381-395 | cell_type | denotes | memory B cells |
| T9 | 452-456 | protein | denotes | CD40 |
| T10 | 494-504 | protein | denotes | NF-kappa B |
| T11 | 506-516 | protein | denotes | NF-kappa B |
| T12 | 533-537 | protein | denotes | CD40 |
| T13 | 571-581 | protein | denotes | NF-kappa B |
| T14 | 639-649 | protein | denotes | NF-kappa B |
| T15 | 674-700 | cell_line | denotes | mouse B cell transfectants |
| T16 | 712-742 | protein | denotes | wild-type or mutant human CD40 |
| T17 | 756-779 | protein | denotes | CD40 cytoplasmic domain |
| T18 | 819-871 | protein | denotes | 10-amino acid CD40 cytoplasmic signaling determinant |
| T19 | 885-895 | protein | denotes | NF-kappa B |
| T20 | 931-943 | protein | denotes | position 234 |
| T21 | 982-986 | protein | denotes | CD40 |
| T22 | 1004-1036 | protein | denotes | TNF receptor-associated factor 2 |
| T23 | 1038-1043 | protein | denotes | TRAF2 |
| T24 | 1046-1051 | protein | denotes | TRAF3 |
| T25 | 1057-1062 | protein | denotes | TRAF5 |
| T26 | 1085-1095 | protein | denotes | NF-kappa B |
| T27 | 1130-1137 | cell_type | denotes | B cells |
| T28 | 1139-1143 | protein | denotes | CD40 |
| T29 | 1152-1162 | protein | denotes | NF-kappa B |
| T30 | 1201-1206 | protein | denotes | TRAF2 |
| T31 | 1211-1216 | protein | denotes | TRAF5 |
| T32 | 1230-1240 | protein | denotes | NF-kappa B |
| T33 | 1275-1295 | protein | denotes | transmembrane domain |
| T34 | 1299-1303 | protein | denotes | CD40 |
| T35 | 1342-1345 | protein | denotes | p23 |
| T36 | 1379-1383 | protein | denotes | CD40 |
| T37 | 1411-1429 | protein | denotes | cytoplasmic domain |
| T38 | 1478-1493 | protein | denotes | I kappa B alpha |
| T39 | 1499-1513 | protein | denotes | I kappa B beta |
| T40 | 1549-1553 | protein | denotes | CD40 |
| T41 | 1576-1580 | protein | denotes | CD40 |
| T42 | 1590-1600 | protein | denotes | NF-kappa B |
| T43 | 1707-1717 | protein | denotes | NF-kappa B |
| T44 | 1760-1764 | protein | denotes | CD40 |
| T45 | 1813-1819 | protein | denotes | ICAM-1 |
| T46 | 1824-1829 | protein | denotes | LFA-1 |
| T47 | 1840-1850 | protein | denotes | NF-kappa B |
| T48 | 1883-1887 | protein | denotes | CD40 |
| T49 | 1914-1918 | protein | denotes | B7-1 |
| T50 | 1920-1923 | protein | denotes | Fas |
| T51 | 1929-1933 | protein | denotes | CD23 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-110 | Sentence | denotes | Characterization of CD40 signaling determinants regulating nuclear factor-kappa B activation in B lymphocytes. |
| S2 | 111-202 | Sentence | denotes | CD40 signaling to B cells is important for generating an effective humoral immune response. |
| S3 | 203-396 | Sentence | denotes | CD40 ligation leads to B cell activation events such as proliferation, Ig secretion, isotype switching, and up-regulation of cell surface molecules, as well as the generation of memory B cells. |
| S4 | 397-518 | Sentence | denotes | Many of these events are dependent upon the ability of CD40 to activate the transcription factor NF-kappa B (NF-kappa B). |
| S5 | 519-743 | Sentence | denotes | To define the CD40 signaling components upstream of NF-kappa B activation and the functional consequences downstream of NF-kappa B activation, we examined mouse B cell transfectants expressing wild-type or mutant human CD40. |
| S6 | 744-907 | Sentence | denotes | Analysis of CD40 cytoplasmic domain truncation and point mutants defined a 10-amino acid CD40 cytoplasmic signaling determinant required for NF-kappa B activation. |
| S7 | 908-1107 | Sentence | denotes | A threonine residue at position 234, previously shown to be important for CD40 association with TNF receptor-associated factor 2 (TRAF2), TRAF3, and TRAF5, was not required for NF-kappa B activation. |
| S8 | 1108-1229 | Sentence | denotes | This suggests that in B cells, CD40-induced NF-kappa B activation can occur independently of TRAF2 and TRAF5 association. |
| S9 | 1230-1430 | Sentence | denotes | NF-kappa B activation was independent of the transmembrane domain of CD40, suggesting that it is independent of p23, a molecule that associates with CD40 in a region other than the cytoplasmic domain. |
| S10 | 1431-1623 | Sentence | denotes | Proteasome-dependent inhibitory kappa B alpha (I kappa B alpha) and I kappa B beta degradation occurred downstream of CD40 ligation and preceded CD40-mediated NF-kappa B nuclear translocation. |
| S11 | 1624-1706 | Sentence | denotes | CD40- or pervanadate-mediated I kappa B tyrosine phosphorylation was not detected. |
| S12 | 1707-1830 | Sentence | denotes | NF-kappa B activation correlated with the ability of CD40 to induce Ab secretion and the up-regulation of ICAM-1 and LFA-1. |
| S13 | 1831-1934 | Sentence | denotes | However, NF-kappa B activation was insufficient for CD40-mediated up-regulation of B7-1, Fas, and CD23. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 96-109 | NP | denotes | B lymphocytes |
| C2 | 129-136 | NP | denotes | B cells |
| C3 | 203-216 | NP | denotes | CD40 ligation |
| C4 | 226-395 | NP | denotes | B cell activation events such as proliferation, Ig secretion, isotype switching, and up-regulation of cell surface molecules, as well as the generation of memory B cells |
| C5 | 405-417 | NP | denotes | these events |
| C6 | 452-456 | NP | denotes | CD40 |
| C7 | 571-592 | NP | denotes | NF-kappa B activation |
| C8 | 639-660 | NP | denotes | NF-kappa B activation |
| C9 | 885-906 | NP | denotes | NF-kappa B activation |
| C10 | 1085-1106 | NP | denotes | NF-kappa B activation |
| C11 | 1130-1137 | NP | denotes | B cells |
| C12 | 1230-1251 | NP | denotes | NF-kappa B activation |
| C13 | 1299-1303 | NP | denotes | CD40 |
| C14 | 1321-1323 | NP | denotes | it |
| C15 | 1347-1357 | NP | denotes | a molecule |
| C16 | 1358-1362 | NP | denotes | that |
| C17 | 1379-1383 | NP | denotes | CD40 |
| C18 | 1549-1562 | NP | denotes | CD40 ligation |
| C19 | 1707-1728 | NP | denotes | NF-kappa B activation |
| C20 | 1760-1764 | NP | denotes | CD40 |
| C21 | 1840-1861 | NP | denotes | NF-kappa B activation |
| R1 | C2 | C1 | coref-ident | B cells,B lymphocytes |
| R2 | C5 | C4 | coref-ident | these events,"B cell activation events such as proliferation, Ig secretion, isotype switching, and up-regulation of cell surface molecules, as well as the generation of memory B cells" |
| R3 | C8 | C7 | coref-ident | NF-kappa B activation,NF-kappa B activation |
| R4 | C9 | C8 | coref-ident | NF-kappa B activation,NF-kappa B activation |
| R5 | C10 | C9 | coref-ident | NF-kappa B activation,NF-kappa B activation |
| R6 | C11 | C2 | coref-ident | B cells,B cells |
| R7 | C12 | C10 | coref-ident | NF-kappa B activation,NF-kappa B activation |
| R8 | C13 | C6 | coref-ident | CD40,CD40 |
| R9 | C14 | C12 | coref-pron | it,NF-kappa B activation |
| R10 | C16 | C15 | coref-relat | that,a molecule |
| R11 | C17 | C13 | coref-ident | CD40,CD40 |
| R12 | C18 | C3 | coref-ident | CD40 ligation,CD40 ligation |
| R13 | C19 | C12 | coref-ident | NF-kappa B activation,NF-kappa B activation |
| R14 | C20 | C17 | coref-ident | CD40,CD40 |
| R15 | C21 | C19 | coref-ident | NF-kappa B activation,NF-kappa B activation |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 20-24 | protein_molecule | denotes | CD40 |
| T2 | 59-81 | protein_complex | denotes | nuclear factor-kappa B |
| T3 | 96-109 | cell_type | denotes | B lymphocytes |
| T4 | 111-115 | protein_molecule | denotes | CD40 |
| T5 | 129-136 | cell_type | denotes | B cells |
| T6 | 178-201 | other_name | denotes | humoral immune response |
| T7 | 203-207 | protein_molecule | denotes | CD40 |
| T8 | 226-250 | other_name | denotes | B cell activation events |
| T9 | 259-272 | other_name | denotes | proliferation |
| T10 | 274-286 | other_name | denotes | Ig secretion |
| T11 | 288-305 | other_name | denotes | isotype switching |
| T12 | 311-324 | other_name | denotes | up-regulation |
| T13 | 328-350 | protein_family_or_group | denotes | cell surface molecules |
| T14 | 381-395 | cell_type | denotes | memory B cells |
| T15 | 452-456 | protein_molecule | denotes | CD40 |
| T16 | 494-504 | protein_complex | denotes | NF-kappa B |
| T17 | 506-516 | protein_complex | denotes | NF-kappa B |
| T18 | 533-537 | protein_molecule | denotes | CD40 |
| T19 | 571-581 | protein_complex | denotes | NF-kappa B |
| T20 | 639-649 | protein_complex | denotes | NF-kappa B |
| T21 | 674-700 | cell_line | denotes | mouse B cell transfectants |
| T22 | 756-760 | protein_molecule | denotes | CD40 |
| T23 | 819-832 | protein_domain_or_region | denotes | 10-amino acid |
| T24 | 833-837 | protein_molecule | denotes | CD40 |
| T25 | 885-895 | protein_complex | denotes | NF-kappa B |
| T26 | 910-927 | amino_acid_monomer | denotes | threonine residue |
| T27 | 931-943 | protein_domain_or_region | denotes | position 234 |
| T28 | 982-986 | protein_molecule | denotes | CD40 |
| T29 | 1004-1036 | protein_molecule | denotes | TNF receptor-associated factor 2 |
| T30 | 1038-1043 | protein_molecule | denotes | TRAF2 |
| T31 | 1046-1051 | protein_molecule | denotes | TRAF3 |
| T32 | 1057-1062 | protein_molecule | denotes | TRAF5 |
| T33 | 1085-1095 | protein_complex | denotes | NF-kappa B |
| T34 | 1130-1137 | cell_type | denotes | B cells |
| T35 | 1139-1143 | protein_molecule | denotes | CD40 |
| T36 | 1152-1162 | protein_complex | denotes | NF-kappa B |
| T37 | 1201-1206 | protein_molecule | denotes | TRAF2 |
| T38 | 1211-1216 | protein_molecule | denotes | TRAF5 |
| T39 | 1230-1240 | protein_complex | denotes | NF-kappa B |
| T40 | 1275-1295 | protein_domain_or_region | denotes | transmembrane domain |
| T41 | 1299-1303 | protein_molecule | denotes | CD40 |
| T42 | 1342-1345 | protein_molecule | denotes | p23 |
| T43 | 1379-1383 | protein_molecule | denotes | CD40 |
| T44 | 1411-1429 | protein_domain_or_region | denotes | cytoplasmic domain |
| T45 | 1478-1493 | protein_molecule | denotes | I kappa B alpha |
| T46 | 1499-1513 | protein_molecule | denotes | I kappa B beta |
| T47 | 1549-1553 | protein_molecule | denotes | CD40 |
| T48 | 1576-1580 | protein_molecule | denotes | CD40 |
| T49 | 1590-1600 | protein_complex | denotes | NF-kappa B |
| T50 | 1707-1717 | protein_complex | denotes | NF-kappa B |
| T51 | 1760-1764 | protein_molecule | denotes | CD40 |
| T52 | 1775-1787 | other_name | denotes | Ab secretion |
| T53 | 1813-1819 | protein_molecule | denotes | ICAM-1 |
| T54 | 1824-1829 | protein_molecule | denotes | LFA-1 |
| T55 | 1840-1850 | protein_complex | denotes | NF-kappa B |
| T56 | 1883-1887 | protein_molecule | denotes | CD40 |
| T57 | 1914-1918 | protein_molecule | denotes | B7-1 |
| T58 | 1920-1923 | protein_molecule | denotes | Fas |
| T59 | 1929-1933 | protein_molecule | denotes | CD23 |