PubMed:9360520 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/9360520","sourcedb":"PubMed","sourceid":"9360520","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/9360520","text":"Autosomal dominant neurohypophyseal diabetes insipidus associated with a missense mutation encoding Gly23--\u003eVal in neurophysin II.\nAutosomal dominant neurohypophyseal diabetes insipidus (ADNDI) is an inherited disease caused by progressive degeneration of the magnocellular neurons of the hypothalamus leading to decreased ability to produce the hormone arginine vasopressin (AVP). Affected individuals are not symptomatic at birth, but usually develop diabetes insipidus at 1-6 yr of age. The genetic locus of the disease is the AVP-neurophysin II (NPII) gene, and mutations that cause ADNDI have been found in both the signal peptide of the prepro-AVP-NPII precursor and within NPII itself. An affected girl who presented at 9 months of age and her similarly affected younger brother and father were all found to have a novel missense mutation (G1758--\u003eT) encoding the amino acid substitution Gly23--\u003eVal within NPII. The mutation was confirmed by restriction endonuclease analysis. A T1-weighted magnetic resonance imaging of the father's pituitary gland demonstrates an attenuated posterior pituitary bright spot. This mutation may be valuable for developing models of dominantly inherited neurodegeneration, as the early age of onset of symptoms suggests that this mutation may be particularly deleterious to the magnocellular neuron.","tracks":[{"project":"NCBIDiseaseCorpus","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease:OMIM:125700"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease:OMIM:125700"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease:OMIM:125700"},{"id":"T4","span":{"begin":200,"end":217},"obj":"DiseaseClass:D030342"},{"id":"T5","span":{"begin":453,"end":471},"obj":"SpecificDisease:D003919"},{"id":"T6","span":{"begin":587,"end":592},"obj":"SpecificDisease:OMIM:125700"},{"id":"T7","span":{"begin":1173,"end":1211},"obj":"DiseaseClass:D020271"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T2","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T3","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T4","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T5","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T6","pred":"source","obj":"NCBIDiseaseCorpus"},{"subj":"T7","pred":"source","obj":"NCBIDiseaseCorpus"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":115,"end":129},"obj":"gene:551"},{"id":"T1","span":{"begin":19,"end":54},"obj":"disease:C0687720"},{"id":"T2","span":{"begin":376,"end":379},"obj":"gene:551"},{"id":"T3","span":{"begin":200,"end":217},"obj":"disease:C0019247"},{"id":"T4","span":{"begin":354,"end":374},"obj":"gene:551"},{"id":"T5","span":{"begin":200,"end":217},"obj":"disease:C0019247"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"}]},{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":36,"end":54},"obj":"HP:0000873"},{"id":"AB1","span":{"begin":453,"end":471},"obj":"HP:0000873"},{"id":"AB2","span":{"begin":1194,"end":1211},"obj":"HP:0002180"}],"attributes":[{"subj":"TI1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"9360520-0#115#129#gene551","span":{"begin":115,"end":129},"obj":"gene551"},{"id":"9360520-0#19#54#diseaseC0687720","span":{"begin":19,"end":54},"obj":"diseaseC0687720"}],"relations":[{"id":"115#129#gene55119#54#diseaseC0687720","pred":"associated_with","subj":"9360520-0#115#129#gene551","obj":"9360520-0#19#54#diseaseC0687720"}],"attributes":[{"subj":"9360520-0#115#129#gene551","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"9360520-0#19#54#diseaseC0687720","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"NCBI-Disease-Test","denotations":[{"id":"T423","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T424","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T425","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T426","span":{"begin":200,"end":217},"obj":"DiseaseClass"},{"id":"T427","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T428","span":{"begin":587,"end":592},"obj":"SpecificDisease"},{"id":"T429","span":{"begin":1173,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"id":"A423","pred":"database_id","subj":"T423","obj":"OMIM:125700"},{"id":"A424","pred":"database_id","subj":"T424","obj":"OMIM:125700"},{"id":"A425","pred":"database_id","subj":"T425","obj":"OMIM:125700"},{"id":"A426","pred":"database_id","subj":"T426","obj":"D030342"},{"id":"A427","pred":"database_id","subj":"T427","obj":"D003919"},{"id":"A428","pred":"database_id","subj":"T428","obj":"OMIM:125700"},{"id":"A429","pred":"database_id","subj":"T429","obj":"D020271"},{"subj":"T423","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T424","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T425","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T426","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T427","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T428","pred":"source","obj":"NCBI-Disease-Test"},{"subj":"T429","pred":"source","obj":"NCBI-Disease-Test"}]},{"project":"NCBI-Disease-Test-Assistant-Knowledge","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"CompositeMention"},{"id":"T2","span":{"begin":115,"end":129},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":150,"end":193},"obj":"CompositeMention"},{"id":"T4","span":{"begin":354,"end":380},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":530,"end":560},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":587,"end":592},"obj":"CompositeMention"},{"id":"T8","span":{"begin":650,"end":668},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":680,"end":684},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":914,"end":918},"obj":"SpecificDisease"},{"id":"T11","span":{"begin":1194,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"},{"subj":"T11","pred":"source","obj":"NCBI-Disease-Test-Assistant-Knowledge"}]},{"project":"NCBI-Disease-Test-4o-NoGuidelineInPrompt","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":150,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":210,"end":217},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":515,"end":522},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":1194,"end":1211},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Test-4o-NoGuidelineInPrompt"}]},{"project":"NCBI-Disease-Test-4o-GuidelineInPrompt","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Test-4o-GuidelineInPrompt"}]},{"project":"NCBI-Disease-Corpus-UpdatedGuideline","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":131,"end":185},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":376,"end":379},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":530,"end":560},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":587,"end":592},"obj":"DiseaseClass"},{"id":"T8","span":{"begin":650,"end":668},"obj":"SpecificDisease"},{"id":"T9","span":{"begin":680,"end":684},"obj":"SpecificDisease"},{"id":"T10","span":{"begin":914,"end":918},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T8","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T9","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"},{"subj":"T10","pred":"source","obj":"NCBI-Disease-Corpus-UpdatedGuideline"}]},{"project":"NCBI-Disease-Corpus-humanintheloop","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":150,"end":185},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":1194,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-humanintheloop"}]},{"project":"NCBI-Disease-Corpus-rezarta1","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":150,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-rezarta1"}]},{"project":"NCBI-Disease-Corpus-All","denotations":[{"id":"T423","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T424","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T425","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T426","span":{"begin":200,"end":217},"obj":"DiseaseClass"},{"id":"T427","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T428","span":{"begin":587,"end":592},"obj":"SpecificDisease"},{"id":"T429","span":{"begin":1173,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"id":"A423","pred":"database_id","subj":"T423","obj":"OMIM:125700"},{"id":"A424","pred":"database_id","subj":"T424","obj":"OMIM:125700"},{"id":"A425","pred":"database_id","subj":"T425","obj":"OMIM:125700"},{"id":"A426","pred":"database_id","subj":"T426","obj":"D030342"},{"id":"A427","pred":"database_id","subj":"T427","obj":"D003919"},{"id":"A428","pred":"database_id","subj":"T428","obj":"OMIM:125700"},{"id":"A429","pred":"database_id","subj":"T429","obj":"D020271"},{"subj":"T423","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T424","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T425","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T426","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T427","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T428","pred":"source","obj":"NCBI-Disease-Corpus-All"},{"subj":"T429","pred":"source","obj":"NCBI-Disease-Corpus-All"}]},{"project":"NCBI-Disease-Corpus-2stage-All","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":150,"end":185},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-2stage-All"}]},{"project":"NCBI-Disease-Corpus-rezarta-All","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":150,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-rezarta-All"}]},{"project":"NCBI-Disease-Corpus-4oGuideline-All","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-4oGuideline-All"}]},{"project":"NCBI-Disease-Corpus-Simple-All","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":193},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":210,"end":217},"obj":"DiseaseClass"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":515,"end":522},"obj":"DiseaseClass"},{"id":"T6","span":{"begin":587,"end":592},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":1194,"end":1259},"obj":"CompositeMention"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-Simple-All"}]},{"project":"NCBI-Disease-Corpus-o3-2","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-o3-2"}]},{"project":"NCBI-Disease-Corpus-high-o3-1","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-1"}]},{"project":"NCBI-Disease-Corpus-high-o3-2","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-high-o3-2"}]},{"project":"12345","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":150,"end":185},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"12345"},{"subj":"T2","pred":"source","obj":"12345"},{"subj":"T3","pred":"source","obj":"12345"},{"subj":"T4","pred":"source","obj":"12345"},{"subj":"T5","pred":"source","obj":"12345"}]},{"project":"123456","denotations":[{"id":"T1","span":{"begin":19,"end":54},"obj":"DiseaseClass"},{"id":"T2","span":{"begin":150,"end":185},"obj":"DiseaseClass"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":587,"end":592},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":1194,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"subj":"T1","pred":"source","obj":"123456"},{"subj":"T2","pred":"source","obj":"123456"},{"subj":"T3","pred":"source","obj":"123456"},{"subj":"T4","pred":"source","obj":"123456"},{"subj":"T5","pred":"source","obj":"123456"},{"subj":"T6","pred":"source","obj":"123456"}]},{"project":"NCBI-Disease-Corpus-GPT5-withguidelines","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":200,"end":217},"obj":"DiseaseClass"},{"id":"T5","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-withguidelines"}]},{"project":"NCBI-Disease-Corpus-GPT5-noguidelines","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T5","span":{"begin":1173,"end":1193},"obj":"Modifier"},{"id":"T6","span":{"begin":1194,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-noguidelines"}]},{"project":"NCBI-Disease-Corpus-GPT5-guidelineprompt","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":200,"end":217},"obj":"DiseaseClass"},{"id":"T5","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":587,"end":592},"obj":"SpecificDisease"},{"id":"T7","span":{"begin":1173,"end":1211},"obj":"DiseaseClass"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"},{"subj":"T7","pred":"source","obj":"NCBI-Disease-Corpus-GPT5-guidelineprompt"}]},{"project":"NCBI-Disease-Corpus-Moderated1","denotations":[{"id":"T1","span":{"begin":0,"end":54},"obj":"SpecificDisease"},{"id":"T2","span":{"begin":131,"end":185},"obj":"SpecificDisease"},{"id":"T3","span":{"begin":187,"end":192},"obj":"SpecificDisease"},{"id":"T4","span":{"begin":200,"end":217},"obj":"DiseaseClass"},{"id":"T5","span":{"begin":453,"end":471},"obj":"SpecificDisease"},{"id":"T6","span":{"begin":587,"end":592},"obj":"SpecificDisease"}],"attributes":[{"subj":"T1","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T2","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T3","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T4","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T5","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"},{"subj":"T6","pred":"source","obj":"NCBI-Disease-Corpus-Moderated1"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"NCBIDiseaseCorpus","color":"#ec93de","default":true},{"id":"DisGeNET","color":"#93ecdf"},{"id":"PubCasesHPO","color":"#ecc593"},{"id":"DisGeNET5_gene_disease","color":"#ab93ec"},{"id":"NCBI-Disease-Test","color":"#94ec93"},{"id":"NCBI-Disease-Test-Assistant-Knowledge","color":"#ec93ae"},{"id":"NCBI-Disease-Test-4o-NoGuidelineInPrompt","color":"#93c8ec"},{"id":"NCBI-Disease-Test-4o-GuidelineInPrompt","color":"#e2ec93"},{"id":"NCBI-Disease-Corpus-UpdatedGuideline","color":"#dc93ec"},{"id":"NCBI-Disease-Corpus-humanintheloop","color":"#93ecc2"},{"id":"NCBI-Disease-Corpus-rezarta1","color":"#eca893"},{"id":"NCBI-Disease-Corpus-All","color":"#9398ec"},{"id":"NCBI-Disease-Corpus-2stage-All","color":"#b2ec93"},{"id":"NCBI-Disease-Corpus-rezarta-All","color":"#ec93cc"},{"id":"NCBI-Disease-Corpus-4oGuideline-All","color":"#93e6ec"},{"id":"NCBI-Disease-Corpus-Simple-All","color":"#ecd893"},{"id":"NCBI-Disease-Corpus-o3-2","color":"#be93ec"},{"id":"NCBI-Disease-Corpus-high-o3-1","color":"#93eca4"},{"id":"NCBI-Disease-Corpus-high-o3-2","color":"#ec939c"},{"id":"12345","color":"#93b6ec"},{"id":"123456","color":"#d0ec93"},{"id":"NCBI-Disease-Corpus-GPT5-withguidelines","color":"#ec93ea"},{"id":"NCBI-Disease-Corpus-GPT5-noguidelines","color":"#93ecd4"},{"id":"NCBI-Disease-Corpus-GPT5-guidelineprompt","color":"#ecba93"},{"id":"NCBI-Disease-Corpus-Moderated1","color":"#a093ec"}]}]}}