PubMed:9353251
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein | denotes | CD30 |
| T2 | 30-35 | protein | denotes | TRAF2 |
| T3 | 77-81 | protein | denotes | TRAF |
| T4 | 126-130 | protein | denotes | CD30 |
| T5 | 136-157 | protein | denotes | cell-surface receptor |
| T6 | 244-264 | protein | denotes | transcription factor |
| T7 | 265-274 | protein | denotes | NF-kappaB |
| T8 | 276-280 | protein | denotes | CD30 |
| T9 | 360-371 | cell_type | denotes | lymphocytes |
| T10 | 413-417 | protein | denotes | CD30 |
| T11 | 495-532 | protein | denotes | type 1 tumor necrosis factor receptor |
| T12 | 534-539 | protein | denotes | TNFR1 |
| T13 | 581-599 | protein | denotes | TRAF-binding sites |
| T14 | 611-615 | protein | denotes | CD30 |
| T15 | 616-634 | protein | denotes | cytoplasmic domain |
| T16 | 685-690 | protein | denotes | TRAF2 |
| T17 | 694-722 | protein | denotes | signal transduction molecule |
| T18 | 748-753 | protein | denotes | TNFR1 |
| T19 | 802-809 | protein | denotes | kinases |
| T20 | 814-835 | protein | denotes | transcription factors |
| T21 | 844-848 | protein | denotes | CD30 |
| T22 | 895-900 | protein | denotes | TRAF2 |
| T23 | 908-926 | protein | denotes | cytoplasmic domain |
| T24 | 930-934 | protein | denotes | CD30 |
| T25 | 969-974 | protein | denotes | TRAF2 |
| T26 | 1002-1007 | protein | denotes | TRAF1 |
| T27 | 1060-1064 | protein | denotes | CD30 |
| T28 | 1159-1164 | protein | denotes | TRAF2 |
| T29 | 1193-1198 | protein | denotes | TRAF2 |
| T30 | 1207-1228 | protein | denotes | coassociated proteins |
| T31 | 1317-1341 | protein | denotes | death-inducing receptors |
| T32 | 1350-1355 | protein | denotes | TNFR1 |
| T33 | 1406-1428 | protein | denotes | dominant-negative form |
| T34 | 1432-1437 | protein | denotes | TRAF2 |
| T35 | 1462-1467 | protein | denotes | TNFR1 |
| T36 | 1542-1546 | protein | denotes | CD30 |
| T37 | 1565-1585 | protein | denotes | TRAF-binding members |
| T38 | 1593-1609 | protein | denotes | TNFR superfamily |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-125 | Sentence | denotes | CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. |
| S2 | 126-275 | Sentence | denotes | CD30 is a cell-surface receptor that can augment lymphocyte activation and survival through its ability to induce the transcription factor NF-kappaB. |
| S3 | 276-372 | Sentence | denotes | CD30, however, has also been implicated in the induction of apoptotic cell death of lymphocytes. |
| S4 | 373-541 | Sentence | denotes | Here we show that one of the effects of CD30 signal transduction is to render cells sensitive to apoptosis induced by the type 1 tumor necrosis factor receptor (TNFR1). |
| S5 | 542-635 | Sentence | denotes | This sensitization is dependent on the TRAF-binding sites within the CD30 cytoplasmic domain. |
| S6 | 636-836 | Sentence | denotes | One of the proteins that binds to these sites is TRAF2, a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors. |
| S7 | 837-1023 | Sentence | denotes | During CD30 signal transduction, we found that binding of TRAF2 to the cytoplasmic domain of CD30 results in the rapid depletion of TRAF2 and the associated protein TRAF1 by proteolysis. |
| S8 | 1024-1165 | Sentence | denotes | These data suggest a model in which CD30 limits its own ability to transduce cell survival signals through signal-coupled depletion of TRAF2. |
| S9 | 1166-1356 | Sentence | denotes | Depletion of intracellular TRAF2 and its coassociated proteins also increased the sensitivity of the cell to undergoing apoptosis during activation of death-inducing receptors such as TNFR1. |
| S10 | 1357-1483 | Sentence | denotes | Consistent with this hypothesis, expression of a dominant-negative form of TRAF2 was found to potentiate TNFR1-mediated death. |
| S11 | 1484-1649 | Sentence | denotes | These studies provide a potential mechanism through which CD30, as well as other TRAF-binding members of the TNFR superfamily, can negatively regulate cell survival. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 30-35 | NP | denotes | TRAF2 |
| C2 | 111-124 | NP | denotes | cell survival |
| C3 | 126-130 | NP | denotes | CD30 |
| C4 | 134-157 | NP | denotes | a cell-surface receptor |
| C5 | 158-162 | NP | denotes | that |
| C6 | 218-221 | NP | denotes | its |
| C7 | 276-280 | NP | denotes | CD30 |
| C9 | 413-437 | NP | denotes | CD30 signal transduction |
| C8 | 391-437 | NP | denotes | one of the effects of CD30 signal transduction |
| C10 | 491-540 | NP | denotes | the type 1 tumor necrosis factor receptor (TNFR1) |
| C11 | 542-560 | NP | denotes | This sensitization |
| C13 | 607-634 | NP | denotes | the CD30 cytoplasmic domain |
| C12 | 577-634 | NP | denotes | the TRAF-binding sites within the CD30 cytoplasmic domain |
| C14 | 643-655 | NP | denotes | the proteins |
| C15 | 656-660 | NP | denotes | that |
| C16 | 670-681 | NP | denotes | these sites |
| C17 | 685-690 | NP | denotes | TRAF2 |
| C19 | 692-722 | NP | denotes | a signal transduction molecule |
| C20 | 723-727 | NP | denotes | that |
| C21 | 748-753 | NP | denotes | TNFR1 |
| C18 | 692-835 | NP | denotes | a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors |
| C22 | 844-868 | NP | denotes | CD30 signal transduction |
| C23 | 895-900 | NP | denotes | TRAF2 |
| C25 | 930-934 | NP | denotes | CD30 |
| C24 | 904-934 | NP | denotes | the cytoplasmic domain of CD30 |
| C26 | 969-974 | NP | denotes | TRAF2 |
| C27 | 979-1007 | NP | denotes | the associated protein TRAF1 |
| C28 | 1043-1050 | NP | denotes | a model |
| C29 | 1054-1059 | NP | denotes | which |
| C30 | 1060-1064 | NP | denotes | CD30 |
| C31 | 1072-1075 | NP | denotes | its |
| C32 | 1159-1164 | NP | denotes | TRAF2 |
| C33 | 1179-1198 | NP | denotes | intracellular TRAF2 |
| C34 | 1203-1206 | NP | denotes | its |
| C35 | 1350-1355 | NP | denotes | TNFR1 |
| C36 | 1432-1437 | NP | denotes | TRAF2 |
| C37 | 1506-1527 | NP | denotes | a potential mechanism |
| C38 | 1536-1541 | NP | denotes | which |
| C39 | 1542-1546 | NP | denotes | CD30 |
| C40 | 1635-1648 | NP | denotes | cell survival |
| R1 | C5 | C4 | coref-relat | that,a cell-surface receptor |
| R2 | C6 | C4 | coref-pron | its,a cell-surface receptor |
| R3 | C7 | C3 | coref-ident | CD30,CD30 |
| R4 | C11 | C8 | coref-ident | This sensitization,one of the effects of CD30 signal transduction |
| R5 | C15 | C14 | coref-relat | that,the proteins |
| R6 | C16 | C12 | coref-ident | these sites,the TRAF-binding sites within the CD30 cytoplasmic domain |
| R7 | C17 | C1 | coref-ident | TRAF2,TRAF2 |
| R8 | C20 | C19 | coref-relat | that,a signal transduction molecule |
| R9 | C21 | C10 | coref-ident | TNFR1,the type 1 tumor necrosis factor receptor (TNFR1) |
| R10 | C18 | C17 | coref-appos | a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors,TRAF2 |
| R11 | C22 | C9 | coref-ident | CD30 signal transduction,CD30 signal transduction |
| R12 | C23 | C17 | coref-ident | TRAF2,TRAF2 |
| R13 | C25 | C7 | coref-ident | CD30,CD30 |
| R14 | C24 | C13 | coref-ident | the cytoplasmic domain of CD30,the CD30 cytoplasmic domain |
| R15 | C26 | C23 | coref-ident | TRAF2,TRAF2 |
| R16 | C27 | C21 | coref-ident | the associated protein TRAF1,TNFR1 |
| R17 | C29 | C28 | coref-relat | which,a model |
| R18 | C30 | C25 | coref-ident | CD30,CD30 |
| R19 | C31 | C30 | coref-pron | its,CD30 |
| R20 | C32 | C26 | coref-ident | TRAF2,TRAF2 |
| R21 | C34 | C33 | coref-pron | its,intracellular TRAF2 |
| R22 | C35 | C27 | coref-ident | TNFR1,the associated protein TRAF1 |
| R23 | C36 | C32 | coref-ident | TRAF2,TRAF2 |
| R24 | C38 | C37 | coref-relat | which,a potential mechanism |
| R25 | C39 | C30 | coref-ident | CD30,CD30 |
| R26 | C40 | C2 | coref-ident | cell survival,cell survival |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein_molecule | denotes | CD30 |
| T2 | 30-35 | protein_molecule | denotes | TRAF2 |
| T3 | 54-73 | other_name | denotes | negative regulation |
| T4 | 77-81 | protein_family_or_group | denotes | TRAF |
| T5 | 126-130 | protein_molecule | denotes | CD30 |
| T6 | 136-157 | protein_family_or_group | denotes | cell-surface receptor |
| T7 | 175-196 | other_name | denotes | lymphocyte activation |
| T8 | 244-264 | protein_family_or_group | denotes | transcription factor |
| T9 | 265-274 | protein_complex | denotes | NF-kappaB |
| T10 | 276-280 | protein_molecule | denotes | CD30 |
| T11 | 336-356 | other_name | denotes | apoptotic cell death |
| T12 | 360-371 | cell_type | denotes | lymphocytes |
| T13 | 413-417 | protein_molecule | denotes | CD30 |
| T14 | 470-479 | other_name | denotes | apoptosis |
| T15 | 495-532 | protein_molecule | denotes | type 1 tumor necrosis factor receptor |
| T16 | 534-539 | protein_molecule | denotes | TNFR1 |
| T17 | 581-599 | protein_domain_or_region | denotes | TRAF-binding sites |
| T18 | 611-615 | protein_molecule | denotes | CD30 |
| T19 | 616-634 | protein_domain_or_region | denotes | cytoplasmic domain |
| T20 | 685-690 | protein_molecule | denotes | TRAF2 |
| T21 | 694-722 | protein_family_or_group | denotes | signal transduction molecule |
| T22 | 748-753 | protein_molecule | denotes | TNFR1 |
| T23 | 802-809 | protein_family_or_group | denotes | kinases |
| T24 | 814-835 | protein_family_or_group | denotes | transcription factors |
| T25 | 844-848 | protein_molecule | denotes | CD30 |
| T26 | 895-900 | protein_molecule | denotes | TRAF2 |
| T27 | 908-926 | protein_domain_or_region | denotes | cytoplasmic domain |
| T28 | 930-934 | protein_molecule | denotes | CD30 |
| T29 | 969-974 | protein_molecule | denotes | TRAF2 |
| T30 | 1002-1007 | protein_molecule | denotes | TRAF1 |
| T31 | 1060-1064 | protein_molecule | denotes | CD30 |
| T32 | 1131-1155 | other_name | denotes | signal-coupled depletion |
| T33 | 1159-1164 | protein_molecule | denotes | TRAF2 |
| T34 | 1193-1198 | protein_molecule | denotes | TRAF2 |
| T35 | 1207-1228 | protein_family_or_group | denotes | coassociated proteins |
| T36 | 1286-1295 | other_name | denotes | apoptosis |
| T37 | 1317-1341 | protein_family_or_group | denotes | death-inducing receptors |
| T38 | 1350-1355 | protein_molecule | denotes | TNFR1 |
| T39 | 1406-1428 | protein_family_or_group | denotes | dominant-negative form |
| T40 | 1432-1437 | protein_molecule | denotes | TRAF2 |
| T41 | 1462-1467 | protein_molecule | denotes | TNFR1 |
| T42 | 1542-1546 | protein_molecule | denotes | CD30 |
| T43 | 1565-1585 | protein_family_or_group | denotes | TRAF-binding members |
| T44 | 1593-1609 | protein_family_or_group | denotes | TNFR superfamily |