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PubMed:9348314 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta.
T2 103-264 Sentence denotes In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression.
T3 265-326 Sentence denotes The molecular basis of GC insensitivity, however, is unknown.
T4 327-536 Sentence denotes Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity of the classic GCR, termed GCR-alpha.
T5 537-751 Sentence denotes In the current study, we demonstrate that GC-insensitive asthma is associated with a significantly higher number of GCR-beta-immunoreactive cells in peripheral blood than GC-sensitive asthmatics or normal controls.
T6 752-891 Sentence denotes Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
T7 892-1058 Sentence denotes These abnormalities can be reproduced by transfection of cell lines with the GCR-beta gene resulting in significant reduction of their GCR-alpha DNA binding capacity.
T8 1059-1206 Sentence denotes We conclude that increased expression of GCR-beta is cytokine inducible and may account for GC insensitivity in this common inflammatory condition.
T1 0-102 Sentence denotes Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta.
T2 103-264 Sentence denotes In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression.
T3 265-326 Sentence denotes The molecular basis of GC insensitivity, however, is unknown.
T4 327-536 Sentence denotes Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity of the classic GCR, termed GCR-alpha.
T5 537-751 Sentence denotes In the current study, we demonstrate that GC-insensitive asthma is associated with a significantly higher number of GCR-beta-immunoreactive cells in peripheral blood than GC-sensitive asthmatics or normal controls.
T6 752-891 Sentence denotes Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
T7 892-1058 Sentence denotes These abnormalities can be reproduced by transfection of cell lines with the GCR-beta gene resulting in significant reduction of their GCR-alpha DNA binding capacity.
T8 1059-1206 Sentence denotes We conclude that increased expression of GCR-beta is cytokine inducible and may account for GC insensitivity in this common inflammatory condition.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 653-656 gene:2908 denotes GCR
T1 594-600 disease:C0004096 denotes asthma
R1 T0 T1 associated_with GCR,asthma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 73-101 protein denotes glucocorticoid receptor beta
T2 355-388 RNA denotes GC receptor (R) pre-messenger RNA
T3 408-411 protein denotes GCR
T4 420-428 protein denotes GCR-beta
T5 514-517 protein denotes GCR
T6 526-535 protein denotes GCR-alpha
T7 653-682 cell_type denotes GCR-beta-immunoreactive cells
T8 887-890 protein denotes GCR
T9 949-959 cell_line denotes cell lines
T10 969-977 protein denotes GCR-beta
T11 1027-1036 protein denotes GCR-alpha
T12 1100-1108 protein denotes GCR-beta
T13 1112-1120 protein denotes cytokine

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
9348314-5#135#138#gene2908 887-890 gene2908 denotes GCR
9348314-5#55#61#diseaseC0004096 807-813 diseaseC0004096 denotes asthma
135#138#gene290855#61#diseaseC0004096 9348314-5#135#138#gene2908 9348314-5#55#61#diseaseC0004096 associated_with GCR,asthma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-102 Sentence denotes Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta.
S2 103-264 Sentence denotes In many chronic inflammatory disorders, glucocorticoid (GC) insensitivity is a challenging clinical problem associated with life-threatening disease progression.
S3 265-326 Sentence denotes The molecular basis of GC insensitivity, however, is unknown.
S4 327-536 Sentence denotes Alternative splicing of the GC receptor (R) pre-messenger RNA generates a second GCR, termed GCR-beta, which does not bind GCs but antagonizes the transactivating activity of the classic GCR, termed GCR-alpha.
S5 537-751 Sentence denotes In the current study, we demonstrate that GC-insensitive asthma is associated with a significantly higher number of GCR-beta-immunoreactive cells in peripheral blood than GC-sensitive asthmatics or normal controls.
S6 752-891 Sentence denotes Furthermore, we show that patients with GC-insensitive asthma have cytokine-induced abnormalities in the DNA binding capability of the GCR.
S7 892-1058 Sentence denotes These abnormalities can be reproduced by transfection of cell lines with the GCR-beta gene resulting in significant reduction of their GCR-alpha DNA binding capacity.
S8 1059-1206 Sentence denotes We conclude that increased expression of GCR-beta is cytokine inducible and may account for GC insensitivity in this common inflammatory condition.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 15-43 NP denotes glucocorticoid insensitivity
C3 73-101 NP denotes glucocorticoid receptor beta
C2 49-101 NP denotes increased expression of glucocorticoid receptor beta
C4 143-176 NP denotes glucocorticoid (GC) insensitivity
C5 288-304 NP denotes GC insensitivity
C6 399-411 NP denotes a second GCR
C7 420-428 NP denotes GCR-beta
C8 430-435 NP denotes which
C9 502-517 NP denotes the classic GCR
C10 526-535 NP denotes GCR-alpha
C11 579-600 NP denotes GC-insensitive asthma
C12 792-813 NP denotes GC-insensitive asthma
C14 883-890 NP denotes the GCR
C13 819-890 NP denotes cytokine-induced abnormalities in the DNA binding capability of the GCR
C15 892-911 NP denotes These abnormalities
C16 949-982 NP denotes cell lines with the GCR-beta gene
C17 1021-1026 NP denotes their
C19 1100-1108 NP denotes GCR-beta
C18 1076-1108 NP denotes increased expression of GCR-beta
R1 C4 C1 coref-ident glucocorticoid (GC) insensitivity,glucocorticoid insensitivity
R2 C5 C4 coref-ident GC insensitivity,glucocorticoid (GC) insensitivity
R3 C6 C3 coref-ident a second GCR,glucocorticoid receptor beta
R4 C7 C6 coref-ident GCR-beta,a second GCR
R5 C8 C7 coref-relat which,GCR-beta
R6 C10 C9 coref-ident GCR-alpha,the classic GCR
R7 C12 C11 coref-ident GC-insensitive asthma,GC-insensitive asthma
R8 C14 C7 coref-ident the GCR,GCR-beta
R9 C15 C13 coref-ident These abnormalities,cytokine-induced abnormalities in the DNA binding capability of the GCR
R10 C17 C16 coref-pron their,cell lines with the GCR-beta gene
R11 C19 C14 coref-ident GCR-beta,the GCR
R12 C18 C2 coref-ident increased expression of GCR-beta,increased expression of glucocorticoid receptor beta

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-29 lipid denotes glucocorticoid
T2 73-101 protein_molecule denotes glucocorticoid receptor beta
T3 111-141 other_name denotes chronic inflammatory disorders
T4 143-157 lipid denotes glucocorticoid
T5 159-161 lipid denotes GC
T6 288-304 other_name denotes GC insensitivity
T7 355-366 protein_family_or_group denotes GC receptor
T8 408-411 protein_family_or_group denotes GCR
T9 420-428 protein_molecule denotes GCR-beta
T10 450-453 lipid denotes GCs
T11 474-498 other_name denotes transactivating activity
T12 514-517 protein_family_or_group denotes GCR
T13 526-535 protein_molecule denotes GCR-alpha
T14 579-600 other_name denotes GC-insensitive asthma
T15 653-661 protein_molecule denotes GCR-beta
T16 686-702 tissue denotes peripheral blood
T17 708-731 multi_cell denotes GC-sensitive asthmatics
T18 735-750 multi_cell denotes normal controls
T19 778-786 multi_cell denotes patients
T20 792-813 other_name denotes GC-insensitive asthma
T21 857-879 other_name denotes DNA binding capability
T22 887-890 protein_family_or_group denotes GCR
T23 949-959 cell_line denotes cell lines
T24 969-977 protein_molecule denotes GCR-beta
T25 1027-1036 protein_molecule denotes GCR-alpha
T26 1100-1108 protein_molecule denotes GCR-beta
T27 1112-1120 protein_family_or_group denotes cytokine
T28 1151-1167 other_name denotes GC insensitivity
T29 1183-1205 other_name denotes inflammatory condition