> top > docs > PubMed:9343231 > annotations

PubMed:9343231 JSONTXT

Annnotations TAB JSON ListView MergeView

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 49-74 DNA denotes BcLF1 and BFRF3 promoters
T2 192-204 DNA denotes viral genome
T3 316-331 protein denotes binding factors
T4 611-641 DNA denotes late promoter-reporter fusions
T5 693-713 cell_line denotes tissue culture cells
T6 883-903 DNA denotes cis-active sequences
T7 1004-1040 DNA denotes viral immediate-early transactivator
T8 1042-1047 DNA denotes ZEBRA
T9 1143-1148 DNA denotes ZEBRA
T10 1242-1262 protein denotes viral DNA polymerase
T11 1432-1456 DNA denotes transcriptional template

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-115 Sentence denotes Late gene expression from the Epstein-Barr virus BcLF1 and BFRF3 promoters does not require DNA replication in cis.
S2 116-205 Sentence denotes Late gene expression follows and is dependent upon lytic replication of the viral genome.
S3 206-432 Sentence denotes Although experimental evidence is lacking, lytic viral DNA replication is believed to remove modifications or binding factors from the genome which serve to repress late gene expression during latency or the early lytic cycle.
S4 433-570 Sentence denotes We have developed a reporter assay to begin characterizing the mechanisms that regulate late gene expression in Epstein-Barr virus (EBV).
S5 571-772 Sentence denotes In this model system, the activities of late promoter-reporter fusions are measured following transient transfection into tissue culture cells expressing EBV during different stages of the lytic cycle.
S6 773-943 Sentence denotes This system faithfully recapitulates late expression patterns from the endogenous virus, implicating specific cis-active sequences in the control of late gene expression.
S7 944-1048 Sentence denotes In addition, these promoters respond only indirectly to the viral immediate-early transactivator, ZEBRA.
S8 1049-1170 Sentence denotes This indirect response is mediated by other viral or virally induced activities downstream of ZEBRA in the lytic cascade.
S9 1171-1406 Sentence denotes In this system, late gene expression is sensitive to inhibitors of the viral DNA polymerase such as phosphonoacetic acid, although the reporters lack a eukaryotic origin of replication and are not replicated under the assay conditions.
S10 1407-1658 Sentence denotes Thus, replication of the transcriptional template is not a prerequisite for expression with late kinetics, a finding inconsistent with the current models which posit a cis-active relationship between lytic EBV DNA replication and late gene expression.
S11 1659-1850 Sentence denotes Rather, analysis of this system has revealed a trans relationship between late gene expression and viral DNA replication and highlights the indirect and complex link between these two events.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 26-74 NP denotes the Epstein-Barr virus BcLF1 and BFRF3 promoters
C2 116-136 NP denotes Late gene expression
C4 188-204 NP denotes the viral genome
C3 167-204 NP denotes lytic replication of the viral genome
C5 249-276 NP denotes lytic viral DNA replication
C6 299-331 NP denotes modifications or binding factors
C7 337-347 NP denotes the genome
C8 348-353 NP denotes which
C9 371-391 NP denotes late gene expression
C10 451-467 NP denotes a reporter assay
C11 492-506 NP denotes the mechanisms
C12 507-511 NP denotes that
C13 521-541 NP denotes late gene expression
C14 545-569 NP denotes Epstein-Barr virus (EBV)
C15 574-591 NP denotes this model system
C16 725-728 NP denotes EBV
C17 773-784 NP denotes This system
C18 840-860 NP denotes the endogenous virus
C19 922-942 NP denotes late gene expression
C20 957-972 NP denotes these promoters
C21 1000-1040 NP denotes the viral immediate-early transactivator
C22 1042-1047 NP denotes ZEBRA
C23 1143-1148 NP denotes ZEBRA
C24 1174-1185 NP denotes this system
C25 1187-1207 NP denotes late gene expression
C26 1542-1560 NP denotes the current models
C27 1561-1566 NP denotes which
C28 1637-1657 NP denotes late gene expression
C29 1679-1690 NP denotes this system
C31 1733-1753 NP denotes late gene expression
C30 1733-1779 NP denotes late gene expression and viral DNA replication
C32 1833-1849 NP denotes these two events
R1 C5 C3 coref-ident lytic viral DNA replication,lytic replication of the viral genome
R2 C7 C4 coref-ident the genome,the viral genome
R3 C8 C6 coref-relat which,modifications or binding factors
R4 C9 C2 coref-ident late gene expression,Late gene expression
R5 C12 C11 coref-relat that,the mechanisms
R6 C15 C10 coref-ident this model system,a reporter assay
R7 C16 C14 coref-ident EBV,Epstein-Barr virus (EBV)
R8 C17 C15 coref-ident This system,this model system
R9 C18 C16 coref-ident the endogenous virus,EBV
R10 C19 C13 coref-ident late gene expression,late gene expression
R11 C20 C1 coref-ident these promoters,the Epstein-Barr virus BcLF1 and BFRF3 promoters
R12 C22 C21 coref-appos ZEBRA,the viral immediate-early transactivator
R13 C23 C21 coref-ident ZEBRA,the viral immediate-early transactivator
R14 C24 C17 coref-ident this system,This system
R15 C25 C19 coref-ident late gene expression,late gene expression
R16 C27 C26 coref-relat which,the current models
R17 C28 C25 coref-ident late gene expression,late gene expression
R18 C29 C24 coref-ident this system,this system
R19 C31 C28 coref-ident late gene expression,late gene expression
R20 C32 C30 coref-ident these two events,late gene expression and viral DNA replication

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-20 other_name denotes Late gene expression
T2 30-48 virus denotes Epstein-Barr virus
T3 92-107 other_name denotes DNA replication
T4 167-184 other_name denotes lytic replication
T5 192-204 DNA_family_or_group denotes viral genome
T6 249-276 other_name denotes lytic viral DNA replication
T7 316-331 protein_family_or_group denotes binding factors
T8 371-391 other_name denotes late gene expression
T9 399-406 other_name denotes latency
T10 414-431 other_name denotes early lytic cycle
T11 453-467 other_name denotes reporter assay
T12 521-541 other_name denotes late gene expression
T13 545-563 virus denotes Epstein-Barr virus
T14 565-568 virus denotes EBV
T15 611-641 DNA_family_or_group denotes late promoter-reporter fusions
T16 693-713 cell_line denotes tissue culture cells
T17 725-728 virus denotes EBV
T18 760-771 other_name denotes lytic cycle
T19 883-903 DNA_family_or_group denotes cis-active sequences
T20 922-942 other_name denotes late gene expression
T21 1004-1040 DNA_domain_or_region denotes viral immediate-early transactivator
T22 1042-1047 DNA_domain_or_region denotes ZEBRA
T23 1143-1148 DNA_domain_or_region denotes ZEBRA
T24 1156-1169 other_name denotes lytic cascade
T25 1187-1207 other_name denotes late gene expression
T26 1242-1262 protein_molecule denotes viral DNA polymerase
T27 1271-1291 other_organic_compound denotes phosphonoacetic acid
T28 1323-1340 other_name denotes eukaryotic origin
T29 1389-1405 other_name denotes assay conditions
T30 1432-1456 DNA_domain_or_region denotes transcriptional template
T31 1499-1512 other_name denotes late kinetics
T32 1575-1598 other_name denotes cis-active relationship
T33 1607-1612 other_name denotes lytic
T34 1613-1616 virus denotes EBV
T35 1637-1657 other_name denotes late gene expression
T36 1706-1724 other_name denotes trans relationship
T37 1733-1753 other_name denotes late gene expression
T38 1758-1779 other_name denotes viral DNA replication