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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-189 Sentence denotes Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
T2 190-466 Sentence denotes Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J.
T3 467-472 Sentence denotes Biol.
T4 473-478 Sentence denotes Chem.
T5 479-484 Sentence denotes 1995:
T6 485-489 Sentence denotes 270:
T7 490-497 Sentence denotes 10631).
T8 498-878 Sentence denotes Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
T9 879-1119 Sentence denotes Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
T10 1120-1272 Sentence denotes The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
T11 1273-1386 Sentence denotes PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
T12 1387-1561 Sentence denotes Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
T13 1562-1671 Sentence denotes Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
T14 1672-1853 Sentence denotes Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
T15 1854-2015 Sentence denotes Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.
T1 0-189 Sentence denotes Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
T2 190-466 Sentence denotes Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J.
T3 467-472 Sentence denotes Biol.
T4 473-478 Sentence denotes Chem.
T5 479-484 Sentence denotes 1995:
T6 485-489 Sentence denotes 270:
T7 490-497 Sentence denotes 10631).
T8 498-878 Sentence denotes Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
T9 879-1119 Sentence denotes Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
T10 1120-1272 Sentence denotes The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
T11 1273-1386 Sentence denotes PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
T12 1387-1561 Sentence denotes Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
T13 1562-1671 Sentence denotes Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
T14 1672-1853 Sentence denotes Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
T15 1854-2015 Sentence denotes Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-56 protein denotes endothelial cell surface adhesion molecules
T2 60-81 protein denotes tumor necrosis factor
T3 149-188 protein denotes nuclear transcription factor NF-kappa B
T4 245-273 protein denotes protein tyrosine phosphatase
T5 275-281 protein denotes PTPase
T6 316-337 protein denotes tumor necrosis factor
T7 339-342 protein denotes TNF
T8 371-410 protein denotes nuclear transcription factor NF-kappa B
T9 414-419 cell_line denotes ML-1a
T10 423-442 cell_line denotes monocytic cell line
T11 504-507 protein denotes TNF
T12 548-566 protein denotes adhesion molecules
T13 653-663 protein denotes NF-kappa B
T14 691-697 protein denotes PTPase
T15 716-719 protein denotes TNF
T16 742-782 protein denotes intracellular adhesion molecule (ICAM)-1
T17 784-824 protein denotes vascular cell adhesion molecule (VCAM)-1
T18 829-877 protein denotes endothelial leukocyte adhesion molecule (ELAM)-1
T19 884-889 cell_line denotes ML-1a
T20 891-933 cell_line denotes human dermal microvessel endothelial cells
T21 935-939 cell_line denotes MVEC
T22 954-957 protein denotes TNF
T23 992-1002 protein denotes NF-kappa B
T24 1112-1118 protein denotes PTPase
T25 1137-1143 protein denotes ICAM-1
T26 1145-1151 protein denotes VCAM-1
T27 1157-1163 protein denotes ELAM-1
T28 1167-1170 protein denotes TNF
T29 1174-1178 cell_line denotes MVEC
T30 1329-1332 protein denotes TNF
T31 1420-1426 protein denotes PTPase
T32 1476-1479 protein denotes TNF
T33 1490-1500 protein denotes NF-kappa B
T34 1543-1560 protein denotes adhesion proteins
T35 1624-1628 cell_line denotes MVEC
T36 1653-1659 protein denotes PTPase
T37 1718-1724 protein denotes PTPase
T38 1810-1845 protein denotes endothelial cell adhesion molecules
T39 1849-1852 protein denotes TNF
T40 1894-1900 protein denotes PTPase

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-189 Sentence denotes Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: role of the nuclear transcription factor NF-kappa B.
S2 190-497 Sentence denotes Recent studies from our laboratory have indicated that protein tyrosine phosphatase (PTPase) inhibitors can down-modulate the tumor necrosis factor (TNF)-mediated activation of the nuclear transcription factor NF-kappa B in ML-1a, a monocytic cell line (Singh and Aggarwal, J. Biol. Chem. 1995: 270: 10631).
S3 498-878 Sentence denotes Since TNF is one of the major inducers of various adhesion molecules in human endothelial cells and their expression is known to require the activation of NF-kappa B, we examined the effect of PTPase inhibitors on the TNF-mediated induction of intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1.
S4 879-1119 Sentence denotes Like ML-1a, human dermal microvessel endothelial cells (MVEC) treated with TNF rapidly activated (within 30 min) NF-kappa B; this effect was completely abolished by co-treatment with phenylarsine oxide (PAO), a specific inhibitor of PTPase.
S5 1120-1272 Sentence denotes The induction of ICAM-1, VCAM-1, and ELAM-1 by TNF in MVEC occurred within 6 h and was also completely down-regulated by PAO in a dose-dependent manner.
S6 1273-1386 Sentence denotes PAO was found to be effective even when added 3 h after TNF, suggesting a rapid mode of action of this inhibitor.
S7 1387-1561 Sentence denotes Besides PAO, other inhibitors of PTPase, including pervanadate and diamide, also blocked TNF-dependent NF-kappa B activation and induction of all the three adhesion proteins.
S8 1562-1671 Sentence denotes Consistent with these results, the attachment of monocytes to MVEC was also blocked by the PTPase inhibitors.
S9 1672-1853 Sentence denotes Thus, overall, our results demonstrate that a PTPase is involved either directly or indirectly in the pathway leading to the induction of endothelial cell adhesion molecules by TNF.
S10 1854-2015 Sentence denotes Because of their role in cell adhesion, PTPase may provide a novel target of drug development for treatment of inflammation, atherogenesis, and tumor metastasis.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 60-81 NP denotes tumor necrosis factor
C2 96-135 NP denotes protein tyrosine phosphatase inhibitors
C3 145-188 NP denotes the nuclear transcription factor NF-kappa B
C4 245-293 NP denotes protein tyrosine phosphatase (PTPase) inhibitors
C5 367-410 NP denotes the nuclear transcription factor NF-kappa B
C6 414-419 NP denotes ML-1a
C7 421-442 NP denotes a monocytic cell line
C8 504-507 NP denotes TNF
C9 540-593 NP denotes various adhesion molecules in human endothelial cells
C10 598-603 NP denotes their
C11 653-663 NP denotes NF-kappa B
C12 691-708 NP denotes PTPase inhibitors
C13 742-877 NP denotes intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1
C14 884-889 NP denotes ML-1a
C15 954-957 NP denotes TNF
C16 992-1003 NP denotes NF-kappa B;
C17 1062-1086 NP denotes phenylarsine oxide (PAO)
C19 1112-1118 NP denotes PTPase
C18 1088-1118 NP denotes a specific inhibitor of PTPase
C20 1137-1163 NP denotes ICAM-1, VCAM-1, and ELAM-1
C21 1174-1178 NP denotes MVEC
C22 1241-1244 NP denotes PAO
C23 1273-1276 NP denotes PAO
C24 1329-1332 NP denotes TNF
C25 1371-1385 NP denotes this inhibitor
C26 1395-1398 NP denotes PAO
C27 1420-1426 NP denotes PTPase
C28 1529-1560 NP denotes all the three adhesion proteins
C29 1624-1628 NP denotes MVEC
C30 1649-1670 NP denotes the PTPase inhibitors
C31 1716-1724 NP denotes a PTPase
C32 1849-1852 NP denotes TNF
C33 1865-1870 NP denotes their
C34 1894-1900 NP denotes PTPase
R1 C4 C2 coref-ident protein tyrosine phosphatase (PTPase) inhibitors,protein tyrosine phosphatase inhibitors
R2 C5 C3 coref-ident the nuclear transcription factor NF-kappa B,the nuclear transcription factor NF-kappa B
R3 C7 C6 coref-appos a monocytic cell line,ML-1a
R4 C8 C1 coref-ident TNF,tumor necrosis factor
R5 C10 C9 coref-pron their,various adhesion molecules in human endothelial cells
R6 C11 C5 coref-ident NF-kappa B,the nuclear transcription factor NF-kappa B
R7 C12 C4 coref-ident PTPase inhibitors,protein tyrosine phosphatase (PTPase) inhibitors
R8 C14 C6 coref-ident ML-1a,ML-1a
R9 C15 C8 coref-ident TNF,TNF
R10 C16 C11 coref-ident NF-kappa B;,NF-kappa B
R11 C18 C17 coref-appos a specific inhibitor of PTPase,phenylarsine oxide (PAO)
R12 C20 C13 coref-ident "ICAM-1, VCAM-1, and ELAM-1","intracellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and endothelial leukocyte adhesion molecule (ELAM)-1"
R13 C22 C17 coref-ident PAO,phenylarsine oxide (PAO)
R14 C23 C22 coref-ident PAO,PAO
R15 C24 C15 coref-ident TNF,TNF
R16 C25 C23 coref-ident this inhibitor,PAO
R17 C26 C25 coref-ident PAO,this inhibitor
R18 C27 C19 coref-ident PTPase,PTPase
R19 C28 C20 coref-ident all the three adhesion proteins,"ICAM-1, VCAM-1, and ELAM-1"
R20 C29 C21 coref-ident MVEC,MVEC
R21 C30 C12 coref-ident the PTPase inhibitors,PTPase inhibitors
R22 C31 C27 coref-ident a PTPase,PTPase
R23 C32 C24 coref-ident TNF,TNF
R24 C33 C31 coref-pron their,a PTPase
R25 C34 C31 coref-ident PTPase,a PTPase

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-56 protein_family_or_group denotes endothelial cell surface adhesion molecules
T2 60-81 protein_family_or_group denotes tumor necrosis factor
T3 104-112 amino_acid_monomer denotes tyrosine
T4 113-135 other_organic_compound denotes phosphatase inhibitors
T5 149-156 protein_complex denotes nuclear
T6 157-177 protein_family_or_group denotes transcription factor
T7 178-188 protein_complex denotes NF-kappa B
T8 245-273 protein_molecule denotes protein tyrosine phosphatase
T9 275-281 protein_molecule denotes PTPase
T10 316-337 protein_family_or_group denotes tumor necrosis factor
T11 339-342 protein_family_or_group denotes TNF
T12 371-410 protein_complex denotes nuclear transcription factor NF-kappa B
T13 414-419 cell_line denotes ML-1a
T14 423-442 cell_line denotes monocytic cell line
T15 504-507 protein_family_or_group denotes TNF
T16 548-566 protein_family_or_group denotes adhesion molecules
T17 653-663 protein_complex denotes NF-kappa B
T18 691-697 protein_family_or_group denotes PTPase
T19 716-719 protein_family_or_group denotes TNF
T20 742-782 protein_molecule denotes intracellular adhesion molecule (ICAM)-1
T21 784-824 protein_molecule denotes vascular cell adhesion molecule (VCAM)-1
T22 829-877 protein_molecule denotes endothelial leukocyte adhesion molecule (ELAM)-1
T23 884-889 cell_line denotes ML-1a
T24 891-933 cell_line denotes human dermal microvessel endothelial cells
T25 935-939 cell_line denotes MVEC
T26 954-957 protein_family_or_group denotes TNF
T27 992-1002 protein_complex denotes NF-kappa B
T28 1062-1080 other_organic_compound denotes phenylarsine oxide
T29 1082-1085 other_organic_compound denotes PAO
T30 1112-1118 protein_family_or_group denotes PTPase
T31 1137-1143 protein_molecule denotes ICAM-1
T32 1145-1151 protein_molecule denotes VCAM-1
T33 1157-1163 protein_molecule denotes ELAM-1
T34 1167-1170 protein_family_or_group denotes TNF
T35 1174-1178 cell_line denotes MVEC
T36 1241-1244 other_organic_compound denotes PAO
T37 1273-1276 other_organic_compound denotes PAO
T38 1329-1332 protein_family_or_group denotes TNF
T39 1395-1398 other_organic_compound denotes PAO
T40 1420-1426 protein_family_or_group denotes PTPase
T41 1438-1449 other_organic_compound denotes pervanadate
T42 1476-1479 protein_family_or_group denotes TNF
T43 1490-1500 protein_complex denotes NF-kappa B
T44 1543-1560 protein_family_or_group denotes adhesion proteins
T45 1624-1628 cell_line denotes MVEC
T46 1653-1659 protein_family_or_group denotes PTPase
T47 1718-1724 protein_family_or_group denotes PTPase
T48 1810-1826 protein_family_or_group denotes endothelial cell
T49 1827-1845 protein_family_or_group denotes adhesion molecules
T50 1849-1852 protein_family_or_group denotes TNF
T51 1879-1892 other_name denotes cell adhesion
T52 1894-1900 protein_family_or_group denotes PTPase
T53 1965-1977 other_name denotes inflammation
T54 1979-1992 other_name denotes atherogenesis
T55 1998-2014 other_name denotes tumor metastasis