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PubMed:9341193 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-223 Sentence denotes The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.
T2 224-492 Sentence denotes Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as one possible mechanism of cellular transformation by human T-cell leukemia virus type 1.
T3 493-643 Sentence denotes In previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive element 1 (TRE1), necessary for transactivation by Tax.
T4 644-784 Sentence denotes We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.
T5 785-903 Sentence denotes In the present work, we have investigated the mechanism(s) whereby Tax transactivates the c-sis/PDGF-B proto-oncogene.
T6 904-1091 Sentence denotes In vitro transcription assays showed that Tax was able to significantly increase the transcriptional activity of a template containing the -257 to +74 region of the c-sis/PDGF-B promoter.
T7 1092-1237 Sentence denotes Electrophoretic mobility shift assay analysis showed that Tax increased the DNA binding activity of both Sp1 and NGFI-A/Egr-1 using a TRE1 probe.
T8 1238-1378 Sentence denotes Analysis of Tax mutants showed that two mutants, IEXC29S and IEXL320G, were unable to significantly transactivate the c-sis/PDGF-B promoter.
T9 1379-1490 Sentence denotes Finally, co-immunoprecipitation analysis revealed that Tax is able to stably bind to both Sp1 and NGFI-A/Egr-1.
T10 1491-1683 Sentence denotes Interestingly, co-immunoprecipitation analysis also revealed that Tax mutant IEXC29S is unable to interact with NGFI-A/Egr-1, whereas Tax mutant IEXL320G is able to interact with NGFI-A/Egr-1.
T1 0-223 Sentence denotes The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.
T2 224-492 Sentence denotes Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as one possible mechanism of cellular transformation by human T-cell leukemia virus type 1.
T3 493-643 Sentence denotes In previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive element 1 (TRE1), necessary for transactivation by Tax.
T4 644-784 Sentence denotes We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.
T5 785-903 Sentence denotes In the present work, we have investigated the mechanism(s) whereby Tax transactivates the c-sis/PDGF-B proto-oncogene.
T6 904-1091 Sentence denotes In vitro transcription assays showed that Tax was able to significantly increase the transcriptional activity of a template containing the -257 to +74 region of the c-sis/PDGF-B promoter.
T7 1092-1237 Sentence denotes Electrophoretic mobility shift assay analysis showed that Tax increased the DNA binding activity of both Sp1 and NGFI-A/Egr-1 using a TRE1 probe.
T8 1238-1378 Sentence denotes Analysis of Tax mutants showed that two mutants, IEXC29S and IEXL320G, were unable to significantly transactivate the c-sis/PDGF-B promoter.
T9 1379-1490 Sentence denotes Finally, co-immunoprecipitation analysis revealed that Tax is able to stably bind to both Sp1 and NGFI-A/Egr-1.
T10 1491-1683 Sentence denotes Interestingly, co-immunoprecipitation analysis also revealed that Tax mutant IEXC29S is unable to interact with NGFI-A/Egr-1, whereas Tax mutant IEXL320G is able to interact with NGFI-A/Egr-1.

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 4-15 protein denotes tax protein
T2 90-137 DNA denotes c-sis/platelet-derived growth factor-B promoter
T3 168-201 protein denotes zinc finger transcription factors
T4 202-205 protein denotes Sp1
T5 210-222 protein denotes NGFI-A/Egr-1
T6 261-323 DNA denotes c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene
T7 331-342 protein denotes Tax protein
T8 550-571 DNA denotes c-sis/PDGF-B promoter
T9 573-597 DNA denotes Tax-responsive element 1
T10 599-603 DNA denotes TRE1
T11 639-642 protein denotes Tax
T12 663-666 protein denotes Sp1
T13 677-689 protein denotes NGFI-A/Egr-1
T14 697-734 protein denotes primary nuclear transcription factors
T15 746-750 DNA denotes TRE1
T16 765-768 protein denotes Tax
T17 852-855 protein denotes Tax
T18 875-902 DNA denotes c-sis/PDGF-B proto-oncogene
T19 946-949 protein denotes Tax
T20 1043-1061 DNA denotes -257 to +74 region
T21 1069-1090 DNA denotes c-sis/PDGF-B promoter
T22 1150-1153 protein denotes Tax
T23 1197-1200 protein denotes Sp1
T24 1205-1217 protein denotes NGFI-A/Egr-1
T25 1226-1236 DNA denotes TRE1 probe
T26 1250-1261 protein denotes Tax mutants
T27 1287-1294 protein denotes IEXC29S
T28 1299-1307 protein denotes IEXL320G
T29 1356-1377 DNA denotes c-sis/PDGF-B promoter
T30 1434-1437 protein denotes Tax
T31 1469-1472 protein denotes Sp1
T32 1477-1489 protein denotes NGFI-A/Egr-1
T33 1557-1560 protein denotes Tax
T34 1568-1575 protein denotes IEXC29S
T35 1603-1615 protein denotes NGFI-A/Egr-1
T36 1625-1628 protein denotes Tax
T37 1636-1644 protein denotes IEXL320G
T38 1670-1682 protein denotes NGFI-A/Egr-1

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-223 Sentence denotes The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1.
S2 224-492 Sentence denotes Transcriptional up-regulation of the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene by the Tax protein of human T-cell leukemia virus type 1 has been implicated as one possible mechanism of cellular transformation by human T-cell leukemia virus type 1.
S3 493-643 Sentence denotes In previous work, we identified an essential site in the c-sis/PDGF-B promoter, Tax-responsive element 1 (TRE1), necessary for transactivation by Tax.
S4 644-784 Sentence denotes We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.
S5 785-903 Sentence denotes In the present work, we have investigated the mechanism(s) whereby Tax transactivates the c-sis/PDGF-B proto-oncogene.
S6 904-1091 Sentence denotes In vitro transcription assays showed that Tax was able to significantly increase the transcriptional activity of a template containing the -257 to +74 region of the c-sis/PDGF-B promoter.
S7 1092-1237 Sentence denotes Electrophoretic mobility shift assay analysis showed that Tax increased the DNA binding activity of both Sp1 and NGFI-A/Egr-1 using a TRE1 probe.
S8 1238-1378 Sentence denotes Analysis of Tax mutants showed that two mutants, IEXC29S and IEXL320G, were unable to significantly transactivate the c-sis/PDGF-B promoter.
S9 1379-1490 Sentence denotes Finally, co-immunoprecipitation analysis revealed that Tax is able to stably bind to both Sp1 and NGFI-A/Egr-1.
S10 1491-1683 Sentence denotes Interestingly, co-immunoprecipitation analysis also revealed that Tax mutant IEXC29S is unable to interact with NGFI-A/Egr-1, whereas Tax mutant IEXL320G is able to interact with NGFI-A/Egr-1.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 19-53 NP denotes human T-cell leukemia virus type 1
C1 0-53 NP denotes The tax protein of human T-cell leukemia virus type 1
C3 86-137 NP denotes the c-sis/platelet-derived growth factor-B promoter
C4 257-323 NP denotes the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene
C6 346-380 NP denotes human T-cell leukemia virus type 1
C5 327-380 NP denotes the Tax protein of human T-cell leukemia virus type 1
C7 457-491 NP denotes human T-cell leukemia virus type 1
C9 546-571 NP denotes the c-sis/PDGF-B promoter
C8 525-571 NP denotes an essential site in the c-sis/PDGF-B promoter
C10 573-604 NP denotes Tax-responsive element 1 (TRE1)
C11 639-642 NP denotes Tax
C12 677-689 NP denotes NGFI-A/Egr-1
C14 746-750 NP denotes TRE1
C13 693-750 NP denotes the primary nuclear transcription factors binding to TRE1
C15 751-756 NP denotes which
C16 827-843 NP denotes the mechanism(s)
C17 844-851 NP denotes whereby
C18 852-855 NP denotes Tax
C19 871-902 NP denotes the c-sis/PDGF-B proto-oncogene
C20 946-949 NP denotes Tax
C21 1065-1090 NP denotes the c-sis/PDGF-B promoter
C22 1150-1153 NP denotes Tax
C23 1192-1217 NP denotes both Sp1 and NGFI-A/Egr-1
C24 1274-1285 NP denotes two mutants
C26 1287-1294 NP denotes IEXC29S
C27 1299-1307 NP denotes IEXL320G
C25 1287-1307 NP denotes IEXC29S and IEXL320G
C28 1352-1377 NP denotes the c-sis/PDGF-B promoter
C29 1388-1419 NP denotes co-immunoprecipitation analysis
C30 1434-1437 NP denotes Tax
C31 1464-1489 NP denotes both Sp1 and NGFI-A/Egr-1
C32 1506-1537 NP denotes co-immunoprecipitation analysis
C33 1557-1575 NP denotes Tax mutant IEXC29S
C34 1603-1615 NP denotes NGFI-A/Egr-1
C35 1625-1644 NP denotes Tax mutant IEXL320G
C36 1670-1682 NP denotes NGFI-A/Egr-1
R1 C6 C2 coref-ident human T-cell leukemia virus type 1,human T-cell leukemia virus type 1
R2 C5 C1 coref-ident the Tax protein of human T-cell leukemia virus type 1,The tax protein of human T-cell leukemia virus type 1
R3 C7 C6 coref-ident human T-cell leukemia virus type 1,human T-cell leukemia virus type 1
R4 C9 C3 coref-ident the c-sis/PDGF-B promoter,the c-sis/platelet-derived growth factor-B promoter
R5 C10 C8 coref-appos Tax-responsive element 1 (TRE1),an essential site in the c-sis/PDGF-B promoter
R6 C14 C8 coref-ident TRE1,an essential site in the c-sis/PDGF-B promoter
R7 C15 C13 coref-relat which,the primary nuclear transcription factors binding to TRE1
R8 C17 C16 coref-relat whereby,the mechanism(s)
R9 C18 C11 coref-ident Tax,Tax
R10 C19 C4 coref-ident the c-sis/PDGF-B proto-oncogene,the c-sis/platelet-derived growth factor-B (PDGF-B) proto-oncogene
R11 C20 C18 coref-ident Tax,Tax
R12 C21 C9 coref-ident the c-sis/PDGF-B promoter,the c-sis/PDGF-B promoter
R13 C22 C20 coref-ident Tax,Tax
R14 C25 C24 coref-appos IEXC29S and IEXL320G,two mutants
R15 C28 C21 coref-ident the c-sis/PDGF-B promoter,the c-sis/PDGF-B promoter
R16 C30 C22 coref-ident Tax,Tax
R17 C31 C23 coref-ident both Sp1 and NGFI-A/Egr-1,both Sp1 and NGFI-A/Egr-1
R18 C32 C29 coref-ident co-immunoprecipitation analysis,co-immunoprecipitation analysis
R19 C33 C26 coref-ident Tax mutant IEXC29S,IEXC29S
R20 C34 C12 coref-ident NGFI-A/Egr-1,NGFI-A/Egr-1
R21 C35 C27 coref-ident Tax mutant IEXL320G,IEXL320G
R22 C36 C34 coref-ident NGFI-A/Egr-1,NGFI-A/Egr-1

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 4-15 protein_molecule denotes tax protein
T2 19-53 virus denotes human T-cell leukemia virus type 1
T3 90-137 DNA_domain_or_region denotes c-sis/platelet-derived growth factor-B promoter
T4 168-179 protein_family_or_group denotes zinc finger
T5 180-201 protein_family_or_group denotes transcription factors
T6 202-205 protein_molecule denotes Sp1
T7 210-222 protein_molecule denotes NGFI-A/Egr-1
T8 261-299 protein_molecule denotes c-sis/platelet-derived growth factor-B
T9 301-307 protein_molecule denotes PDGF-B
T10 331-342 protein_molecule denotes Tax protein
T11 346-380 virus denotes human T-cell leukemia virus type 1
T12 430-453 other_name denotes cellular transformation
T13 457-491 virus denotes human T-cell leukemia virus type 1
T14 550-562 protein_molecule denotes c-sis/PDGF-B
T15 573-597 DNA_domain_or_region denotes Tax-responsive element 1
T16 599-603 DNA_domain_or_region denotes TRE1
T17 639-642 protein_molecule denotes Tax
T18 663-666 protein_molecule denotes Sp1
T19 677-689 protein_molecule denotes NGFI-A/Egr-1
T20 697-712 protein_family_or_group denotes primary nuclear
T21 713-734 protein_family_or_group denotes transcription factors
T22 746-750 DNA_domain_or_region denotes TRE1
T23 765-768 protein_molecule denotes Tax
T24 852-855 protein_molecule denotes Tax
T25 875-887 protein_molecule denotes c-sis/PDGF-B
T26 904-933 other_name denotes In vitro transcription assays
T27 946-949 protein_molecule denotes Tax
T28 989-1013 other_name denotes transcriptional activity
T29 1043-1061 DNA_domain_or_region denotes -257 to +74 region
T30 1069-1081 protein_molecule denotes c-sis/PDGF-B
T31 1150-1153 protein_molecule denotes Tax
T32 1197-1200 protein_molecule denotes Sp1
T33 1205-1217 protein_molecule denotes NGFI-A/Egr-1
T34 1226-1230 DNA_domain_or_region denotes TRE1
T35 1250-1253 protein_molecule denotes Tax
T36 1287-1294 protein_molecule denotes IEXC29S
T37 1299-1307 protein_molecule denotes IEXL320G
T38 1356-1368 protein_molecule denotes c-sis/PDGF-B
T39 1434-1437 protein_molecule denotes Tax
T40 1469-1472 protein_molecule denotes Sp1
T41 1477-1489 protein_molecule denotes NGFI-A/Egr-1
T42 1506-1537 other_name denotes co-immunoprecipitation analysis
T43 1557-1560 protein_molecule denotes Tax
T44 1568-1575 protein_molecule denotes IEXC29S
T45 1603-1615 protein_molecule denotes NGFI-A/Egr-1
T46 1625-1628 protein_molecule denotes Tax
T47 1636-1644 protein_molecule denotes IEXL320G
T48 1670-1682 protein_molecule denotes NGFI-A/Egr-1

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 32-40 Phenotype denotes leukemia HP:0001909
T2 359-367 Phenotype denotes leukemia HP:0001909
T3 470-478 Phenotype denotes leukemia HP:0001909

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 25-40 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T2 352-367 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525
T3 463-478 Disease denotes T-cell leukemia http://purl.obolibrary.org/obo/MONDO_0005525

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 19-24 OrganismTaxon denotes human 9606
T2 346-351 OrganismTaxon denotes human 9606
T3 457-462 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 25-31 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T2 96-104 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T3 173-179 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T4 267-275 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T5 352-358 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T6 463-469 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 25-31 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T2 96-104 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T3 267-275 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T4 352-358 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T5 463-469 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084